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Home > Category > Pharmaceutical >

Market Research Report

Cancer Vaccine Developments to 2013

Published by Espicom Business Intelligence Contact us : +1-860-674-8796
Published 2007/09 Content info 183+ PAGES
Product code ES55740
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Description TOC

Table of Contents
  • EXECUTIVE SUMMARY
  • INTRODUCTION
    • What is a cancer vaccine?
      • Figure 1. Potential advantages of therapeutic vaccines for cancer
    • Prophylactic vaccines
      • Overview
        • Table 1. Infectious agents involved in cancer
      • Limitations
    • Therapeutic vaccines
      • Overview
        • Figure 2. Vaccines in Phase II/III development by vaccine type
      • Ag/adjuvant vaccines
      • Whole cell tumour vaccines
      • Dendritic cell vaccines
      • Viral vectors and DNA vaccines
        • DNA vaccines
        • Vector-based vaccines
      • Idiotype vaccines
    • Antigens
      • Carcinoembryonic antigen
      • Ganglioside molecules
      • Heat shock proteins
      • MART-1
      • MUC1
      • NY-ESO-1
      • Prostate specific antigen
      • Sialyl Tn
      • Telomerase
      • Tyrosinase
    • Adjuvants
      • AS04
      • Bacillus Calmette Guerin
      • Interleukins
      • Granulocyte monocyte-colony stimulating factor
      • Incomplete Freund' s adjuvant
      • Keyhole limpet hemocyanin
      • Montanide ISA-51
      • QS-21
    • Monitoring the immune response
      • Proliferation
      • Peptide-major histocompatibility complex multimers
      • ELIS pot
      • Intracellular cytokine assays
    • Challenges of developing vaccines
      • General challenges
        • Antigen selection
        • Adjuvants
        • Generating the correct immune response
        • Long-term immune memory
      • Cancer-vaccine specific challenges
        • Function of thymus
        • Heterogeneity in immune responses
        • Evasion of immune system
        • Tumour-induced immunosuppression
        • Induction of autoimmunity
      • Product standardisation and characterisation
  • MARKET FUTURE
    • Potential targets
      • Tumour types
        • Figure 3. Vaccines in Phase II/III development by indication
      • Disease incidence
        • Figure 4. US cancer statistics
      • Disease settings
    • Combination therapy
      • Figure 5. Potential combination therapy with cancer vaccines
    • Clinical trial designs
      • Proposed clinical trial design
        • Table 2. Proposed clinical trial designs for cancer vaccines
      • Endpoints
        • Patient selection
        • Survival
        • Other time-to-event endpoints
        • Response rate
        • Endpoint modifications
        • Patient-reported outcomes and quality-of-life endpoints
        • Biologic markers
      • Regulatory challenges
      • Market leaders
        • Figure 6. Vaccines in Phase II/III development by company
        • Figure 7. Factors faced by vaccines from their competitors
      • Cost effectiveness
      • Market growth
        • Potential market size
          • Figure 8. Growth drivers and resistors in the therapeutic cancer vaccine market
        • Competition
      • Cervical cancer vaccines: novel challenges
        • Figure 9. Issues faced by human papillomavirus vaccines
      • HPV vaccines
        • Gardasil
        • Cervarix
      • Vaccination population
        • Australia
        • Canada
        • Europe
          • Belgium
          • France
          • Switzerland
        • US
      • Vaccine cost
        • US Government immunisation schemes
      • European reimbursement
        • Sweden
        • UK
    • Less developed countries
    • Safety issues
    • Screening
    • Future research
  • MAJOR AGREEMENTS
    • The advantage of collaboration
      • Figure 10. The benefits of collaboration
      • Table 3. Agreements that could shape the cancer vaccine market
    • The Biomira and Merck KGaA story
      • Stimuvax
    • The Geron and Merck & Co story
      • GRNVAC 1
    • The GSK and Ludwig Institute for Cancer Research story
      • MA GE-A3
    • The Oxford BioMedica and sanofi-aventis story
      • TroVax
    • The Roche and Transgene story
      • TG4001
    • Terminated agreements: big pharma burns its fingers
      • Table 4. Terminated agreements between biotech companies and big pharma
    • Canvaxin
      • CancerVax and Serono
        • The agreement
        • Why did the agreement end?
    • Melacine
      • Corixa and Schering-Plough
        • The agreement
        • Why did the agreement end?
    • GMK Vaccine
      • Progenics Pharmaceuticals and Bristol-Myers Squibb
        • The agreement
        • Why did the agreement end?
    • Insegia
      • Aphton and sanofi pasteur
        • The agreement
        • Why did the agreement end?
