Abstract
Epigenetics is one of the fastest-growing areas of the biological sciences.
It' s also a budding industry. This new report offers in-depth analysis of:
- The definition, history, and current status of epigenetics
- Current and potential commercial applications
- An epigenetic approach to cancer etiology
- The epigenetics of noncancerous diseases
- DNA methylation and histone modifications as biomarkers
- The companies involved and their products
- Epigenetic therapeutics: demethylating agents, histone modifications, and
combinations
- The drivers of the epigenetics industry, plus recent major industry deals
and patent applications
- Results of a quantitative online survey of individuals involved in
epigenetics R&D
Epigenetics: Technologies, Applications, and the Commercial Landscape
provides an overview of the scientific and technological landscape from which
both the diagnostic and therapeutic sectors of the nascent "epigenetics
industry" are emerging, plus a qualitative analysis of the scientific,
technological, and commercial achievements and challenges facing both sectors.
Biologists are recognizing that to understand human health and disease, they
need to know more than the DNA sequence of any genes. Equally, if not more
important, they need to know how cells use the information encoded in the
genome. That information is essentially stagnant if a gene lies dormant. What
turns genes on and off, and under what circumstances? That is what epigenetics
is all about: how genomic information encoded in the DNA sequence is regulated
by various nonDNA factors. The science and technology of epigenetics are aimed
at understanding and, ultimately, manipulating the various chemical and
physical chromatin modifications that control gene expression.
This report focuses on the 2 major types of epigenetic control factors:
- DNA methylation patterns formed by the presence of methyl molecules (-CH3)
attached to CpG dinucleotides along the entire length of the DNA double helix
- Various covalent modifications to the histone proteins around which the
DNA helix is wound
Epigenetics: Technologies, Applications, and the Commercial Landscape
is a valuable tool for anyone involved in epigenetics R&D, portfolio
management, and commercialization of diagnostics and therapeutics.
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