Identifying Drug-Resistant Bacterial Infections: Opportunity and Activity in the Diagnostics Arena

Table of Contents

• Executive Summary
• Strategic Considerations
• Stakeholder Implications
• Impact of Drug Resistance
• Role of Diagnostics in Guiding Treatment
• Key Antibacterial Drug-Resistant Pathogens
• Staphylococcus
• Sites of Infection
• Mechanism of Resistance
• Enterobacteriaceae
• Sites of Infection
• Mechanism of Resistance
• Streptococcus
• Sites of Infection
• Mechanism of Resistance
• Antibacterial Diagnostic Technologies: Status and Next Steps
• Phenotypic Test Technology
• Molecular Test Technology
• Biological Markers
• C-Reactive Protein
• Procalcitonin
• Other Biomarkers
• Select Key Players in Antibacterial Diagnostics
• Accelr8 Technology
• Acolyte Biomedica
• AdvanDx
• Becton Dickinson
• BioMerieux
• Cepheid
• HandyLab
• Roche
• Outlook for Diagnostics
• Point-of-Care Testing
• Impact of Diagnostics on Drug Development
• Remaining Challenges
• Bibliography

Tables

• 1. Mechanisms of Bacterial Resistance to Select Antibiotic Classes of Drugs
• 2. Key Outcome Parameters of Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus (MRSA and MSSA)
• 3. Select Existing and Emerging Bacterial Detection and Susceptibility Diagnostic Technologies
• 4. Select Companies and Their Diagnostic Products
• 5. Advantages and Disadvantages of Developing Diagnostics for Antibacterial Resistance

Figures

• 1. Timeline of Discovery of New Classes of Antibiotics
• 2. Common Pathogens Implicated in Hospital-Acquired Infections
• 3. Mechanisms of Antibiotic Drug Resistance
• 4. Mechanisms of Transferring or Spreading Drug Resistance