DNA Microarrays and Their Materials

TABLE OF CONTENTS

INTRODUCTION

• STUDY GOALS AND OBJECTIVES
• REASONS FOR DOING THIS STUDY
• CONTRIBUTION OF THE STUDY
• SCOPE AND FORMAT
• METHODOLOGY AND INFORMATION SOURCES
• AUTHOR'S CREDENTIALS
• RELATED PUBLICATIONS
• BCC ONLINE SERVICES
• DISCLAIMER

SUMMARY

• Summary Table:
  U.S. MARKETS FOR DNA MICROARRAYS AND MICROARRAY MATERIALS, THROUGH 2007 ($ MILLIONS)
• Summary Figure:
  U.S. MARKETS FOR DNA MICROARRAYS AND MICROARRAY MATERIALS, 2002 AND 2007 ($ MILLIONS)

INDUSTRY STRUCTURE

• INTRODUCTION
  • INTRODUCTION (CONTINUED)
• MICROARRAYS AND MICROFLUIDICS DEVICES
  • PRODUCERS OF DNA BIOCHIPS AND MICROARRAYS: PHOTOLITHOGRAPHIC CHIPS AND GLASS ARRAYS
  • Photolithographic Microarrays
  • Affymetrix Substrates
  • Affymetrix Biomolecules
  • Sequence Information of Affymetrix Biomolecules
  • Affymetrix Marker Molecules
  • Overall Production Costs
  • Photolithographic Microarray Developers
  • Photolithographic Microarray Processors
• Table 1 FIRMS OFFERING AFFYMETRIX SLIDE PROCESSING
  • THE GLASS ARRAY INDUSTRY
  • A Brief History of Glass Microarrays
  • Spotted and Unspotted Glass Arrays
  • Spotted and Unspotted Glass Arrays (Continued)
  • Spotted Arrays
• Table 2 SPOTTED DNA MICROARRAY MANUFACTURERS, 2002
  • Unspotted Arrays
  • Unspotted Arrays (Continued)
• Table 3 VENDORS OF SUPPLIES AND EQUIPMENT TO THE UNSPOTTED MICROARRAY MARKET
  • Microarray Production by Volume: High-volume Producers
• Table 4 HIGH-VOLUME DNA MICROARRAY PRODUCERS (GLASS AND PHOTOLITHOGRAPHIC), 2002
  • The Low-volume Microarray Industry
• Table 5 MICROARRAY PRODUCTION ON A VOLUME BASIS, 2002 AND 2007 (%)
  • Licensing in the Microarray Industry
  • A Brief History of Licensing in the Microarray Industry
  • Licensing Involving Fluorophores
  • Effects of Licensing on the U.S. Industry
• Table 6 EFFECTS OF LICENSING ON THE DNA MICROARRAY INDUSTRY
  • Barrier to Foreign Competition
  • Barriers to Entry of New Technology
  • Decreased Competition
  • Intellectual Property Involving Biomolecules
• Table 7 METHODS FOR HANDLING INTELLECTUAL PROPERTY (IP) IN MICROARRAY AND BIOCHIP PRODUCTION
  • Sequence Information Producers
  • Costs
  • Litigation Possibilities
  • Overall Use
  • THE PROTEIN CHIP INDUSTRY
• Table 8 PROTEIN MICROARRAY PRODUCERS
• Table 9 PROTEIN PRODUCERS OF BIOCHIPS, BY TYPE
  • THE MICROFLUIDICS CHIP INDUSTRY
• Table 10 FIRMS IN THE MICROFLUIDICS INDUSTRY
  • MATERIALS FOR MICROARRAYS AND MICROFLUIDICS DEVICES
    • MATERIALS FOR MICROARRAYS .. (CONTINUED)
    • BIOCHIP AND MICROARRAY SUBSTRATES
    • Glass Substrates
• Table 11 GLASS AND POLYMER USE IN SUBSTRATES, 2002 AND 2007 (%)
  • Unspotted Substrate Producers
• Table 12 SUPPLIERS OF UNSPOTTED GLASS SUBSTRATES FOR BIOCHIPS, 2002
  • The Spotted Glass Substrate Industry
  • History of the Agreement Between Amersham and Surmodics
  • Polymer Substrates
• Table 13 SUPPLIERS OF POLYMER SUBSTRATES FOR BIOCHIPS, 2002
  • Silicon Substrates
  • BIOMOLECULES
  • DNA Producers
  • DNA Oligomers
• Table 14 CAPTIVE AND OPEN PRODUCTION OF DNA OLIGOMERS FOR MICROARRAYS, 2002 AND 2007
  • Open Production of DNA Oligomers in Glass Arrays
  • A Brief History of DNA Oligomer Production
• Table 15 OLIGOMERIC DNA PRODUCERS, 2002
  • Oligo Pricing
  • Purified Oligomers
  • Oligomer Modifications
  • Production of cDNA in the Glass Array Industry
• Table 16 COMMERCIAL PRODUCERS OF CLONED DNA FOR MICROARRAYS
• Table 17 CAPTIVE VS. OPEN cDNA PRODUCTION
  • MARKER MOLECULES
• Table 18 DNA LABEL SUPPLIERS, 2002
  • Fluorophore Labeling Types
  • Direct Label Producers
• Table 19 DIRECT DNA LABEL PRODUCERS
  • Indirect Label Producers
• Table 20 INDIRECT DNA LABEL PRODUCERS