      • Theratope
        • Biomira and Merck KGaA
          • The agreement
          • Why did the agreement end?
  • FAILED CANCER VACCINES
    • Figure 11. Reasons why cancer vaccines may have failed in clinical trials
    • Cancer vaccines that have failed in Phase II /II development
      • Table 5. Major cancer vaccine failures
    • Canvaxin failure leads to CancerVax merger
      • Product history
      • Why did the vaccine fail?
    • GMK Vaccine loses BMS backing following inferior results
      • Product history
      • Why did the vaccine fail?
    • GVAX highlights limits of patient-specific vaccines
      • Product history
      • Why did the vaccine fail?
    • Insegia problems force Aphton' s bankruptcy
      • Product history
      • Why did the vaccine fail?
        • Table 6. Insegia Phase III results showing survival by Ab response
    • Melacine; launched and disappeared
      • Product history
      • Why did the vaccine fail?
    • PANVAC-VF failure forces liquidation of Therion
      • Product history
      • Why did the vaccine fail?
    • Early Reniale data still waiting for confirmation
      • Product history
      • Why did the vaccine fail?
    • Theratope disappointment wards off Merck
      • Product history
      • Why did the vaccine fail?
  • LAUNCHED PRODUCTS
    • Vaccines currently on the market
      • Table 7. Vaccines currently on the market
    • OncoVAX
      • Intracel
      • The market(s)
      • The technology
      • Results to date
    • M-Vax
      • AVAX Technologies
        • The market(s)
        • The technology
        • Results to date
    • Gardasil
      • Sanofi Pasteur MSD
        • The market(s)
        • The technology
        • Results to date
    • Cervarix
      • GlaxoSmithKline
        • The market(s)
        • The technology
        • Results to date
    • Estimated sales
      • Gardasil
        • Sanofi Pasteur MSD (sanofi-aventis' joint venture with Merck & Co)
          • Sales forecasts and assumptions
          • Table 8. Sales forecast for Gardasil
      • Cervarix
        • GlaxoSmithKline
        • Sales forecasts and assumptions
          • Table 9. Sales forecast for Cervarix
  • VACCINES IN DEVELOPMENT
    • Table 10. Who' s developing what in Phase II/III?
    • Key launches
      • Table 11. Key vaccine launches to 2013
      • Figure 12. Key vaccine launches by indication
      • Figure 13. Key vaccine launches by vaccine type
  • BREAST CANCER
    • Overview
      • Figure 14. Development phase breakdown for breast cancer
      • Figure 15. Vaccine type breakdown for breast cancer
    • Why is vaccine therapy being explored for breast cancer?
    • Vaccines in Phase II development
      • Table 12. Vaccines in Phase II development for breast cancer
    • Vaccines in Phase I development
      • Table 13. Vaccines in Phase I development for breast cancer
    • Vaccines of interest
      • AE37
      • dHER2 vaccine
      • NeuVax
  • HAEMATOLOGICAL CANCER
    • Overview
      • Figure 16. Development phase breakdown for haematological cancer
      • Figure 17. Vaccine type breakdown for haematological cancer
    • Why is vaccine therapy being explored for non-Hodgkin' s lymphoma?
    • Why is vaccine therapy being explored for leukaemia?
    • Vaccines in Phase III development
      • Table 14. Vaccines in Phase III development for haematological cancers
    • Vaccines in Phase II development
      • Table 15. Vaccines in Phase II development for haematological cancers
    • Vaccines in Phase I development
      • Table 16. Vaccines in Phase I development for haematological cancers
    • BiovaxID
    • Biovest International (Accentia Biopharmaceuticals)
      • The technology
        • Figure 18. The process involved in manufacturing BiovaxID
      • Pivotal trial
      • Other important trials
      • Results to date
      • Next major event/milestone
      • Agreements
      • Market size
      • Competitors
      • Analysis
        • Strengths
        • Weaknesses
    • FavId
      • Favrille
        • The technology
          • Figure 19. The process involved in manufacturing FavId
      • Pivotal trial
      • Other important trials
      • Results to date
      • Next major event/milestone
      • Agreements
      • Market size
      • Competitors
      • Analysis
        • Strengths
        • Weaknesses
    • MyVax
      • Genitope
        • The technology
          • Figure 20. The process involved in manufacturing MyVax
        • Pivotal trial
        • Other important trials
        • Results to date
        • Next major event/milestone
        • Market size
        • Competitors
        • Analysis
          • Strengths
          • Weaknesses
    • PR1 vaccine
      • The Vaccine Company
        • The technology
        • Pivotal trial
        • Other important trials
        • Results to date
        • Next major event/milestone
        • Market size
        • Competitors
        • Analysis
          • Strengths
          • Weaknesses
    • Other vaccines of interest
      • Oncophage
  • LUNG CANCER
    • Overview
      • Figure 21. Development phase breakdown for lung cancer
      • Figure 22. Vaccine type breakdown for lung cancer
    • Why is vaccine therapy being explored for lung cancer?
