DNA Diagnostics: Technologies and Global Markets

Table of Contents

Chapter- 1: SUMMARY

• SUMMARY TABLE GLOBAL MARKET FOR CLINICAL DNA DIAGNOSTICS, BY SEGMENT, THROUGH 2013 ($ MILLIONS)
• SUMMARY FIGURE GLOBAL MARKET FOR CLINICAL DNA DIAGNOSTICS, BY SEGMENT, 2008-2013 ($ MILLIONS)

Chapter- 2: OVERVIEW

• INTRODUCTION TO GENOMIC DIAGNOSTICS
• INTRODUCTION TO GENOMIC … (CONTINUED)
• INTRODUCTION TO GENOMIC … (CONTINUED)
• EXPRESSION PROFILING AND DISEASE
• EXPRESSION PROFILING AND INFECTIOUS DISEASE
• DNA SEQUENCING FOR GENOTYPING AND DIAGNOSIS
• CLINICAL PHARMACOLOGY
• MUTATION DETECTION AND GENOTYPING FOR SPECIFIC GENES
• IDENTIFICATION OF NEW DISEASE GENES

Chapter-3: REGULATORY FACTORS

• SUCCESSES AND LIMITATIONS OF GENETIC TESTING
• REGULATORY POLICIES
• FOOD AND DRUG ADMINISTRATION: NEW GUIDELINES
• INTERNAL STANDARDS FOR DNA DIAGNOSTICS
• INSURANCE
• INSURANCE (CONTINUED)
• MARKETING DIRECTLY TO CONSUMERS
• MARKET FOR CLINICAL DNA DIAGNOSTICS, BY PRODUCT
• TABLE 1 GLOBAL MARKET FORECAST FOR DNA DIAGNOSTICS PRODUCTS, THROUGH 2013 ($ MILLIONS)
• FIGURE 1 GLOBAL MARKET FORECAST FOR DNA DIAGNOSTICS PRODUCTS, 2005-2013 ($ MILLIONS)
• FIGURE 2 GLOBAL DNA DIAGNOSTICS MARKET, BY PRODUCT SHARE, 2008 (%)
• FIGURE 2 (CONTINUED)
• FIGURE 3 GLOBAL DNA DIAGNOSTICS MARKET, BY PRODUCT SHARE, 2013 (%)

