Report: Membrane Technology for Biopharmaceuticals TOC

INTRODUCTION

STUDY GOALS AND OBJECTIVES
REASONS FOR DOING STUDY
CONTRIBUTION OF THE STUDY AND FOR WHOM
SCOPE AND FORMAT
METHODOLOGY
INFORMATION SOURCES
AUTHORS CREDENTIALS
RELATED BCC WORK CREDENTIALS
BCC ON-LINE SERVICES
DISCLAIMER

SUMMARY

Summary Table:
U.S. MARKET VALUE OF MEMBRANE TECHNOLOGY FOR THE LIFE SCIENCE INDUSTRY, THROUGH 2009 ($ MILLIONS)
Summary Figure:
U.S. MARKET VALUE OF MEMBRANE TECHNOLOGY FOR THE LIFE SCIENCE INDUSTRY, 2002-2009

INDUSTRY OVERVIEW

HISTORY OF THE INDUSTRY

Table 1 A BRIEF HISTORY OF MEMBRANES IN THE LIFE SCIENCES
Table 1 (CONTINUED)

BIOPHARMACEUTICALS

DRUG DISCOVERY, DEVELOPMENT AND MANUFACTURING

Drug Discovery, Development...(Continued)

Figure 1 NEW DRUGS: FROM DISCOVERY TO MANUFACTURING

Approval Process Improving
Harmonization

DRUG DEVELOPMENT COSTS

Research Funding

Government Funding
Venture Capital Funding
Corporate Funding

COMMERCIAL BIOTECH DRUGS

Table 2 NEW DRUG APPROVALS IN RELATION TO R&D SPENDING, 1999-2003 (NUMBER, $ BILLIONS)
Figure 2 NEW DRUG APPROVALS IN RELATION TO R&D SPENDING, 1992-2003 (NUMBER, $ BILLIONS)
Table 3 TOP TEN BIOTECH DRUGS, GLOBAL MARKET, 2003 ($ MILLIONS)

ORPHAN DRUGS
BIOGENERICS

Table 4 LEADING BIOPHARMACEUTICALS FACING GENERIC STATUS

MEMBRANE TECHNOLOGY

MEMBRANE MATERIALS

Table 5 CHARACTERISTICS OF MEMBRANE MATERIALS

MODULES
CONFIGURATION
MOLECULAR WEIGHT CUTOFF
FLUX

Fouling

METHODS OF FILTRATION

DIRECT FLOW FILTRATION
CROSSFLOW FILTRATION

MEMBRANE TECHNOLOGY TYPES

REVERSE OSMOSIS
NANOFILTRATION
ULTRAFILTRATION
MICROFILTRATION

MF vs. UF in Bioseparations

Table 6 BIOPHARMACEUTICAL APPLICATIONS OF UF AND MF

ELECTRODEIONIZATION

COMPETITIVE TECHNOLOGIES

Table 7 VALUE OF THE U.S. MARKET FOR MEMBRANE FILTRATION AND COMPETITIVE BIOSEPARATION METHODS, THROUGH 2009 ($ MILLIONS )
Figure 3 VALUE OF THE U.S. MARKET FOR MEMBRANE FILTRATION AND COMPETITIVE BIOSEPARATION METHODS, 2002-2009 ($ MILLIONS)

LIFE SCIENCE APPLICATIONS FOR MEMBRANE TECHNOLOGY

LIFE SCIENCE APPLICATIONS FOR MEMBRANE TECHNOLOGY

LIFE SCIENCE APPLICATIONS FOR ...(CONTINUED)

Table 8 VALUE OF THE U.S. MARKET FOR MEMBRANE TECHNOLOGIES BY LIFE SCIENCE APPLICATIONS, THROUGH 2009 ($ MILLIONS)
Figure 4 VALUE OF THE U.S. MARKET FOR MEMBRANE TECHNOLOGIES BY LIFE SCIENCE APPLICATIONS, 2002-2009 ($ MILLIONS)

