Medical Imaging Reagents

TABLE OF CONTENTS

INTRODUCTION

• STUDY GOAL AND OBJECTIVES
• REASONS FOR DOING THE STUDY
• CONTRIBUTIONS OF THE STUDY AND FOR WHOM
• SCOPE AND FORMAT
• METHODOLOGY
• INFORMATION SOURCES
• RELATED PUBLICATIONS
• AUTHOR'S CREDENTIALS
• BCC ON-LINE SERVICES
  • INTERNET

• MEDICAL DIAGNOSTICS
  • MEDICAL REAGANTS
• Summary Table:
  U.S. SALES OF MEDICAL IMAGING REAGENTS BY TYPE, THROUGH 2008 ($ MILLIONS)
• Summary Figure:
  U.S. SALES OF MEDICAL IMAGING REAGENTS BY TYPE, 2001-2008 ($ MILLIONS)

• WHAT IS MEDICAL IMAGING?
• HISTORY OF IMAGING
• Table 1 HISTORY OF IMAGING
• Table 1 (CONTINUED)
  • TYPES OF IMAGING TECHNIQUES
    • X-RAYS AND COMPUTED TOMOGRAPHY (CT)
    • Computed Tomography Angiograms (CTA)
    • Single Photon/Positron Emission Computed Tomography (SPECT/PET)
    • ULTRASOUND
    • B-Mode Imaging
    • PW Mode and Color Doppler Imaging
    • MAGNETIC RESONANCE IMAGING (MRI)
    • RADIOPHARMACEUTICAL IMAGING OR NUCLEAR MEDICINE
    • Radiopharmaceutical Imaging or Nuclear Medicine (Continued)
• Table 2 USE OF CT/X-RAY, ULTRASOUND AND MRI
  • THE IMAGING REAGENTS
• Table 3 CHARACTERISTICS OF IMAGING TECHNIQUES
  • IONIC CONTRAST MEDIA
  • NON-IONIC CONTRAST MEDIUM
• Table 4 ADVANTAGES OF NON-IONIC VS. IONIC CONTRAST AGENTS
  • X-RAY AND CT REAGENTS
  • Barium Sulphate
  • Properties of Barium Sulphate
  • Some Other Agents Used with Barium Sulphate
  • Iodine Containing Agents
• Table 5 TYPES OF IODINE CONTAINING IMAGING REAGENTS FOR X-RAY/CT
• Table 5 (CONTINUED)
• Table 6 TYPES OF IONIC AND NON-IONIC IODINE CONTAINING IMAGING REAGENTS FOR X-RAY/CT
  • Gadolinium Containing Agents
  • Safety of CT
  • ULTRASOUND AGENTS
  • Microbubble Compositions
  • Ultrasound Gels
  • Safety of Ultrasound
  • MRI CONTRAST AGENTS
  • Safety of MRI
  • RADIOPHARMACEUTICALS OR NUCLEAR MEDICINE
  • Positron Emission Tomography (PET)
  • Safety of Radiopharmaceuticals
• Table 7 USEFUL CLASSICAL RADIOPHARMACEUTICALS BY APPLICATION
• Table 7 (CONTINUED)

• REGULATORY ASPECTS
  • REGULATORY ASPECTS (CONTINUED)
• Table 8 NEW AND GENERIC DRUG APPROVALS OF THE IMAGING REAGENTS, 2000-2003

