Abstract
Overview
The field of therapeutic vaccines and immunotherapies is rapidly emerging as a
promising area. Use of passive immunotherapy (i.e., antibody) products, for
prevention of infection or for treatment of many diseases, including cancer,
is widespread. In addition, some nonspecific immunomodulators on the market
are used to treat certain cancers. However, there is considerable interest in
the development of novel, active specific immunotherapies and therapeutic
vaccines for cancer. No active specific immunotherapy products have yet
reached the market in the United States, but we may be getting close. Progress
is also being made in the development of therapeutic vaccines and
immunotherapies for treatment of chronic infectious diseases.
Immunotherapies and Vaccines for Cancer and Infectious Diseases reviews
current pharmacological options for 12 major cancers being targeted by
companies developing cancer immunotherapies or vaccines. While a large number
of drugs are available for these particular cancers, poor survival rates
demonstrate there is a clear need for more effective treatments. We then
include a discussion of currently available immunotherapies for chronic
infections, and infectious disease vaccines that are on the market.
We consider strategies companies are using to develop cancer immunotherapies
and vaccines, as well as different types of infectious disease vaccines, and
highlight the R&D challenges for these sectors. A large number of smaller
biopharmaceutical companies, and a more limited number of major pharmaceutical
companies, are developing a wide range of different approaches to stimulate
the immune system.
The many different product candidates that are in development for the 12
cancers targeted in this report are reviewed. In addition, we briefly touch
upon the numerous vaccines and immunotherapies that are in development for
other cancers.
In our section on infectious disease, we discuss novel prophylactic vaccines
that are in development for prevention of a wide range of different diseases.
We then focus on therapeutic vaccines and immunotherapies being developed for
treatment of chronic infections.
Immunotherapies and Vaccines for Cancer and Infectious Diseases
examines a number of business considerations and trends in the fields of
infectious disease and cancer immunotherapies and vaccines. Interviews with
nine experts in this area are provided, giving their perspectives on the
progress being made, and the challenges and hurdles faced by researchers and
companies working in this emerging field.
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