The Dynamic Media, Sera and Reagent Market in the Cell Culture Industry

TABLE OF CONTENTS

• STUDY OBJECTIVES
• REASONS FOR DOING THIS STUDY
• CONTRIBUTIONS TO THE STUDY
• SCOPE OF THE STUDY
• METHODOLOGY
• INFORMATION SOURCES
• ANALYST'S CREDENTIALS
• RELATED BCC PUBLICATIONS
• BCC ON-LINE SERVICES
• INTERNET

• Summary Table:
  U.S. SALES OF MEDIA, SERA AND REAGENTS IN CELL CULTURE, THROUGH 2008 ($ MILLIONS)
• Summary Figure:
  U.S. SALES OF MEDIA, SERA AND REAGENTS IN CELL CULTURE, 2001-2008 ($ MILLIONS)

• DEFINITIONS
• MAIN TYPES OF CELL CULTURES
  • PRIMARY CULTURES
  • CONTINUOUS CULTURES
  • CULTURE MORPHOLOGY
• CELL CULTURE MEDIA
• Table 1 THE MAIN TYPES OF BASAL MEDIA FOR MAMMALIAN CELLS
  • BASIC CONSTITUENTS OF MEDIA
  • Inorganic Salts
• Table 2 THE ROLES OF DIFFERENT INORGANIC NUTRIENTS
  • Buffering Systems
  • Energy Source
  • Amino Acids
  • Vitamins
  • Proteins and Peptides
  • Fatty Acids and Lipids
  • Trace Elements
  • Antibiotics
  • Serum
  • STORAGE OF MEDIA
  • SERUM
• Table 3 LIST OF TYPES OF SERA
  • CONSTITUENTS OF SERUM
  • Growth Factors
  • Albumin
  • Transferrin
  • Protease Inhibitors
• Table 4 NORMAL RANGE OF CONCENTRATION OF SERUM CONSTITUENTS
  • SOURCES OF SERUM
  • Fetal Bovine Serum (FBS)
  • Calf Serum
  • Serum Types
  • Other Animal Sera
  • Other Animal Sera (Continued)
  • POTENTIAL PROBLEMS WITH SERUM
  • Lack of Reproducibility
  • Contamination
  • Cost and Availability
  • Effect on Downstream Processing
  • SERUM SELECTION
  • SERUM FREE MEDIUM
    • SERUM FREE MEDIUM COMPOSITION/CONSTITUENTS
    • Basal Medium
    • Lipids
    • Buffers
    • Trace Elements
    • Mechanical Stabilizers and Adhesion Factors
• Table 5 SERUM-CONTAINING MEDIUM VS. SERUM-FREE MEDIUM
  • REAGENTS
    • BIOLOGICAL RESPONSE MODIFIERS
    • Growth Factors
    • Types of Growth Factors
• Table 6 LIST OF SELECTED GROWTH FACTORS
• Table 6 (CONTINUED)
  • Cytokines, Lymphokines and Interleukins
• Table 7 CLASSIFICATION OF CYTOKINES, LYMPHOKINES AND INTERLUKINS BASED ON STRUCTURE
• Table 8 LIST OF SELECTED LYMPHOKINES AND CYTOKINES
• Table 9 LIST OF SELECTED INTERLEUKINS
  • Chemokines
• Table 10 LIST OF SELECTED CHEMOKINES
  • Attachment Factors
• Table 11 LIST OF SELECTED ATTACHMENT FACTORS
  • Serum Replacers or Serum Extenders
• Table 12 SELECTED REAGENTS THAT SUPPLEMENT REDUCED SERUM OR SERUM-FREE MEDIA

• FDA AND EDQM REGULATIONS
• REGULATIONS FOR IMPORTS AND EXPORTS
  • U.S.
  • EC
  • PREVENTION OF BSE IN PAST AND FUTURE BY THE FDA
  • Prevention of BSE in Past and Future by the FDA (Continued)
  • PRODUCTS APPROVED BY THE FDA IN 2002 AND 2003
• Table 13 PRODUCTS APPROVED BY FDA IN 2002 AND 2003
• Table 13 (CONTINUED)
• Table 13 (CONTINUED)