• MARKET SHARE OF IMAGING REAGENTS
• Table 9 MARKET SHARE OF COMPANIES IN MEDICAL IMAGING REAGENTS, 2002 (%)
• Figure 1 MARKET SHARE OF COMPANIES IN MEDICAL IMAGING REAGENTS, 2002 (%)
  • MARKET SHARE OF X-RAY AND CT IMAGING REAGENTS
• Table 10 MARKET SHARE OF COMPANIES IN X-RAYS AND CT IMAGING REAGENTS, 2002 (%)
• Figure 2 MARKET SHARE OF COMPANIES IN X-RAYS AND CT IMAGING REAGENTS, 2002 (%)
  • MARKET SHARE OF ULTRASOUND IMAGING REAGENTS
• Table 11 MARKET SHARE OF COMPANIES IN ULTRASOUND IMAGING REAGENTS, 2002 (%)
• Figure 3 MARKET SHARE OF COMPANIES IN ULTRASOUND IMAGING REAGENTS, 2002 (%)
  • MARKET SHARE OF MRI IMAGING REAGENTS
• Table 12 MARKET SHARE OF COMPANIES IN MRI REAGENTS, 2002 (%)
• Figure 4 MARKET SHARE OF COMPANIES IN MRI REAGENTS, 2002 (%)
  • MARKET SHARE OF RADIOPHARMACEUTICAL IMAGING REAGENTS
• Table 13 MARKET SHARE OF COMPANIES IN RADIOPHARMACEUTICAL IMAGING REAGENTS, 2002 (%)
• Figure 5 MARKET SHARE OF COMPANIES IN RADIOPHARMACEUTICAL REAGENTS, 2002 (%)
  • DEMAND AND USE
    • DEMAND AND USE (CONTINUED)

• MARKET PICTURE OF IONIC AND NON-IONIC REAGENTS IN IMAGING
• Table 14 U.S. SALES OF IONIC AND NON-IONIC AGENTS, THROUGH 2008 ($ MILLIONS)
• Figure 6 U.S. SALES OF IONIC AND NON-IONIC AGENTS, 2001-2008 ($ MILLIONS)
  • X-RAY AND COMPUTED TOMOGRAPHY (CT) REAGENTS
• Table 15 REAGENTS USED IN X-RAY/CT
• Table 15 (CONTINUED)
• Table 16 U.S. SALES OF X-RAY/CT AGENTS, THROUGH 2008 ($ MILLIONS)
• Figure 7 U.S. SALES OF X-RAY/CT AGENTS, 2001-2008 ($ MILLIONS)
• Table 17 U.S. SALES OF IONIC AND NON-IONIC REAGENTS IN X-RAY/CT IMAGING, THROUGH 2008 ($ MILLIONS)
• Figure 8 U.S. SALES OF IONIC AND NON-IONIC REAGENTS IN X-RAY/CT IMAGING, 2001-2008 ($ MILLIONS)
  • ULTRASOUND REAGENTS
• Table 18 REAGENTS USED IN ULTRASOUND
• Table 18 (CONTINUED)
• Table 19 U.S. SALES OF ULTRASOUND REAGENTS, THROUGH 2008 ($ MILLIONS)
• Figure 9 U.S. SALES OF ULTRASOUND REAGENTS, 2001-2008 ($ MILLIONS)
  • MRI CONTRAST AGENTS
• Table 20 CONTRAST AGENTS USED IN MRI
• Table 21 U.S. SALES OF MRI AGENTS, THROUGH 2008 ($ MILLIONS)
• Figure 10 U.S. SALES OF MRI AGENTS, 2001-2008 ($ MILLIONS)
  • NUCLEAR IMAGING REAGENTS/RADIOPHARMACEUTICAL IMAGING AGENTS
    • NUCLEAR IMAGING REAGENTS .. (CONTINUED)
• Table 22 CONTRAST AGENTS USED IN RADIOPHARMACEUTICALS
• Table 22 (CONTINUED)
• Table 22 (CONTINUED)
• Table 22 (CONTINUED)
• Table 23 U.S. SALES OF RADIOPHARMACEUTICAL IMAGING REAGENTS, THROUGH 1008 ($ MILLIONS)
• Figure 11 U.S. SALES OF RADIOPHARMACEUTICAL IMAGING REAGENTS, 2001-2008 ($ MILLIONS)

• Table 24 X-RAY CONTRAST AGENTS UNDER DEVELOPMENT
• Table 25 ULTRASOUND CONTRAST AGENTS UNDER DEVELOPMENT
• Table 26 MRI CONTRAST AGENTS UNDER DEVELOPMENT
• Table 27 RADIOPARMACEUTICAL CONTRAST AGENTS UNDER DEVELOPMENT

