Promising New Approaches for Discovering Ion-Channel Modulators

Table of Contents

Introduction

Ion-Channel Overview

• Function and Classification
• Many Potential Targets
• Undesirable Targets and HERG
• Few Marketed Ion-Channel Modulators

Screening Assays for the Discovery of Ion-Channel Modulators

• Traditional Screening Methods
• The Road to Higher Throughput
• New Screening Technologies
• Improved Fluorescent Assays
• High-Throughput Patch Clamping
• In Silico Methods

The Role of Specialist Companies

Corporate Highlights

• Icagen
• Lectus Therapeutics
• Neurion Pharmaceuticals
• Neuromed
• NeuroSearch
• Xention Discovery

Outlook for the Discovery of Ion-Channel Modulators