• MEDIA
  • MARKET LEADERS OF MEDIA USED IN CELL CULTURE
• Table 14 MAJOR SUPPLIERS OF MEDIA USED IN CELL CULTURE
• Table 14 (CONTINUED)
• Table 14 (CONTINUED)
• Table 14 (CONTINUED)
• Table 15 ESTIMATED MARKET SHARE FOR U.S. SUPPLIERS AND MANUFACTURERS OF MEDIA, 2002
• Figure 1 ESTIMATED MARKET SHARE FOR U.S. SUPPLIERS AND MANUFACTURERS OF MEDIA, 2002
  • MARKET LEADERS OF SERA USED IN CELL CULTURE
• Table 16 MAJOR SUPPLIERS OF SERA USED IN CELL CULTURE
• Table 16 (CONTINUED)
• Table 17 ESTIMATED MARKET SHARE FOR U.S. SUPPLIERS AND MANUFACTURERS OF SERA, 2002
• Figure 2 ESTIMATED MARKET SHARE FOR U.S. SUPPLIERS AND MANUFACTURERS OF SERA, 2002 (%)
  • MARKET LEADERS OF REAGENTS USED IN CELL CULTURE
• Table 18 MAJOR SUPPLIERS OF REAGENTS USED IN CELL CULTURE
• Table 18 (CONTINUED)
• Table 18 (CONTINUED)
• Table 18 (CONTINUED)
  • FACTORS INFLUENCING DEMAND AND USE
    • NEED BY THE END CONSUMER (BIOTECH INDUSTRY)
    • DEMAND FOR SPECIALTY MEDIA
    • FACTORS AFFECTING PRODUCTION OF SERUM
  • QUALITY CONTROL
    • Reagents and Materials
    • Cell Lines
    • Other Sources of Contamination
    • Antibiotics
  • PRICES
• Table 19 PRICES OF CLASSICAL MEDIA, 1999-2003 ($/L)
• Table 20 PRICES OF SERA, 2003 ($/100ML)

• NEW DEVELOPMENTS
• Table 21 NEW PRODUCTS BY SIGMA ALDRICH IN 2003
• Table 21 (CONTINUED)
• Table 22 NEW PRODUCTS BY IRVINE SCIENTIFIC IN 2003
• Table 22 (CONTINUED)
  • MARKET BY PRODUCT TYPE
    • MEDIA
• Table 23 U.S. SALES OF MEDIA USED IN CELL CULTURE (SERUM FREE AND SERUM REQUIRING), THROUGH 2008 ($ MILLIONS)
• Figure 3 U.S. SALES OF MEDIA USED IN CELL CULTURE (SERUM FREE AND SERUM REQUIRING), 2001-2008 ($ MILLIONS)
• Table 24 U.S. SALES OF MEDIA USED IN CELL CULTURE (LIQUID AND POWDER), THROUGH 2008 ($ MILLIONS)
• Figure 4 U.S. SALES OF MEDIA USED IN CELL CULTURE (LIQUID AND POWDER), 2001-2008 ($ MILLIONS)
  • SERA
• Table 25 U.S. SALES OF SERA USED IN CELL CULTURE BY TYPE, THROUGH 2008 ($ MILLIONS)
• Figure 5 U.S. SALES OF SERA USED IN CELL CULTURE BY TYPE, 2001-2008 ($ MILLIONS)
  • REAGENTS
• Table 26 U.S. SALES OF REAGENTS USED IN CELL CULTURE, THROUGH 2008 ($ MILLIONS)
• Figure 6 U.S. SALES OF REAGENTS USED IN CELL CULTURE, 2001-2008 ($ MILLIONS)