• AFFYMETRIX, INC.
• GENISPHERE, INC.
• XENOPORE CORP.
• SURMODICS
• IDT
• ENZO LIFE SCIENCES, INC.
• ICONIX PHARMACEUTICALS, INC.
• INCYTE CORP.
• AGILENT TECHNOLOGIES
• AMERSHAM BIOSCIENCES
• PERKINELMER
• QIAGEN GMBH
• SIGMA-GENOSYS
• BD BIOSCIENCES CLONTECH
• CORNING, INC.
• GENICON SCIENCES CORP.

TECHNOLOGY OVERVIEW

• WHAT IS A BIOCHIP?
• STATIC BIOCHIPS
  • WHAT A STATIC BIOCHIP IS
• Table 21 STATIC BIOCHIP COMPONENTS
  • Substrates
  • Probe Molecules
  • Marker Molecules
  • WHAT A DNA MICROARRAY DOES
  • What a DNA Microarray Does (Continued)
  • Quantification Using Microarrays
  • The Larger Gene Expression Picture
  • The Larger Gene Expression Picture (Continued)
  • The Larger Gene Expression Picture (Continued)
  • The Larger Gene Expression Picture (Continued)
  • Microarray Design
• Table 22 KEY CHALLENGES IN DESIGNING MICROARRAY PROBES
  • Base Pair Mismatches
  • Poor Binding
  • Hybridization
  • Variable Signal Strengths
  • Interpretation of Microarrays
  • Intramicroarray Variability
  • Intermicroarray Variability
  • Variations in Analysis
  • Challenges to Microarray Materials
• Table 23 CHALLENGES TO MATERIALS USED IN MICROARRAYS
  • Substrates
  • Probes
  • Marker Molecules
  • DNA Microarray Performance Requirements
• Table 24 DNA MICROARRAY REQUIREMENTS
  • Firm Tethering
  • Unhindered Binding
  • Using Larger DNA Molecules
  • No Cross-contamination
  • Unreactive Surface
  • Current DNA Microarrays
  • PHOTOLITHOGRAPHY TECHNOLOGY
  • Photolithography Technology (Continued)
  • The Incomplete Reaction Problem
  • Probe Design
  • Development Trends
  • GLASS ARRAYS
  • Amersham's Coating Technology
  • Agilent Technology
  • Probe Technology
  • COMPARISON OF INKJET AND PHOTOLITHOGRAPHIC TECHNOLOGY
• Table 25 COMPARISON OF PHOTOLITHOGRAPHIC AND INKJET BIOCHIP PRODUCTION TECHNOLOGIES
  • Production Rates
  • Requires Masks
  • Adaptability
  • Cross-contamination
  • Feature Size
  • Probe Accessibility
  • Probe Purity
  • Overall Performance
  • Market Acceptance
  • PROTEIN MICROARRAYS
• Table 26 CHALLENGES IN DETECTING PROTEINS
  • Difficult to Detect
  • Complex in Formation
  • Lack of Binding
  • Posttranslational Modification
  • Costs
  • Competing Technologies
  • Summary
  • MATERIALS TECHNOLOGY
    • SUBSTRATES
    • A Brief History of Substrate Development
• Table 27 COMPARISON OF POROUS AND NONPOROUS SUBSTRATES
  • Materials
  • Coatings
  • Control of Spot Size
  • Diffusion Mechanisms
  • Glass and Polymer Substrates
• Table 28 COMPARISON OF POLYMER AND GLASS SUBSTRATES FOR BIOCHIPS AND ARRAYS
  • High-throughput Applicability
  • Can Be Used with Photolithography or Inkjet?
  • Surface Smoothness and Machinability
  • Easily Coated
  • Types of Coatings
  • The Importance of Coatings
  • Relevance of Coatings in the Courtroom
  • Glass Coating Technology for Substrates
  • UV Coatings
  • Covalent Coatings
• Table 29 COMPARISON OF UV AND COVALENT COATINGS FOR SUBSTRATES
  • Utility with Production Technologies
  • Free Radicals
  • Monolayers
  • Spacer Requirements
  • Patents
  • Markets
  • PROBE TECHNOLOGY
• Table 30 PROBE REQUIREMENTS
  • Selectivity
  • Tight Binding
  • Ease of Manufacture
  • cDNA Technology
• Table 31 PROBLEMS WITH PCR
  • Time Consuming
  • Breakdown
  • Accuracy
  • Expensive
  • Sensitivity
  • Selectivity
  • MARKER TECHNOLOGY
• Table 32 COMPARISON OF DETECTOR TECHNOLOGY
  • Accuracy
  • Sensitivity
  • Ease of Use
  • Challenges in Labeling DNA Microarrays
• Table 33 CHALLENGES IN THE MICROARRAY LABELING PROCESS
  • Specific Binding
  • Must Fluoresce or Signal in Proportion to Binding
  • Must Not Hinder Hybridization
  • Must Be Stable
  • Must Emit a Clean Signal
  • MICROFLUIDICS TECHNOLOGY
• Table 34 COMPARISON OF STATIC AND DYNAMIC BIOCHIPS AND ARRAYS
  • USE
  • FLOW
  • SUBSTRATES
  • APPLICATIONS
  • EASE OF USE
  • Ease of Use (Continued)