• PATENTS BY TECHNOLOGY
• Table 28 NUMBER OF PATENTS BY TECHNOLOGY, 1998-2003
• Table 28 (CONTINUED)
• Figure 12 NUMBER OF PATENTS, 1998-2003
• Figure 13 NUMBER OF PATENTS BY YEAR, 1998-2003 (% OF TOTAL)
• Figure 13 (CONTINUED)
• Table 29 SIGNIFICANT PATENTS OF X-RAY /CT REAGENTS, 1998-2003
• Table 29 (CONTINUED)
• Table 29 (CONTINUED)
• Table 29 (CONTINUED)
• Table 29 (CONTINUED)
• Table 29 (CONTINUED)
• Table 29 (CONTINUED)
• Table 30 SIGNIFICANT PATENTS OF ULTRASOUND REAGENTS, 1998-2003
• Table 30 (CONTINUED)
• Table 30 (CONTINUED)
• Table 30 (CONTINUED)
• Table 30 (CONTINUED)
• Table 30 (CONTINUED)
• Table 31 SIGNIFICANT PATENTS OF MAGNETIC RESONANCE IMAGING REAGENTS, 1998-2003
• Table 31 (CONTINUED)
• Table 31 (CONTINUED)
• Table 31 (CONTINUED)
• Table 31 (CONTINUED)
• Table 31 (CONTINUED)
• Table 32 SIGNIFICANT PATENTS OF RADIOPHARMACEUTICAL REAGENTS, 1998-2003
• Table 32 (CONTINUED)
• Table 32 (CONTINUED)
• Table 32 (CONTINUED)
• Table 33 SIGNIFICANT PATENTS OF OTHER IMAGING REAGENTS1, 1998-2003
• Table 33 (CONTINUED)
• Table 33 (CONTINUED)
  • PATENTS BY COMPANY
• Table 34 PATENTS BY ACUSPHERE INC. FOR REAGENTS USED IN IMAGING TECHNOLOGY, 1998-2003
• Table 35 PATENTS BY AMERSHAM HEALTH/ NYCOMED FOR REAGENTS USED IN IMAGING TECHNOLOGY, 1998-2003
• Table 35 (CONTINUED)
• Table 36 PATENTS BY ALLIANCE PHARMACEUTICALS CORP. FOR REAGENTS USED IN IMAGING TECHNOLOGY, 1998-2003
• Table 37 PATENTS BY BRACCO FOR REAGENTS USED IN IMAGING TECHNOLOGY, 1998-2003
• Table 38 PATENTS BY EPIX MEDICAL INC. FOR REAGENTS USED IN IMAGING TECHNOLOGY, 1998-2003
• Table 39 PATENTS BY EZ-EM INC. FOR REAGENTS USED IN IMAGING TECHNOLOGY, 1998-2003
• Table 40 PATENTS BY IMARX THERAPEUTICS FOR REAGENTS USED IN IMAGING TECHNOLOGY, 1998-2003
• Table 41 PATENTS BY IMMUNOMEDICS FOR REAGENTS USED IN IMAGING TECHNOLOGY, 1998-2003
• Table 42 PATENTS BY MALLINCKRODT MEDICAL FOR REAGENTS USED IN IMAGING TECHNOLOGY, 1998-2003
• Table 43 PATENTS BY MOLECULAR BIOSYSTEMS FOR REAGENTS USED IN IMAGING TECHNOLOGY, 1998-2003
• Table 44 PATENTS BY NEORX FOR REAGENTS USED IN IMAGING TECHNOLOGY, 1998-2003
• Table 45 PATENTS BY PHARMACYCLICS FOR REAGENTS USED IN IMAGING TECHNOLOGY, 1998-2003
• Table 46 PATENTS BY SCHERING AG FOR REAGENTS USED IN IMAGING TECHNOLOGY, 1998-2003
• Table 47 PATENTS BY POINT BIOMEDICAL FOR REAGENTS USED IN IMAGING TECHNOLOGY, 1998-2003
• Table 48 PATENTS BY SONUS PHARMACEUTICALS FOR REAGENTS USED IN IMAGING TECHNOLOGY, 1998-2003
  • PATENTS BY COUNTRY
• Table 49 U.S. PATENTS BY COUNTRY, 1998-2003
• Figure 14 U.S. PATENTS BY COUNTRY, 1998-2003
• Table 50 TRENDS OF PATENTS ISSUED BY COUNTRY, 1998-2003
• Figure 15 TOTAL U.S. NUMBER OF PATENTS ISSUED BY COUNTRY, 1998-2003
• Figure 16 PERCENT OF PATENTS ISSUED BY COUNTRY, 1998-2003 (%)
• PATENTS BY ASIGNEE
• Table 51 SHARE OF U.S. PATENTS BY ASIGNEE, 1998-2003
• Figure 17 MARKET SHARE OF U.S. PATENTS BY ASSIGNEE, 1998-2003 (NUMBER OF PATENTS)
• Figure 18 MARKET SHARE OF U.S PATENTS BY ASSIGNEE, 1998-2003 (%)