Chapter-4: MARKET FOR CLINICAL DNA DIAGNOSTICS BY TECHNOLOGY, THROUGH 2013

• MICROARRAY DIAGNOSTICS
• TABLE 2 GLOBAL MARKET FORECAST FOR DNA MICROARRAY PRODUCTS IN CLINICAL DIAGNOSTICS, THROUGH 2013 ($ MILLIONS)
• FIGURE 4 GLOBAL MARKET FORECAST FOR DNA MICROARRAY PRODUCTS IN CLINICAL DIAGNOSTICS, 2005-2013 ($ MILLIONS)
• PLANAR DNA MICROARRAYS
• TABLE 3 MAJOR SUPPLIERS OF PLANAR DNA MICROARRAYS
• BEAD MICROARRAYS
• TABLE 4 MAJOR SUPPLIERS OF BEAD MICROARRAYS
• ELECTRONIC MICROARRAYS
• EMERGING TECHNOLOGY: NANOPARTICLE ARRAYS
• Verigene (Nanosphere, Chicago, IL)
• Nanoplex Technologies (Mountain View, CA)
• PCR-BASED DIAGNOSTICS
• TABLE 5 GLOBAL MARKET FORECAST FOR PCR-BASED PRODUCTS IN CLINICAL DIAGNOSTICS, THROUGH 2013 ($ MILLIONS)
• FIGURE 5 GLOBAL MARKET FORECAST FOR ISH PRODUCTS IN CLINICAL DIAGNOSTICS, 2005-2013 ($ MILLIONS)
• TABLE 6 MAJOR SUPPLIERS OF PCR-BASED ASSAYS
• PCR-BASED TECHNOLOGIES FOR DIAGNOSTICS
• LightCycler (Roche Molecular Systems, Pleasanton, CA)
• TaqMan DNA probes (Applied Biosystems, Foster City, CA)
• Invader (Third Wave Technologies, Madison, WI)
• Tag-It Mutation Assay (Tm Bioscience)
• ReadIt Depolymerization Assay (Promega, Madison, WI)
• IN SITU HYBRIDIZATION DIAGNOSTICS
• TABLE 7 GLOBAL MARKET FORECAST FOR ISH PRODUCTS IN CLINICAL DIAGNOSTICS, THROUGH 2013 ($ MILLIONS)
• FIGURE 6 GLOBAL MARKET FORECAST FOR ISH PRODUCTS IN CLINICAL DIAGNOSTICS, 2005-2013 ($ MILLIONS)
• INTRODUCTION TO ISH PRODUCTS
• INTRODUCTION TO ISH PRODUCTS (CONTINUED)
• TECHNOLOGY
• FIBER FISH
• HER-2 FISH TESTING
• IMMUNOHISTOCHEMISTRY
• TABLE 8 COMPARISON OF FISH AND IHC PRODUCTS FOR DIAGNOSTIC TESTING
• EMERGING TECHNOLOGIES IN IN SITU HYBRIDIZATION
• BIOCHIPS/LAB-ON-A-CHIP
• THE MARKET FOR LAB-ON-A-CHIP PRODUCTS
• TABLE 9 GLOBAL MARKET FORECAST FOR LOAC PRODUCTS IN CLINICAL DIAGNOSTICS, THROUGH 2013 ($ MILLIONS)
• FIGURE 7 GLOBAL MARKET FORECAST FOR LOAC PRODUCTS IN CLINICAL DIAGNOSTICS, 2005-2013 ($ MILLIONS)
• The Market for Lab-on-a-… (Continued)
• MICROFLUIDIC DEVICES
• Microfluidic Devices (Continued)
• EMERGING DIAGNOSTIC ASSAYS
• THE TREND TOWARDS SINGLE CELL MEASUREMENTS
• Genetic Typing of Single Cells
• Single Cell Sequencing
• Copy Number Variations in Single Cells
• Combined Immunotyping and Single Cell Expression Analysis
• DIAGNOSING THE EPIGENOME