• PATENTS BY PRODUCT
• Table 27 NUMBER OF PATENTS FOR MEDIA, SERA AND THE REAGENTS USED IN CELL CULTURES IN EACH YEAR (1998-2002)
• Figure 7 NUMBER OF PATENTS FOR MEDIA, SERA AND THE REAGENTS USED IN CELL CULTURES IN EACH YEAR (1998-2002)
• Table 28 SIGNIFICANT PATENTS FOR MEDIA USED IN CELL CULTURE, 1998-2002
• Table 28 (CONTINUED)
• Table 29 PATENTS FOR MEDIA USED IN CELL CULTURE, 2003
• Table 30 SIGNIFICANT PATENTS FOR SERA USED IN CELL CULTURE, 1998-2002
• Table 30 (CONTINUED)
• Table 31 PATENTS FOR SERA USED IN CELL CULTURE, 2003
• Table 32 SIGNIFICANT PATENTS FOR REAGENTS USED IN CELL CULTURE, 1998-2002
• Table 33 PRODUCT-RELATED PATENT BREAKDOWN, 1998-2003
• Figure 8 PRODUCT-RELATED PATENT BREAKDOWN, 1998-2003
  • PATENTS BY COMPANY
• Table 34 PATENTS BY QUALITY BIOLOGICAL, 1998-2003
• Table 35 PATENTS BY IRVINE SCIENTIFIC, 1998-2003
• Table 36 PATENTS BY INVITROGEN, 1998-2003
• Table 37 PATENTS BY LIFE TECHNOLOGIES, 1998-2003
• Table 38 PATENTS BY BECTON DICKINSON, 1998-2003
  • TRENDS BY EMPHASIS
• Table 39 SHARES OF PATENTS ISSUED BY EMPHASIS, 1998-2003
• Figure 9 SHARES OF PATENTS ISSUED BY EMPHASIS, 1998-2003
  • PATENTS BY COUNTRY
• Table 40 U.S. PATENTS BY COUNTRY, 1998-2003
• Figure 10 U.S. PATENTS BY COUNTRY, 1998-2003
• Table 41 TRENDS OF PATENTS ISSUED BY COUNTRY, 1998-2003
• Figure 11 TRENDS OF PATENTS ISSUED BY COUNTRY, 1998-2003
  • PATENTS BY ASSIGNEE
• Table 42 SHARES OF U.S. PATENTS BY ASSIGNEE, 1998-2003
• Figure 12 SHARES OF U.S. PATENTS BY ASSIGNEE, 1998-2003

• RESEARCH SEGMENT
• Table 43 U.S. EXPENDITURE OF MEDIA, SERA AND REAGENTS IN RESEARCH SEGMENT, THROUGH 2008 ($ MILLIONS)
• Figure 13 U.S. EXPENDITURE OF MEDIA, SERA AND REAGENTS IN RESEARCH SEGMENT, 2001-2008 ($ MILLIONS)
  • PRODUCTION SEGMENT
• Table 44 U.S. SALES OF MEDIA, SERA AND REAGENTS IN PRODUCTION SEGMENT, THROUGH 2008 ($ MILLIONS)
• Figure 14 U.S. SALES OF MEDIA, SERA AND REAGENTS IN PRODUCTION SEGMENT, 2001-2008 ($ MILLIONS)
  • CONTRACT SEGMENT
• Table 45 U.S. SALES OF MEDIA, SERA AND REAGENTS IN CONTRACT SEGMENT, THROUGH 2008 ($ MILLIONS)
• Figure 15 U.S. SALES OF MEDIA, SERA AND REAGENTS IN CONTRACT SEGMENT, 2001-2008 ($ MILLIONS)
  • OTHER SEGMENTS
• Table 46 U.S. SALES OF MEDIA, SERA AND REAGENTS IN OTHER SEGMENTS, THROUGH 2008 ($ MILLIONS)
• Figure 16 U.S. SALES OF MEDIA, SERA AND REAGENTS IN OTHER SEGMENTS, 2001-2008 ($ MILLIONS)
  • NEW AND IMPROVED USES

