Cancer Vaccines: Drug Pipeline Update 2009

Investigators

Includes 231 principal investigators plus their collaborators. There is direct access from inside the application to web pages of all principal investigators.

Note: You are able to sort and find drugs according to investigators and partners from drop-down menus in the application. You may also sort and find drugs according to country of investigator.

Drug name & Synonyms

Lists commercial, generic and code names for drugs. In all more than 400 names

Developmental stage

This Drug Pipeline Update contains 210 cancer vaccine drugs in active development and 401 developmental projects:

• #40 developmental projects have reached market approval
• #2 developmental projects have been registered
• #3 projects in pre-registration
• #11 projects in Phase III
• #133 projects in Phase II
• #83 projects in Phase I
• #122 projects in Preclinical
• #7 projects in other developmental stages

Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.

Indications

Included vaccine drugs are in development for 117 different indications, where of 60 are different cancer indications. All drugs are in development for the treatment of cancer.

Note: You are able to sort and find drugs according to type of indication from drop-down menu in the application.

Targets

Identified drugs are linked to more than 133 different targets, divided into 44 classifications of molecular function:

• Auxiliary transport protein activity
• Carboxypeptidase activity
• Catalytic activity
• Cell adhesion molecule activity
• Chaperone activity
• Cofactor binding
• Complement activity
• Cysteine-type peptidase activity
• Cytokine activity
• DNA topoisomerase activity
• DNA-directed DNA polymerase activity
• DNA-methyltransferase activity
• G-protein coupled receptor activity
• Growth factor activity
• Heat shock protein activity
• Hormone activity
• Hydrolase activity
• Isomerase activity
• Kinase activity
• Kinase regulator activity
• Ligand-dependent nuclear receptor activity
• Ligase activity
• Metallopeptidase activity
• MHC class I receptor activity
• Molecular function unknown
• Motor activity
• Oxidoreductase activity
• Peptidase activity
• Peptide hormone
• Protease inhibitor activity
• Protein binding
• Protein serine/threonine kinase activity
• Protein-tyrosine kinase activity
• Receptor activity
• Receptor signaling complex scaffold activity
• Receptor signaling protein serine/threonine kinase activity
• RNA-directed DNA polymerase activity
• Serine-type peptidase activity
• Structural constituent of cytoskeleton
• Transcription factor activity
• Transcription regulator activity
• Transmembrane receptor activity
• Transmembrane receptor protein tyrosine kinase activity
• Transporter activity

Identified targets are categorized into 23 different primary and alternate sub-cellular localizations:

• Centrosome
• Clathrin-coated vesicle
• Cytoplasm
• Cytosol
• Endoplasmic reticulum
• Endosome
• Extracellular
• Extracellular matrix
• Golgi apparatus
• Integral to membrane
• Lysosome
• Mitochondrial matrix
• Mitochondrial membrane
• Mitochondrion
• Nuclear membrane
• Nucleolus
• Nucleus
• Perinuclear region
• Peroxisomal matrix
• Plasma membrane
• Sarcoplasmic reticulum
• Secreted
• Secretory granule

Note: You are able to sort and find drugs according to target gene name, molecular function of target, and target localization from drop-down menus in the application.

Target Expression Profile

Direct links are provided from inside the application to 145 protein expression profiles of 95 drug targets in various human tissues and cancer types, cell lines and primary cells, including up to:

• 48 different normal tissue types
• 20 different types of cancer
• 47 cell lines
• 12 samples of primary blood cells

Pathway Referals

Identified targets have been cross referenced against their invovlement in different cellular pathways, according to BioCarta, KEGG and NetPath.

• BioCarta 185 Pathways
• KEGG 64 Pathways
• NetPath 20 Signaling Pathways

Note: You are able to sort and find drugs according to targeted pathways from drop-down menues in the application.

Mechanism

In total there are 157 different drug mechanism of action represented in this Drug Pipeline Update.

Note: You are able to sort and find drugs according to mechanism of action from drop-down menu in the application.

Compound

Identified drug compounds are described by:

Compound type, Chemical name, CAS Number and molecular weight

Note: You are able to sort and find drugs according to compound type from drop-down menu in the application.

Drug Profile

Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information:

Drug Name & Synonyms

Presentation of drug name and synonyms

Principal Investigator & Partners

Presentation of principal investigator and partners

Target and Molecular Function of Target

Described target(s) is/are presented with: Official Gene Symbol - Official Gene Name [Species/Homo Sapiens] - Molecular Function

Target Localization

Described target(s) is/are presented with primary and alternate localizations.

Target Expression Profiles

Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:

• 48 different normal tissue types
• 20 different types of cancer
• 47 cell lines
• 12 samples of primary blood cells

Targeted Pathways

Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, and NetPath.

Mechanism

Drug mechanism of action

Developmental Projects

Summary field of developmental projects for the drug, including indication, developmental stage and status.

Example:

• Cancer, myeloma - Phase II Clinical Trial - Active
• Cancer, prostate - Phase III Clinical Trial - Ceased

Drug Description

Short introduction to drug

Compound Data

Compound type, Chemical name, CAS Number and molecular weight

Patent Data

Available patent information related to the drug is presented here.

Business & Markets

• Collaborations and deals
• Approvals and submissions
• Analyst comments

Phase III Data

Available Phase III development data, developmental history and scientific data.

Phase II Data

Available Phase II development data, developmental history and scientific data.

Phase I Data

Available Phase I development data, developmental history and scientific data.

Preclinical Data

Available preclinical development data, developmental history and scientific data.

Licensing Information

Availability for licensing

Application Features

Use 13 different parameters, available in drop-down menus, to find and sort among drugs

• Drug status
• Clinical Trial Status
• Principle Investigator
• Partners
• Indication
• Developmental Stage
• Compound Type
• Mechanism
• Target
• Molecular Function of Target
• Target Localization
• Targeted Pathways
• Free text search of entire drug profile contents

Direct linkage from inside the application to related internet resources

• Drug data is linked to search engines like Google and PubMed
• Drug target data is linked directly to BioCarta, Human Protein Atlas, KEGG, and NetPath
• Direct links to company web pages of principal investigators

Export and sharing of information Found information is easily shared with others over e-mail, file export (xls) or in print

System Requirements

• AMD-Athlon/Pentium II PC
• Windows 98/NT4/2000/ME/XP/VISTA
• 8x-speed CD Rom drive
• SVGA 16 bit display. (32 bit recommended)
• 32 MB of available RAM (128 MB recommended)
• Internet access (for related internet resources)