LABORATORY-SCALE APPLICATIONS

GENOMICS RESEARCH

TRANSFER MEMBRANES

Types of Blots

Southern Blot
Western Blot
Colony or Plaque Blot

Transfer Membrane Manufacturers/Products

Table 9 TRANSFER MEMBRANE MANUFACTURERS/PRODUCTS

DNA MICROARRAYS

DNA Microarray Membranes
DNA Array Manufacturers/Products

Table 10 DNA MICROARRAY MANUFACTURERS/PRODUCTS

PROTEOMICS RESEARCH

PROTEIN ARRAYS

Protein Array Membranes
Protein Array Manufacturers/Products

Table 11 PROTEIN ARRAY MANUFACTURERS/ PRODUCTS

CANDIDATE DRUG SCREENING

MULTI-WELL FILTER PLATES

ADMET Screening
Solubility Assays
PAMPA-Parallel Artificial Membrane Permeation Assays
Caco-2 and Other Cell-Based Transport Assays
Bound vs. Free Drug Assays
Total Drug Analysis
DNA Sample Preparation
Multiwell Filter Plate Manufacturers/Products

Table 12 MULTIWELL FILTER PLATE MANUFACTURERS/PRODUCTS
Table 12 (CONTINUED)
Table 12 (CONTINUED)
Table 12 (CONTINUED)

LAB-SCALE SEPARATIONS

SYRINGE FILTERS

Syringeless Filters
Syringe/ Syringeless Filter Manufacturers/ Products

Table 13 SYRINGE AND SYRINGELESS FILTER MANUFACTURERS
Table 13 (CONTINUED)
Table 13 (CONTINUED)
Table 13 (CONTINUED)

BOTTLE-TOP FILTERS

Bottletop Filter Manufacturers/ Products

Table 14 BOTTLETOP FILTER MANUFACTURERS/PRODUCTS
Table 14 (CONTINUED)

MOLECULAR SEPARATIONS SYSTEMS

Stirred Cell Systems

Stirred Cell Manufacturers/ Products

Table 15 STIRRED CELL MANUFACTURERS/PRODUCTS

Centrifugal Devices

Centrifuge Filter Manufacturers/ Products

Table 16 CENTRIFUGAL FILTER MANUFACTURERS
Table 16 (CONTINUED)

TFF Systems

TFF Replacing Centrifugal, Stirred Cell Systems
TFF System Manufacturers/Products

Table 17 LAB-SCALE, PILOT-SCALE, SMALL PRODUCTION-SCALE TFF SYSTEMS
Table 17 (CONTINUED)
Table 17 (CONTINUED)

LABORATORY WATER

VALIDATING LAB WATER SYSTEMS

Lab Water System Manufacturers/Products

Table 18 LABORATORY WATER SYSTEM MANUFACTURERS/PRODUCTS
Table 18 (CONTINUED)

VALUE OF THE U.S. MARKET FOR LAB-SCALE DEVICES/SYSTEMS

TRANSFER MEMBRANES
MICROARRAYS
MULTIWELL PLATES
SYRINGE FILTERS, BOTTLETOP FILTERS
MOLECULAR SEPARATION SYSTEMS
LABORATORY WATER SYSTEMS

Table 19 VALUE OF THE U.S. MARKET FOR MEMBRANE TECHNOLOGIES IN LAB-SCALE APPLICATIONS BY DEVICE/SYSTEM TYPE, THROUGH 2009 ($ MILLIONS)
Figure 5 VALUE OF THE U.S. MARKET FOR MEMBRANE TECHNOLOGIES IN LAB-SCALE APPLICATIONS BY DEVICE/SYSTEM TYPE, 2002-2009 ($ MILLIONS)

CELL CULTURING APPLICATIONS

OVERVIEW
CELL CULTURE SYSTEMS

CELL CULTURE INSERTS

Membrane Insert Manufacturers/Products

Becton Dickinson
Millipore
Corning

CELL CULTURE REACTORS

Cell Culture Reactor Manufacturers/Products

Table 20 CELL CULTURE REACTOR MANUFACTURERS/PRODUCTS
Table 20 (CONTINUED)

VALUE OF THE U.S. MARKET FOR CELL CULTURE SYSTEMS

VALUE OF THE U.S. MARKET FOR...(CONTINUED)

Table 21 VALUE OF THE U.S. MARKET FOR MEMBRANE TECHNOLOGIES IN CELL CULTURE SYSTEMS, THROUGH 2009 ($ MILLIONS)
Figure 6 VALUE OF THE U.S. MARKET FOR CELL CULTURE SYSTEMS, 2002-2009 ($ MILLIONS)