• Table 52 U.S. SALES OF MEDICAL IMAGING REAGENTS BY APPLICATION, THROUGH 2008 ($ MILLIONS)
• Figure 19 U.S. SALES OF MEDICAL IMAGING REAGENTS BY APPLICATION, 2001-2008 ($ MILLIONS)
• Figure 20 MARKET SHARE OF MEDICAL IMAGING REAGENTS BY APPLICATION, 2003
• Figure 20 (CONTINUED)
  • CARDIOVASCULAR
• Table 53 U.S. SALES OF TYPES OF MEDICAL IMAGING REAGENTS IN CARDIOVASCULAR APPLICATIONS, THROUGH 2008 ($ MILLIONS)
• Figure 21 U.S. SALES OF TYPES OF MEDICAL IMAGING REAGENTS IN CARDIOVASCULAR APPLICATIONS, 2001-2008 ($ MILLIONS)
• Figure 22 MARKET SHARE OF CARDIOVASCULAR IMAGING REAGENTS, 2003 (%)
• Figure 22 (CONTINUED)
  • CENTRAL NERVOUS SYSTEM (CNS)
• Table 54 U.S. SALES OF TYPES OF MEDICAL IMAGING REAGENTS IN CENTRAL NERVOUS SYSTEM, THROUGH 2008 ($ MILLIONS)
• Figure 23 U.S. SALES OF TYPES OF MEDICAL IMAGING REAGENTS IN CENTRAL NERVOUS SYSTEM IMAGING, 2001-2008 ($ MILLIONS)
• Figure 24 MARKET SHARE OF CENTRAL NERVOUS SYSTEM IMAGING REAGENTS, 2003 (%)
• Figure 24 (CONTINUED)
  • GASTRO INTESTINAL (GIT) AND LIVER
• Table 55 U.S. SALES OF TYPES OF MEDICAL IMAGING REAGENTS IN GASTROINTESTINAL AND LIVER IMAGING, THROUGH 2008 ($ MILLIONS)
• Figure 25 U.S. SALES OF TYPES OF MEDICAL IMAGING REAGENTS IN GASTRO INTESTINAL AND LIVER IMAGING, 2001-2003 AND 2008 ($ MILLIONS)
• Figure 26 MARKET SHARE OF GASTROINTESTAINAL AND LIVER IMAGING REAGENTS, 2003 (%)
• Figure 26 (CONTINUED)
  • ONCOLOGY
• Table 56 U.S. SALES OF TYPES OF MEDICAL IMAGING REAGENTS IN ONCOLOGY IMAGING, THROUGH 2008 ($ MILLIONS)
• Figure 27 U.S. SALES OF TYPES OF MEDICAL IMAGING REAGENTS IN ONCOLOGY IMAGING, 2001-2008 ($ MILLIONS)
• Figure 28 MARKET SHARE OF ONCOLOGY IMAGING REAGENTS, 2003 ($ MILLIONS)
  • OTHERS
• Table 57 U.S. SALES OF TYPES OF MEDICAL IMAGING REAGENTS IN "OTHER" IMAGING, THROUGH 2008 ($ MILLIONS)
• Figure 29 U.S. SALES OF TYPES OF MEDICAL IMAGING REAGENTS IN "OTHER" IMAGING, 2001-2008 ($ MILLIONS)
• Figure 30 MARKET SHARE OF "OTHER" IMAGING REAGENTS, 2003 (%)
• Figure 30 (CONTINUED)