PRODUCTS

• INTRODUCTION
• THE OVERALL BIOCHIP MARKET
• Table 35 MARKETS FOR DNA AND PROTEIN MICROARRAYS AND MICROFLUIDICS DEVICES, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
• Figure 1 MARKETS FOR DNA AND PROTEIN MICROARRAYS AND MICROFLUIDICS DEVICES, 2002 AND 2007 ($ MILLIONS)
  • THE OVERALL BIOCHIP MARKET (CONTINUED)
  • DNA MICROARRAYS
• Table 36 PHOTOLITHOGRAPHY AND GLASS MICROARRAY MARKETS, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
• Figure 2 PHOTOLITHOGRAPHY AND GLASS MICROARRAY MARKETS, 2002, 2003 AND 2007 ($ MILLIONS)
  • DNA GLASS ARRAYS
• Table 37 SPOTTED AND UNSPOTTED GLASS ARRAY MARKETS, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
• Figure 3 SPOTTED AND UNSPOTTED GLASS ARRAY MARKETS, 2002, 2003 AND 2007 ($ MILLIONS)
  • Industry Trends
  • Industry Trends (Continued)
• Table 38 COMPARISON OF PRESPOTTED AND UNSPOTTED MICROARRAYS
  • Ease of Use
  • Production Methodology
  • Costs
  • Unspotted Arrays by Market
• Table 39 UNSPOTTED GLASS MICROARRAYS IN INDUSTRY AND ACADEMIA, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
• Figure 4 UNSPOTTED GLASS MICROARRAYS IN INDUSTRY AND ACADEMIA, 2002, 2003 AND 2007 ($ MILLIONS)
  • Microarrays by Type
• Table 40 GLASS MICROARRAYS BY TYPE: cDNA AND OLIGO, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
• Figure 5 GLASS MICROARRAYS BY TYPE: cDNA AND OLIGO, 2002, 2003 AND 2007 ($ MILLIONS)
  • CDNA and Oligo Microarrays by Market
• Table 41 cDNA AND OLIGO GLASS MICROARRAYS IN INDUSTRY, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
• Figure 6 cDNA AND OLIGO GLASS MICROARRAYS IN INDUSTRY, 2002, 2003 AND 2007 ($ MILLIONS)
• Table 42 cDNA AND OLIGO GLASS MICROARRAYS USED IN ACADEMIC RESEARCH, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
• Figure 7 cDNA AND OLIGO GLASS MICROARRAYS USED IN ACADEMIC RESEARCH, 2002, 2003 AND 2007 ($ MILLIONS)
  • MATERIALS USED IN MICROARRAYS
• Table 43 MATERIALS USED IN DNA MICROARRAYS, THROUGH 2007 ($ MILLIONS)
• Figure 8 MATERIALS USED IN DNA MICROARRAYS, 2002 AND 2007 ($ MILLIONS)
  • SUBSTRATES
  • Coated and Uncoated Substrates
• Table 44 GLASS SUBSTRATES BY COATING, AS USED IN GLASS ARRAYS, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
• Figure 9 GLASS SUBSTRATES BY COATING, AS USED IN GLASS ARRAYS, 2002 AND 2007 ($ MILLIONS)
  • Glass Substrates by Coating Type
• Table 45 GLASS SUBSTRATES BY COATING, AS USED IN GLASS ARRAYS, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
• Figure 10 GLASS SUBSTRATES BY COATING, AS USED IN GLASS ARRAYS, 2002 AND 2007 ($ MILLIONS)
• Table 46 GLASS SUBSTRATES BY COATING TYPE, 2002 AND 2007 (%)