PROCESS-SCALE APPLICATIONS

Table 22 PROCESS-SCALE BIOTECH PURIFICATIONS

CONVENTIONAL MANUFACTURING

REVAMPED REGULATIONS

PROTEIN SEPARATIONS/CONCENTRATION

Figure 7 BIOPHARMACEUTICALS MANUFACTURE
Figure 8 VACCINE MANUFACTURE
Figure 9 ANTIBIOTIC AND VITAMIN MANUFACTURE

BIOPROCESSING MEMBRANES AND SYSTEMS

Bioprocessing Equipment Manufacturers/Products

Table 23 UF, MF MEMBRANE/SYSTEM MANUFACTURERS AND PRODUCTS
Table 23 (CONTINUED)
Table 23 (CONTINUED)

VIRUS REMOVAL

VIRUS FILTERS

Table 24 VIRUSES FOUND IN BIOPHARMACEUTICAL PRODUCTION

Virus Filter Manufacturers/Products

Table 25 VIRUS FILTER MANUFACTURERS/PRODUCTS

MEMBRANE CHROMATOGRAPHY

MEMBRANE ADSORBERS

Membrane Adsorber Manufacturers/Products

Table 26 MEMBRANE ADSORBER MANUFACTURERS/PRODUCTS
Table 26 (CONTINUED)

CHIRAL SEPARATIONS
COMPENDIAL WATERS

PROCESS WATER MEMBRANE AND SYSTEMS

Manufacturers of Process Water Treatment Membranes/Systems

Table 27 PROCESS WATER EQUIPMENT MANUFACTURERS/PRODUCTS

VALUE OF THE U.S. MARKET FOR PROCESS-SCALE DEVICES/SYSTEMS

Table 28 MANUFACTURERS USING MEMBRANES IN APPROVED BIOTECH DRUG PRODUCTION

THE BIOMANUFACTURING CRUNCH
MF BIOPROCESSING
UF BIOPROCESSING
VIRUS REDUCTION
MEMBRANE CHROMATOGRAPHY
PROCESS WATER TREATMENT

Table 29 VALUE OF THE U.S. MARKET FOR MEMBRANE TECHNOLOGIES BY PROCESS-SCALE DEVICE/SYSTEM TYPE, THROUGH 2009 ($ MILLIONS)
Figure 10 VALUE OF THE U.S. MARKET BY PROCESS-SCALE DEVICE/SYSTEM TYPE, 2002-2009 ($ MILLIONS)

PATENTS, TRENDS AND TECHNICAL DEVELOPMENTS

PATENT SURVEY

PATENTS BY APPLICATION

Table 30 PATENT SURVEY BY APPLICATION (APRIL 1, 1999-MARCH 31, 2004)
Table 30 (CONTINUED)
Figure 11 PATENT SURVEY BY APPLICATION (APRIL 1, 1999-MARCH 31, 2004)

BY COMPANY

Table 31 PATENT SURVEY BY COMPANY (APRIL 1, 1999-MARCH 31, 2004)
Figure 12 PATENT SURVEY BY COMPANY (APRIL 1, 1999-MARCH 31, 2004)

TRENDS

DISPOSABLE MANUFACTURING

Disposable Manufacturing (Continued)

TECHNICAL DEVELOPMENTS

POLYMER BRUSH ADSORBERS
ANTIBODY-BASED NANOTUBE MEMBRANES
LIPID MEMBRANE CELL CULTURE MICROARRAYS
P-FILM
GRADIFLOW

INTERNATIONAL ASPECTS

Table 32 GLOBAL BIOTECH AND PHARMA R&D SPENDING, 1995-2003 ($ BILLIONS)
Figure 13 GLOBAL BIOTECH AND PHARMA R&D SPENDING, 1995-2003 ($ BILLIONS)
Table 33 GLOBAL BIOTECH AND PHARMA R&D SPENDING BY COUNTRY, 2003 ($ MILLIONS)
Figure 14 GLOBAL BIOTECH AND PHARMA R&D SPENDING BY COUNTRY, 2003 ($ MILLIONS)

WESTERN EUROPE

Table 34 BIOTECH COMPANIES AND PRODUCT PIPELINES IN EUROPE, 2002
Figure 15 BIOTECH COMPANIES AND PRODUCT PIPELINES IN EUROPE, 2002

