Opportunities in Chiral Technology

TABLE OF CONTENTS

INTRODUCTION

• STUDY OBJECTIVES
• REASONS FOR DOING THIS STUDY
• CONTRIBUTIONS TO THE STUDY
• SCOPE OF THE STUDY
• METHODOLOGY
• INFORMATION SOURCES
• ABOUT THE AUTHOR
• RELATED BCC REPORTS
• BCC ONLINE SERVICES
  • INTERNET

SUMMARY

Summary Table:
SALES OF CHIRAL TECHNOLOGY PRODUCTS BY CATEGORY IN THE U.S., THROUGH 2008 ($ MILLIONS)

• Summary Figure:
  SALES OF CHIRAL TECHNOLOGY PRODUCTS BY CATEGORY IN THE U.S., 2001-2008 ($ MILLIONS)

OVERVIEW

• WHAT IS CHIRALITY?
  • ISOMERISM
  • Structural Isomerism
  • Chain or Nuclear Isomerism
  • Position Isomerism
  • Functional Group Isomerism
  • Stereoisomerism
  • Geometric Isomerism
  • Optical Isomerism
  • Tautomerism
• DESIGNATION OF OPTICAL ISOMERS
• THE NATURE OF CHIRAL ISOMERISM
• IMPORTANCE OF CHIRALITY IN PHARMACEUTICALS

TWO ASPECTS OF CHIRAL TECHNOLOGY: SEPARATION AND SYNTHESIS

• TWO ASPECTS OF CHIRAL TECHNOLOGY: (CONTINUED)
• SYNTHESIS
  • PARTIAL ASYMMETRIC SYNTHESIS
  • ABSOLUTE ASYMMETRIC SYNTHESIS
  • RETROSYNTHESIS
  • Functional Group Strategies
  • Topological Strategies
  • Transform-Based Strategies
  • Structure-Goal Strategies
  • Stereochemical Strategies
  • TYPES OF REACTIONS INVOLVED IN CHIRAL SYNTHESIS
  • Conserved Chirality
  • Enzyme Catalysts in Conserved Chirality
  • Chirality Inversion
  • Asymmetric Induction
• Table 1 MATERIALS USED FOR CHIRAL SYNTHETIC REACTIONS
  • PRODUCTS FOR CHIRAL SYNTHESIS
  • Chiral Intermediates
  • Chiral Amino Acids
  • Chiral Epoxides and Glycidols
  • Substituted Chiral Propionic Acids
• Table 2 NOTABLE CHIRAL INTERMEDIATES
  • Catalysts
  • Asymmetric Chemical Catalysts
• Table 3 NOTABLE CHIRAL CATALYSTS
  • Chiral Hydrogenation Catalysts
  • Sharpless and Jacobsen Epoxidation Catalysts
  • Sharpless and Jacobsen Epoxidation Catalysts (Continued)
  • Sharpless Dihydroxylation Catalyst
  • Regis Technologies' Doyle Catalysts
  • Asymmetric Hydroformylation
  • Diels-Alder Catalysts
  • Aldol Condensation Catalysts
  • Friedel-Crafts Catalysts
• Table 4 CHIRAL CHEMICAL CATALYSTS VS. ENZYME CATALYSTS
  • Chiral Biocatalysts (Enzymes)
  • Chiral Biocatalysts (Enzymes) (Continued)
  • Chiral Auxiliaries
  • Some Chiral Auxiliary Compounds
  • Other Chiral Synthesis Materials
  • Chiral Acid and Base Catalysts
  • Chiral Reagents
  • Chiral Solvents
  • Catalytic Antibodies
  • SEPARATION
    • SEPARATION (CONTINUED)
    • PHYSICAL SEPARATION TECHNOLOGIES
    • Crystallization
    • Chiral Crystallization Principles
    • Preferential Crystallization
    • Diastereomeric Crystallization
    • Diastereomeric Crystallization (Continued)
    • Precipitating (Resolving) Agents
• Table 5 RESOLVING AGENTS FOR DIASTEREOMER CRYSTALLIZATION
• Table 5 (CONTINUED)
  • Chromatographic Methods
  • The Principle of Chiral Chromatography
  • Types of Preparative Chiral Chromatography
  • Preparative Chiral Chromatography Stationary Phases
  • Solvent Extraction
  • ENZYME-BASED KINETIC SEPARATION TECHNOLOGY
  • Enzyme-Based Kinetic Separation Technology (Continued)
  • How Do Enzymes Work?
• Table 6 MAJOR APPLICATIONS OF ENZYMATIC KINETIC RESOLUTION
  • OTHER SEPARATIVE TECHNIQUES
  • Magnetic Separation
  • Receptor-Based Resolution
  • Nanotechnology

REGULATORY ASPECTS

• REGULATIONS GOVERNING CHIRAL TECHNOLOGY
  • FEDERAL REGULATIONS
  • Developing a Single Stereoisomer after the Racemate is Studied
  • Developing A Single Stereoisomer After The Racemate Is Studied (Continued)
  • Impurity Limits
  • NON-FEDERAL RULES AND REGULATIONS
• NEW APPROVALS
• Table 7 NEW AND GENERIC APPROVALS OF CHIRAL DRUGS EXISTING AS ISOMERS, 2001-2003
• Table 7 (CONTINUED)
• Table 7 (CONTINUED)
• Table 7 (CONTINUED)
• Table 7 (CONTINUED)
• Table 7 (CONTINUED)

