Apoptosis: Promise or Deception?

Table of Contents

Apoptosis: Promise or deception?

Table of Contents

BSG General Working Model & Methodology

Key findings

Introduction

• Figure 1. Generalized illustration, depicting the key elements involved in the apoptotic pathways.
• Table 1. Common gene/protein defects in apoptotic pathways and associated mechanism

Multipathway Regulators

• Table 2 Overview of Apoptosis Targets Under Development

Projects on the p53 Pathway Increasing Again

• Box 1. The Agreement Between Sanofi-Aventis and Introgen Therapeutics
• Table 3. Overview of p53 Based Therapies in Clinical Trial
• New Attention to p53 Gene Therapy
• Activating p53 with Small-Molecule Drugs
• Are p53-MDM2 interacting peptides the future?
• Will 2nd generation of antisense that targets mdm2 deliver?
• Drug discovery to develop inhibitors of the p53-MDM2 interaction
• The importance of Aurora Kinase inhibitors

The Bcl-2 Pathway: Antisense versus New Approaches

• Table 4. Overview of Bcl-2 and Bcl-XL Based Therapies in Clinical Trial
• Has Genasense Lost its Sting?
• Box 2 The Collaboration Between Genta and Aventis
• Improved Bcl-2 Antisense Takes Off
• Peptides and Small Molecules Mimics: Option to Bcl-2 Antisense
• Other Drugs Mediating a Bcl-2 Pathway-Induced Cell Death

Death Receptors a Powerful Way To Apoptosis

• Table 5. Overview of Death Receptor Based Therapies in Clinical Trial
• Monoclonal Antibodies Towards TRAIL Receptor: Expanded Clinical Trials
• A Soluble Form of TRAIL Finally in Phase I trial
• Attempts Made for Fas Ligand System

Time Ripe for Inhibitors of Apoptosis Proteins

• Table 6. Overview of IAP Based Therapies in Clinical Trial
• Way Around Drug Resistance
• Survivin: Cell Death Inhibitor Or Not? Still an Excellent Target
• Smac/Diablo: Peptides and Small Molecule Mimetics

Modulators of the Caspase Pathway on Way

• Table 7. Overview of Caspase Based Therapies in Clinical Trial
• Companies with Focus on Caspase
• Newly Discovered Compound Affecting the Activity of Caspases

Appendix A Company Profiles

Abbreviation List