UK
FRANCE
GERMANY
ITALY
THE NETHERLANDS
SPAIN
BELGIUM
SWEDEN
DENMARK
NORWAY
FINLAND
ICELAND

EASTERN EUROPE

ESTONIA
CROATIA
LITHUANIA
RUSSIA

MIDDLE EAST

ISRAEL

ASIA

CHINA
JAPAN
INDIA
TAIWAN
SINGAPORE
SOUTH KOREA

REST OF WORLD

AUSTRALIA
BRAZIL

GLOBAL LIFE SCIENCE MEMBRANE MARKET

GLOBAL LIFE SCIENCE MEMBRANE ... (CONTINUED)

INDUSTRY STRUCTURE

Table 35 LIFE SCIENCE EQUIPMENT CUSTOMERS (%)
Figure 16 LIFE SCIENCE EQUIPMENT CUSTOMERS (%)

BIOTECH AND BIG PHARMA

BLURRING BOUNDARIES
MANUFACTURERS OF MEMBRANES, DEVICES AND SYSTEMS SUPPORTING THE LIFE SCIENCE INDUSTRY

Manufacturers of Membranes, Devices ...(Continued)
Consolidation
The Urge to Merge

Table 36 MEMBRANE INDUSTRY MERGERS AND ACQUISITIONS RELATED TO THE LIFE SCIENCES (1994-JULY 2004)

PARTNERING AGREEMENTS

Table 37 SELECTED PARTNERING AGREEMENTS (2000-JULY 2004)
Table 37 (CONTINUED)

MARKET SHARE

Table 38 ESTIMATED COMPANY MARKET SHARES IN THE LIFE SCIENCE MEMBRANE INDUSTRY, 2004 (%)
Figure 17 ESTIMATED COMPANY MARKET SHARES IN THE LIFE SCIENCE MEMBRANE INDUSTRY, 2004 (%)
Table 39 MAJOR MANUFACTURERS AND PRODUCT TYPES

ECOMMERCE

COMPANY PROFILES

20/20 GENESYSTEMS
ADVANTEC MFS, INC.
AMBION
AMERSHAM BIOSCIENCES/GE
ASAHI KASEI
BECTON DICKINSON

Discovery Labware
BD Clontech

BIOVEST INTERNATIONAL
CORNING, INC.
CUNO, INC.
ELGA LABWATER
EMEMBRANE
FIBERCELL SYSTEMS, INC.
GE OSMONICS
HYDRANAUTICS
IONICS, INC.
INTEGRA BIOSCIENCES
KOCH MEMBRANE SYSTEMS
MEISSNER FILTRATION PRODUCTS, INC.
MILLIPORE
PALL
PCI MEMBRANES
SCHLEICHER & SCHUELL
SARTORIUS AG
SPECTRUM LABORATORIES
STERLITECH
SYNDER FILTRATION
SYNTHECON
TAMI INDUSTRIES
TORAY INDUSTRIES
TRISEP
USFILTER/SIEMENS AG
WHATMAN PLC

APPENDIX

CONTACTS

Table 40 MANUFACTURERS DIRECTORY
Table 40 (CONTINUED)
Table 40 (CONTINUED)
Table 40 (CONTINUED)
Table 40 (CONTINUED)
Table 40 (CONTINUED)
Table 40 (CONTINUED)
Table 40 (CONTINUED)
Table 40 (CONTINUED)
Table 40 (CONTINUED)
Table 40 (CONTINUED)
Table 40 (CONTINUED)
Table 40 (CONTINUED)
Table 40 (CONTINUED)
Table 40 (CONTINUED)
Table 40 (CONTINUED)

PATENTS

Table 41 PATENT SURVEY
Table 41 (CONTINUED)
Table 41 (CONTINUED)
Table 41 (CONTINUED)
Table 41 (CONTINUED)
Table 41 (CONTINUED)