INDUSTRY STRUCTURE

• MARKET LEADERS
  • CHIRAL INTERMEDIATES
• Table 8 ESTIMATED MARKET SHARES FOR SUPPLIERS AND MANUFACTURERS OF CHIRAL INTERMEDIATES, 2002 (%)
• Figure 1 ESTIMATED MARKET SHARES FOR SUPPLIERS AND MANUFACTURERS OF CHIRAL INTERMEDIATES, 2002 (%)
  • CHIRAL CHEMICAL CATALYSTS
• Table 9 SUPPLIERS AND MANUFACTURERS OF CHIRAL CHEMICAL CATALYSTS
  • CHIRAL BIOCATALYSTS (ENZYMES)
• Table 10 ESTIMATED MARKET SHARES FOR SUPPLIERS AND MANUFACTURERS OF CHIRAL BIOCATALYSTS, 2002 (%)
• Figure 2 ESTIMATED MARKET SHARES FOR SUPPLIERS AND MANUFACTURERS OF CHIRAL BIOCATALYSTS, 2002 (%)
  • CHIRAL CHROMATOGRAPHY REAGENTS
• Table 11 ESTIMATED MARKET SHARES FOR SUPPLIERS AND MANUFACTURERS OF CHIRAL CHROMATOGRAPHY REAGENTS, 2002 (%)
• Figure 3 ESTIMATED MARKET SHARES FOR SUPPLIERS AND MANUFACTURERS OF CHIRAL CHROMATOGRAPHY REAGENTS, 2002 (%)
  • CHIRAL KINETIC RESOLUTION
• Table 12 ESTIMATED MARKET SHARES FOR SUPPLIERS AND MANUFACTURERS OF CHIRAL KINETIC RESOLUTION ENZYMES, 2002
• Figure 4 ESTIMATED MARKET SHARES FOR SUPPLIERS AND MANUFACTURERS OF CHIRAL KINETIC RESOLUTION ENZYMES, 2000 (%)
  • CHIRAL ANALYSIS
• Table 13 ESTIMATED MARKET SHARES FOR SUPPLIERS AND MANUFACTURERS OF CHIRAL ANALYSIS INSTRUMENTS, 2002
• Figure 5 ESTIMATED MARKET SHARES FOR SUPPLIERS AND MANUFACTURERS OF CHIRAL ANALYSIS INSTRUMENTS, 2002 (%)
  • TYPES OF INDUSTRIES
  • DEMAND AND USE OF CHIRAL DRUGS
  • THE CHANGING CHIRAL INDUSTRY

THE CHIRAL SYNTHESIS MARKET

• Table 14 SALES OF CHIRAL SYNTHETIC MATERIALS IN THE U.S., THROUGH 2008 ($ MILLIONS)
• Figure 6 SALES OF CHIRAL SYNTHETIC MATERIALS IN THE U.S., 2001-2008 ($ MILLIONS)
• Figure 7 ESTIMATED MARKET SHARE OF CHIRAL SYNTHESIS MATERIALS, 2002 (%)
  • MARKET BY TYPE
    • CHIRAL INTERMEDIATES
    • Estimating Sales Values
    • Chiral Intermediates Industry Leaders
• Table 15 SALES OF CHIRAL INTERMEDIATES IN THE U.S., THROUGH 2008 ($ MILLIONS)
  • CHIRAL CHEMICAL CATALYSTS
• Table 16 SALES OF CHIRAL CHEMICAL CATALYSTS IN THE U.S., THROUGH 2008 ($ MILLIONS)
  • CHIRAL BIOCATALYSTS (ENZYMES)
  • Chiral Biocatalysts (Enzymes) (Continued)
• Table 17 SALES OF CHIRAL BIOCATALYSTS IN THE U.S., THROUGH 2008 ($ THOUSANDS)
  • CHIRAL AUXILIARIES
• Table 18 SALES OF CHIRAL AUXILIARIES IN THE U.S., THROUGH 2008 ($ MILLIONS)
  • OTHER CHIRAL SYNTHESIS MATERIALS
• Table 19 SALES OF OTHER CHIRAL SYNTHESIS MATERIALS IN THE U.S., THROUGH 2008 ($ MILLIONS)

THE CHIRAL SEPARATION MARKET

• Table 20 SALES OF CHIRAL SEPARATION MATERIALS IN THE U.S., THROUGH 2008 ($ MILLIONS)
• Figure 8 SALES OF CHIRAL SEPARATION MATERIALS IN THE U.S., 2001-2008 ($ MILLIONS)
• Figure 9 ESTIMATED MARKET SHARES OF CHIRAL SEPARATION PRODUCTS, 2002 (%)
  • MARKET BY TYPE
    • CRYSTALLIZATION
• Table 21 SALES OF CHIRAL CRYSTALLIZING AGENTS IN THE U.S., THROUGH 2008 ($ MILLIONS)
  • CHIRAL CHROMATOGRAPHY
• Table 22 SALES OF CHIRAL CHROMATOGRAPHY REAGENTS AND COLUMNS IN THE U.S., THROUGH 2008 ($ MILLIONS)
  • SOLVENT EXTRACTION
• Table 23 SALES OF CHIRAL SOLVENT EXTRACTION REAGENTS AND INSTRUMENTS IN THE U.S., THROUGH 2008 ($ MILLIONS)
  • KINETIC RESOLUTION
• Table 24 SALES IN CHIRAL KINETIC RESOLUTION IN THE U.S., THROUGH 2008 ($ MILLIONS)

