Target Product Profiles: Physician Insights on Key Attributes - Peripheral Arterial Disease - A therapy that reduces the need for revascularization by more than 20% for the treatment of peripheral arterial disease (intermittent claudication).

Table of Contents

• Introduction
  • Using Target Product Profi les in Your Market Strategy
  • Report Contents
  • Target Product Profi le Methodology
• Etiology and Pathophysiology
  • Overview
  • Structure of the Normal Blood Vessel Wall
  • Pathophysiology
    • Plaque Rupture-Arterial Occlusion and Its Causes
    • Endothelial Dysfunction-Response-to-Injury Hypothesis
    • Endothelial Dysfunction-Platelet Activation and Aggregation
    • Endothelial Dysfunction-Reduced Vasodilation and the Role of Nitric Oxide
    • Oxidative Modifi cation-Oxidized LDL and Infl ammation
    • Emerging Mechanisms Implicated in the Pathophysiology of PAD
    • Pathophysiology of Limb Ischemia
  • Etiology
    • Modifi able Risk Factors
    • Infl ammatory Markers as Measures of Risk
• Target Product Profi le Discussion-Peripheral Arterial Disease (Intermittent Claudication)
  • Target Product Profi le Summary for Peripheral Arterial Disease (Intermittent Claudication)-2011
  • Assessing Drug Development Opportunities
  • Physician Survey Results
    • Effi cacy
    • Safety and Tolerability
    • Delivery
    • Estimated Patient Share
  • Pricing Potential
  • Forecasted 2016 Pricing Environment
  • Competitors to Watch
  • Emerging Product Profi les