• UNITED STATES
• EUROPE
• JAPAN
• REST OF THE WORLD
• WORLDWIDE SALES OF X-RAY IMAGING REAGENTS
• Table 58 WORLDWIDE SALES OF X-RAY IMAGING REAGENTS BY REGION, THROUGH 2008 ($ MILLIONS)
• Figure 31 WORLDWIDE SALES OF X-RAY IMAGING REAGENTS BY REGION, 2001-2008 ($ MILLIONS)
  • WORLDWIDE SALES OF ULTRASOUND IMAGING REAGENTS
• Table 59 WORLDWIDE SALES OF ULTRASOUND IMAGING REAGENTS BY REGION, THROUGH 2008 ($ MILLIONS)
• Figure 32 WORLDWIDE SALES OF ULTRASOUND IMAGING REAGENTS BY REGION, 2001-2008 ($ MILLIONS)
  • WORLDWIDE SALES OF MRI IMAGING REAGENTS
• Table 60 WORLDWIDE SALES OF MRI IMAGING REAGENTS BY REGION, THROUGH 2008 ($ MILLIONS)
• Figure 33 WORLDWIDE SALES OF MRI IMAGING REAGENTS BY REGION, 2001-2008 ($ MILLIONS)
  • WORLDWIDE SALES OF RADIOPHARMACEUTICALS/ NUCLEAR IMAGING REAGENTS
• Table 61 WORLDWIDE SALES OF RADIOPHARMACEUTICALS/ NUCLEAR IMAGING REAGENTS BY REGION, THROUGH 2008 ($ MILLIONS)
• Figure 34 WORLDWIDE SALES OF RADIOPHARMACEUTICALS/ NUCLEAR IMAGING REAGENTS BY REGION, 2001-2008 ($ MILLIONS)
  • WORLDWIDE SALES AND MARKET SHARE OF IMAGING REAGENTS, BY REGION
• Table 62 WORLDWIDE SALES OF IMAGING REAGENTS, BY REGION, THROUGH 2008 ($ MILLIONS)
• Figure 35 WORLDWIDE SALES OF IMAGING REAGENTS, BY REGION, 2001-2008 ($ MILLIONS)
• Figure 36 WORLDWIDE MARKET SHARE OF IMAGING REAGENTS, 2003 (%)

• ACUSPHERE INC.
• ADVANCED MAGNETICS INC.
• ALLIANCE PAHARMACEUTICALS CORP.
• AMERSHAM HEALTH
• BRACCO DIAGNOSTICS INC.
• CYTOGEN CORPORATION
• EPIX MEDICAL INC.
• E-Z-EM, INC.
• HOVIONE
• IMARX THERAPEUTICS
• IMMUNOMEDICS, INC.
• KING PHAMACEUTICALS INC.
• LAFAYETTE PHARMACEUTICALS, INC.
• MALLINCKRODT MEDICAL
  • MALLINCKRODT MEDICAL (CONTINUED)
• NEORX
• PHARMACYCLICS
• SCHERING AG
  • BERLEX LABORATORIES
  • MEDRAD, INC.
  • Medrad, Inc. (Continued)
• POINT BIOMEDICAL
• SONUS PHARMACEUTICALS

LIST OF TABLES

Summary Table:
U.S. SALES OF MEDICAL IMAGING REAGENTS BY TYPE, THROUGH 2008 ($ MILLIONS)

Table 1 HISTORY OF IMAGING

Table 2 USE OF CT/X-RAY, ULTRASOUND AND MRI

Table 3 CHARACTERISTICS OF IMAGING TECHNIQUES

Table 4 ADVANTAGES OF NON-IONIC VS. IONIC CONTRAST AGENTS

Table 5 TYPES OF IODINE CONTAINING IMAGING REAGENTS FOR X-RAY/CT

Table 6 TYPES OF IONIC AND NON-IONIC IODINE CONTAINING IMAGING REAGENTS FOR X-RAY/CT

Table 7 USEFUL CLASSICAL RADIOPHARMACEUTICALS BY APPLICATION

Table 8 NEW AND GENERIC DRUG APPROVALS OF THE IMAGING REAGENTS, 2000-2003

Table 9 MARKET SHARE OF COMPANIES IN MEDICAL IMAGING REAGENTS, 2002 (%)