CHIRAL ANALYSIS MARKET

• Table 25 SALES OF CHIRAL ANALYSIS MATERIALS IN THE U.S., THROUGH 2008 ($ MILLIONS)
• Figure 10 SALES OF CHIRAL ANALYSIS MATERIALS IN THE U.S., 2001-2008 ($ MILLIONS)
• Figure 11 ESTIMATED MARKET SHARES FOR SUPPLIERS AND MANUFACTURERS OF CHIRAL ANALYSIS, 2002 (%)
  • MARKET BY TYPE
    • MARKET BY TYPE (CONTINUED)
    • CHIRAL ANALYTICAL CHROMATOGRAPHY
    • Chiral Liquid Chromatography
    • Chiral Liquid Chromatography (Continued)
    • Chiral Gas Chromatography
• Table 26 AGENTS USED TO FORM CHIRAL DERIVATIVES FOR GC ANALYSIS
• Table 27 ADVANTAGES OF CHIRAL LIQUID CHROMATOGRAPHY VS. CHIRAL GAS CHROMATOGRAPHY
  • Capillary Electrophoresis
  • Chiral Supercritical Fluid Chromatography
  • Chiral Supercritical Fluid Chromatography (Continued)
• Table 28 SALES IN CHIRAL ANALYTICAL CHROMATOGRAPHY IN THE U.S., THROUGH 2008 ($ MILLIONS)
  • CHIRAL POLARIMETRY
  • Polarimetry Principles
• Table 29 SALES OF REAGENTS IN CHIRAL POLARIMETRY IN THE U.S., THROUGH 2008 ($ MILLIONS)
  • NUCLEAR MAGNETIC RESONANCE
• Table 30 SALES IN CHIRAL NMR-SHIFT REAGENTS IN THE U.S., THROUGH 2008 ($ MILLIONS)
  • OTHER CHIRAL ANALYTICAL TECHNIQUES
  • Calorimetry
  • Enzymatic Assay
  • Immunoassay
  • Isotope Dilution
  • X-Ray Crystallography
  • X-Ray Crystallography (Continued)

TECHNOLOGY

• DEVELOPMENTS
• SIGNIFICANT PATENTS
  • PATENTS BY TECHNOLOGY
• Table 31 PATENTS BY TECHNOLOGY, 1998-2003
• Table 31 (CONTINUED)
• Figure 12 NUMBER OF PATENTS BY TECHNOLOGY, PER YEAR, 1998-2003
• Figure 13 TOTAL NUMBER OF PATENTS, SYNTHESIS VS. SEPARATION, 1998-2003 (%)
• Table 32 SIGNIFICANT PATENTS, SYNTHESIS IN CHIRAL TECHNOLOGY, 1998-2003
• Table 32 (CONTINUED)
• Table 32 (CONTINUED)
• Table 32 (CONTINUED)
• Table 32 (CONTINUED)
• Table 32 (CONTINUED)
• Table 32 (CONTINUED)
• Table 32 (CONTINUED)
• Table 32 (CONTINUED)
• Table 32 (CONTINUED)
• Table 32 (CONTINUED)
• Table 32 (CONTINUED)
• Table 32 (CONTINUED)
• Table 33 SIGNIFICANT PATENTS IN CHIRAL TECHNOLOGY, BY SEPARATION TECHNIQUE, 1998-2003
• Table 33 (CONTINUED)
• Table 33 (CONTINUED)
• Table 33 (CONTINUED)
  • PATENTS BY APPLICATIONS
• Table 34 SIGNIFICANT PATENTS IN CHIRAL TECHNOLOGY, BY DISEASE SECTOR, 1998-2003
• Table 34 (CONTINUED)
  • PATENTS BY COMPANY
• Table 35 PATENTS BY ABBOTT LABORATORIES IN CHIRAL TECHNOLOGY, 1998-2003
• Table 36 PATENTS BY BECKMAN COULTER IN CHIRAL TECHNOLOGY, 1998-2003
• Table 37 PATENTS BY BEND RESEARCH IN CHIRAL TECHNOLOGY, 1998-2003
• Table 38 PATENTS BY BIOCATALYTICS, INC. IN CHIRAL TECHNOLOGY, 1998-2003
• Table 39 PATENTS BY BRISTOL-MEYERS SQUIBB, INC. IN CHIRAL TECHNOLOGY, 1998-2003
• Table 40 PATENTS BY BOULDER SCIENTIFIC IN CHIRAL TECHNOLOGY, 1998-2003
• Table 41 PATENTS BY CELEGEN IN CHIRAL TECHNOLOGY, 1998-2003
• Table 42 PATENTS BY CHIROTECH TECHNOLOGY IN CHIRAL TECHNOLOGY, 1998-2003
• Table 43 PATENTS BY DAICEL CHEMICAL INDUSTRIES IN CHIRAL TECHNOLOGY, 1998-2003
• Table 44 PATENTS BY DSM FINE CHEMICALS IN CHIRAL TECHNOLOGY, 1998-2003
• Table 45 PATENTS BY EASTMAN CHEMICAL CO. IN CHIRAL TECHNOLOGY, 1998-2003
• Table 46 PATENTS BY GENZYME IN CHIRAL TECHNOLOGY, 1998-2003
• Table 47 PATENTS BY GREAT LAKES CHEMICAL CORP. IN CHIRAL TECHNOLOGY, 1998-2003
• Table 48 PATENTS BY LONZA GROUP IN CHIRAL TECHNOLOGY, 1998-2003
• Table 49 PATENTS BY MACHEREY-NAGEL & CO. IN CHIRAL TECHNOLOGY, 1998-2003
• Table 50 PATENTS BY MERCK & CO. IN CHIRAL TECHNOLOGY, 1998-2003
• Table 51 PATENTS BY NOVASEP IN CHIRAL TECHNOLOGY, 1998-2003
• Table 52 PATENTS BY PFIZER IN CHIRAL TECHNOLOGY, 1998-2003
• Table 53 PATENTS BY PHARM-ECO IN CHIRAL TECHNOLOGY, 1998-2003
• Table 54 PATENTS BY RHODIA IN CHIRAL TECHNOLOGY, 1998-2003
  • PATENTS BY COUNTRY
• Table 55 U.S. PATENTS BY COUNTRY, 1998-2003
• Figure 14 U.S. PATENTS BY COUNTRY, 1998-2003
  • PATENTS BY ASSIGNEE
• Table 56 NUMBER AND SHARE OF U.S. PATENTS BY ASSIGNEE, 1998-2003
• Figure 15 NUMBER OF U.S. PATENTS BY ASSIGNEE, 1998-2003
• Figure 16 SHARES OF U.S PATENTS BY ASSIGNEE, 1998-2003 (%)