  • BIOMOLECULES
  • DNA Probes by Type
  • CDNA
  • CDNA by Markets: Pharmaceutical
  • Academic Markets
• Table 47 MARKETS FOR cDNA IN GLASS MICROARRAYS, THROUGH 2007 ($ MILLIONS)
• Figure 11 MARKETS FOR cDNA IN GLASS MICROARRAYS, 2002, 2003 AND 2007 ($ MILLIONS)
  • Oligomeric DNA
  • Oligomeric DNA by Production Methodology
• Table 48 COMPARISON OF IN SITU AND INDEPENDENTLY SYNTHESIZED DNA OLIGOMERS
  • Production Technology
  • Oligomer Length
  • Accuracy and Quality Control
  • Cross-contamination
  • Production Costs
• Table 49 MARKETS FOR DNA OLIGOMERS AND AMIDITES IN DNA MICROARRAYS, THROUGH 2007 ($ MILLIONS)
  • Protein Probes
  • MARKER MOLECULES
• Table 50 COMPARISON OF DIRECT AND INDIRECT LABELING
• Table 51 DIRECT AND INDIRECT LABELING, 2002, 2003 AND 2007 (%)
  • Marker Molecules by Technology
• Table 52 COMPARISON OF VARIOUS MARKER MOLECULE TECHNOLOGIES
  • Stability
  • Instrumentation
  • Costs
• Table 53 MARKER MOLECULE MARKETS, THROUGH 2007 ($ MILLIONS)

MARKET APPLICATIONS

• INTRODUCTION
• DNA MICROARRAY MARKETS
• Table 54 INDUSTRIAL AND ACADEMIC MICROARRAY MARKETS, THROUGH 2007 (UNITS AND $ THOUSANDS)
  • MICROARRAY APPLICATIONS
• Table 55 COMPARISON OF THREE PROPOSED MICROARRAY APPLICATIONS: EXPRESSION PROFILING, DIAGNOSIS AND SNP DETECTION
  • Current Use
  • Technology Developments
  • Diagnostics
  • Theoretical Underpinnings of Microarray Applications
  • Expression Profiling
  • SNPs
  • Diagnostics
  • THE ACADEMIC RESEARCH MARKET
    • MICROARRAY PRODUCTION IN ACADEMIA
• Table 56 REASONS FOR CORE FACILITIES
  • Microarray Production in Academia (Continued)
  • Microarray Production in Academia (Continued)
  • Numbers of Core Facilities
• Table 57 ACADEMIC MARKETS FOR MICROARRAYS (INCLUDING PROCESSING COSTS), THROUGH 2007 (UNITS AND $ THOUSANDS)
  • Pricing of Arrays in Academia
  • Array Costs
• Table 58 BREAKDOWN OF COSTS FOR RUNNING A GLASS ARRAY IN ACADEMIA
  • Substrate/Oligomer Costs
  • Processing Costs
  • Amplification
  • Hybridization
  • DNA Synthesis Kit
  • Marker Molecules
  • Photolithographic
  • Glass Arrays
  • MICROARRAY FUNDING
  • The Catch-22 of NIH Funding
  • INDUSTRIAL MARKET APPLICATIONS
    • TYPES OF MICROARRAYS USED BY INDUSTRY: GLASS AND PHOTOLITHOGRAPHIC ARRAYS
• Table 59 INDUSTRIAL MARKETS FOR MICROARRAYS (INCLUDING PROCESSING COSTS), THROUGH 2007 (UNITS AND DOLLARS IN THOUSANDS)
  • Pricing of Microarrays Used in Industry
  • Photolithographic Arrays
  • Glass Arrays
  • Processing Costs
  • Trends in Microarray Use
  • Trends in Microarray Use (Continued)

