Neurodegenerative Diseases: Next-Generation Drugs for Four Major Disorders Overview

Table of Contents

Chapter 1

• INTRODUCTION AND REVIEW OF THE NEURODEGENERATIVE DISEASES: PATHOLOGY, CAUSES, DIAGNOSIS, AND EPIDEMIOLOGY
• 1.1. Report Focus: Alzheimer' s Disease, Parkinson' s Disease, Huntington' s Disease, Amyotrophic Lateral Sclerosis
• 1.2. Report Organization
• 1.3. Alzheimer' s Disease
  • Pathology of Alzheimer' s Disease
  • Causes of Alzheimer' s Disease
  • Diagnosis of Alzheimer' s Disease
  • Epidemiology of Alzheimer' s Disease
• 1.4. Parkinson' s Disease
  • Pathology of Parkinson' s Disease
  • Causes of Parkinson' s Disease
  • Diagnosis of Parkinson' s Disease
  • Epidemiology of Parkinson' s Disease
• 1.5. Huntington' s Disease
  • Pathology of Huntington' s Disease.
  • Causes of Huntington' s Disease
  • Diagnosis of Huntington' s Disease
  • Epidemiology of Huntington' s Disease
• 1.6. Amyotrophic Lateral Sclerosis
  • Pathology of Amyotrophic Lateral Sclerosis
  • Causes of Amyotrophic Lateral Sclerosis
  • Diagnosis of Amyotrophic Lateral Sclerosis
  • Epidemiology of Amyotrophic Lateral Sclerosis

Chapter 2

• CURRENT PHARMACOLOGIC TREATMENT OPTIONS
• 2.1. Alzheimer' s Disease
  • Cholinesterase Inhibitors
    • *Aricept (donepezil HCl)
    • *Exelon (rivastigmine tartrate)
    • *Razadyne (galantamine HBr
  • NMDA Receptor Antagonists
    • *Namenda (memantine HCl)
  • Other Treatments
• 2.2. Parkinson' s Disease
  • Levodopa
  • Dopamine Agonists
    • *Mirapex (pramipexole DiHCl
    • *Requip (ropinirole HCl)
    • *Neupro (rotigotine)
    • *Apokyn (apomorphine)
    • *Trivastal (piribedil)
  • COMT Inhibitors
    • *Tasmar (tolcapone)
    • *Comtan (entacapone)
  • MAO Inhibitors
    • *Selegiline
    • *Azilect (rasagiline)
  • Other Treatments for Motor Symptoms
    • *Anticholinergics
    • *Amantadine
  • Treatments for Non-Motor Symptoms
• 2.3. Huntington' s Disease
  • Dopamine Depletors
    • *Xenazine (tetrabenazine)
  • Other Treatments
• 2.4. Amyotrophic Lateral Sclerosis
  • Glutamate Antagonists
    • *Rilutek (riluzole)
  • Other Treatments

