Inflammatory Disease Therapeutics: Pipelines and Competitive Dynamics

Table of Contents

• Chapter 1. Introduction: The Immune System and the Inflammatory Response
  • 1.1. The Immune System
  • 1.2. Immune Dysfunction and Autoimmune Disease
• Chapter 2. Review of Inflammatory Diseases: Epidemiology, Pathology, Diagnosis, and Symptoms
  • 2.1. Rheumatoid Arthritis (RA)
    • Pathology of RA
    • Causes of RA
    • Diagnosis of RA
    • Epidemiology of RA
  • 2.2. Inflammatory Bowel Disease (IBD)
    • Pathology of IBD
    • Causes of IBD
    • Diagnosis of IBD
    • Epidemiology of IBD
  • 2.3. Psoriasis
    • Pathology of Psoriasis
    • Causes of Psoriasis
    • Diagnosis of Psoriasis
    • Epidemiology of Psoriasis
  • 2.4. Lupus
    • Pathology of Lupus
    • Causes of Lupus
    • Diagnosis of Lupus
    • Epidemiology of Lupus
  • 2.5. Multiple Sclerosis (MS)
    • Pathology of MS
    • Causes of MS
    • Diagnosis of MS
    • Epidemiology of MS
  • 2.6. Asthma
    • Pathology of Asthma
    • Causes of Asthma
    • Diagnosis of Asthma
    • Epidemiology of Asthma
• Chapter 3. Current Pharmacologic Treatment Options
  • 3.1. Rheumatoid Arthritis
    • Analgesics and NSAIDs
    • Corticosteroids
    • Synthetic DMARDs
    • -Methotrexate
    • -Arava (leflunomide)
    • -Other DMARDs
    • Biologic DMARDs
    • -Enbrel (etanercept)
    • -Remicade (infliximab)
    • -Humira (adalimumab)
    • -Kineret (anakinra)
  • 3.2. Inflammatory Bowel Disease
    • Aminosalicylates
    • Corticosteroids
    • Immunomodulators
    • -Azathioprine and 6-mercaptopurine
    • -Methotrexate
    • -Cyclosporine
    • -Remicade (infliximab)
    • Antibiotics
  • 3.3. Psoriasis
    • Topical Therapies
    • -Corticosteroids
    • -Vitamin D3 and A Analogs
    • -Coal Tar
    • -Anthralin
    • -Salicylic Acid
    • Light Therapy
    • Systemic Therapy
    • -Methotrexate
    • -Cyclosporine
    • -Oral Retinoids
    • -Hydroxyurea
    • -Amevive (alefacept)
    • -Raptiva (efalizumab)
    • -Enbrel (etanercept)
  • 3.4. Lupus
    • NSAIDs
    • Antimalarials
    • Corticosteroids
    • Immunomodulators
  • 3.5. Multiple Sclerosis
    • Corticosteroids
    • Disease-Modifying Agents
    • -Interferon ﾟ
    • -Copaxone (glatiramer acetate)
    • -Novantrone (mitoxantrone)
    • -Tysabri (natalizumab)
    • Other Immunomodulators
  • 3.6. Asthma
    • Quick-Relief Medications
    • -Bronchodilators
    • -Oral Corticosteroids
    • Long-Term Control Medications
    • -Inhaled Corticosteroids
    • -Bronchodilators
    • -Mast Cell Stabilizers
    • -Leukotriene Modifiers
    • -Xolair (omalizumab)
• Chapter 4. Compounds in Development: The Next Generation of Drugs for Inflammatory Diseases
  • 4.1. New Approaches to Inflammatory Diseases
    • Cytokine Inhibitors
    • Anti-Inflammatory Cytokines
    • Compounds Targeting T-Cell Antigens
    • CD20-Targeted Monoclonal Antibodies
    • Complement Inhibitors
    • Adhesion Molecule Blockers
    • Chemokine Receptor Antagonists
    • Protease Inhibitors
    • -TACE
    • -ICE
    • -Cathepsin S
    • Kinase Inhibitors
    • -p38 MAP Kinase
    • -JNK