MARKET BY APPLICATIONS

• OVERALL SALES FORECAST
• Table 57 SALES OF CHIRAL TECHNOLOGY-ENABLING PRODUCTS BY MAJOR APPLICATION, THROUGH 2008 ($ MILLIONS)
• Figure 17 SALES OF CHIRAL TECHNOLOGY-ENABLING PRODUCTS BY MAJOR APPLICATIONS, 2001-2008 ($ MILLIONS)
• Table 58 SALES OF CHIRAL TECHNOLOGY-ENABLING PRODUCTS BY PRODUCT TYPE, THROUGH 2008 ($ MILLIONS)
• Table 59 PERCENT (%) OF CHIRAL TECHNOLOGY-ENABLING PRODUCTS BY PRODUCT TYPE, 2002
  • SPECIFIC APPLICATIONS
    • PHARMACEUTICALS
• Table 60 SALES OF CHIRAL TECHNOLOGY-ENABLING PRODUCTS BY PHARMACEUTICAL APPLICATION, THROUGH 2008 ($ MILLIONS)
• Table 61 U.S. SALES OF PHARMACEUTICALS, 1998-2002 ($ MILLIONS)
• Table 62 U.S. EXPENDITURES IN R&D IN THE PHARMACEUTICAL INDUSTRY, 1998-2002 ($ MILLIONS)
• Table 63 U.S. SALES OF SYNTHETIC CHIRAL DRUGS BY MAJOR APPLICATIONS, THROUGH 2008 ($ BILLIONS)
  • RETROSPECTIVE AND PROSPECTIVE CHIRAL DRUG ACTIVITIES
  • Retrospective Applications
  • Prospective Applications
  • ANALGESICS
  • Analgesics (Continued)
  • Ibuprofen and Other Profens
  • Naproxen
• Table 64 CHIRAL ANALGESICS
  • ANESTHETICS
• Table 65 CHIRAL ANESTHETICS
• Table 65 (CONTINUED)
  • ANTI-INFECTIVE PRODUCTS
  • Semisynthetic Antibiotics with Chiral Components
• Table 66 CHIRAL ADDUCTS USED TO PRODUCE SEMISYNTHETIC ANTIBIOTICS
  • Synthetic Chiral Anti-infectives
  • Antiviral Compounds
• Table 67 SYNTHETIC CHIRAL ANTI-INFECTIVE DRUGS
  • CARDIOVASCULAR SYSTEM PRODUCTS
  • ACE Inhibitors
• Table 68 CHIRAL ACE INHIBITORS
  • Angiotensin II Receptor Antagonists
  • Beta-Blockers
• Table 69 CHIRAL BETA-BLOCKERS
• Table 69 (CONTINUED)
  • Calcium Channel Blockers
  • Calcium Channel Blockers (Continued)
• Table 70 CHIRAL CALCIUM CHANNEL BLOCKERS
  • Cholesterol-Lowering Agents
• Table 71 CHIRAL HMG-CoA REDUCTASE INHIBITORS
  • Dedicated Antiarrhythmic Drugs
• Table 72 CHIRAL DEDICATED ANTIARRHYTHMIA DRUGS
  • Diuretics
• Table 73 CHIRAL DIURETICS
  • Vasodilators
• Table 74 CHIRAL VASODILATORS
  • Other Antihypertensive Drugs
  • CENTRAL NERVOUS SYSTEM AGENTS
  • Anticonvulsant Drugs
• Table 75 CHIRAL ANTICONVULSANT DRUGS
  • ADD/ADHD Drugs
  • Parkinson's Disease Agents
• Table 76 CHIRAL PARKINSON'S DISEASE AGENTS
  • Sedatives and Tranquilizers
• Table 77 CHIRAL SEDATIVES AND TRANQUILIZERS
  • Stimulants and Antidepressants
• Table 78 CHIRAL STIMULANTS AND ANTIDEPRESSANTS
  • ENDOCRINE SYSTEM DISORDER PRODUCTS
  • Antidiabetic Agents
• Table 79 CHIRAL ANTIDIABETES DRUGS
  • GASTROINTESTINAL PRODUCTS
• Table 80 CHIRAL GASTROINTESTINAL DRUGS
  • HEMATOLOGY PRODUCTS
• Table 81 CHIRAL HEMATOLOGY DRUGS
  • ONCOGENIC (CANCER-TREATMENT) PRODUCTS
• Table 82 CHIRAL ONCOGENIC DRUGS
  • Paclitaxel and Docetaxel
  • Other New Anticancer Agents
  • RESPIRATORY SYSTEM PRODUCTS
  • Cough and Cold Remedies
• Table 83 POPULAR CHIRAL COUGH AND COLD REMEDIES
  • Products for More Serious Respiratory Problems
• Table 84 CHIRAL DRUGS FOR ASTHMA AND OTHER CHRONIC RESPIRATORY DISEASES
  • BIOCHEMICAL PRODUCTS
• Table 85 SALES OF CHIRAL TECHNOLOGY-ENABLING PRODUCTS FOR BIOMEDICAL APPLICATIONS, THROUGH 2008 ($ MILLIONS)
  • AMINO ACIDS
  • Amino Acids (Continued)
• Table 86 COMMERCIAL METHODS FOR MANUFACTURING NATURAL AMINO ACIDS
  • Amino Acids in Chiral Drug Development
  • HYDROXY ACIDS
  • OLIGONUCLEOTIDES
  • PEPTIDES
  • SUGARS AND OTHER OLIGOSACCHARIDES
  • VITAMINS
• Table 87 CHIRAL VITAMINS AND THEIR MANUFACTURING METHODS
• Table 87 (CONTINUED)
  • PESTICIDES
• Table 88 SALES OF CHIRAL TECHNOLOGY-ENABLING PRODUCTS FOR PESTICIDE APPLICATIONS, THROUGH 2008 ($ MILLIONS)
  • CHIRAL PESTICIDE OVERVIEW
• Table 89 U.S. PESTICIDE CONSUMPTION, 1999 (MILLION POUNDS)
  • Chiral Pesticide Overview (Continued)
  • PESTICIDE CHIRALITY
• Table 90 CHEMICAL PESTICIDE CHIRALITY
• Table 90 (CONTINUED)
• Table 90 (CONTINUED)
• Table 91 NUMBER OF CHIRAL VS. NON-CHIRAL PESTICIDE PRODUCTS
• Figure 18 SHARE OF CHIRAL PRODUCTS IN PESTICIDES (%)
  • HERBICIDES
  • FUNGICIDES
  • INSECTICIDES
  • Insecticides (Continued)
  • OTHER PRODUCTS
• Table 92 SALES OF OTHER CHIRAL TECHNOLOGY-ENABLING PRODUCTS, THROUGH 2008 ($ MILLIONS)
  • AROMA AND FLAVOR CHEMICALS
  • Chiral Aroma/Flavor Compounds
• Table 93 NOTABLE CHIRAL AROMA AND FLAVOR COMPOUNDS
  • ASSISTIVES
  • DYES AND PIGMENTS
  • LIQUID CRYSTALS
  • NONLINEAR OPTICAL MATERIALS
  • POLYMERS

