Abstract
Introduction
Hematopoietic stem cell transplantation (HSCT) has evolved considerably over
the past 50 years, driven by developments in stem cell sources, donor
identification and conditioning regimens. Nowadays, it has a range of
applications, including the treatment of certain hematologic malignancies.
However, further research efforts are required to expand its use and improve
patient outcomes.
Scope of this research
- Usage data for HSCT and overview of the procedure in terms of stem cell
donors, stem cell sources, and conditioning regimens
- Discussion of the use of drug therapy in HSCT conditioning and in the
management of complications, including current research and development trends
- Unmet needs and research priorities in the field of HSCT
- Stakeholder opinions based on qualitative interviews with key opinion
leaders from the US and EU
Research and analysis highlights
The use of HSCT has been increasing in the past decades, driven by
developments in stem cell sources and conditioning regimens. However, it seems
to remain an underutilized treatment, with many patients being referred for a
transplant only at advanced stages of disease, where cure is less likely.
The development of reduced-intensity conditioning (RIC) regimens is one of the
major advances in the field of HSCT. Current research evaluating monoclonal
antibodies and radioimmunotherapy may help increase the efficacy and
specificity of conditioning therapy.
The effective management of graft-versus-host disease (GVHD) is an unmet need
in the field of HSCT. The availability of better preclinical models,
prognostic tools, and effective therapies are considered R&D priorities.
Monoclonal antibodies may have a role in the treatment of GVHD but further
research is required to investigate their potential.
Key reasons to purchase this research
- Obtain analysis of current HSCT usage data and trends in the use of stem
cell donors, stem cell sources, and conditioning regimens
- Obtain an overview of current drug use in HSCT conditioning and in the
management of HSCT complications, including graft-versus-host disease
- Identify unmet needs and research priorities in the field of HSCT
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