Global Biochip Markets: Microarrays and Lab-on-a-Chip

Table of Contents

• INTRODUCTION
  • STUDY GOALS AND OBJECTIVES
  • REASONS FOR DOING THE STUDY
  • CONTRIBUTION OF THE STUDY AND FOR WHOM
  • SCOPE AND FORMAT
  • METHODOLOGY
  • INFORMATION SOURCES
  • RELATED BCC REPORTS
  • DISCLAIMER
• SUMMARY
  • Summary Table:
  • GLOBAL VALUE OF BIOCHIP PRODUCTS BY TYPE, THROUGH 2013 ($ MILLIONS)
  • Summary Figure:
  • GLOBAL VALUE OF BIOCHIP PRODUCTS BY TYPE, 2006-2013 ($ MILLIONS)
• OVERVIEW
  • INTRODUCTION
  • Table 1 BIOLOGY DOWNSIZING REVOLUTION
  • Figure 1 EVOLUTION OF BIOCHIPS
    • BIOCHIP TYPES
  • Figure 2 CLASSIFICATION OF BIOCHIPS
  • Table 2 COMPARISON OF THE TWO MAJOR BIOCHIP TYPES
  • Table 3 BIOCHIP NOMENCLATURE
    • BIOCHIP TECHNOLOGIES COVERED IN THIS REPORT
  • Table 4 SCOPE OF THIS REPORT
    • MARKET POTENTIAL OF BIOCHIPS
  • Table 5 GLOBAL VALUE OF BIOCHIP MARKET BY END USE, THROUGH 2013 ($ MILLIONS)
  • Table 6 GLOBAL VALUE OF BIOCHIP PRODUCTS BY GEOGRAPHY, THROUGH 2013 ($ MILLIONS)
    • DRIVING FORCES FOR GROWTH IN BIOCHIPS MARKETS
  • Table 7 BIOCHIP MARKET GROWTH DRIVING FORCES
  • Table 7 (CONTINUED)
    • BIOCHIPS: A CONVERGENCE OF DIVERSE TECHNOLOGIES
  • Table 8 MULTIDISCIPLINARY FIELD OF BIOCHIPS
    • LIFE CYCLE STATUS OF BIOCHIP PRODUCTS
  • Table 9 LIFE CYCLE STATUS OF BIOCHIP TYPES
    • COMMERCIAL STATUS OF BIOCHIPS
      • MICROARRAYS
      • LOAC
    • THE BIOCHIP INDUSTRY
  • Table 10 BIOCHIP INDUSTRY KEY COMPETITORS
• MICROARRAY TECHNOLOGIES
  • INTRODUCTION
    • THE NANOSCALE WORLD
  • Table 11 THE NANOSCALE WORLD
  • Table 12 MICROARRAY TYPES
  • Table 13 COMPARISON OF DNA AND PROTEIN MICROARRAY TECHNOLOGIES
    • The Nanoscale World (Continued)
  • DNA MICROARRAY TECHNOLOGIES
    • INTRODUCTION
  • Table 14 DNA MICROARRAY PLATFORM FEATURES
    • Introduction (Continued)
  • Table 15 DNA MICROARRAY PLATFORM COMPARISON FOR MAJOR MANUFACTURERS
    • Introduction (Continued)
      • STEPS IN THE DNA MICROARRAY EXPERIMENT
      • DNA MICROARRAY APPLICATIONS
  • Table 16 DNA MICROARRAY APPLICATIONS
    • Gene Expression Profiling
  • Table 17 PROBES FOR GENE EXPRESSION DNA MICROARRAYS
    • Gene Expression Profiling (Continued)
  • Table 18 EXAMPLE APPLICATIONS OF GENE EXPRESSION PROFILING
  • Figure 3 GENETIC ANALYSIS TECHNOLOGY COMPETITIVE SPACE
  • Table 19 GENETIC ANALYSIS TECHNOLOGIES COMPARISON
  • Figure 4 COMPETITIVE SPACE FOR GENE
  • Table 20 PLATFORMS FOR HIGH THROUGHPUT QUANTITATIVE GENE EXPRESSION ANALYSIS
  • Table 21 GENE EXPRESSION PLATFORMS OF TWO LEADING DNA ARRAY MANUFACTURERS
  • Table 22 PROBE SENSITIVITY AND SPECIFICITY
    • SNP Analysis
  • Figure 5 SNP ANALYSIS PLATFORMS
    • Epigenetic Analysis
  • Figure 6 EPIGENOMICS WITHIN THE MOLECULAR BIOLOGY PARADIGM