BIOTECH DRUGS IN U.S. PIPELINE

Table 42 BIOTECHNOLOGY MEDICINES IN DEVELOPMENT-HIV/AIDS
Table 43 BIOTECHNOLOGY MEDICINES IN DEVELOPMENT-AUTOIMMUNE DISORDERS
Table 43 (CONTINUED)
Table 44 BIOTECHNOLOGY MEDICINES IN DEVELOPMENT-BLOOD DISORDERS
Table 45 BIOTECHNOLOGY MEDICINES IN DEVELOPMENT-CANCER AND RELATED CONDITIONS
Table 45 (CONTINUED)
Table 45 (CONTINUED)
Table 45 (CONTINUED)
Table 45 (CONTINUED)
Table 45 (CONTINUED)
Table 45 (CONTINUED)
Table 45 (CONTINUED)
Table 45 (CONTINUED)
Table 45 (CONTINUED)
Table 45 (CONTINUED)
Table 45 (CONTINUED)
Table 46 BIOTECHNOLOGY MEDICINES IN DEVELOPMENT-DIABETES AND RELATED CONDITIONS
Table 47 BIOTECHNOLOGY MEDICINES IN DEVELOPMENT-DIGESTIVE DISORDERS
Table 47 (CONTINUED)
Table 48 BIOTECHNOLOGY MEDICINES IN DEVELOPMENT-EYE CONDITIONS
Table 49 BIOTECHNOLOGY MEDICINES IN DEVELOPMENT-GENETIC DISORDERS
Table 50 BIOTECHNOLOGY MEDICINES IN DEVELOPMENT-GROWTH DISORDERS
Table 50 (CONTINUED)
Table 51 BIOTECHNOLOGY MEDICINES IN DEVELOPMENT-HEART DISEASE
Table 51 (CONTINUED)
Table 52 BIOTECHNOLOGY MEDICINES IN DEVELOPMENT-INFECTIOUS DISEASES
Table 52 (CONTINUED)
Table 52 (CONTINUED)
Table 52 (CONTINUED)
Table 53 BIOTECHNOLOGY MEDICINES IN DEVELOPMENT-INFERTILITY
Table 54 BIOTECHNOLOGY MEDICINES IN DEVELOPMENT-NEUROLOGIC DISORDERS
Table 54 (CONTINUED)
Table 55 BIOTECHNOLOGY MEDICINES IN DEVELOPMENT-RESPIRATORY DISORDERS
Table 55 (CONTINUED)
Table 55 (CONTINUED)
Table 56 BIOTECHNOLOGY MEDICINES IN DEVELOPMENT-SKIN DISORDERS
Table 56 (CONTINUED)
Table 57 BIOTECHNOLOGY MEDICINES IN DEVELOPMENT-TRANSPLANTATION
Table 57 (CONTINUED)
Table 58 BIOTECHNOLOGY MEDICINES IN DEVELOPMENT-OTHER
Table 58 (CONTINUED)
Table 58 (CONTINUED)

APPROVED BIOTECH DRUGS

Table 59 APPROVED BIOTECH DRUGS (AS OF FEBRUARY 2004)
Table 59 (CONTINUED)
Table 59 (CONTINUED)
Table 59 (CONTINUED)
Table 59 (CONTINUED)
Table 59 (CONTINUED)
Table 59 (CONTINUED)
Table 59 (CONTINUED)
Table 59 (CONTINUED)
Table 59 (CONTINUED)
Table 59 (CONTINUED)
Table 59 (CONTINUED)