Chapter 3

• COMPOUNDS IN DEVELOPMENT: THE NEXT GENERATION OF DRUGS FOR NEURODEGENERATIVE DISEASES
• 3.1. Alzheimer' s Disease
  • Cholinergic Dysfunction
    • *Neuro-Hitech/Xel Pharmaceuticals
    • *Debiopharm
    • *Memory Pharmaceuticals/Roche
    • *AstraZeneca/Targacept
    • *Abbott Laboratories
    • *EnVivo Pharmaceuticals
    • *CoMentis
    • TorreyPines Therapeutics
    • Merck & Co.
    • ANAVEX Life Sciences
    • Medivation/Pfizer
  • Glutamatergic Dysfunction
    • *Forest Laboratories/Merz Pharma
    • *Evotec
    • *Cortex Pharmaceuticals
    • Lexicon Pharmaceuticals
    • Addex Pharmaceuticals
  • Serotonergic Dysfunction
    • EPIX Pharmaceuticals/GlaxoSmithKline
    • Suven Life Sciences
    • Memory Pharmaceuticals
  • Histaminergic Dysfunction
  • Amyloid Cascade: Inhibiting Production
    • Eli Lilly
    • Humanetics/Mount Sinai School of Medicine
    • ExonHit Therapeutics
    • Eisai
    • CoMentis/Astellas Pharma
    • Noscira
    • JADO Technologies
    • RemeGenix
    • Medisyn Technologies
    • Neurobiological Technologies
    • Galapagos
    • Others
  • Amyloid Cascade: Stimulating Removal
    • Elan/Wyeth
    • Eli Lilly
    • Novartis Pharma/Cytos Biotechnology
    • Merck & Co./Acumen Pharmaceuticals
    • Intellect Neurosciences
    • Others
    • Pfizer/TransTech Pharma
  • Amyloid Cascade: Preventing Aggregation
    • BELLUS Health
    • Prana Biotechnology
    • *Adeona Pharmaceuticals
    • *Elan/Transition Therapeutics
    • *ProteoTech
    • *Archer Pharmaceuticals
    • *D-Pharm
    • *Probiodrug
    • *Neuro-Hitech
    • *PharmAthene
    • *Nymox Pharmaceutical
    • *AC Immune
  • Tau Pathology
    • *TauRx Pharmaceuticals
    • *Allon Therapeutics
    • *Noscira
    • *Oligomerix
  • Neuroprotection
    • *Newron Pharmaceuticals
    • *Intellect Neurosciences
    • *Panacea Pharmaceuticals
  • Neurorestoration
    • *Ceregene
    • *NsGene
    • *ENKAM Pharmaceuticals
  • Cholesterol and Energy Homeostasis
    • *GlaxoSmithKline
    • *Accera
    • *Resverlogix
  • Second Messenger Modulation
    • *Helicon Therapeutics
    • *Memory Pharmaceuticals
    • *deCODE Genetics
    • *Sanofi-Aventis
• 3.2. Parkinson' s Disease
  • Dopaminergic Dysfunction
    • *Vernalis
    • *Spherics
    • *XenoPort
    • *NeuroDerm
    • *Amarin
    • *Depomed
    • *Axxonis Pharma
    • *Solvay Pharmaceuticals
    • *Neurogen
    • *NeuroSearch
    • *NuPathe
    • *Newron Pharmaceuticals/Merck Serono
    • *Synosia Therapeutics
    • *Paion
    • *Targacept/GlaxoSmithKline
    • Intra-Cellular Therapies
    • Adenosine A2A Receptor Modulation
  • Adenosite A2A Receptor Modulation
    • Biogen Idec/Vernalis
    • Schering-Plough
    • Synosia Therapeutics
    • Others
  • Glutamatergic and Noradrenergic Dysfunction
    • Faust Pharmaceuticals
    • Addex Pharmaceuticals/Merck & Co.
    • Neurim Pharmaceuticals
    • VistaGen Therapeutics
    • Santhera Pharmaceuticals/Juvantia Pharma
  • Alpha-Synuclein Pathology
    • TauRx Pharmaceuticals
    • FoldRx Pharmaceuticals
    • ProteoTech
    • BioArctic Neuroscience
    • Rentschler Biotechnologie
    • Prana Biotechnology
    • Panacea Pharmaceuticals
    • Alnylam Pharmaceuticals
  • Neuroprotection
    • Aeolus Pharmaceuticals
    • Vasogen
    • Trophos
    • Zenobia Therapeutics
  • Neurorestoration
    • Neurologix
    • Ceregene/Genzyme
    • Oxford BioMedica
    • Amsterdam Molecular Therapeutics
    • NeuroNova
    • NsGene
    • ArmaGen Technologies
    • Sangamo BioSciences
• 3.3. Huntington' s Disease
  • Dopamine Overactivity
    • NeuroSearch
  • Glutamatergic Dysfunction
    • Cortex Pharmaceuticals
    • VistaGen
  • Huntingtin Pathology: Genetic Therapy
    • Isis Pharmaceuticals
    • Targeted Genetics
    • Alnylam Pharmaceuticals/Medtronic
  • Huntingtin Pathology: Preventing Aggregation
    • Raptor Pharmaceuticals
    • Repligen
    • Prana Biotechnology
    • Adeona Pharmaceuticals
    • Vertex Pharmaceuticals
  • Neuroprotection
    • Amarin
    • Intellect Neurosciences
    • Trophos
    • Neurologix
    • KeyNeurotek Pharmaceuticals
  • Neurorestoration
    • Ceregene
    • ENKAM Pharmaceuticals
    • Neurobiological Technologies
• 3.4. Amyotrophic Lateral Sclerosis
  • Glutamatergic Dysfunction
    • Teva Pharmaceutical Industries
    • Faust Pharmaceuticals
  • SOD1 Pathology
    • CytRx
    • RXi Pharmaceuticals
    • Isis Pharmaceuticals
    • Amorfix Life Sciences/Biogen Idec
  • Neuroprotection
    • Aeolus Pharmaceuticals
    • Trophos
    • Maas Biolab
  • Trophic Factors
    • Sangamo BioSciences
    • NeuroNova
    • Oxford BioMedica
    • Ceregene
    • Genzyme/NsGene
    • Insmed
    • Sygnis Pharma
  • Microtubule Stabilization
    • KineMed

Chapter 4

• CONCLUSIONS AND OUTLOOK

References

• Company Index with Web Addresses