Abstract
Introduction
As a result of the increasing switch from live-attenuated and killed
whole-cell vaccines to subunit antigens, there is a need for novel antigen
delivery technologies to improve vaccine efficacy and safety. This report
assesses key strategies, technologies and products for vaccine antigen
delivery. It provides an overview of opportunities and challenges for the
sector and a future outlook.
Scope of this research
In-depth analysis of key vaccine antigen delivery technologies Thorough
assessment of the potential for selected vaccine antigen delivery technologies
Review of industry and academic stakeholder opinions involved in the vaccine
antigen delivery sector In-depth discussion of key opportunities and risks for
novel vaccine antigen delivery technologies
Research and analysis highlights
There is a significant need for novel vaccine antigen delivery technologies
following the increasing switch from live-attenuated and killed whole-cell
vaccines to subunit antigens. Key drivers for the sector are the need for
increased immunogenicity and safety as well as for vaccine formulations
combining delivery systems and adjuvant.
Virus-like particles and virosomes, both benefiting from the successful track
record of already marketed vaccines, have the best potential in the short- to
mid term. ISCOM-based technologies could be valuable for therapeutic vaccines,
while liposomes and micro-/nanoparticles will not play a major role for
vaccine delivery in the foreseeable future.
Antigen stability, safety and immunogenicity are the key hurdles for novel
antigen delivery technologies. In times of restricted healthcare budgets,
pricing and manufacturing costs need to be kept to a minimum. The limited
understanding of the detailed molecular mechanisms for many technologies poses
a further challenge.
Key reasons to purchase this research
- Review profiles of key vaccine antigen delivery technologies both marketed
and in clinical development and assess their future potential
- Gain insight into the current state of vaccine antigen delivery
technologies and their future opportunities and challenges
- Benefit from opinions of key industry and academic stakeholders in the
vaccine antigen delivery field
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