Abstract
Introduction
Generalized anxiety disorder (GAD) is a prevalent psychiatric disorder in the
major pharmaceutical markets, and drug therapy is considered the most
effective treatment. The therapy market for GAD is crowded and includes many
generic players, creating a diffi cult environment for launching new agents.
Nonetheless, several emerging agents are set to challenge current market
leaders.
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- GAD can be very debilitating, causing those affected to signifi cantly
limit their activities. How many people in the major pharmaceutical markets
we cover (United States, France, Germany, Italy, Spain, United Kingdom, and
Japan) have GAD? What brain structures and neurotransmitters have been
implicated in its development? How is the disease diagnosed?
- A variety of drug classes are used to treat GAD. What are the most
popular therapies for GAD? What are their benefi ts and drawbacks?
- Several new agents for GAD should launch in the next few years. What
agents are in the pipeline for GAD, and are they likely to replace any
existing agents? What changes can be expected in the GAD market over the next
fi ve years?
Scope
- Overview of GAD: disease description, diagnosis, and
pathophysiology.
- Epidemiology: total prevalent cases, diagnosed and drug-treated
populations.
- Current therapies: selective serotonin reuptake inhibitors,
serotonin and norepinephrine reuptake inhibitors, and benzodiazepines.
- Emerging therapies: Sanofi -Aventis' s Saredutant, Pfi zer' s Lyrica,
Pfi zer' s PD-332334, Takeda/Lundbeck' s Lu AA21004, Synosia Therapeutics' Rufi
namide, Sepracor' s SEP- 225441 and AstraZeneca' s AZD-7325.
- GAD market: 2007 statistics, outlook for emerging agents.
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