INTERNATIONAL ASPECTS

• INTERNATIONAL ASPECTS
• Table 94 WORLDWIDE SALES OF CHIRAL TECHNOLOGY-ENABLING PRODUCTS: GEOGRAPHIC BREAKDOWN, THROUGH 2008 ($ MILLIONS)
• Figure 19 WORLDWIDE SALES OF CHIRAL TECHNOLOGY-ENABLING PRODUCTS: GEOGRAPHIC BREAKDOWN, 2001-2008 ($ MILLIONS)
• Figure 20 WORLDWIDE SALES OF CHIRAL TECHNOLOGY-ENABLING PRODUCTS: GEOGRAPHIC BREAKDOWN, 2002 (% OF TOTAL)
• Figure 20 (CONTINUED)
• Table 95 WORLDWIDE SALES OF SYNTHETIC CHIRAL DRUGS, THROUGH 2008 ($ BILLIONS)
• Figure 21 WORLDWIDE SALES OF SYNTHETIC CHIRAL DRUGS, 2001-2008 ($ BILLIONS)

COMPANY PROFILES

• ABBOTT LABORATORIES
• ALTUS BIOLOGICS, INC.
• AVECIA, INC.
• BASF CORP.
• BECKMAN COULTER
• BEND RESEARCH, INC.
• BIOCATALYTICS, INC.
• BOULDER SCIENTIFIC
• CAMBREX CORP.
  • CAMBREX CORP. (CONTINUED)
• CELGENE CORP.
• DIVERSA CORP.
  • DIVERSA CORP. (CONTINUED)
• DIGITAL SPECIALTY CHEMICALS
• DSM FINE CHEMICALS
• DAICEL CHEMICAL INDUSTRIES
  • CHIRAL TECHNOLOGIES
• DAVOS CHEMICAL CORP.
• DOWPHARMA
• EASTMAN CHEMICAL CO.
• FISHER SCIENTIFIC, INTL.
• GENENCOR INTERNATIONAL, INC.
• GENZYME CORP.
• GREAT LAKES CHEMICAL CO.
• JASCO, INC.
• JOHNSON MATTHEY PLC
• JOHNSON MATTHEY CATALYSTS
• J.T.BAKER, INC.
• LONZA GROUP, LTD.
  • LONZA, INC.
• MACHEREY-NAGEL, INC.
• MAXYGEN
• MERCK KGAA
  • EMD BIOSCIENCES INC.
  • EMD CHEMICALS, INC.
  • EMD CHEMICALS, INC.
  • EMD LEXIGEN RESEARCH CENTER CORP.
  • EMD PHARMACEUTICALS, INC.
  • VWR INTERNATIONAL, INC.
  • DEY, INC.
  • NITRAGIN, INC.
• NOVASEP, INC.
• PHARM-ECO
• PFIZER
• PDR-CHIRAL, INC.
• PERKIN ELMER, INC.
• PHENOMENEX, INC.
• PPG-SIPSY
• RHODIA, INC.
• ROCHE DIAGNOSTICS CORP.
• RUDOLPH INSTRUMENTS
• REGIS TECHNOLOGIES, INC.
• SEDERE, INC.
• SIGMA-ALDRICH
• SEPRACOR, INC.
• SK ENERGY & CHEMICAL
• STREM CHEMICALS, INC.
• SYNTHETECH, INC.
• SYNTHON CHIRAGENICS CORP.
• THERMOGEN, INC.
• UNIVERSAL PHARMA TECHNOLOGIES, LLC

LIST OF TABLES

Summary Table:
SALES OF CHIRAL TECHNOLOGY PRODUCTS BY CATEGORY IN THE U.S., THROUGH 2008 ($ MILLIONS)

Table 1 MATERIALS USED FOR CHIRAL SYNTHETIC REACTIONS

Table 2 NOTABLE CHIRAL INTERMEDIATES

Table 3 NOTABLE CHIRAL CATALYSTS

Table 4 CHIRAL CHEMICAL CATALYSTS VS. ENZYME CATALYSTS

