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Agenda

UPDATE：February 15, 2008
Note: The agenda might be subject to change without notice.

Summit 1: Computational Methods and Informatics Tools to Move Therapeutic Projects Forward

• Informatics in biomarkers and translation research
• Systems biology/research applied in drug discovery and development
• Predictive models from discovery to clinic
• IT infrastructure and integrative informatics

Summit 2: The Next Wave of Antibody-Based Therapies

• Trends in antibody discovery, engineering and development - antibodies, next generation antibodies, antibody alternatives
• Protein & antibody therapeutics trials and updates
• Trends in licensing, M&A and partnering deals in protein and antibody R&D

Summit 3: Global Drug Development and Partnering Strategies

• Global partnering strategies & case studies
• Venture outlook in pharma/biotech for next 5 years
• War stories and deal strategies
• Partnering between pharma and academia

Summit 4: Imaging in Drug Development

• Applications of imaging in early / late stage drug development
• Picking the right imaging modality for your disease area
• Imaging quantification and analysis
• Image data collection

1. Transforming Technologies

• Transforming Technologies Applied in Early Discovery
  • Applications of novel technologies to discover new targets and new approaches that will quickly bring a compound from hit to lead
  • RNAi and siRNA
  • Phenotypic compound profiling/Phenotypic screening
  • High content, functional assays allowing broader access to targets and cell-lines
  • Information systems and analysis software
  • Nucleic Acid Technologies
  • Cell-based and stem-cell based technologies
• Transforming Technologies Applied in Preclinical and Early Clinical (Phase 1 and 2)
  • Molecular Imaging (MRI, PET, CT)
  • DNA Chips and SNP Technologies
  • Biomarkers
  • Micordosing/Exploratory IND approaches
  • Translational medicine services, technologies and integration
  • Circulating Tumor Cells for cancer

2. Cancer Drug Discovery and Development

• Cancer Stem Cells
• Cancer Vaccines
• Emerging Cancer Therapeutics
• Cancer Biologics
• Translational Research Approaches to Move Oncology Drugs Quickly to POC

3. Cardio-Metabolic Disease Drug Discovery and Development

• Link between LDL and Heart Disease
• Link between Biomarkers and Clinical Outcomes
• Targets in the Clinic - CETP, PPAR, GLP-1
• New Directions & Applications from Bench to Clinic
• Novel Targets and New Discoveries

4. Anti-Infective Drug Discovery and Development

• Current Status/Risk of Community-acquired Pathogens Such as MRSA and Others
• Role of Government and Granting Agencies in the Development of New Antibiotics?
• Do Pathogenic Agents Pose a Real Bioterrorist Threat?
• Emerging Therapeutics for Infectious Diseases
• Translational Research Approaches to Move Anti-Infectives Quickly to POC

5. Neurodegenerative Disease Drug Discovery and Development

• Interaction between Neuroinflammation and Neurodegeneration
• Interaction of Metabolism and Nervous System
• Neuroimmunology - Interplay between nervous system and immune system
• Vaccines, stem cells and other neuroprotective therapies
• Biomarkers, imaging and animal models

6. Inflammation as an Underlying Mechanism Across Multiple Diseases

• Translating Inflammation Targets and Pathways to Clinical Efficacy
• Emerging Therapeutics and Strategies
• Toll Receptors in Inflammation

7. Orphan Diseases: Fast-Tracking Orphan Drugs and Scientific Advances

• Regulatory Update on Orphan Disease Drug Approvals
• Changing Face of Foundations in support of Orphan Disease R&D
• Development & Clinical Updates on Orphan Drugs

8. The Next Generation of Therapeutics: Emerging Biologics, Stem Cells and RNAi

• Next Generation Antibody Therapeutics and Antibody Fragments
• Stem Cell and RNAi Therapeutics Progressing to the Clinic
• Proteins, Peptides and other Targets for Drug Development

9. Translational Medicine/Research: Comparing Different Strategies for Different Diseases

• Translational Medicine: Animal Models and Predictive Assays
  • Case Studies of Translational Medicine Used to Confirm Target Engagement
  • Biomarkers to Demonstrate Target/Compound Interaction, Pharmacodynamic Activity and Safety
  • Patient Stratification & Drug Response
  • Case Studies of Disease and Disease Modification
• Translational Medicine: Clinical Biomarker Validation and Imaging
  • Analytical - accuracy, precision and linearity
  • Clinical - efficacy and safety
• Translational Medicine: Case Studies
• Translational Medicine: Validating Discovery Biomarkers from Preclinical to POC

10. R&D Strategies

• TR&D Strategies: Building a Robust Pipeline
  • Building innovative platforms to boost your pipeline through partnering, licensing and acquisitions with pharma, biotech and academia
  • Patent expiration, portfolio and lifecycle management for small molecules, antibodies, antibody alternatives and vaccines
  • Integrating internal & external research on diverse portfolios
  • Possible Panel: "What is the future of the pharmaceutical industry...new round of acquisitions, large pharma mergers what will the business model of the future be?
• TR&D Strategy: Creating a Culture of Innovation
  • Creating and Sustaining an Innovation Environment
  • Reorganizing for cross-functional experiences and efficiency
  • Managing innovation across countries and territories

• Workshop A: Effectively Implementing Exploratory INDs and Biomarker Studies
• Workshop B: Preclinical and Clinical Applications of Circulating Tumor Cells in Cancer Drug Development
• Workshop C: Immunogenicity Prediction for New Biologics

Note: The agenda might be subject to change without notice.