LIST OF TABLES

Summary Table: U.S. MARKET VALUE OF MEMBRANE TECHNOLOGY FOR THE LIFE SCIENCE INDUSTRY, THROUGH 2009 ($ MILLIONS)
Table 1 A BRIEF HISTORY OF MEMBRANES IN THE LIFE SCIENCES
Table 2 NEW DRUG APPROVALS IN RELATION TO R&D SPENDING, 1992-2003 (NUMBER, $ BILLIONS)
Table 3 TOP TEN BIOTECH DRUGS, GLOBAL MARKET, 2003 ($ MILLIONS)
Table 4 LEADING BIOPHARMACEUTICALS FACING GENERIC STATUS
Table 5 CHARACTERISTICS OF MEMBRANE MATERIALS
Table 6 BIOPHARMACEUTICAL APPLICATIONS OF UF AND MF
Table 7 VALUE OF THE U.S. MARKET FOR MEMBRANE FILTRATION AND COMPETITIVE BIOSEPARATION METHODS, THROUGH 2009 ($ MILLIONS )
Table 8 VALUE OF THE U.S. MARKET FOR MEMBRANE TECHNOLOGIES BY LIFE SCIENCE APPLICATIONS, THROUGH 2009 ($ MILLIONS)
Table 9 TRANSFER MEMBRANE MANUFACTURERS/PRODUCTS
Table 10 DNA MICROARRAY MANUFACTURERS/PRODUCTS
Table 11 PROTEIN ARRAY MANUFACTURERS/PRODUCTS
Table 12 MULTIWELL FILTER PLATE MANUFACTURERS/PRODUCTS
Table 13 SYRINGE AND SYRINGELESS FILTER MANUFACTURERS
Table 14 BOTTLETOP FILTER MANUFACTURERS/PRODUCTS
Table 15 STIRRED CELL MANUFACTURERS/PRODUCTS
Table 16 CENTRIFUGAL FILTER MANUFACTURERS
Table 17 LAB-SCALE, PILOT-SCALE, SMALL PRODUCTION-SCALE TFF SYSTEMS
Table 18 LABORATORY WATER SYSTEM MANUFACTURERS/PRODUCTS
Table 19 VALUE OF THE U.S. MARKET FOR MEMBRANE TECHNOLOGIES IN LAB-SCALE APPLICATIONS BY DEVICE/SYSTEM TYPE, THROUGH 2009 ($ MILLIONS)
Table 20 CELL CULTURE REACTOR MANUFACTURERS/PRODUCTS
Table 21 VALUE OF THE U.S. MARKET FOR MEMBRANE TECHNOLOGIES IN CELL CULTURE SYSTEMS, THROUGH 2009 ($ MILLIONS)
Table 22 PROCESS-SCALE BIOTECH PURIFICATIONS
Table 23 UF, MF MEMBRANE/SYSTEM MANUFACTURERS AND PRODUCTS
Table 24 VIRUSES FOUND IN BIOPHARMACEUTICAL PRODUCTION
Table 25 VIRUS FILTER MANUFACTURERS/PRODUCTS
Table 26 MEMBRANE ADSORBER MANUFACTURERS/PRODUCTS
Table 27 PROCESS WATER EQUIPMENT MANUFACTURERS/PRODUCTS
Table 28 MANUFACTURERS USING MEMBRANES IN APPROVED BIOTECH DRUG PRODUCTION
Table 29 VALUE OF THE U.S. MARKET FOR MEMBRANE TECHNOLOGIES BY PROCESS-SCALE DEVICE/SYSTEM TYPE, THROUGH 2009 ($ MILLIONS)
Table 30 PATENT SURVEY BY APPLICATION (APRIL 1, 1999-MARCH 31, 2004)
Table 31 PATENT SURVEY BY COMPANY (APRIL 1, 1999-MARCH 31, 2004)
Table 32 GLOBAL BIOTECH AND PHARMA R&D SPENDING, 1995-2003 ($ BILLIONS)
Table 33 GLOBAL BIOTECH AND PHARMA R&D SPENDING BY COUNTRY, 2003 ($ MILLIONS)
Table 34 BIOTECH COMPANIES AND PRODUCT PIPELINES IN EUROPE, 2002
Table 35 LIFE SCIENCE EQUIPMENT CUSTOMERS (%)
Table 36 MEMBRANE INDUSTRY MERGERS AND ACQUISITIONS RELATED TO THE LIFE SCIENCES (1994-JULY 2004)
Table 37 SELECTED PARTNERING AGREEMENTS (2000-JULY 2004)
Table 38 ESTIMATED COMPANY MARKET SHARES IN THE LIFE SCIENCE MEMBRANE INDUSTRY, 2004 (%)
Table 39 MAJOR MANUFACTURERS AND PRODUCT TYPES
Table 40 MANUFACTURERS DIRECTORY
Table 41 PATENT SURVEY
Table 42 BIOTECHNOLOGY MEDICINES IN DEVELOPMENT-HIV/AIDS
Table 43 BIOTECHNOLOGY MEDICINES IN DEVELOPMENT-AUTOIMMUNE DISORDERS
Table 44 BIOTECHNOLOGY MEDICINES IN DEVELOPMENT-BLOOD DISORDERS
Table 45 BIOTECHNOLOGY MEDICINES IN DEVELOPMENT-CANCER AND RELATED CONDITIONS
Table 46 BIOTECHNOLOGY MEDICINES IN DEVELOPMENT-DIABETES AND RELATED CONDITIONS
Table 47 BIOTECHNOLOGY MEDICINES IN DEVELOPMENT-DIGESTIVE DISORDERS
Table 48 BIOTECHNOLOGY MEDICINES IN DEVELOPMENT-EYE CONDITIONS
Table 49 BIOTECHNOLOGY MEDICINES IN DEVELOPMENT-GENETIC DISORDERS
Table 50 BIOTECHNOLOGY MEDICINES IN DEVELOPMENT-GROWTH DISORDERS
Table 51 BIOTECHNOLOGY MEDICINES IN DEVELOPMENT-HEART DISEASE
Table 52 BIOTECHNOLOGY MEDICINES IN DEVELOPMENT-INFECTIOUS DISEASES
Table 53 BIOTECHNOLOGY MEDICINES IN DEVELOPMENT-INFERTILITY
Table 54 BIOTECHNOLOGY MEDICINES IN DEVELOPMENT-NEUROLOGIC DISORDERS
Table 55 BIOTECHNOLOGY MEDICINES IN DEVELOPMENT-RESPIRATORY DISORDERS
Table 56 BIOTECHNOLOGY MEDICINES IN DEVELOPMENT-SKIN DISORDERS
Table 57 BIOTECHNOLOGY MEDICINES IN DEVELOPMENT-TRANSPLANTATION
Table 58 BIOTECHNOLOGY MEDICINES IN DEVELOPMENT-OTHER
Table 59 APPROVED BIOTECH DRUGS (AS OF FEBRUARY 2004)