Table 5 RESOLVING AGENTS FOR DIASTEREOMER CRYSTALLIZATION

Table 6 MAJOR APPLICATIONS OF ENZYMATIC KINETIC RESOLUTION

Table 7 NEW AND GENERIC APPROVALS OF CHIRAL DRUGS EXISTING AS ISOMERS, 2001-2003

Table 8 ESTIMATED MARKET SHARES FOR SUPPLIERS AND MANUFACTURERS OF CHIRAL INTERMEDIATES, 2002 (%)

Table 9 SUPPLIERS AND MANUFACTURERS OF CHIRAL CHEMICAL CATALYSTS

Table 10 ESTIMATED MARKET SHARES FOR SUPPLIERS AND MANUFACTURERS OF CHIRAL BIOCATALYSTS, 2002 (%)

Table 11 ESTIMATED MARKET SHARES FOR SUPPLIERS AND MANUFACTURERS OF CHIRAL CHROMATOGRAPHY REAGENTS, 2002 (%)

Table 12 ESTIMATED MARKET SHARES FOR SUPPLIERS AND MANUFACTURERS OF CHIRAL KINETIC RESOLUTION ENZYMES, 2002

Table 13 ESTIMATED MARKET SHARES FOR SUPPLIERS AND MANUFACTURERS OF CHIRAL ANALYSIS INSTRUMENTS, 2002

Table 14 SALES OF CHIRAL SYNTHETIC MATERIALS IN THE U.S., THROUGH 2008 ($ MILLIONS)

Table 15 SALES OF CHIRAL INTERMEDIATES IN THE U.S., THROUGH 2008 ($ MILLIONS)

Table 16 SALES OF CHIRAL CHEMICAL CATALYSTS IN THE U.S., THROUGH 2008 ($ MILLIONS)

Table 17 SALES OF CHIRAL BIOCATALYSTS IN THE U.S., THROUGH 2008 ($ THOUSANDS)

Table 18 SALES OF CHIRAL AUXILIARIES IN THE U.S., THROUGH 2008 ($ MILLIONS)

Table 19 SALES OF OTHER CHIRAL SYNTHESIS MATERIALS IN THE U.S., THROUGH 2008 ($ MILLIONS)

Table 20 SALES OF CHIRAL SEPARATION MATERIALS IN THE U.S., THROUGH 2008 ($ MILLIONS)

Table 21 SALES OF CHIRAL CRYSTALLIZING AGENTS IN THE U.S., THROUGH 2008 ($ MILLIONS)

Table 22 SALES OF CHIRAL CHROMATOGRAPHY REAGENTS AND COLUMNS IN THE U.S., THROUGH 2008 ($ MILLIONS)

Table 23 SALES OF CHIRAL SOLVENT EXTRACTION REAGENTS AND INSTRUMENTS IN THE U.S., THROUGH 2008 ($ MILLIONS)

Table 24 SALES IN CHIRAL KINETIC RESOLUTION IN THE U.S., THROUGH 2008 ($ MILLIONS)

Table 25 SALES OF CHIRAL ANALYSIS MATERIALS IN THE U.S., THROUGH 2008 ($ MILLIONS)

Table 26 AGENTS USED TO FORM CHIRAL DERIVATIVES FOR GC ANALYSIS

Table 27 ADVANTAGES OF CHIRAL LIQUID CHROMATOGRAPHY VS. CHIRAL GAS CHROMATOGRAPHY

Table 28 SALES IN CHIRAL ANALYTICAL CHROMATOGRAPHY IN THE U.S., THROUGH 2008 ($ MILLIONS)

Table 29 SALES OF REAGENTS IN CHIRAL POLARIMETRY IN THE U.S., THROUGH 2008 ($ MILLIONS)