Chapter-5: MARKETS BY APPLICATION

• OVERALL MARKET FOR DNA DIAGNOSTICS BY APPLICATION
• TABLE 10 GLOBAL DNA DIAGNOSTICS MARKET BY APPLICATION, THROUGH 2013 ($ MILLIONS)
• FIGURE 8 GLOBAL DNA DIAGNOSTICS MARKET BY APPLICATION, 2005-2013 ($ MILLIONS)
• FIGURE 9 GLOBAL DNA DIAGNOSTICS MARKET BY APPLICATION, 2008 (%)
• FIGURE 10 GLOBAL DNA DIAGNOSTICS MARKET FORECAST BY APPLICATION, 2013 ($ MILLIONS)
• PRENATAL AND NEWBORN GENETIC SCREENING
• TABLE 11 GLOBAL MARKET FORECAST FOR PRENATAL AND NEWBORN DNA SCREENING BY PRODUCT, THROUGH 2013 ($ MILLIONS)
• FIGURE 11 GLOBAL MARKET FORECAST FOR PRENATAL AND NEWBORN DNA SCREENING BY PRODUCT, 2005-2013 ($ MILLIONS)
• CARRIER SCREENING
• Prenatal Diagnostic Testing
• Amniocentesis
• Chorionic Villus Sampling (CVS)
• Genetic Counseling
• PREIMPLANTATION DIAGNOSIS,
• NEWBORN SCREENING
• TABLE 12 NEWBORN SCREENING RECOMMENDED BY THE AMERICAN COLLEGE OF MEDICAL GENETICS
• TABLE 12 (CONTINUED)
• TABLE 13 STATES WITH MANDATED NEWBORN SCREENING FOR AT LEAST 20 OF THE RECOMMENDED ACMG DISORDERS
• Prenatal and Post-Natal Genetic Testing: An Example
• INFECTIOUS DISEASE DIAGNOSTICS
• TABLE 14 GLOBAL MARKET FORECAST FOR INFECTIOUS DISEASE DNA DIAGNOSTICS BY PRODUCT, THROUGH 2013 ($ MILLIONS)
• FIGURE 12 GLOBAL MARKET FORECAST FOR INFECTIOUS DISEASE DNA DIAGNOSTICS BY PRODUCT, 2005-2013 ($ MILLIONS)
• HIV/AIDS
• TABLE 15 MAJOR SUPPLIERS OF HIV GENOTYPIC RESISTANCE TESTS
• PRODUCTS
• Monogram Biosciences (formerly ViroLogic)
• PhenoSense GT
• PhenoSense HIV
• GeneSeq HIV
• PhenoSense Entry
• Replication Capacity (RC)
• PHARMACOGENOMICS AND HIV THERAPY
• ONCOLOGY DIAGNOSTICS AND HISTOPATHOLOGY
• TABLE 16 GLOBAL MARKET FORECAST FOR ONCOLOGY DNA DIAGNOSTICS BY PRODUCT, THROUGH 2013 ($ MILLIONS)
• FIGURE 13 GLOBAL MARKET FORECAST FOR ONCOLOGY DNA DIAGNOSTICS BY PRODUCT, 2005-2013 ($ MILLIONS)
• Leukemias
• Chronic Myeloid Leukemia (CML)
• Genetic Marker of CML
• Gleevec
• IDENTITY DIAGNOSTICS, PATERNITY AND FORENSICS
• TABLE 17 GLOBAL MARKET FORECAST FOR IDENTITY AND PATERNITY DNA DIAGNOSTICS BY PRODUCT, THROUGH 2013 ($ MILLIONS)
• FIGURE 14 GLOBAL MARKET FORECAST FOR IDENTITY AND PATERNITY DNA DIAGNOSTICS BY PRODUCT, 2005-2013 ($ MILLIONS
• PATERNITY TESTING
• Technology
• Pricing and Target Consumers
• Accreditation
• Legal Issues
• International News
• International News (Continued)
• TABLE 18 MAJOR PLAYERS IN PATERNITY TEST SERVICES
• Veterinary Identity Testing
• OTHER APPLICATIONS
• TABLE 19 GLOBAL MARKET FORECAST FOR DNA DIAGNOSTICS IN OTHER CLINICAL APPLICATIONS, BY PRODUCT, THROUGH 2013 ($ MILLIONS)
• FIGURE 15 GLOBAL MARKET FORECAST FOR DNA DIAGNOSTICS IN OTHER APPLICATIONS BY PRODUCT, 2005-2013 ($ MILLIONS)
• PHARMACOGENOMICS DIAGNOSTIC TESTING
• DRUG METABOLISM
• P450 ISOZYMES AND PHARMACEUTICALS
• TABLE 20 DRUG METABOLISM AND CYTOCHROME P450 ISOZYMES
• P450 Isozyme CYP3A
• P450 Isozyme CYP2D6
• P450 Isozyme CYP2C9
• P450 Isozyme 2C19
• P450 Isozyme 1A2
• P450 DIAGNOSTIC TESTING
• TABLE 21 MAJOR SUPPLIERS OF CYTOCHROME P450 TESTING
• FOR RESEARCH PURPOSES
• TABLE 21 (CONTINUED)
• Presymptomatic Testing