Table 10 MARKET SHARE OF COMPANIES IN X-RAYS AND CT IMAGING REAGENTS, 2002 (%)

Table 11 MARKET SHARE OF COMPANIES IN ULTRASOUND IMAGING REAGENTS, 2002 (%)

Table 12 MARKET SHARE OF COMPANIES IN MRI REAGENTS, 2002 (%)

Table 13 MARKET SHARE OF COMPANIES IN RADIOPHARMACEUTICAL IMAGING REAGENTS, 2002 (%)

Table 14 U.S. SALES OF IONIC AND NON-IONIC AGENTS, THROUGH 2008 ($ MILLIONS)

Table 15 REAGENTS USED IN X-RAY/CT

Table 16 U.S. SALES OF X-RAY/CT AGENTS, THROUGH 2008 ($ MILLIONS)

Table 17 U.S. SALES OF IONIC AND NON-IONIC REAGENTS IN X-RAY/CT IMAGING, THROUGH 2008 ($ MILLIONS)

Table 18 REAGENTS USED IN ULTRASOUND

Table 19 U.S. SALES OF ULTRASOUND REAGENTS, THROUGH 2008 ($ MILLIONS)

Table 20 CONTRAST AGENTS USED IN MRI

Table 21 U.S. SALES OF MRI AGENTS, THROUGH 2008 ($ MILLIONS)

Table 22 CONTRAST AGENTS USED IN RADIOPHARMACEUTICALS

Table 23 U.S. SALES OF RADIOPHARMACEUTICAL IMAGING REAGENTS, THROUGH 1008 ($ MILLIONS)

