Microarrays: Technologies, Applications, Markets

Table of Contents

Chapter 1. Introduction--Current State of Microarray Technology

• 1.1. A Brief History of Microarray Technology
• 1.2. DNA Microarray Technologies
  • -Array Manufacturing Technologies
    • --Synthesized Oligonucleotide Arrays
    • --Spotted Arrays
    • --Virtual Arrays
    • --Universal Arrays
• 1.3. Protein Microarray Technology
• 1.4. Experimental Considerations
  • -Sample Preparation and Processing
    • --RNA Isolation
    • --Target Amplification
    • --Labeling
    • --Hybridization
  • -Data Collection, Processing, and Analysis
    • --Detection
    • --Data Processing and Analysis

Chapter 2. Applications of DNA Microarray Technology

• 2.1. Gene Expression
  • -Evolution of Gene Expression
  • -Gene Expression Microarrays
    • --Catalog Arrays
    • --Custom Arrays
    • --Homebrew Arrays
    • --Bead Arrays
  • -Research Applications
    • --Basic Research
    • --Pharmaceutical Research
    • --Diagnostic Gene Expression
• 2.2. Microarrays for Other Applications
  • -Genotyping Applications
    • --Microarray-Based Commercial Genotyping Activity
    • --Microarray-Based Genotyping Applications
  • -Microbial Applications
  • -Comparative Genomic Hybridization

Chapter 3. Future Directions for DNA Microarray Technology

• 3.1. Technologies
  • -Variations of Basic DNA Microarray Technology
  • -High-Throughput Array Technology
  • -Variant Array Types
  • -General Comments
• 3.2. Future Directions in Microarray Applications
  • -Basic Research
  • -Drug Discovery and Development
  • -Diagnostics
  • -General Comments

Chapter 4. The Microarray Market

• 4.1. Competition in the Microarray Market
  • -Custom Array Market
  • -High-Throughput Array Market
  • -New Players
• 4.2. Growth Trends in the Microarray Market
• 4.3. Deal-Making in the Microarray Market

Chapter 5. Expert Interviews and Selected Company Profiles

• 5.1. Expert Interviews
  • -Matthew Cooper, PhD, Biogen Idec
  • -David Craford, Affymetrix
  • -Jennifer Dent, CombiMatrix
  • -Wendell Jones, PhD and Steve Casey, Expression Analysis
  • -Kyle Kolaja, Iconix
  • -Mel Kronick, PhD, Agilent Technologies
  • -Shawn Levy, PhD, Vanderbilt Microarray Shared Resource
  • -Stanley Rose, PhD, NimbleGen
• 5.2. Extended Company Profiles
  • -Affymetrix
  • -Agilent Technologies
  • -CombiMatrix
  • -GE Healthcare Bio-Sciences
  • -NimbleGen
• 5.3. Selected Company Profiles
  • -Agilix Corporation
  • -Axon Instruments
  • -Gene Logic
  • -High Throughput Genomics
  • -Illumina
  • -Luminex
  • -MetriGenix
  • -Nanogen
  • -Pamgene
  • -Silicon Genetics