Ono: Pipeline, Products, Performance, Potential

Table of Contents

• Latest Results

EXECUTIVE SUMARY

• Introduction
• Current Financial Position
  • Company Performance
  • Geographic Segment Performance
• Company Strategy
  • R&D Strategy
  • Key Agreements
  • Employees
• Product Performance Forecasts
• Pipeline Analysis
  • Discontinued R&D
• Conclusions/Outlook

THERAPEUTIC AREA FOCUS

R&D PIPELINE

CARDIOVASCULAR

• Marketed Products
  • Opalmon
  • Others
• R&D Projects
  • Arocyte/Cereact
• Growth Forecast

RESPIRATORY

• Marketed Products
  • Onon
  • Others
• R&D Projects
• Growth Forecast

INFLAMATION

• Marketed Products
  • Foipan
  • Others
• R&D Projects
  • ONO-5334
  • Recalbon
• Growth Forecast

CNS

• Marketed Products
  • Kinedak
• R&D Projects
  • ONO-2333Ms
  • ONO-2540
• Growth Forecast

METABOLISM

• Marketed Products
• R&D Projects
  • Glactiv
• Growth Forecast

OTHERS

• Marketed Products
  • Staybala
  • Others
• R&D Projects
  • CNS 7056
  • Emend
  • ONO-4538
  • ONO-8539
  • RC-1291

APPENDIX 1 - FINANCIAL PERFORMANCE

• Full Year Results 2007

APPENDIX 2 - KEY CORPORATE EVENTS

APPENDIX 3 - KEY AGREMENTS

• Array BioPharma Inc
• BioFocus DPI Plc
• CeNeS Pharmaceuticals Plc
• Dainippon Sumitomo Pharma
• Dong-A Pharmaceuticals Co Ltd
• GlaxoSmithKline
• Kyorin Pharmaceutical Co Ltd
• Locus Pharmaceuticals Inc
• Medarex Inc
• Merck & Co
• Nissan Chemical Industries Ltd
• Novartis
• Recordati
• Sapphire Therapeutics Inc
• Santen Pharmaceutical Co Ltd
• UCB

APPENDIX 4 - IN FRA STRUCTURE

• Research and Development Facilities
• Manufacturing Facilities

APPENDIX 5 - KEY PHARMACEUTICAL SUBSIDIARIES / JOINT VENTURES

• Subsidiaries
• Joint Ventures

APPENDIX 6 - PRODUCT INDEX