    • Dna Methylation
  • Figure 7 EPIGENETIC CHANGES TO DNA AFFECT GENE EXPRESSION
    • Histones
  • Figure 8 HISTONE TAIL REGIONS MODIFIED BY HAT AND HDAC
    • DNA and Histone Analysis Workflow
  • Figure 9 UPSTREAM AND DOWNSTREAM STEPS IN EPIGENETIC ANALYSIS
    • DNA Methylation Microarrays
    • Chip-On-Chip
  • Figure 10 CHIP-ON-CHIP PROCEDURE
  • Table 23 CHIP ASSAYS
  • Table 24 TECHNOLOGIES FOR MAPPING GENOMIC LOCATION OF CHROMATIN PROTEINS AND ENZYMES
    • Epigenetic Microarrays
  • Figure 11 MICROARRAY FEATURE DENSITY
  • Figure 12 MICROARRAY RESOLUTION
  • Table 25 MICROARRAY GENOME CONTENT
  • Table 26 PLATFORMS FOR HIGH DENSITY OLIGONUCLEOTIDE EPIGENETICS ARRAYS
    • Cytogenetic Analysis
  • Table 27 COMPARISON OF CHROMOSOMAL CHANGE DETECTION TECHNOLOGIES
    • Cytogenetic Analysis (Continued)
  • Figure 13 COMPETITIVE SPACE FOR CNV ANALYSIS
    • Cytogenetic Analysis (Continued)
  • Table 28 CGH MICROARRAY PROBE PLATFORMS
  • Table 29 CGH MICROARRAY TRENDS
    • Cytogenetic Analysis (Continued)
• Table 30 FUTURE TECHNOLOGY NEEDS FOR CGH MICROARRAYS
  • miRNA Analysis
    • miRNA Analysis (Continued)
  • Table 31 TECHNICAL CHALLENGES FOR MIRNAS
    • ARRAYS ON BEADS
  • Table 32 ARRAYS ON BEADS
    • CATALOG AND CUSTOM DNA MICROARRAYS
    • SUPPLY OF REAGENTS AND SAMPLE PREPARATION FOR MICROARRAYS
    • TOXICOGENOMICS
    • DNA SEQUENCING
  • Figure 14 COMPARISON OF SANGER WITH UHTS DNA SEQUENCING TECHNOLOGIES
  • Table 33 SINGLE MOLECULE SEQUENCING TECHNOLOGY
  • Table 34 COMPARISON OF SELECTED DNA SEQUENCING PLATFORMS
  • Figure 15 COMPETITIVE SPACE FOR HIGH THROUGHPUT GENOMIC ANALYSIS
  • Table 35 BIOCHIP CONTENT IN NHGRI GRANTEES FOR NEXT GENERATION DNA SEQUENCING, 2005
  • Table 35 (CONTINUED)
  • Table 36 NEXT GENERATION DNA SEQUENCING COMPANIES
    • RESEQUENCING APPROACHES IN DIAGNOSTICS
    • DNA MICROARRAY MANUFACTURING
  • Figure 16 DNA MICROARRAY MANUFACTURING TECHNOLOGIES
    • DNA Microarray Manufacturing (Continued)
  • Table 37 DNA MICROARRAY PROBE DENSITY TRENDS
    • DNA MICROARRAY TECHNOLOGY TRENDS
    • DNA MICROARRAY TECHNOLOGY CHALLENGES
  • Figure 17 DNA MICROARRAY COST-VOLUME CURVE
    • PROTEIN MICROARRAY TECHNOLOGIES
    • INTRODUCTION
  • Figure 18 IMPORTANCE OF PROTEINS
    • PROTEOMICS WORKFLOW
  • Figure 19 PROTEIN ANALYSIS APPROACHES CONTRASTED
    • PROTEIN MICROARRAY DESIGN FEATURES
  • Table 38 PROTEIN MICROARRAY PLATFORMS
    • PROTEIN MICROARRAY APPLICATIONS AS RESEARCH TOOLS
  • Table 39 PROTEIN MICROARRAYS AS RESEARCH TOOLS
    • Protein Microarray Applications as ? (Continued)
      • PROTEIN MICROARRAY TYPES
  • Table 40 PROTEIN MICROARRAY PRODUCT TYPES
    • Protein Microarray Types (Continued)
    • Protein Microarray Types (Continued)
      • PROTEIN MICROARRAY TECHNOLOGY CHALLENGES