 LIST OF TABLES

Summary Table:
U.S. MARKETS FOR DNA MICROARRAYS AND MICROARRAY MATERIALS, THROUGH 2007 ($ MILLIONS)

Table 1 FIRMS OFFERING AFFYMETRIX SLIDE PROCESSING

Table 2 SPOTTED DNA MICROARRAY MANUFACTURERS, 2002

Table 3 VENDORS OF SUPPLIES AND EQUIPMENT TO THE UNSPOTTED MICROARRAY MARKET

Table 4 HIGH-VOLUME DNA MICROARRAY PRODUCERS (GLASS AND PHOTOLITHOGRAPHIC), 2002

Table 5 MICROARRAY PRODUCTION ON A VOLUME BASIS, 2002 AND 2007 (%)

Table 6 EFFECTS OF LICENSING ON THE DNA MICROARRAY INDUSTRY

Table 7 METHODS FOR HANDLING INTELLECTUAL PROPERTY (IP) IN MICROARRAY AND BIOCHIP PRODUCTION

Table 8 PROTEIN MICROARRAY PRODUCERS

Table 9 PROTEIN PRODUCERS OF BIOCHIPS, BY TYPE

Table 10 FIRMS IN THE MICROFLUIDICS INDUSTRY

Table 11 GLASS AND POLYMER USE IN SUBSTRATES, 2002 AND 2007 (%)

Table 12 SUPPLIERS OF UNSPOTTED GLASS SUBSTRATES FOR BIOCHIPS, 2002

Table 13 SUPPLIERS OF POLYMER SUBSTRATES FOR BIOCHIPS, 2002

Table 14 CAPTIVE AND OPEN PRODUCTION OF DNA OLIGOMERS FOR MICROARRAYS, 2002 AND 2007

Table 15 OLIGOMERIC DNA PRODUCERS, 2002

Table 16 COMMERCIAL PRODUCERS OF CLONED DNA FOR MICROARRAYS

Table 17 CAPTIVE VS. OPEN cDNA PRODUCTION

Table 18 DNA LABEL SUPPLIERS, 2002

Table 19 DIRECT DNA LABEL PRODUCERS

Table 20 INDIRECT DNA LABEL PRODUCERS

Table 21 STATIC BIOCHIP COMPONENTS

Table 22 KEY CHALLENGES IN DESIGNING MICROARRAY PROBES

Table 23 CHALLENGES TO MATERIALS USED IN MICROARRAYS

Table 24 DNA MICROARRAY REQUIREMENTS

Table 25 COMPARISON OF PHOTOLITHOGRAPHIC AND INKJET BIOCHIP PRODUCTION TECHNOLOGIES

Table 26 CHALLENGES IN DETECTING PROTEINS

Table 27 COMPARISON OF POROUS AND NONPOROUS SUBSTRATES

Table 28 COMPARISON OF POLYMER AND GLASS SUBSTRATES FOR BIOCHIPS AND ARRAYS

Table 29 COMPARISON OF UV AND COVALENT COATINGS FOR SUBSTRATES

Table 30 PROBE REQUIREMENTS

Table 31 PROBLEMS WITH PCR

Table 32 COMPARISON OF DETECTOR TECHNOLOGY

Table 33 CHALLENGES IN THE MICROARRAY LABELING PROCESS

Table 34 COMPARISON OF STATIC AND DYNAMIC BIOCHIPS AND ARRAYS

Table 35 MARKETS FOR DNA AND PROTEIN MICROARRAYS AND MICROFLUIDICS DEVICES, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)

Table 36 PHOTOLITHOGRAPHY AND GLASS MICROARRAY MARKETS, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)

Table 37 SPOTTED AND UNSPOTTED GLASS ARRAY MARKETS, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)

Table 38 COMPARISON OF PRESPOTTED AND UNSPOTTED MICROARRAYS

Table 39 UNSPOTTED GLASS MICROARRAYS IN INDUSTRY AND ACADEMIA, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)