LIST OF FIGURES

Summary Figure: U.S. MARKET VALUE OF MEMBRANE TECHNOLOGY FOR THE LIFE SCIENCE INDUSTRY, 2002-2009
Figure 1 NEW DRUGS: FROM DISCOVERY TO MANUFACTURING
Figure 2 NEW DRUG APPROVALS IN RELATION TO R&D SPENDING, 1992-2003 (NUMBER, $ BILLIONS)
Figure 3 VALUE OF THE U.S. MARKET FOR MEMBRANE FILTRATION AND COMPETITIVE BIOSEPARATION METHODS, 2002-2009 ($ MILLIONS)
Figure 4 VALUE OF THE U.S. MARKET FOR MEMBRANE TECHNOLOGIES BY LIFE SCIENCE APPLICATIONS, 2002-2009 ($ MILLIONS)
Figure 5 VALUE OF THE U.S. MARKET FOR MEMBRANE TECHNOLOGIES IN LAB-SCALE APPLICATIONS BY DEVICE/SYSTEM TYPE, 2002-2009 ($ MILLIONS)
Figure 6 VALUE OF THE U.S. MARKET FOR CELL CULTURE SYSTEMS, 2002-2009 ($ MILLIONS)
Figure 7 BIOPHARMACEUTICALS MANUFACTURE
Figure 8 VACCINE MANUFACTURE
Figure 9 ANTIBIOTIC AND VITAMIN MANUFACTURE
Figure 10 VALUE OF THE U.S. MARKET BY PROCESS-SCALE DEVICE/SYSTEM TYPE, 2002-2009 ($ MILLIONS)
Figure 11 PATENT SURVEY BY APPLICATION (APRIL 1, 1999-MARCH 31, 2004)
Figure 12 PATENT SURVEY BY COMPANY (APRIL 1, 1999-MARCH 31, 2004)
Figure 13 GLOBAL BIOTECH AND PHARMA R&D SPENDING, 1995-2003 ($ BILLIONS)
Figure 14 GLOBAL BIOTECH AND PHARMA R&D SPENDING BY COUNTRY, 2003 ($ MILLIONS)
Figure 15 BIOTECH COMPANIES AND PRODUCT PIPELINES IN EUROPE, 2002
Figure 16 LIFE SCIENCE EQUIPMENT CUSTOMERS (%)
Figure 17 ESTIMATED COMPANY MARKET SHARES IN THE LIFE SCIENCE MEMBRANE INDUSTRY, 2004 (%)

Membrane Technology for Biopharmaceuticals

TABLE OF CONTENTS

LIST OF TABLES

LIST OF FIGURES