  • Table 41 PROTEIN MICROARRAY TECHNICAL CHALLENGES
    • Protein Microarray Technology Challenges (Continued)
      • PROTEIN MICROARRAY TECHNOLOGY TRENDS
  • Table 42 PROTEIN MICROARRAY TECHNOLOGY TRENDS
    • EMERGING MICROARRAY TECHNOLOGIES
  • Table 43 EMERGING MICROARRAY TECHNOLOGIES
    • GLYCOMICS MICROARRAYS
      • Glycomics Microarrays (Continued)
    • TISSUE MICROARRAYS
      • Tissue Microarrays (Continued)
    • FUNCTIONAL CELL MICROARRAYS
  • Table 44 U.S. GOVERNMENT INITIATIVES PROMOTING EMERGING MICROARRAYS
    • MICROARRAY TECHNOLOGY TRENDS
  • Table 45 MICROARRAY TECHNOLOGY TRENDS
    • MICROARRAY TECHNOLOGY TRENDS (CONTINUED)
• LAB-ON-A-CHIP TECHNOLOGIES
  • INTRODUCTION
  • Table 46 MICROFLUIDICS PRODUCT LIFE CYCLE STAGE
  • Table 47 LOAC SUBSTRATE TECHNOLOGIES
    • LAB-ON-A-CHIP TYPES
  • Table 48 LAB-ON-A-CHIP TYPES
    • IN-VITRO PROTEOMICS
    • ELECTROPHORESIS ON A CHIP
    • STRUCTURAL PROTEOMICS
    • PCR ON A CHIP
    • IMMUNOASSAYS ON A CHIP
      • Immunoassays on a Chip (Continued)
  • Table 49 IMMUNOASSAY-ON-A-CHIP APPLICATIONS
    • LAB-ON-A-CHIP MAJOR APPLICATIONS
  • Table 50 LAB-ON-A-CHIP MARKET SEGMENTS
  • Table 50 (CONTINUED)
  • Table 51 MICROFLUIDIC SYSTEMS ADVANTAGES FOR BIOCHEMICAL ANALYSIS
    • LAB-ON-A-CHIP KEY TECHNOLOGY TRENDS
  • Table 52 LAB-ON-A-CHIP KEY TECHNOLOGY TRENDS
  • Table 53 LOAC TECHNOLOGY PLATFORMS
    • LAB-ON-A-CHIP TECHNOLOGY CHALLENGES
  • Table 54 LAB-ON-A-CHIP TECHNOLOGY CHALLENGES
    • LAB-ON-A-CHIP TECHNOLOGY ... (CONTINUED)
• LIST OF TABLES
  • Summary Table:
  • GLOBAL VALUE OF BIOCHIP PRODUCTS BY TYPE, THROUGH 2013 ($ MILLIONS)
  • Table 1 BIOLOGY DOWNSIZING REVOLUTION
  • Table 2 COMPARISON OF THE TWO MAJOR BIOCHIP TYPES
  • Table 3 BIOCHIP NOMENCLATURE
  • Table 4 SCOPE OF THIS REPORT
  • Table 5 GLOBAL VALUE OF BIOCHIP MARKET BY END USE, THROUGH 2013 ($ MILLIONS)
  • Table 6 GLOBAL VALUE OF BIOCHIP PRODUCTS BY GEOGRAPHY, THROUGH 2013 ($ MILLIONS)
  • Table 7 BIOCHIP MARKET GROWTH DRIVING FORCES
  • Table 8 MULTIDISCIPLINARY FIELD OF BIOCHIPS
  • Table 9 LIFE CYCLE STATUS OF BIOCHIP TYPES
  • Table 10 BIOCHIP INDUSTRY KEY COMPETITORS
  • Table 11 THE NANOSCALE WORLD
  • Table 12 MICROARRAY TYPES
  • Table 13 COMPARISON OF DNA AND PROTEIN MICROARRAY TECHNOLOGIES
  • Table 14 DNA MICROARRAY PLATFORM FEATURES
  • Table 15 DNA MICROARRAY PLATFORM COMPARISON FOR MAJOR MANUFACTURERS
  • Table 16 DNA MICROARRAY APPLICATIONS
  • Table 17 PROBES FOR GENE EXPRESSION DNA MICROARRAYS
  • Table 18 EXAMPLE APPLICATIONS OF GENE EXPRESSION PROFILING
  • Table 19 GENETIC ANALYSIS TECHNOLOGIES COMPARISON
  • Table 20 PLATFORMS FOR HIGH THROUGHPUT QUANTITATIVE GENE EXPRESSION ANALYSIS
  • Table 21 GENE EXPRESSION PLATFORMS OF TWO LEADING DNA ARRAY MANUFACTURERS
