RNAi: Broad Application, Expansive Opportunity, 2nd Edition

Table of Contents

1 Executive Summary

2 Small Interfering RNAs

• Background of small interfering RNAs
• Current Frontier of Research in RNAi

3 Market Drivers

• Cost of drug development
• Diseases ideal for siRNA therapeutics

4 Other RNAi Technology in Target Validation and Therapeutics

• Antisense
• Ribozyme
• Aptamers
• Peptide Nucleic Acids
• Morpholinos

5 Other Rival Technologies in Target Validation

• Gene knockouts

6 Related Technologies Critical to High Throughput Target Validation

• Protein profiling technology
• Phenotype profiling technology

7 Company Profiles

• Profiles of companies developing siRNA therapeutics
• Profiles of companies developing siRNA mediated target validation
• Profiles of companies supplying siRNA related reagents

8 Trends

• Strengths
• Weaknesses
• Opportunities