Table 40 GLASS MICROARRAYS BY TYPE: cDNA AND OLIGO, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)

Table 41 cDNA AND OLIGO GLASS MICROARRAYS IN INDUSTRY, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)

Table 42 cDNA AND OLIGO GLASS MICROARRAYS USED IN ACADEMIC RESEARCH, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)

Table 43 MATERIALS USED IN DNA MICROARRAYS, THROUGH 2007 ($ MILLIONS)

Table 44 GLASS SUBSTRATES BY COATING, AS USED IN GLASS ARRAYS, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)

Table 45 GLASS SUBSTRATES BY COATING, AS USED IN GLASS ARRAYS, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)

Table 46 GLASS SUBSTRATES BY COATING TYPE, 2002 AND 2007 (%)

Table 47 MARKETS FOR cDNA IN GLASS MICROARRAYS, THROUGH 2007 ($ MILLIONS)

Table 48 COMPARISON OF IN SITU AND INDEPENDENTLY SYNTHESIZED DNA OLIGOMERS

Table 49 MARKETS FOR DNA OLIGOMERS AND AMIDITES IN DNA MICROARRAYS, THROUGH 2007 ($ MILLIONS)

Table 50 COMPARISON OF DIRECT AND INDIRECT LABELING

Table 51 DIRECT AND INDIRECT LABELING, 2002, 2003 AND 2007 (%)

Table 52 COMPARISON OF VARIOUS MARKER MOLECULE TECHNOLOGIES

Table 53 MARKER MOLECULE MARKETS, THROUGH 2007 ($ MILLIONS)

Table 54 INDUSTRIAL AND ACADEMIC MICROARRAY MARKETS, THROUGH 2007 (UNITS AND $ THOUSANDS)

Table 55 COMPARISON OF THREE PROPOSED MICROARRAY APPLICATIONS: EXPRESSION PROFILING, DIAGNOSIS AND SNP DETECTION

Table 56 REASONS FOR CORE FACILITIES

Table 57 ACADEMIC MARKETS FOR MICROARRAYS (INCLUDING PROCESSING COSTS), THROUGH 2007 (UNITS AND $ THOUSANDS)

Table 58 BREAKDOWN OF COSTS FOR RUNNING A GLASS ARRAY IN ACADEMIA

Table 59 INDUSTRIAL MARKETS FOR MICROARRAYS (INCLUDING PROCESSING COSTS), THROUGH 2007 (UNITS AND DOLLARS IN THOUSANDS)  

LIST OF FIGURES

Summary Figure:
U.S. MARKETS FOR DNA MICROARRAYS AND MICROARRAY MATERIALS, 2002 AND 2007 ($ MILLIONS)

Figure 1 MARKETS FOR DNA AND PROTEIN MICROARRAYS AND MICROFLUIDICS DEVICES, 2002 AND 2007 ($ MILLIONS)

Figure 2 PHOTOLITHOGRAPHY AND GLASS MICROARRAY MARKETS, 2002, 2003 AND 2007 ($ MILLIONS)

Figure 3 SPOTTED AND UNSPOTTED GLASS ARRAY MARKETS, 2002, 2003 AND 2007 ($ MILLIONS)

Figure 4 UNSPOTTED GLASS MICROARRAYS IN INDUSTRY AND ACADEMIA, 2002, 2003 AND 2007 ($ MILLIONS)

Figure 5 GLASS MICROARRAYS BY TYPE: cDNA AND OLIGO, 2002, 2003 AND 2007 ($ MILLIONS)

Figure 6 cDNA AND OLIGO GLASS MICROARRAYS IN INDUSTRY, 2002, 2003 AND 2007 ($ MILLIONS)

Figure 7 cDNA AND OLIGO GLASS MICROARRAYS USED IN ACADEMIC RESEARCH, 2002, 2003 AND 2007 ($ MILLIONS)

Figure 8 MATERIALS USED IN DNA MICROARRAYS, 2002 AND 2007 ($ MILLIONS)

Figure 9 GLASS SUBSTRATES BY COATING, AS USED IN GLASS ARRAYS, 2002 AND 2007 ($ MILLIONS)

Figure 10 GLASS SUBSTRATES BY COATING, AS USED IN GLASS ARRAYS, 2002 AND 2007 ($ MILLIONS)

Figure 11 MARKETS FOR cDNA IN GLASS MICROARRAYS, 2002, 2003 AND 2007 ($ MILLIONS)