Report: Market Dynamics: Bone Substitutes and Growth Factors- Can BMPs Become the New Gold Standard? TOC

Table of Contnets

Overview

Introduction

A detailed look at the market for bone graft substitutes, bone morphogenic proteins and other biological compounds used in orthopaedic indications. Country coverage is US, Japan, France, Germany, Italy, Spain, UK.

DRIVERS AND TRENDS

The introduction of bone morphogenic proteins (BMPs) can turn the bone graft market on its head. Though overpriced at present, these products have the potential to eclipse all other products on the market including synthetic substitutes, allografts, demineralized bone matrices (DBMs), and machined bone.

What does the future hold for the bone graft markets in the US, France, Germany, Italy, Spain, the UK and Japan?
Which market segments have potential now and which will be profitable in the future?
Where will growth in specific geographic markets occur in bone grafting?

BONE GROWTH FACTORS

Analysis of current and future BMP and AGF products

Clinical trials data for products that will be available in the near and distant future
Discussion of BMP and AGF market drivers on a global and country-specific basis
Comparison of currently and soon-to-be available products

EXPERT OPINION

Learn about the future of the bone graft substitute market from the people who will be deciding it

Transcripts and summaries of interviews with surgeon opinion leaders in the bone graft substitute arena, including discoverers of bone morphogenic proteins (BMPs)
US, European and Asian opinion leaders were interviewed

STRATEGIC ANALYSIS

Understand what factors are driving the bone graft market

Listing of all currently available products and those in development
Average pricing and usage patterns of all bone graft products including allografts, autografts, DBMs, BMPs, synthetics, and machined bone
Discussion of recent events that have shaken up the market

GLOBAL AND EUROPEAN OVERVIEW

Vital market data for seven aggregate global markets and five aggregate European markets gives a picture of the market today and shows where and when future growth will occur

Market value and volume for over 5 market segments, forecasted to 2006
Discussion of global and European competitive landscape

SEVEN INDIVIDUAL COUNTRY MARKET CHAPTERS

Country specific information for the seven major bone graft substitute markets (US, Japan, France, Germany, Italy, Spain and the UK), both today and forecasted out for the next five years, segmented into specific areas of high and low growth

Country specific healthcare overview and recent reforms, as well as the effects of these reforms on the future of the bone graft substitute market
Country specific bone substitute market trends for the overall market and individual segments
Analysis and forecasts of the market value, volume and competitive landscape of each country’s bone graft substitute market segmented as follows:
Autografts
Allografts (pure allograft and machined bone)
Demineralized Bone Matrices (DBMs)
Bone Morphogenic Protein (BMPs)
Synthetics (i.e. calcium sulphate, calcium phosphate, etc.)

COMPANY PROFILES

Extensive listing (over 45 companies) of all players in the bone graft substitute market

Discussion of all bone graft substitute products on the market and in development
Recent events which affect the company’s standing in the marketplace

ACTION POINTS

BMPs are more precious than gold (standard) ’Edon’t miss out but know what you’re getting into!

BMPs are being posited as having the potential to drastically alter the bone substitute market and eclipse all other technologies in this over $700 million arena. Clinical trials data has shown them to be as efficacious as autograft, the gold standard in bone grafting, in certain indications. However, there is still not a great deal of data available conclusively proving their efficacy and their price is prohibitively high in most instances. BMPs certainly have enormous potential but it is not yet clear whether they will meet the great expectations which have been placed upon them.

Boost DBM profits by heavy marketing in Europe and running clinical trials that are product and indication specific

DBM use in Europe is extremely small. This is not, however, due to lack of desire by European surgeons to use these products as much as it is due to a lack of availability of DBMs in this region. European thought leaders express very positive views regarding the potential of DBMs but have been unable to realize this potential due to marketing barriers. Europe represents a huge untapped potential market for DBMs. These profits can be maximized by investing in clinical trials that are product and indication specific, to ensure that the efficacy of DBMs is presented in an indisputably positive light.

Autologous growth factor (AGF) systems are getting mixed reviews ’Eonly time will tell but the future does not look good

AGF systems are being marketed as cheap but effective alternatives to BMPs. Although some surgeons believe this, very few feel that these systems have nearly as great a potential as BMPs. Some even feel that their use can harm the patient. The prevailing sentiment regarding AGF systems at the present time is that they are a promising idea that has not yet found its ideal indication.

