Abstract
Introduction
Antibiotic drug resistance is a perpetual and growing source of medical need;
however, diagnostics that can identify drug-resistant pathogens are limited in
number. As bacteria develop resistance to more agents and classes of
antibiotics, the need for rapid diagnostics that can provide diagnostic
accuracy and help in patient management (i.e., by helping physicians
administer appropriate therapy quickly) will grow urgent. Diagnostics
companies should take heed of the significant market opportunity thus
presented.
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Antibiotic drug resistance continues to plague the community and hospital
settings. Which setting is more lucrative for the uptake of diagnostics?
What features are needed to penetrate these settings? Currently, most
diagnostics identifying drug-resistant pathogens are designed to detect
methicillin-resistant Staphylococcus aureus (MRSA). Which pathogens
represent future opportunities? Many diagnostics (e.g., phenotypic tests,
molecular tests) are now available to detect pathogens and determine
antibiotic susceptibility. Where do future opportunities lie? What
challenges must be overcome? With the availability of better diagnostics
for identification of resistant pathogens, treatment practices in the
community and the hospital are likely to be impacted. How will the
widespread use of diagnostics affect drug development and use of current
drugs? Will it increase or decrease use of drugs such as daptomycin,
linezolid, and tigecycline?
Decision Resources, Inc. 4-2
Scope
- Impact of drug resistance and role of diagnostics: overview of
resistance issues in the hospital and community settings and the crucial but
limited role diagnostics play.
- Key antibacterial drug-resistant pathogens: overview of key
drug-resistant pathogens in the community and hospital settings, and their
drug-resistance mechanisms.
- Antibacterial diagnostic technologies: a review of technologies,
including phenotypic and molecular tests as well as biological markers.
- Key players: valuable profiles of important companies in the
antibacterial diagnostics arena, including information on their current and
emerging products.
- Outlook: opportunities and challenges to developing antibacterial
diagnostics and the effect of new antibacterial diagnostics on the
pharmaceutical industry.
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