Table 24 X-RAY CONTRAST AGENTS UNDER DEVELOPMENT

Table 25 ULTRASOUND CONTRAST AGENTS UNDER DEVELOPMENT

Table 26 MRI CONTRAST AGENTS UNDER DEVELOPMENT

Table 27 RADIOPARMACEUTICAL CONTRAST AGENTS UNDER DEVELOPMENT

Table 28 NUMBER OF PATENTS BY TECHNOLOGY, 1998-2003

Table 29 SIGNIFICANT PATENTS OF X-RAY /CT REAGENTS, 1998-2003

Table 30 SIGNIFICANT PATENTS OF ULTRASOUND REAGENTS, 1998-2003

Table 31 SIGNIFICANT PATENTS OF MAGNETIC RESONANCE IMAGING REAGENTS, 1998-2003

Table 32 SIGNIFICANT PATENTS OF RADIOPHARMACEUTICAL REAGENTS, 1998-2003

Table 33 SIGNIFICANT PATENTS OF OTHER IMAGING REAGENTS1, 1998-2003

Table 34 PATENTS BY ACUSPHERE INC. FOR REAGENTS USED IN IMAGING TECHNOLOGY, 1998-2003

Table 35 PATENTS BY AMERSHAM HEALTH/ NYCOMED FOR REAGENTS USED IN IMAGING TECHNOLOGY, 1998-2003

Table 36 PATENTS BY ALLIANCE PHARMACEUTICALS CORP. FOR REAGENTS USED IN IMAGING TECHNOLOGY, 1998-2003

Table 37 PATENTS BY BRACCO FOR REAGENTS USED IN IMAGING TECHNOLOGY, 1998-2003

Table 38 PATENTS BY EPIX MEDICAL INC. FOR REAGENTS USED IN IMAGING TECHNOLOGY, 1998-2003

Table 39 PATENTS BY EZ-EM INC. FOR REAGENTS USED IN IMAGING TECHNOLOGY, 1998-2003

Table 40 PATENTS BY IMARX THERAPEUTICS FOR REAGENTS USED IN IMAGING TECHNOLOGY, 1998-2003

Table 41 PATENTS BY IMMUNOMEDICS FOR REAGENTS USED IN IMAGING TECHNOLOGY, 1998-2003

Table 42 PATENTS BY MALLINCKRODT MEDICAL FOR REAGENTS USED IN IMAGING TECHNOLOGY, 1998-2003

Table 43 PATENTS BY MOLECULAR BIOSYSTEMS FOR REAGENTS USED IN IMAGING TECHNOLOGY, 1998-2003

Table 44 PATENTS BY NEORX FOR REAGENTS USED IN IMAGING TECHNOLOGY, 1998-2003

Table 45 PATENTS BY PHARMACYCLICS FOR REAGENTS USED IN IMAGING TECHNOLOGY, 1998-2003

Table 46 PATENTS BY SCHERING AG FOR REAGENTS USED IN IMAGING TECHNOLOGY, 1998-2003

Table 47 PATENTS BY POINT BIOMEDICAL FOR REAGENTS USED IN IMAGING TECHNOLOGY, 1998-2003

Table 48 PATENTS BY SONUS PHARMACEUTICALS FOR REAGENTS USED IN IMAGING TECHNOLOGY, 1998-2003

Table 49 U.S. PATENTS BY COUNTRY, 1998-2003

Table 50 TRENDS OF PATENTS ISSUED BY COUNTRY, 1998-2003

Table 51 SHARE OF U.S. PATENTS BY ASIGNEE, 1998-2003

Table 52 U.S. SALES OF MEDICAL IMAGING REAGENTS BY APPLICATION, THROUGH 2008 ($ MILLIONS)

Table 53 U.S. SALES OF TYPES OF MEDICAL IMAGING REAGENTS IN CARDIOVASCULAR APPLICATIONS, THROUGH 2008 ($ MILLIONS)

Table 54 U.S. SALES OF TYPES OF MEDICAL IMAGING REAGENTS IN CENTRAL NERVOUS SYSTEM, THROUGH 2008 ($ MILLIONS)

Table 55 U.S. SALES OF TYPES OF MEDICAL IMAGING REAGENTS IN GASTROINTESTINAL AND LIVER IMAGING, THROUGH 2008 ($ MILLIONS)

Table 56 U.S. SALES OF TYPES OF MEDICAL IMAGING REAGENTS IN ONCOLOGY IMAGING, THROUGH 2008 ($ MILLIONS)

Table 57 U.S. SALES OF TYPES OF MEDICAL IMAGING REAGENTS IN "OTHER" IMAGING, THROUGH 2008 ($ MILLIONS)

Table 58 WORLDWIDE SALES OF X-RAY IMAGING REAGENTS BY REGION, THROUGH 2008 ($ MILLIONS)

Table 59 WORLDWIDE SALES OF ULTRASOUND IMAGING REAGENTS BY REGION, THROUGH 2008 ($ MILLIONS)

Table 60 WORLDWIDE SALES OF MRI IMAGING REAGENTS BY REGION, THROUGH 2008 ($ MILLIONS)

Table 61 WORLDWIDE SALES OF RADIOPHARMACEUTICALS/ NUCLEAR IMAGING REAGENTS BY REGION, THROUGH 2008 ($ MILLIONS)

Table 62 WORLDWIDE SALES OF IMAGING REAGENTS, BY REGION, THROUGH 2008 ($ MILLIONS)

LIST OF FIGURES

Summary Figure:
U.S. SALES OF MEDICAL IMAGING REAGENTS BY TYPE, 2001-2008 ($ MILLIONS)

Figure 1 MARKET SHARE OF COMPANIES IN MEDICAL IMAGING REAGENTS, 2002 (%)

Figure 2 MARKET SHARE OF COMPANIES IN X-RAYS AND CT IMAGING REAGENTS, 2002 (%)

Figure 3 MARKET SHARE OF COMPANIES IN ULTRASOUND IMAGING REAGENTS, 2002 (%)

Figure 4 MARKET SHARE OF COMPANIES IN MRI REAGENTS, 2002 (%)

Figure 5 MARKET SHARE OF COMPANIES IN RADIOPHARMACEUTICAL REAGENTS, 2002 (%)

Figure 6 U.S. SALES OF IONIC AND NON-IONIC AGENTS, 2001-2008 ($ MILLIONS)

