Biomarker and Diagnostic Opportunities in Clinical Research for Neurological Diseases

Table of Contents

• Executive Summary
  • Strategic Considerations
  • Stakeholder Implications
• Introduction
• Diagnosing Neurological Diseases
• Diagnostic Imaging Applications
• Biomarkers in Clinical Trials
• Indication-Specifi c Biomarkers of Interest
  • Alzheimer' s Disease and Mild Cognitive Impairment
  • Multiple Sclerosis
  • Parkinson' s Disease
  • Amyotrophic Lateral Sclerosis
  • Huntington' s Disease
• Biomarker and Diagnostic Neurology Deals
  • Indication-Specifi c Deals
  • Company-Specifi c Deals
• Outlook

Sidebar

• Commonly Used Imaging Technologies in Clinical Neurology

Expert Commentary

• “Value of Licensing Biomarkers of Alzheimer' s Disease”
• Q&A with Rainer Voegeli, Ph.D., Commercial Director at Proteome Sciences

Tables

• 1. Descriptions of Select Neurological Diseases
• 2. Top Five Currently Recruiting Clinical Trials in Neurology, Largest Enrollment
• 3. Diagnostic Tests for Multiple Sclerosis
• 4. Inheritance Patterns of Huntington' s Disease
• 5. Biomarker and Diagnostic Neurology Deals in the First Half of 2009
• 6. Biomarker and Diagnostic Deals Involving Large-Cap Healthcare Companies, 2004- First Half 2009

Figures

• 1. Biomarker-Based, Closed-Enrollment, Completed Neurology Clinical Trials by Phase and Indication, September 2009
• 2. Biomarker-Based, Closed-Enrollment, Active Neurology Clinical Trials by Phase and Indication, September 2009
• 3. Biomarker-Based, Open-Enrollment, Currently Recruiting Neurology Clinical Trials by Phase and Indication, September 2009
• 4. Biomarker-Based, Open-Enrollment, Not Currently Recruiting Neurology Clinical Trials by Phase and Indication, September 2009
• 5. Amyloid Plaques and Neurofi brillary Tangles in Alzheimer' s Disease
• 6. Rate of Dopaminergic Neuron Loss over the Course of Parkinson' s Disease
• 7. Number of Neurology Biomarker and Diagnostic Deals, 2004-First Half 2009
• 8. Neurology Deals: Biomarkers vs. Diagnostics, 2004-First Half 2009
• 9. Number of Neurology Biomarker and Diagnostic Deals, by Deal Focus, 2004-First Half 2009
• 10. Number of Neurology Biomarker and Diagnostic Deals, by Indication, 2004-First Half 2009
• 11. Companies with the Most Neurology Biomarker and Diagnostic Deals, 2004-First Half of 2009
• 12. Number of Neurology Biomarker and Diagnostic Deals, by Company Type, 2004-First Half 2009