    • -NF-kB
    • PPAR-y Ligands
  • 4.2. Setbacks
  • 4.3. Rheumatoid Arthritis
    • Cytokine Inhibitors
    • -Regeneron Pharmaceuticals
    • -Targeted Genetics
    • -Domantis/Peptech
    • -Fulcrum Pharmaceuticals
    • -Nastech Pharmaceutical
    • Compounds Targeting T-Cell Antigens
    • -Bristol-Myers Squibb
    • Complement Inhibitors
    • -Alexion Pharmaceuticals
    • Kinase Inhibitors
    • -Rigel Pharmaceuticals
    • -Plexxikon/Phenomix
  • 4.4. Inflammatory Bowel Disease
    • Cytokine Inhibitors
    • -Abbott Laboratories
    • -Protein Design Labs
    • Anti-Inflammatory Cytokines
    • -Berlex Laboratories
    • Compounds Targeting T-Cell Antigens
    • -Protein Design Labs
    • Adhesion Molecule Blockers
    • -Isis Pharmaceuticals
    • -Millennium Pharmaceuticals
    • Kinase Inhibitors
    • -Serono/InDex Pharmaceuticals
  • 4.5. Psoriasis
    • Cytokine Inhibitors
    • -Isotechnika
    • -CombinatoRx
    • Compounds Targeting T-Cell Antigens
    • -TolerRx
    • Growth Factor Inhibitors
    • -Antisense Therapeutics; Isis Pharmaceuticals
    • Immunomodulators
    • -Biogen Idec/Fumapharm
    • Vitamin D Analogs
    • -QuatRx Pharmaceuticals
    • -Cytochroma
  • 4.6. Lupus
    • Immunomodulators
    • -La Jolla Pharmaceutical
    • -Genelabs Technologies
    • Cytokine Inhibitors
    • -Medarex/MedImmune
    • BLyS Antagonists
    • -Human Genome Sciences
    • -ZymoGenetics/Serono
    • -Amgen
    • -Biogen Idec/Genentech
    • Complement Inhibitors
    • -Elusys Therapeutics
  • 4.7. Multiple Sclerosis
    • Immunosuppressants
    • -Genzyme Oncology
    • -Novartis Pharmaceuticals
    • Cytokines
    • -Transition Therapeutics
    • -Nastech Pharmaceutical
    • -Serono/Syntonix Pharmaceuticals
    • -Maxygen
    • -Biovation
    • -Nautilus Biotech
    • -Bolder Biotechnology
    • -Pepgen
    • Peptide Vaccines
    • -Immune Response
    • -Neurocrine Biosciences
    • -BioMS Medical
  • 4.8. Asthma
    • Cytokine Inhibitors
    • -Protein Design Labs/Roche
    • -GlaxoSmithKline
    • -Amgen
    • -Amrad/Merck
    • -Cambridge Antibody Technology
    • -Regeneron Pharmaceuticals
    • -Isis Pharmaceuticals
    • -Sirna Therapeutics
    • -MedImmune/Genaera
    • Chemokine Receptor Antagonists
    • -GlaxoSmithKline
    • -Merck
    • -AnorMED
    • -Novartis Pharmaceuticals
    • -Cambridge Antibody Technology
    • Phosphodiesterase-4 Inhibitors
    • -Altana
    • -Celgene
    • -Glenmark Pharmaceuticals/Forest Laboratories
    • -Toll-Like Receptor Agonists
    • -Dynavax Technologies
    • -Coley Pharmaceutical Group/Sanofi-Aventis
    • -Hybridon
    • -Corixa
    • Syk Kinase Inhibitors
    • -Rigel Pharmaceuticals/Pfizer
    • -sanofi-aventis
• Chapter 5. Company Research Programs
  • 5.1. Abbott Laboratories
  • 5.2. Amgen
  • 5.3. Biogen Idec
  • 5.4. Celgene
  • 5.5. ChemoCentryx
  • 5.6. GlaxoSmithKline
  • 5.7. Isis Pharmaceuticals
  • 5.8. Medarex
  • 5.9. Millennium Pharmaceuticals
  • 5.10. Protein Design Labs
  • 5.11. Regeneron Pharmaceuticals
  • 5.12. Rigel Pharmaceuticals
  • 5.13. Serono
  • 5.14. TolerRx
  • 5.15 Vertex Pharmaceuticals