Figure 7 U.S. SALES OF X-RAY/CT AGENTS, 2001-2008 ($ MILLIONS)

Figure 8 U.S. SALES OF IONIC AND NON-IONIC REAGENTS IN X-RAY/CT IMAGING, 2001-2008 ($ MILLIONS)

Figure 9 U.S. SALES OF ULTRASOUND REAGENTS, 2001-2008 ($ MILLIONS)

Figure 10 U.S. SALES OF MRI AGENTS, 2001-2008 ($ MILLIONS)

Figure 11 U.S. SALES OF RADIOPHARMACEUTICAL IMAGING REAGENTS, 2001-2008 ($ MILLIONS)

Figure 12 NUMBER OF PATENTS, 1998-2003

Figure 13 NUMBER OF PATENTS BY YEAR, 1998-2003 (% OF TOTAL)

Figure 14 U.S. PATENTS BY COUNTRY, 1998-2003

Figure 15 TOTAL U.S. NUMBER OF PATENTS ISSUED BY COUNTRY, 1998-2003

Figure 16 PERCENT OF PATENTS ISSUED BY COUNTRY, 1998-2003 (%)

Figure 17 MARKET SHARE OF U.S. PATENTS BY ASSIGNEE, 1998-2003 (NUMBER OF PATENTS)

Figure 18 MARKET SHARE OF U.S PATENTS BY ASSIGNEE, 1998-2003 (%)

Figure 19 U.S. SALES OF MEDICAL IMAGING REAGENTS BY APPLICATION, 2001-2008 ($ MILLIONS)

Figure 20 MARKET SHARE OF MEDICAL IMAGING REAGENTS BY APPLICATION, 2003

Figure 21 U.S. SALES OF TYPES OF MEDICAL IMAGING REAGENTS IN CARDIOVASCULAR APPLICATIONS, 2001-2008 ($ MILLIONS)

Figure 22 MARKET SHARE OF CARDIOVASCULAR IMAGING REAGENTS, 2003 (%)

Figure 23 U.S. SALES OF TYPES OF MEDICAL IMAGING REAGENTS IN CENTRAL NERVOUS SYSTEM IMAGING, 2001-2008 ($ MILLIONS)

Figure 24 MARKET SHARE OF CENTRAL NERVOUS SYSTEM IMAGING REAGENTS, 2003 (%)

Figure 25 U.S. SALES OF TYPES OF MEDICAL IMAGING REAGENTS IN GASTRO INTESTINAL AND LIVER IMAGING, 2001-2003 AND 2008 ($ MILLIONS)

Figure 26 MARKET SHARE OF GASTROINTESTAINAL AND LIVER IMAGING REAGENTS, 2003 (%)

Figure 27 U.S. SALES OF TYPES OF MEDICAL IMAGING REAGENTS IN ONCOLOGY IMAGING, 2001-2008 ($ MILLIONS)

Figure 28 MARKET SHARE OF ONCOLOGY IMAGING REAGENTS, 2003 ($ MILLIONS)

Figure 29 U.S. SALES OF TYPES OF MEDICAL IMAGING REAGENTS IN "OTHER" IMAGING, 2001-2008 ($ MILLIONS)

Figure 30 MARKET SHARE OF "OTHER" IMAGING REAGENTS, 2003 (%)

Figure 31 WORLDWIDE SALES OF X-RAY IMAGING REAGENTS BY REGION, 2001-2008 ($ MILLIONS)

Figure 32 WORLDWIDE SALES OF ULTRASOUND IMAGING REAGENTS BY REGION, 2001-2008 ($ MILLIONS)

Figure 33 WORLDWIDE SALES OF MRI IMAGING REAGENTS BY REGION, 2001-2008 ($ MILLIONS)

Figure 34 WORLDWIDE SALES OF RADIOPHARMACEUTICALS/ NUCLEAR IMAGING REAGENTS BY REGION, 2001-2008 ($ MILLIONS)

Figure 35 WORLDWIDE SALES OF IMAGING REAGENTS, BY REGION, 2001-2008 ($ MILLIONS)

Figure 36 WORLDWIDE MARKET SHARE OF IMAGING REAGENTS, 2003 (%)