Cancer Stem Cells: Emerging Therapeutic, Diagnostic and Market Opportunities (2008)

Table of Contents

Executive Summary

Chapter 1 Cancer Stem Cells

• 1.1 Introduction
• 1.2 What are CSCs?
• 1.3 Different Cancers
• 1.4 Markets
• 1.5 Unmet Need
• 1.6 Research and Development

Chapter 2 Research and Development

• 2.1 Background
• 2.2 Research
• 2.3 Drug Development

Chapter 3 Drug Discovery

• Summary
• 3.1 Thinking Differently
• 3.2 Resistance to Therapy
• 3.3 The Stem Cell Niche
• 3.4 Metabotropic Receptors
• 3.5 Telomerase
• 3.6 Notch
• 3.7 Hedgehog and Wnt
• 3.8 Bmi-1s
• 3.9 CSC-Targeting Viruses
• 3.10 Metastasis
• 3.11 MicroRNAs
• 3.12 CSC Markers
• 3.13 Drug Pipeline

Chapter 4 Diagnostics

• Summary
• 4.1 Background
• 4.2 CSC Markers
• 4.3 Circulating Tumour Cells
• 4.4 The Invasiveness Gene Signature
• 4.5 Microarrays
• 4.6 Hedgehog Activity
• 4.7 Sox 2
• 4.8 Other

Chapter 5 Emerging Markets and Opportunities

• Summary
• 5.1 Drug Discovery
• 5.2 Diagnostics
• 5.3 Markets

Chapter 6 Patents

• Summary
• 6.1 Patents

Chapter 7 Conclusions

• 7.1 Overview
• 7.2 Drug Discovery and Pipeline
• 7.3 Diagnostics

Appendix 1

List of Figures

• Figure 2.1 Journal publications relating to Cancer Stem Cells, 2000-2006
• Figure 2.2 Patents relating to Cancer Stem Cells, 1999-2006
• Figure 2.3 Global academic research groups working on Cancer Stem Cells
• Figure 4.1 Diagnostic strategies for the targeting of Cancer Stem Cells
• Figure 5.1 Opportunities in the therapeutic targeting of Cancer Stem Cells
• Figure 5.2 Opportunities relating to Cancer Stem Cell models
• Figure 5.9 Sales (2004) and projected growth of targeted cancer therapies
• Figure 6.1 Patents relating to Cancer Stem Cells, 1999-2007, by year (Source: Delphion)
• Figure 7.1 Development pipeline of candidate molecules that target CSCs
• Figure 7.2 Potential strategies for the therapeutic targeting of Cancer Stem Cells
• Figure 7.3 Challenges in the therapeutic targeting of Cancer Stem Cells

List of Tables

• Table 2.1 Overview of the global CSC-targeting drug development pipeline
• Table 3.1 Table 3.1 (a-e) CSC markers and potential drug targets currently in research and development candidate in the drug development pipeline
• Table 3.2 Development pipeline of CSC-targeting candidate drug molecules
• Table 4.1 (a-b) CSC Markers

Appendices

• Appendix 1 (a-g) Summary of 56 research groups working on or in areas relating to cancer stem cells, by organisation, researcher, summary, cancer type and country