Challenges and Opportunities in Developing Chemopreventive Agents

Table of Contents

• Executive Summary
  • Strategic Considerations
  • Stakeholder Implications
• Overview of the Chemoprevention Strategy
• Classes of Chemopreventive Agents
  • Anti-Infl ammatory Agents
    • Nonspecifi c Nonsteroidal Anti-Infl ammatory Drugs
    • Cyclooxygenase-2 Inhibitors
    • Lipoxygenase Inhibitors
  • Antimutagens
    • Dithiolethiones
    • Isothiocyanates
  • Modulators of Cancer-Associated Pathways
    • Epidermal Growth Factor Receptor
    • TGFβ/Smad
  • Modulators of Nuclear-Receptor Superfamily
  • Bioactive Food Components
    • Tea Polyphenols
    • Vitamin E
    • Lycopene
    • Curcuminoids
• Preclinical Animal Models
• Chemoprevention Trials: Lessons from the Past
  • Breast Cancer
  • Prostate Cancer
• Chemopreventive Agents in Development for Breast Cancer
  • Selective Estrogen Receptor Modulators
  • Aromatase Inhibitors
  • Retinoids
• Chemopreventive Agents in Development for Prostate Cancer
  • 5-α-Reductase Inhibitors
  • Selenium
• Challenges in Chemopreventive Agent Development
  • Patient Perception Barriers Affecting Clinical Trial Participation
  • Insurance Policy Affecting Reimbursement of Chemopreventive Agents
  • Intellectual Property Barriers Affecting R&D and Investment Recovery
• Opportunities in Chemopreventive Agent Development
  • FDA-Approved Agents
    • EGFR Inhibitors
    • HMG-CoA Reductase Inhibitors
    • Angiogenesis Inhibitors
    • Matrix Metalloproteinases
  • Combination Therapies
  • Strategic Alliances with Nutraceutical Companies
  • Biomarker Development
  • Veterinary Oncology
• Future Perspectives

Tables

• 1. Classes of Potential Chemopreventive Agents
• 2. Potential Chemopreventive Bioactive Food Components
• 3. Animal Models for the Screening and Development of Chemopreventive Agents
• 4. Chemopreventive Agents and Related Clinical Trials for Breast Cancer
• 5. Chemopreventive Agents and Related Clinical Trials for Prostate Cancer
• 6. Key Challenges and Proposed Solutions for Chemopreventive Agent Development
• 7. Potential Chemopreventive Molecular Targets and Agents

Figures

• 1. Carcinogenesis and Chemoprevention