• LATIN AMERICA
• Table 47 LATIN AMERICAN SALES OF MEDIA, SERA AND REAGENTS IN CELL CULTURE, THROUGH 2008 ($ MILLIONS)
• Figure 17 SALES OF MEDIA, SERA AND REAGENTS IN CELL CULTURE IN LATIN AMERICA, 2001-2008 ($ MILLIONS)
  • EUROPE
• Table 48 EUROPEAN SALES OF MEDIA, SERA AND REAGENTS IN CELL CULTURE, THROUGH 2008 ($ MILLIONS)
• Figure 18 SALES OF MEDIA, SERA AND REAGENTS IN CELL CULTURE IN EUROPE, 2001-2008 ($ MILLIONS)
  • ASIA
    • ISRAEL
    • INDIA
    • JAPAN
    • CHINA
• Table 49 ASIAN SALES OF MEDIA, SERA AND REAGENTS IN CELL CULTURE, THROUGH 2008 ($ MILLIONS)
• Figure 19 SALES OF MEDIA, SERA AND REAGENTS IN CELL CULTURE IN ASIA, 2001-2008 ($ MILLIONS)
  • CANADA
• Table 50 CANADIAN SALES OF MEDIA, SERA AND REAGENTS IN CELL CULTURE, THROUGH 2008 ($ MILLIONS)
• Figure 20 SALES OF MEDIA, SERA AND REAGENTS IN CELL CULTURE IN CANADA, 2001-2008 ($ MILLIONS)
  • OTHERS AND GLOBAL SALES BY REGION
• Table 51 WORLDWIDE SALES OF MEDIA, SERA AND REAGENTS IN CELL CULTURE BY REGION, THROUGH 2008 ($ MILLIONS)
• Figure 21 WORLDWIDE SALES OF MEDIA, SERA AND REAGENTS IN CELL CULTURE BY REGION, 2001-2008 ($ MILLIONS)
• Table 52 WORLDWIDE MARKET SEGMENT OF MEDIA, SERA AND REAGENTS IN CELL CULTURE, 2002 (%)
• Figure 22 WORLDWIDE MARKET SEGMENTATION OF MEDIA, SERA AND REAGENTS IN CELL CULTURE, 2002 (%)

• ADVANCED BIOTECHNOLOGIES, INC. (ABI)
• ABGENIX INC.
• ATLANTA BIOLOGICALS, INC.
• ATHENAES/ BIOLOGICAL RESEARCH FACULTY & FACILITY, INC. (BRFF)
• BETCON DICKINSON CO. (BD)
• BIOGEN, INC.
• BIOVAIL CORPORATION
• BIORECLAMATION INC.
• BIOSOURCE INTERNATIONAL, INC.
• CAMBREX CORPORATION
• CELL APPLICATIONS, INC.
• CENTOCOR INC.
• GENENTECH, INC.
• HYCLONE
• ICN BIOMEDICALS, INC.
• IRVINE SCIENTIFIC
• INVITROGEN CORPORATION
• JRH BIOSCIENCES INC.
• MEDIATECH, INC.
• MEDIMMUNE, INC.
• PEPROTECH, INC.
• PROTEIN DESIGN LABS
• QUALITY BIOLOGICAL INC.
• R&D SYSTEMS INC.
• ROCHE APPLIED SCIENCE
• SIGMA ALDRICH
• SEROLOGICALS CORPORATION
• SPECIALITY MEDIA INC.
• SCHERING-PLOUGH CORPORATION
• UNITED STATES BIOLOGICAL (U.S. BIOLOGICAL)

• GLOSSARY
  • GLOSSARY (CONTINUED)

LIST OF TABLES

Summary Table:
U.S. SALES OF MEDIA, SERA AND REAGENTS IN CELL CULTURE, THROUGH 2008 ($ MILLIONS)

