Pipeline 1 covers the latest trends and challenges in biologics formulation and development with a focus on: improving time to market via early formulations and characterization, overcoming aggregation challenges, utilizing enabling analytical methodologies, managing tech transfer challenges, using experimental design and high-throughput principles, scaling up from R&D to production, and overcoming challenges in lyophilization, spray drying, and foam drying. The conferences feature novel case studies, in-depth scientific presentations, and poster sessions. Time has been designated for interactive discussions with industry thought leaders during the BuzZ Sessions and panels. It is perfect for those new to the field, as well as those who require in-depth analysis of the latest trends, technologies, and techniques.

Pipeline 2 features the nitty gritty ‘hands-on’ strategies for Bioprocessing from purification and recovery to scaling up and achieving large-scale manufacturing. Membrane Proteins, an important protein class, are highlighted through case studies and protocols addressing the unique challenges for extraction, expression and purification. Proteins’ distinct properties and demands along with the underlying technologies that support revelations will be interwoven throughout Pipeline 2 as part of the quest to ‘tame’ proteins for use in bioprocesses.

Pipeline 3 reveals where the development of protein therapeutics stands today. Protein leaders discuss their efforts of designing and testing protein-based biomedicines, including the most successful therapeutic, monoclonal antibodies. Recombinant proteins and the engineered fusion proteins show promise for new therapies with enhanced specificity and moderated immunogenicity. The final piece of the pipeline addresses the innovative approaches that draw on peptides to overcome intrinsic challenges in pursuit of the next-generation protein therapeutics.

Although most scientists would argue that protein expression science is mature, challenges still remain.  New expression methods and technologies continue to provide improved protein yield, stability, and structure. Pipeline 4 continues the strong tradition of addressing research and development throughout the protein expression pipeline from initial steps, to efficient expression system design.  Case studies will shed light on the manufacture of modified gene cells as well as cell clone characterization and purification of proteins from high producers.  In its 13th year, Protein Expression, the backbone for PepTalk, provides the foundation for other therapeutic production pipelines.