Table 30 SALES IN CHIRAL NMR-SHIFT REAGENTS IN THE U.S., THROUGH 2008 ($ MILLIONS)

Table 31 PATENTS BY TECHNOLOGY, 1998-2003

Table 32 SIGNIFICANT PATENTS, SYNTHESIS IN CHIRAL TECHNOLOGY, 1998-2003

Table 33 SIGNIFICANT PATENTS IN CHIRAL TECHNOLOGY, BY SEPARATION TECHNIQUE, 1998-2003

Table 34 SIGNIFICANT PATENTS IN CHIRAL TECHNOLOGY, BY DISEASE SECTOR, 1998-2003

Table 35 PATENTS BY ABBOTT LABORATORIES IN CHIRAL TECHNOLOGY, 1998-2003

Table 36 PATENTS BY BECKMAN COULTER IN CHIRAL TECHNOLOGY, 1998-2003

Table 37 PATENTS BY BEND RESEARCH IN CHIRAL TECHNOLOGY, 1998-2003

Table 38 PATENTS BY BIOCATALYTICS, INC. IN CHIRAL TECHNOLOGY, 1998-2003

Table 39 PATENTS BY BRISTOL-MEYERS SQUIBB, INC. IN CHIRAL TECHNOLOGY, 1998-2003

Table 40 PATENTS BY BOULDER SCIENTIFIC IN CHIRAL TECHNOLOGY, 1998-2003

Table 41 PATENTS BY CELEGEN IN CHIRAL TECHNOLOGY, 1998-2003

Table 42 PATENTS BY CHIROTECH TECHNOLOGY IN CHIRAL TECHNOLOGY, 1998-2003

Table 43 PATENTS BY DAICEL CHEMICAL INDUSTRIES IN CHIRAL TECHNOLOGY, 1998-2003

Table 44 PATENTS BY DSM FINE CHEMICALS IN CHIRAL TECHNOLOGY, 1998-2003

Table 45 PATENTS BY EASTMAN CHEMICAL CO. IN CHIRAL TECHNOLOGY, 1998-2003

Table 46 PATENTS BY GENZYME IN CHIRAL TECHNOLOGY, 1998-2003

Table 47 PATENTS BY GREAT LAKES CHEMICAL CORP. IN CHIRAL TECHNOLOGY, 1998-2003

Table 48 PATENTS BY LONZA GROUP IN CHIRAL TECHNOLOGY, 1998-2003

Table 49 PATENTS BY MACHEREY-NAGEL & CO. IN CHIRAL TECHNOLOGY, 1998-2003

Table 50 PATENTS BY MERCK & CO. IN CHIRAL TECHNOLOGY, 1998-2003

Table 51 PATENTS BY NOVASEP IN CHIRAL TECHNOLOGY, 1998-2003

Table 52 PATENTS BY PFIZER IN CHIRAL TECHNOLOGY, 1998-2003

Table 53 PATENTS BY PHARM-ECO IN CHIRAL TECHNOLOGY, 1998-2003

Table 54 PATENTS BY RHODIA IN CHIRAL TECHNOLOGY, 1998-2003

Table 55 U.S. PATENTS BY COUNTRY, 1998-2003

Table 56 NUMBER AND SHARE OF U.S. PATENTS BY ASSIGNEE, 1998-2003

Table 57 SALES OF CHIRAL TECHNOLOGY-ENABLING PRODUCTS BY MAJOR APPLICATION, THROUGH 2008 ($ MILLIONS)

Table 58 SALES OF CHIRAL TECHNOLOGY-ENABLING PRODUCTS BY PRODUCT TYPE, THROUGH 2008 ($ MILLIONS)

Table 59 PERCENT (%) OF CHIRAL TECHNOLOGY-ENABLING PRODUCTS BY PRODUCT TYPE, 2002

Table 60 SALES OF CHIRAL TECHNOLOGY-ENABLING PRODUCTS BY PHARMACEUTICAL APPLICATION, THROUGH 2008 ($ MILLIONS)

Table 61 U.S. SALES OF PHARMACEUTICALS, 1998-2002 ($ MILLIONS)

Table 62 U.S. EXPENDITURES IN R&D IN THE PHARMACEUTICAL INDUSTRY, 1998-2002 ($ MILLIONS)

Table 63 U.S. SALES OF SYNTHETIC CHIRAL DRUGS BY MAJOR APPLICATIONS, THROUGH 2008 ($ BILLIONS)

Table 64 CHIRAL ANALGESICS

Table 65 CHIRAL ANESTHETICS

Table 66 CHIRAL ADDUCTS USED TO PRODUCE SEMISYNTHETIC ANTIBIOTICS

Table 67 SYNTHETIC CHIRAL ANTI-INFECTIVE DRUGS

Table 68 CHIRAL ACE INHIBITORS

Table 69 CHIRAL BETA-BLOCKERS

Table 70 CHIRAL CALCIUM CHANNEL BLOCKERS

Table 71 CHIRAL HMG-CoA REDUCTASE INHIBITORS

Table 72 CHIRAL DEDICATED ANTIARRHYTHMIA DRUGS

Table 73 CHIRAL DIURETICS

Table 74 CHIRAL VASODILATORS

Table 75 CHIRAL ANTICONVULSANT DRUGS

Table 76 CHIRAL PARKINSON'S DISEASE AGENTS

Table 77 CHIRAL SEDATIVES AND TRANQUILIZERS

Table 78 CHIRAL STIMULANTS AND ANTIDEPRESSANTS

Table 79 CHIRAL ANTIDIABETES DRUGS

Table 80 CHIRAL GASTROINTESTINAL DRUGS

Table 81 CHIRAL HEMATOLOGY DRUGS

Table 82 CHIRAL ONCOGENIC DRUGS

Table 83 POPULAR CHIRAL COUGH AND COLD REMEDIES

Table 84 CHIRAL DRUGS FOR ASTHMA AND OTHER CHRONIC RESPIRATORY DISEASES

Table 85 SALES OF CHIRAL TECHNOLOGY-ENABLING PRODUCTS FOR BIOMEDICAL APPLICATIONS, THROUGH 2008 ($ MILLIONS)