Table 1 THE MAIN TYPES OF BASAL MEDIA FOR MAMMALIAN CELLS

Table 2 THE ROLES OF DIFFERENT INORGANIC NUTRIENTS

Table 3 LIST OF TYPES OF SERA

Table 4 NORMAL RANGE OF CONCENTRATION OF SERUM CONSTITUENTS

Table 5 SERUM-CONTAINING MEDIUM VS. SERUM-FREE MEDIUM

Table 6 LIST OF SELECTED GROWTH FACTORS

Table 7 CLASSIFICATION OF CYTOKINES, LYMPHOKINES AND INTERLUKINS BASED ON STRUCTURE

Table 8 LIST OF SELECTED LYMPHOKINES AND CYTOKINES

Table 9 LIST OF SELECTED INTERLEUKINS

Table 10 LIST OF SELECTED CHEMOKINES

Table 11 LIST OF SELECTED ATTACHMENT FACTORS

Table 12 SELECTED REAGENTS THAT SUPPLEMENT REDUCED SERUM OR SERUM-FREE MEDIA

Table 13 PRODUCTS APPROVED BY FDA IN 2002 AND 2003

Table 14 MAJOR SUPPLIERS OF MEDIA USED IN CELL CULTURE

Table 15 ESTIMATED MARKET SHARE FOR U.S. SUPPLIERS AND MANUFACTURERS OF MEDIA, 2002

Table 16 MAJOR SUPPLIERS OF SERA USED IN CELL CULTURE

Table 17 ESTIMATED MARKET SHARE FOR U.S. SUPPLIERS AND MANUFACTURERS OF SERA, 2002

Table 18 MAJOR SUPPLIERS OF REAGENTS USED IN CELL CULTURE

Table 19 PRICES OF CLASSICAL MEDIA, 1999-2003 ($/L)

Table 20 PRICES OF SERA, 2003 ($/100ML)

Table 21 NEW PRODUCTS BY SIGMA ALDRICH IN 2003

Table 22 NEW PRODUCTS BY IRVINE SCIENTIFIC IN 2003

Table 23 U.S. SALES OF MEDIA USED IN CELL CULTURE (SERUM FREE AND SERUM REQUIRING), THROUGH 2008 ($ MILLIONS)

Table 24 U.S. SALES OF MEDIA USED IN CELL CULTURE (LIQUID AND POWDER), THROUGH 2008 ($ MILLIONS)

Table 25 U.S. SALES OF SERA USED IN CELL CULTURE BY TYPE, THROUGH 2008 ($ MILLIONS)

Table 26 U.S. SALES OF REAGENTS USED IN CELL CULTURE, THROUGH 2008 ($ MILLIONS)

Table 27 NUMBER OF PATENTS FOR MEDIA, SERA AND THE REAGENTS USED IN CELL CULTURES IN EACH YEAR (1998-2002)

Table 28 SIGNIFICANT PATENTS FOR MEDIA USED IN CELL CULTURE, 1998-2002

Table 29 PATENTS FOR MEDIA USED IN CELL CULTURE, 2003

Table 30 SIGNIFICANT PATENTS FOR SERA USED IN CELL CULTURE, 1998-2002

Table 31 PATENTS FOR SERA USED IN CELL CULTURE, 2003

Table 32 SIGNIFICANT PATENTS FOR REAGENTS USED IN CELL CULTURE, 1998-2002

Table 33 PRODUCT-RELATED PATENT BREAKDOWN, 1998-2003

Table 34 PATENTS BY QUALITY BIOLOGICAL, 1998-2003

Table 35 PATENTS BY IRVINE SCIENTIFIC, 1998-2003

Table 36 PATENTS BY INVITROGEN, 1998-2003

Table 37 PATENTS BY LIFE TECHNOLOGIES, 1998-2003

Table 38 PATENTS BY BECTON DICKINSON, 1998-2003

Table 39 SHARES OF PATENTS ISSUED BY EMPHASIS, 1998-2003

Table 40 U.S. PATENTS BY COUNTRY, 1998-2003

Table 41 TRENDS OF PATENTS ISSUED BY COUNTRY, 1998-2003

Table 42 SHARES OF U.S. PATENTS BY ASSIGNEE, 1998-2003

Table 43 U.S. EXPENDITURE OF MEDIA, SERA AND REAGENTS USED IN CELL CULTURE IN RESEARCH SEGMENT, THROUGH 2008 ($ MILLIONS)

Table 44 U.S. SALES OF MEDIA, SERA AND REAGENTS USED IN CELL CULTURE IN PRODUCTION SEGMENT, THROUGH 2008 ($ MILLIONS)

Table 45 U.S. SALES OF MEDIA, SERA AND REAGENTS USED IN CELL CULTURE IN CONTRACT SEGMENT, THROUGH 2008 ($ MILLIONS)

Table 46 U.S. SALES OF MEDIA, SERA AND REAGENTS USED IN CELL CULTURE IN OTHER SEGMENTS, THROUGH 2008 ($ MILLIONS)

Table 47 LATIN AMERICAN SALES OF MEDIA, SERA AND REAGENTS USED IN CELL CULTURE, THROUGH 2008 ($ MILLIONS)

Table 48 EUROPEAN SALES OF MEDIA, SERA AND REAGENTS USED IN CELL CULTURE, THROUGH 2008 ($ MILLIONS)

