What Strategies Will Yield Novel Treatments for Autoimmune Disease?

Table of Contents

• Executive Summary
  • Strategic Considerations
• Introduction
• Overview of Autoimmune Diseases
  • Pathophysiology and Etiology
  • Epidemiology
• Novel Targets and New Approaches to Treating Autoimmune Disease
  • Novel Targets
    • Sphingosine-1-Phosphate Receptor Modulators
    • Janus Kinases
    • Matrix Metalloproteinases
    • Tolerance Induction
    • PDE Inhibitors
  • Novel Treatment Methods
    • Antisense
    • Hematopoietic Stem Cell Transplant
    • Cell Therapy for the Treatment of Type 1 Diabetes
• New Approaches to Drug-Target and Biomarker Discovery for Autoimmune Diseases
  • Genetic Analysis
  • Proteomics: Mass Spectrometry, Protein and Antibody Arrays
    • Mass Spectrometry
    • Microarrays
  • Flow Cytometry
  • Lipidomics
  • Imaging
• Company Profi les
  • Alba Therapeutic
  • Bayhill Therapeutics
  • BioSeek
  • MultiCell Technologies
  • Novocell
  • Osiris Therapeutics
  • Osprey Pharmaceuticals
• Outlook
  • Ongoing Unmet Need Creates Opportunity
  • Potential Curative Therapies on the Horizon
  • Other Future Yields of Today' s Autoimmune R&D

Tables:

• 1. Overview of Select Autoimmune Diseases
• 2. Select Drug Classes Used to Treat Autoimmune Diseases
• 3. Select Novel Targets for the Treatment of Autoimmune Disease
• 4. Select Novel Approaches to Autoimmune Therapy
• 5. Select Companies Investigating Autoimmune Disease, 2008

Figures:

• 1. Prevalent Cases of Select Autoimmune Diseases in the United States, 2007
• 2. Sites of Action of Current and Experimental Immunosuppressive Agents