  • Table 22 PROBE SENSITIVITY AND SPECIFICITY
  • Table 23 CHIP ASSAYS
  • Table 24 TECHNOLOGIES FOR MAPPING GENOMIC LOCATION OF CHROMATIN PROTEINS AND ENZYMES
  • Table 25 MICROARRAY GENOME CONTENT
  • Table 26 PLATFORMS FOR HIGH DENSITY OLIGONUCLEOTIDE EPIGENETICS ARRAYS
  • Table 27 COMPARISON OF CHROMOSOMAL CHANGE DETECTION TECHNOLOGIES
  • Table 28 CGH MICROARRAY PROBE PLATFORMS
  • Table 29 CGH MICROARRAY TRENDS
  • Table 30 FUTURE TECHNOLOGY NEEDS FOR CGH MICROARRAYS
  • Table 31 TECHNICAL CHALLENGES FOR MIRNAS
  • Table 32 ARRAYS ON BEADS
  • Table 33 SINGLE MOLECULE SEQUENCING TECHNOLOGY
  • Table 34 COMPARISON OF SELECTED DNA SEQUENCING PLATFORMS
  • Table 35 BIOCHIP CONTENT IN NHGRI GRANTEES FOR NEXT GENERATION DNA SEQUENCING, 2005
  • Table 36 NEXT GENERATION DNA SEQUENCING COMPANIES
  • Table 37 DNA MICROARRAY PROBE DENSITY TRENDS
  • Table 38 PROTEIN MICROARRAY PLATFORMS
  • Table 39 PROTEIN MICROARRAYS AS RESEARCH TOOLS
  • Table 40 PROTEIN MICROARRAY PRODUCT TYPES
  • Table 41 PROTEIN MICROARRAY TECHNICAL CHALLENGES
  • Table 42 PROTEIN MICROARRAY TECHNOLOGY TRENDS
  • Table 43 EMERGING MICROARRAY TECHNOLOGIES
  • Table 44 U.S. GOVERNMENT INITIATIVES PROMOTING EMERGING MICROARRAYS
  • Table 45 MICROARRAY TECHNOLOGY TRENDS
  • Table 46 MICROFLUIDICS PRODUCT LIFE CYCLE STAGE
  • Table 47 LOAC SUBSTRATE TECHNOLOGIES
  • Table 48 LAB-ON-A-CHIP TYPES
  • Table 49 IMMUNOASSAY-ON-A-CHIP APPLICATIONS
  • Table 50 LAB-ON-A-CHIP MARKET SEGMENTS
  • Table 51 MICROFLUIDIC SYSTEMS ADVANTAGES FOR BIOCHEMICAL ANALYSIS
  • Table 52 LAB-ON-A-CHIP KEY TECHNOLOGY TRENDS
  • Table 53 LOAC TECHNOLOGY PLATFORMS
  • Table 54 LAB-ON-A-CHIP TECHNOLOGY CHALLENGES
• LIST OF FIGURES
  • Summary Figure:
  • GLOBAL VALUE OF BIOCHIP PRODUCTS BY TYPE, 2006-2013 ($ MILLIONS)
  • Figure 1 EVOLUTION OF BIOCHIPS
  • Figure 2 CLASSIFICATION OF BIOCHIPS
  • Figure 3 GENETIC ANALYSIS TECHNOLOGY COMPETITIVE SPACE
  • Figure 4 COMPETITIVE SPACE FOR GENE
  • Figure 5 SNP ANALYSIS PLATFORMS
  • Figure 6 EPIGENOMICS WITHIN THE MOLECULAR BIOLOGY PARADIGM
  • Figure 7 EPIGENETIC CHANGES TO DNA AFFECT GENE EXPRESSION
  • Figure 8 HISTONE TAIL REGIONS MODIFIED BY HAT AND HDAC
  • Figure 9 UPSTREAM AND DOWNSTREAM STEPS IN EPIGENETIC ANALYSIS
  • Figure 10 CHIP-ON-CHIP PROCEDURE
  • Figure 11 MICROARRAY FEATURE DENSITY
  • Figure 12 MICROARRAY RESOLUTION
  • Figure 13 COMPETITIVE SPACE FOR CNV ANALYSIS
  • Figure 14 COMPARISON OF SANGER WITH UHTS DNA SEQUENCING TECHNOLOGIES
  • Figure 15 COMPETITIVE SPACE FOR HIGH THROUGHPUT GENOMIC ANALYSIS
  • Figure 16 DNA MICROARRAY MANUFACTURING TECHNOLOGIES
  • Figure 17 DNA MICROARRAY COST-VOLUME CURVE
  • Figure 18 IMPORTANCE OF PROTEINS
  • Figure 19 PROTEIN ANALYSIS APPROACHES CONTRASTED