Table 49 ASIAN SALES OF MEDIA, SERA AND REAGENTS USED IN CELL CULTURE, THROUGH 2008 ($ MILLIONS)

Table 50 CANADIAN SALES OF MEDIA, SERA AND REAGENTS USED IN CELL CULTURE, THROUGH 2008 ($ MILLIONS)

Table 51 WORLDWIDE SALES OF MEDIA, SERA AND REAGENTS USED IN CELL CULTURE BY REGION, THROUGH 2008 ($ MILLIONS)

Table 52 WORLDWIDE MARKET SEGMENT OF MEDIA, SERA AND REAGENTS USED IN CELL CULTURE, 2002 (%)  

LIST OF FIGURES

Summary Figure:
U.S. SALES OF MEDIA, SERA AND REAGENTS IN CELL CULTURE, 2001-2008 ($ MILLIONS)

Figure 1 ESTIMATED MARKET SHARE FOR U.S. SUPPLIERS AND MANUFACTURERS OF MEDIA, 2002

Figure 2 ESTIMATED MARKET SHARE FOR U.S. SUPPLIERS AND MANUFACTURERS OF SERA, 2002 (%)

Figure 3 U.S. SALES OF MEDIA (SERUM FREE AND SERUM REQUIRING), 2001-2008 ($ MILLIONS)

Figure 4 U.S. SALES OF MEDIA (LIQUID AND POWDER), 2001-2008 ($ MILLIONS)

Figure 5 U.S. SALES OF SERA BY TYPE, 2001-2008 ($ MILLIONS)

Figure 6 U.S. SALES OF REAGENTS (USED IN CELL CULTURE), 2001-2008 ($ MILLIONS)

Figure 7 NO. OF PATENTS FOR MEDIA, SERA AND THE REAGENTS USED IN CELL CULTURES IN EACH YEAR (1998-2002)

Figure 8 PRODUCT-RELATED PATENT BREAKDOWN, 1998-2003

Figure 9 SHARES OF PATENTS ISSUED BY EMPHASIS, 1998-2003

Figure 10 U.S. PATENTS BY COUNTRY, 1998-2003

Figure 11 TRENDS OF PATENTS ISSUED BY COUNTRY, 1998-2003

Figure 12 SHARES OF U.S. PATENTS BY ASSIGNEE, 1998-2003

Figure 13 U.S. EXPENDITURE OF MEDIA, SERA AND REAGENTS USED IN CELL CULTURE IN RESEARCH SEGMENT, 2001-2008 ($ MILLIONS)

Figure 14 U.S. SALES OF MEDIA, SERA AND REAGENTS USED IN CELL CULTURE IN PRODUCTION SEGMENT, 2001-2008 ($ MILLIONS)

Figure 15 U.S. SALES OF MEDIA, SERA AND REAGENTS USED IN CELL CULTURE IN CONTRACT SEGMENT, 2001-2008 ($ MILLIONS)

Figure 16 U.S. SALES OF MEDIA, SERA AND REAGENTS USED IN CELL CULTURE IN OTHER SEGMENTS, 2001-2008 ($ MILLIONS)

Figure 17 SALES OF MEDIA, SERA AND REAGENTS USED IN CELL CULTURE IN LATIN AMERICA, 2001-2008 ($ MILLIONS)

Figure 18 SALES OF MEDIA, SERA AND REAGENTS USED IN CELL CULTURE IN EUROPE, 2001-2008 ($ MILLIONS)

Figure 19 SALES OF MEDIA, SERA AND REAGENTS USED IN CELL CULTURE IN ASIA, 2001-2008 ($ MILLIONS)

Figure 20 SALES OF MEDIA, SERA AND REAGENTS USED IN CELL CULTURE IN CANADA, 2001-2008 ($ MILLIONS)

Figure 21 WORLDWIDE SALES OF MEDIA, SERA AND REAGENTS USED IN CELL CULTURE BY REGION, 2001-2008 ($ MILLIONS)

Figure 22 WORLDWIDE MARKET SEGMENTATION OF MEDIA, SERA AND REAGENTS USED IN CELL CULTURE, 2002 (%)