Can Pathway-Based Approaches Overcome the Problems of Target-Based Drug Discovery?

Table of Contents

Introduction

The Success of Traditional Pathway Studies

The Need for New Pathway-Based Knowledge and Approaches

Elucidating Signaling Pathways and Identifying Drug Targets

• Technologies
  • Yeast Two-Hybrid Assay
  • Tandem Affinity Purification
  • RNAi
• Strategies
  • Cellzome's Study of the TNF-ƒ¿/NF-ƒÈB Signal Transduction Pathway
  • Hybrigenics' Study of Signal Transduction Pathways in Drosophila

Pathway-Based Drug Screening Technologies and Strategies

• BioImage's Redistribution Technology
• Bionaut's Sentinel Line Technology
• BioSeek's BioMAP Systems
• Avalon Pharmaceuticals' Pathology-Based Screens

Novartis's Pathway-Based Drug Discovery Strategy

Corporate Highlights

• Bionaut Pharmaceuticals
• BioSeek
• Cellzome
• BioImage
• Hybrigenics

Outlook for Pathway-Based Drug Discovery