Chapter-6: PATENT ANALYSIS

• PATENTS BY TECHNOLOGY
• TABLE 22 DNA DIAGNOSTICS, ISSUED PATENTS BY TECHNOLOGY, JANUARY 2005-JANUARY 2008
• FIGURE 16 DNA DIAGNOSTICS, ISSUED PATENTS BY TECHNOLOGY, JANUARY 2005-JANUARY 2008 (%)
• PATENTS BY REGION
• TABLE 23 DNA DIAGNOSTICS, ISSUED PATENTS BY REGION, JANUARY 2005-JANUARY 2008
• TABLE 23 (CONTINUED)
• PATENTS BY MEDICAL APPLICATION
• TABLE 24 DNA DIAGNOSTICS, ISSUED PATENTS BY PRIMARY APPLICATION, JANUARY 2005-JANUARY 2008
• FIGURE 17 DNA DIAGNOSTICS, ISSUED PATENTS BY PRIMARY APPLICATION, JANUARY 2005-JANUARY 2008 (%)
• SIGNIFICANT PATENT NEWS
• KEY PATENT ACTIVITY IN PCR
• KEY PATENT ACTIVITY IN BREAST CANCER TYPING
• RECENT KEY PATENTS IN DNA DIAGNOSTICS
• Recent Key Patents in DNA … (Continued)
• Recent Key Patents in DNA … (Continued)
• Recent Key Patents in DNA … (Continued)

Chapter-6: INDUSTRY STRUCTURE

• TABLE 25 MARKET SHARE OF COMPANIES INVOLVED IN MICROARRAY DIAGNOSTICS, 2008 ($ MILLIONS)
• TABLE 26 MARKET SHARE OF COMPANIES INVOLVED IN PCR DIAGNOSTICS, 2008 ($ MILLIONS)
• TABLE 27 MARKET SHARE OF COMPANIES INVOLVED IN ISH DIAGNOSTICS, 2008 ($ MILLIONS)
• TABLE 28 MARKET SHARE OF COMPANIES INVOLVED IN LAB-ON-A-CHIP DIAGNOSTICS, 2008 ($ MILLIONS)
• INDUSTRY STRUCTURE (CONTINUED)

Chapter-8: COMPANY PROFILES

• 454 LIFE SCIENCES
• ABBOTT DIAGNOSTICS
• ADVANDX
• AFFYMETRIX, INC.
• AGILENT TECHNOLOGIES INC.
• AMBION INC.
• APPLIED BIOSYSTEMS GROUP
• APPLIED BIOSYSTEMS GROUP (CONTINUED)
• APPLIED IMAGING CORP.
• AUTOGENOMICS, INC.
• BAYER DIAGNOSTICS
• BECKMAN COULTER, INC.
• BECTON DICKINSON
• BIOMERIEUX SA
• BIOMICRO SYSTEMS, INC.
• BIO-RAD LABORATORIES
• CALIPER LIFE SCIENCES, INC.
• CALLIDA GENOMICS INC./HYSEQ
• CELERA DIAGNOSTICS
• CEPHEID
• CHEMICON INTERNATIONAL, INC., DIVISION OF SEROLOGICALS CORP.
• CHIRON CORP.
• CLINICAL DATA, INC
• CURAGEN CORP
• DECODE GENETICS
• DIGENE CORP.
• DNA DIAGNOSTICS CENTER
• EUROGENTEC
• EXACT SCIENCES CORP.
• FOCUS DIAGNOSTICS
• GE HEALTHCARE
• GEN-PROBE INCORPORATED
• GEN-PROBE INCORPORATED (CONTINUED)
• ILLUMINA
• INVITROGEN DYNAL AS
• LABORATORY CORPORATION OF AMERICA (LABCORP)
• LUMINEX CORP
• MICRONICS
• MONOGRAM BIOSCIENCES, INC.
• MYRIAD GENETICS
• NANOGEN INC.
• ORCHID BIOSCIENCES
• OXFORD GENE TECHNOLOGY IP LTD.
• PRODESSE INC.
• PYROSEQUENCING/BIOTAGE AB
• QIAGEN N.V.
• QUEST DIAGNOSTICS
• ROCHE (F. HOFFMANN-LA ROCHE LTD)
• SEQUENOM INC.
• STRATAGENE CORP. / HYCOR BIOMEDICAL INC.
• SORENSON GENOMICS, INC.
• THERMO FISHER SCIENTIFIC, INC.
• THIRD WAVE TECHNOLOGIES, INC.
• TRANSGENOMIC INC.
• U.S. GENOMICS
• VIROLOGIC, INC.
• WYETH-AYERST, INC.
• WYETH-AYERST, INC. (CONTINUED)