Opportunities in Menopausal Treatments: Will New Therapies Overtake Hormone Replacement?

Table of Contents

Contents

Executive Summary

• Strategic Considerations
• Stakeholder Implications

Introduction

Overview of Menopause

• Defi nition and Description
• Symptoms of Menopause
  • Vasomotor Symptoms
  • Osteoporosis
  • Increased Cardiovascular Disease Risk
  • Insomnia
  • Depression
  • Other Symptoms

Current Treatments for Menopausal Symptoms

• Hormone Replacement Therapy
• Selective Estrogen Receptor Modulators
• Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors
• Gabapentin
• Other Treatments

Emerging Treatments for Menopausal Symptoms

• Wyeth' s Pristiq
• Wyeth' s Bazedoxifene/Conjugated Estrogen Combination
• Depomed' s Gabapentin
• Schering-Plough' s Esmirtazapine

Outlook for the Menopausal Symptom Market

Tables

• 1. Common Brands of Hormone Replacement Therapy
• 2. Common Selective Serotonin Reuptake Inhibitors and Serotonin and Norepinephrine Reuptake Inhibitors
• 3. Emerging Agents for the Treatment of Menopausal Symptoms
• 4. Sales of Agents to Treat Menopausal Symptoms, 2008

Figures

• 1. Endocrine Changes Associated with Menopause
• 2. Worldwide Sales of Hormone Replacement Therapy, 2003-2008