    • Vaccines in Phase II development
      • Table 17. Vaccines in Phase III development for lung cancer
    • Vaccines in Phase II development
      • Table 18. Vaccines in Phase II development for lung cancer
    • Vaccines in Phase I development
      • Table 19. Vaccines in Phase I development for lung cancer
    • Lucanix
      • NovaRx
        • The technology
      • Pivotal trial
      • Other important trials
      • Results to date
      • Next major event/milestone
      • Agreements
      • Market size
      • Competitors
      • Analysis
        • Strengths
        • Weaknesses
  • MAGE-A3
    • GlaxoSmithKline
      • The technology
      • Pivotal trial
      • Other important trials
      • Results to date
      • Next major event/milestone
      • Agreements
      • Market size
      • Competitors
      • Analysis
        • Strengths
        • Weaknesses
    • Stimuvax
      • Biomira/Merck KGaA
        • The technology
        • Pivotal trial
        • Other important trials
        • Results to date
        • Next major event/milestone
        • Agreements
        • Market size
        • Competitors
        • Analysis
          • Strengths
          • Weaknesses
    • Other vaccines of interest
      • IDM -2101
      • IN GN 225
  • GENITO-URINARY CANCER
    • Overview
      • Figure 23. Development phase breakdown for genito-urinary cancer
      • Figure 24. Vaccine type breakdown for genito-urinary cancer
    • Why is vaccine therapy being explored for prostate cancer?
    • Why is vaccine therapy being explored for renal cell carcinoma?
    • Vaccines in Phase II development
      • Table 20. Vaccines in Phase III development for genito-urinary cancers
    • Vaccines in Phase II development
      • Table 21. Vaccines in Phase II development for genito-urinary cancers
    • Vaccines in Phase I development
    • Table 22. Vaccines in Phase I development for genito-urinary cancers
  • DCVax-Prostate
    • Northwest Biotherapeutics
      • The technology
      • Pivotal trial
      • Other important trials
      • Results to date
      • Next major event/milestone
      • Market size
      • Competitors
      • Analysis
        • Strengths
        • Weaknesses
    • GVAX vaccine
      • Cell Genesys
        • The technology
        • Pivotal trials
        • Other important trials
        • Results to date
        • Next major event/milestone
        • Agreements
        • Market size
        • Competitors
        • Analysis
          • Strengths
          • Weaknesses
    • Oncophage
      • Antigenics
        • The technology
        • Pivotal trial
        • Other important trials
        • Results to date
        • Next major event/milestone
        • Market size
        • Competitors
        • Analysis
          • Strengths
          • Weaknesses
  • Provenge
    • Dendreon
      • The technology
      • Pivotal trial
      • Other important trials
      • Results to date
      • Next major event/milestone
      • Market size
      • Competitors
      • Analysis
        • Strengths
        • Weaknesses
    • TroVax
      • Oxford BioMedica/sanofi-aventis
        • The technology
        • Pivotal trial
        • Other important trials
        • Results to date
        • Next major event/milestone
        • Agreements
        • Market size
        • Competitors
        • Analysis
          • Strengths
          • Weaknesses
      • Other vaccines of interest
        • GRNVAC 1
        • Onyvax-P
        • Reniale
  • GYNAECOLOGICAL CANCER
    • Overview
      • Figure 25. Development phase breakdown for gynaecological cancer
      • Figure 26. Vaccine type breakdown for gynaecological cancer
    • Why is vaccine therapy being explored for ovarian cancer?
    • Vaccines in Phase II development
      • Table 23. Vaccines in Phase III development for gynaecological cancers
    • Vaccines in Phase II development
      • Table 24. Vaccines in Phase II development for gynaecological cancers
    • Vaccines in Phase I development
      • Table 25. Vaccines in Phase I development for gynaecological cancers
    • Amolimogene
      • MGI Pharma
        • The technology
        • Pivotal trial
        • Other important trials
        • Results to date
        • Next major event/milestone
        • Market size
        • Competitors
        • Analysis
          • Strengths
          • Weaknesses
    • TG4001
      • Transgene/Roche
        • The technology
        • Pivotal trial
        • Other important trials
        • Results to date
        • Next major event/milestone
        • Agreements
        • Market size
        • Competitors
        • Analysis
          • Strengths
          • Weaknesses
      • Other vaccines of interest
        • CV ac
        • HspE7
  • GASTROINTESTINAL CANCER
    • Overview
      • Figure 27. Development phase breakdown for gastrointestinal cancer
      • Figure 28. Vaccine type breakdown for gastrointestinal cancer
    • Why is vaccine therapy being explored for pancreatic cancer?
