Newsletter: The Diabetes Report TOC

R&D Update
- Study validates tight blood sugar control
- Generex commences new Oral-lyn studies
- Brain plays key role in diabetes therapy
- Emory receives grant for advancing islet transplantation in Type I diabetes
- Study finds more fractures and lower BMD in premenopausal females with Type I diabetes

R&D Update
- Rosiglitazone added early to SU therapy effective in older Type II diabetes patients; combined with fenofibrate improves metabolic parameters; may improve memory in males
- Generex' Metformin Gum shows similar PK profile to tablets
- Hh protein shown to block fat production and produce more bone
- CIDR to use Illumina whole-genome genotyping solutions to support study for Type II diabetes collaboration
- deCODE discovers major genetic risk factor for Type II diabetes
- PhytoMedical plans to accelerate development of cinnamon-derived compound for Type II diabetes
- Extensive analysis confirms Lipitor' s safety
- Positive results in Phase IIb dose-ranging study of MannKind' s Technosphere insulin in Type II diabetes
- New evidence for increased CV mortality risk associated with SUs
- Novartis to file Galvus in 2006
- ConjuChem' s PC-DAC:Exendin-4 advancing into Phase I/II trial
- Metaglidasen as effective as rosiglitazone and pioglitazone in preclinical study
- Takeda' s SYR-322 in Phase III stage; ATL-962 enters Phase II studies
Product News
- GSK post-marketing reports warn of macular oedema with rosiglitazone products
- Sanwa releases Seibule
- Ajinomoto and Astellas file Fastic/Starsis sNDA for Type II diabetes
- Ranbaxy launches Volix
Agreement News
- BI returns tesofensine rights to NeuroSearch

R&D Update
- UNSW produces new SC line
- Generex granted US patent in connection with RapidMist device
- Geron reports improved production method for hESC-derived islet cells
Product News
- Generex receives scheduling for Oral-lyn pre-NDS meeting
- EC and FDA approve Exubera for treatment of Type I and II diabetes
Agreement News
- PS closes diabetes partnership
- HGS receives milestone payment from GSK for GSK716155
- Vitro and PhosphoSolutions enter SC proteomics collaboration
- Pfizer acquires rights to Exubera from sanofi-aventis
- ChemGenex and Merck enter diabetes agreement

R&D Update
- UVa scientists to search for new treatments for DNP
- Ranirestat improves peripheral nerve function in DSP
- King initiates Phase II trial evaluating MRE0094 in diabetic foot ulcers
- Mosapride may improve appetite loss associated with diabetes
- Corautus and CSEMC to study VEGF-2 for CLI
- Molecular link between hyperglycaemia and retinopathy identified
- Sangamo plans Phase II trial of SB-509 in DN
- Discovery of glucagon secretion mechanism may lead to improved therapies for diabetics
- Quigley' s SAB strongly supports next stage of development
- Regranex gel confirmed as effective treatment for diabetic neuropathic foot ulcers

The Diabetes Report