Table 86 COMMERCIAL METHODS FOR MANUFACTURING NATURAL AMINO ACIDS

Table 87 CHIRAL VITAMINS AND THEIR MANUFACTURING METHODS

Table 88 SALES OF CHIRAL TECHNOLOGY-ENABLING PRODUCTS FOR PESTICIDE APPLICATIONS, THROUGH 2008 ($ MILLIONS)

Table 89 U.S. PESTICIDE CONSUMPTION, 1999 (MILLION POUNDS)

Table 90 CHEMICAL PESTICIDE CHIRALITY

Table 91 NUMBER OF CHIRAL VS. NON-CHIRAL PESTICIDE PRODUCTS

Table 92 SALES OF OTHER CHIRAL TECHNOLOGY-ENABLING PRODUCTS, THROUGH 2008 ($ MILLIONS)

Table 93 NOTABLE CHIRAL AROMA AND FLAVOR COMPOUNDS

Table 94 WORLDWIDE SALES OF CHIRAL TECHNOLOGY-ENABLING PRODUCTS: GEOGRAPHIC BREAKDOWN, THROUGH 2008 ($ MILLIONS)

Table 95 WORLDWIDE SALES OF SYNTHETIC CHIRAL DRUGS, THROUGH 2008 ($ BILLIONS)  

LIST OF FIGURES

Summary Figure:
SALES OF CHIRAL TECHNOLOGY PRODUCTS BY CATEGORY IN THE U.S., 2001-2008 ($ MILLIONS)

Figure 1 ESTIMATED MARKET SHARES FOR SUPPLIERS AND MANUFACTURERS OF CHIRAL INTERMEDIATES, 2002 (%)

Figure 2 ESTIMATED MARKET SHARES FOR SUPPLIERS AND MANUFACTURERS OF CHIRAL BIOCATALYSTS, 2002 (%)

Figure 3 ESTIMATED MARKET SHARES FOR SUPPLIERS AND MANUFACTURERS OF CHIRAL CHROMATOGRAPHY REAGENTS, 2002 (%)

Figure 4 ESTIMATED MARKET SHARES FOR SUPPLIERS AND MANUFACTURERS OF CHIRAL KINETIC RESOLUTION ENZYMES, 2000 (%)

Figure 5 ESTIMATED MARKET SHARES FOR SUPPLIERS AND MANUFACTURERS OF CHIRAL ANALYSIS INSTRUMENTS, 2002 (%)

Figure 6 SALES OF CHIRAL SYNTHETIC MATERIALS IN THE U.S., 2001-2008 ($ MILLIONS)

Figure 7 ESTIMATED MARKET SHARE OF CHIRAL SYNTHESIS MATERIALS, 2002 (%)

Figure 8 SALES OF CHIRAL SEPARATION MATERIALS IN THE U.S., 2001-2008 ($ MILLIONS)

Figure 9 ESTIMATED MARKET SHARES OF CHIRAL SEPARATION PRODUCTS, 2002 (%)

Figure 10 SALES OF CHIRAL ANALYSIS MATERIALS IN THE U.S., 2001-2008 ($ MILLIONS)

Figure 11 ESTIMATED MARKET SHARES FOR SUPPLIERS AND MANUFACTURERS OF CHIRAL ANALYSIS, 2002 (%)

Figure 12 NUMBER OF PATENTS BY TECHNOLOGY, PER YEAR, 1998-2003

Figure 13 TOTAL NUMBER OF PATENTS, SYNTHESIS VS. SEPARATION, 1998-2003 (%)

Figure 14 U.S. PATENTS BY COUNTRY, 1998-2003

Figure 15 NUMBER OF U.S. PATENTS BY ASSIGNEE, 1998-2003

Figure 16 SHARES OF U.S PATENTS BY ASSIGNEE, 1998-2003 (%)

Figure 17 SALES OF CHIRAL TECHNOLOGY-ENABLING PRODUCTS BY MAJOR APPLICATIONS, 2001-2008 ($ MILLIONS)

Figure 18 SHARE OF CHIRAL PRODUCTS IN PESTICIDES (%)

Figure 19 WORLDWIDE SALES OF CHIRAL TECHNOLOGY-ENABLING PRODUCTS: GEOGRAPHIC BREAKDOWN, 2001-2008 ($ MILLIONS)

Figure 20 WORLDWIDE SALES OF CHIRAL TECHNOLOGY-ENABLING PRODUCTS: GEOGRAPHIC BREAKDOWN, 2002 (% OF TOTAL)

Figure 21 WORLDWIDE SALES OF SYNTHETIC CHIRAL DRUGS, 2001-2008 ($ BILLIONS)