LIST OF TABLES

Table 1: Global Bone Graft Substitute and Growth Factor Market Value, $US (m), 2001-2006e
Table 2: Global Bone Graft Substitute and Growth Factor Market Volume, Procedures, 2001-2006e
Table 3: US Potential Procedures for BMPs in 2001
Table 4: 2002 Global Bone Graft Manufacturers with Products on the Market or in Development
Table 5: US Bone Graft Procedures by Indication, % 2001
Table 6: US Bone Graft Substitute Product Pricing, 2001
Table 7: Summary of Average Amount of Bone Graft Substitute Materials Used by Procedure
Table 8: Global Bone Graft Substitute and Growth Factor Market Value, $US (m), 2001-2006e
Table 9: Global Bone Graft Substitute and Growth Factor Market Volume, Procedures, 2001-2006e
Table 10: Segmented Global Bone Graft Substitute and Growth Factor Market Value, $US (m), 2001-2006e
Table 11: Segmented Global Bone Graft Substitute and Growth Factor Market Volume, Procedures, 2001-2006e
Table 12: European Bone Graft Substitute and Growth Factor Market Value, $US (m), 2001-2006e
Table 13: European Bone Graft Substitute and Growth Factor Market Volume, Procedures, 2001-2006e
Table 14: Segmented European Bone Graft Substitute and Growth Factor Market Value, $US (m), 2001-2006e
Table 15: Segmented European Bone Graft Substitute and Growth Factor Market Volume, Procedures, 2001-2006e
Table 16: US Bone Graft Market Volume, Procedures, 2001-2006e
Table 17: US Bone Graft Market Value, $US (millions), 2001-2006e
Table 18: 2001 Segmented US Bone Graft Market Shares by Value
Table 19: French Bone Graft Market Volume, Procedures, 2001-2006e
Table 20: French Bone Graft Market Value, $US (m), Euro (m), 2001-2006e
Table 21: German Bone Graft Market Volume, Procedures, 2001-2006e
Table 22: German Bone Graft Market Value, $US (m), Euro (m), 2001-2006e
Table 23: Italian Bone Graft Market Volume, Procedures, 2001-2006e
Table 24: Italian Bone Graft Market Value, $US (m), Euro (m), 2001-2006e
Table 25: Spanish Bone Graft Market Volume, Procedures, 2001-2006e
Table 26: Spanish Bone Graft Market Value, $US (m), Euro (m) 2001-2006e
Table 27: UK Bone Graft Market Volume, Procedures, 2001-2006e
Table 28: UK Bone Graft Market Value, $US (m), Pounds (m) 2001-2006e
Table 29: Japanese Bone Graft Market Volume, Procedures, 2001-2006e
Table 30: Japanese Bone Graft Market Value, $US (m), Yen (m) 2001-2006e
LIST OF FIGURES
Figure 1: A Comparison of Bone Graft Materials
Figure 2: Bone Substitute Efficacy According to Opinion Leaders
Figure 3: 2001 US Bone Graft Market Shares by Value
Figure 4: Biological Methods for Treating Fractures
Figure 5: A Comparison of Bone Graft Materials
Figure 6: Potential for BMPs Based on US 2001 Bone Graft Procedures
Figure 7: Mechanical Methods for Treating Fractures
Figure 8: Major Classes of Bone Graft Materials
Figure 9: Comparison of Allografts and Synthetics by Specific Composition
Figure 10: Relative Importance of Bone Substitute Material Importance According to Opinion Leaders
Figure 11: Efficacy of Bone Substitute Materials
Figure 12: Opinion Leader Usage of Bone Grafting Materials
Figure 13: Global Bone Graft Substitute and Growth Factor Market Value, $US (m), 2001-2006e
Figure 14: Global Bone Graft Substitute and Growth Factor Market Volume, Procedures, 2001-2006e
Figure 15: Segmented Global Bone Graft Substitute and Growth Factor Market Value, $US (m), 2001-2006e
Figure 16: Segmented Global Bone Graft Substitute and Growth Factor Market Volume, Procedures, 2001-2006e
Figure 17: European Bone Graft Substitute and Growth Factor Market Value, $US (m), 2001-2006e
Figure 18: European Bone Graft Substitute and Growth Factor Market Volume, Procedures, 2001-2006e
Figure 19: Segmented European Bone Graft Substitute and Growth Factor Market Value, $US (m), 2001-2006e
Figure 20: Segmented European Bone Graft Substitute and Growth Factor Market Volume, Procedures, 2001-2006e
Figure 21: Major International Players in the European Bone Graft Substitute Market
Figure 22: US Bone Graft Market Volume, Procedures, 2001-2006e
Figure 23: US Bone Graft Market Value, $US (millions), 2001-2006e
Figure 24: 2001 Segmented US Bone Graft Market Shares by Value
Figure 25: French Bone Graft Market Volume, Procedures, 2001-2006e
Figure 26: French Bone Graft Market Value, $US (millions), 2001-2006e
Figure 27: German Bone Graft Market Volume, Procedures, 2001-2006e
Figure 28: German Bone Graft Market Value, $US (millions), 2001-2006e
Figure 29: Italian Bone Graft Market Volume, Procedures, 2001-2006e
Figure 30: Italian Bone Graft Market Value, $US (millions), 2001-2006e
Figure 31: Spanish Bone Graft Market Volume, Procedures, 2001-2006e
Figure 32: Spanish Bone Graft Market Value, $US (millions), 2001-2006e
Figure 33: UK Bone Graft Market Volume, Procedures, 2001-2006e 163F
Figure 34: UK Bone Graft Market Value, $US (millions), 2001-2006e
Figure 35: Japanese Bone Graft Market Volume, Procedures, 2001-2006e
Figure 36: Japanese Bone Graft Market Value, $US (millions), 2001-2006e
Figure 37: 2001 Japanese Bone Graft Substitute Market Shares by Value