    • Why is vaccine therapy being explored for colorectal cancer?
    • Vaccines in Phase III development
      • Table 26. Vaccines in Phase III development for gastrointestinal cancers
    • Vaccines in Phase II development
      • Table 27. Vaccines in Phase II development for gastrointestinal cancers
    • Vaccines in Phase I development
      • Table 28. Vaccines in Phase I development for gastrointestinal cancers
    • GV1001
      • Pharmexa
        • The technology
        • Pivotal trials
        • Other important trials
        • Results to date
        • Next major event/milestone
        • Market size
        • Competitors
        • Analysis
          • Strengths
          • Weaknesses
    • OncoVAX
      • Intracel
        • The technology
        • Pivotal trial
        • Other important trials
        • Results to date
        • Next major event/milestone
        • Market size
        • Competitors
        • Analysis
          • Strengths
          • Weaknesses
    • TroVax
      • Oxford BioMedica/sanofi-aventis
        • The technology
        • Other important trials
        • Results to date
          • Phase II results of TroVax plus CT in CRC
          • Phase II results of TroVax adjuvant therapy in CRC
        • Next major event/milestone
        • Agreements
        • Market size
        • Competitors
        • Analysis
          • Strengths
          • Weaknesses
      • Other vaccines of interest
        • Avicine
        • Gastrimmune
        • Oncophage
  • BRAIN CANCER
    • Overview
      • Figure 29. Development phase breakdown for brain cancer
      • Figure 30. Vaccine type breakdown for brain cancer
    • Why is vaccine therapy being explored for brain cancer?
    • Vaccines in Phase II development
      • Table 29. Vaccines in Phase II development for brain cancer
    • Vaccines in Phase I development
      • Table 30. Vaccines in Phase I development for brain cancer
    • CDX-110
      • Celldex Therapeutics
        • The technology
        • Pivotal trial
        • Other important trials
        • Results to date
        • Next major event/milestone
        • Market size
        • Competitors
        • Analysis
          • Strengths
          • Weaknesses
    • DCVax-Brain
    • Northwest Biotherapeutics
      • The technology
      • Pivotal trial
      • Other important trials
      • Results to date
      • Next major event/milestone
      • Market size
      • Competitors
      • Analysis
        • Strengths
        • Weaknesses
    • Other vaccines of interest
      • Oncophage
  • MELANOMA/SARCOMA
    • Overview
      • Figure 31. Development phase breakdown for melanoma/sarcoma
      • Figure 32. Vaccine type breakdown for melanoma/sarcoma
    • Why is vaccine therapy being explored for melanoma?
    • Vaccines in Phase II development
      • Table 31. Vaccines in Phase III development for melanoma/sarcoma
    • Vaccines in Phase II development
      • Table 32. Vaccines in Phase II development for melanoma/sarcoma
    • Vaccines in Phase I development
      • Table 33. Vaccines in Phase I development for melanoma/sarcoma
    • Allovectin-7
      • Vical
        • The technology
        • Pivotal trial
        • Other important trials
        • Results to date
        • Next major event/milestone
        • Agreements
        • Market size
        • Competitors
        • Analysis
          • Strengths
          • Weaknesses
    • MDX-1379
      • Medarex/Bristol-Myers Squibb
        • The technology
        • Pivotal trial
        • Other important trials
        • Results to date
        • Next major event/milestone
        • Agreements
        • Market size
        • Competitors
        • Analysis
          • Strengths
          • Weaknesses
    • M-Vax
      • AVAX Technologies
        • The technology
        • Pivotal trial
        • Other important trials
        • Results to date
        • Next major event/milestone
        • Market size
        • Competitors
        • Analysis
          • Strengths
          • Weaknesses
    • Oncophage
      • Antigenics
        • The technology
        • Pivotal trial
        • Other important trials
        • Results to date
        • Next major event/milestone
        • Market size
        • Competitors
        • Analysis
          • Strengths
          • Weaknesses
    • Other vaccines of interest
      • Uvidem
  • OTHER VACCINES
    • Overview
      • Vaccines in Phase II development
        • Table 34. Vaccines in Phase II development for other cancers
    • Vaccines in Phase I development
      • Table 35. Vaccines in Phase I development for other cancers
  • SOURCES
    • Espicom sources
    • Others
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