CNS Biomarkers Players, products and prospects

EXECUTIVE SUMMARY

• Figure 1: Growth in biomarker market 2007-2015
  • What are biomarkers?
  • Why are they important?
    • Figure 2: Potential impact of biomarkers on disease pathways
  • What technologies are involved?
  • What impact will biomarkers have on R&D?
    • Figure 3: Potential impact of biomarkers on R&D
  • Who are the major biomarker players and in what research area?
  • Cancer biomarker companies
  • Cardiovascular biomarker companies
  • CNS biomarkers companies
  • Company Analysis Criteria
    • Biomarker technology & platforms
    • Association/clinical studies
    • Management strategy
    • Application & potential

CNS MARKET & REVENUES

• Market revenues - global
  • Figure 1: Global CNS drugs sales (2007)
• Market revenues - leading brands
  • Figure 2: Leading CNS brands (2007)
• Market revenues - leading players
  • Figure 3: Top 10 CNS players (2007 revenues)
• CNS EPIDEMIOLOGY, DIAGNOSIS, SCREENING & TREATMENT
  • Epidemiology
    • Table 1: CNS statistics for the most common CNS disorders, 2008
  • Diagnosis
    • Table 2: Indication for CT and MRI in the CNS
  • Screening
  • Current & future treatment
    • Table 3: Classes of CNS drugs approved for acute and chronic conditions
  • Future treatment
    • Figure 4: CNS drugs in clinical development
• CNS BIOMARKERS
  • CNS biomarker R&D
    • Figure 5: Imaging biomarkers as surrogate endpoints
    • Table 4: Types of biomarker
  • Known CNS biomarkers
    • Table 5: Commercially available known CNS biomarker diagnostics
  • Probable and possible valid CNS biomarkers
    • Table 6: Probable CNS biomarkers diagnostics
    • Table 7: Possible CNS biomarkers diagnostics

CNS BIOMARKER OPPORTUNITIES & CHALLENGES

• Opportunities
  • Figure 7: CNS biomarker opportunities
• Challenges
  • Figure 8: CNS biomarker challenges
• BIOMARKER MARKET
  • Biomarker market revenues - global
    • Figure 9: Global biomarker sales in 2007
  • CNS biomarker market revenues - global
    • Figure 10: Global CNS biomarker sales in 2007
  • Future biomarker market revenues - global
    • Figure 11: Global biomarker sales in 2015
  • Future CNS biomarker market revenues - global
    • Figure 12: Global CNS biomarker sales in 2015
• CNS BIOMARKER TRENDS
  • Table 8: Recent deals in the oncology biomarkers
  • Pharma deals
  • Collaborations with CNS discovery companies
  • Collaborations with academics and consortia
• BIOMARKER ANALYSIS
  • DNA biomarkers
  • Proteomic biomarkers
  • Metabolomic biomarkers
  • Electrophysiology biomarkers
  • Imaging biomarkers
• KEY BIOMARKER COMPANIES ANALYSED
• KEY BIOMARKER EVALUATION CRITERIA

CNS BIOMARKER- COMPANY ANALYSIS

• Affymetrix
  • Biomarker novelty & technology platform
  • Association studies/clinical data
  • Management strategy
  • Application & market potential
  • Biomarker analysis
• Applied Neuro Solutions
  • Biomarker novelty & technology platform
  • Association studies/clinical data
  • Management strategy
  • Application & market potential
  • Biomarker analysis
• Banyan Biomarkers
  • Biomarker novelty & technology platform
    • Figure 14: Source Of Banyans TNI biomarkers
  • Association studies/clinical data
  • Management strategy
  • Application & market potential
  • Biomarker analysis
• BG Medicine
  • Biomarker novelty & technology platform
  • Association studies/clinical data
  • Management strategy
  • Application & market potential
  • Biomarker analysis
• Biosite, Inc.
  • Biomarker novelty & technology platform
  • Association studies/clinical data
  • Management strategy
  • Application & market potential
  • Biomarker analysis
• Biospective
  • Biomarker novelty & technology platform
  • Association studies/clinical data
  • Management strategy
  • Application & market potential
  • Biomarker analysis
• Celera, Inc.
  • Biomarker novelty & technology platform
  • Association studies/clinical data
  • Management strategy
  • Application & market potential
  • Biomarker analysis
• Clinical Data Inc.
  • Biomarker novelty & technology platform
  • Association studies/clinical data
  • Management strategy
  • Application & market potential
  • Biomarker analysis
• Curidium Medica
  • Biomarker novelty & technology platform
  • Association studies/clinical data
    • Figure 17: Curidium' s PsychINDx test for schizophrenia/bipolar disorder
  • Management strategy
  • Application & market potential
• Digilab Peptidomics
  • Biomarker novelty & technology platform
  • Association studies/clinical data
  • Management strategy
  • Application & market potential
  • Biomarker analysis
• EnVivo Pharmaceuticals
  • Biomarker novelty & technology platform
  • Association studies/clinical data
  • Management strategy
  • Application & market potential
  • Biomarker analysis
• Innogenetics NV
  • Biomarker novelty & technology platform
    • Figure 18: Innogenetic multiparameter analysis
  • Association studies/clinical data
  • Management strategy
  • Application & market potential
  • Biomarker analysis
• KineMed, Inc
  • Biomarker novelty & technology platform
    • Figure 19: KineMarker technology platform
  • Association studies/clinical data
  • Management strategy
  • Application & market potential
  • Biomarker analysis
• Lipomics Technologies
  • Biomarker novelty & technology platform
  • Association studies/clinical data
  • Management strategy
  • Application & market potential
  • Biomarker analysis
• Luminex Corporation
  • Biomarker novelty & technology platform
  • Association studies/clinical data
  • Management strategy
    • Figure 20: Luminex is capturing end-user market share
  • Application & market potential
  • Biomarker analysis
• Memory Pharmaceuticals Corporation
  • Biomarker novelty & technology platform
  • Association studies/clinical data
  • Management strategy
  • Application & market potential
  • Biomarker analysis
• Metabolon, Inc.
  • Biomarker novelty & technology platform
    • Figure 21: Metabolon integrated analytic platform
  • Association studies/clinical data
  • Management strategy
  • Application & market potential
  • Biomarker analysis
• Nanogen, Inc.
  • Biomarker novelty & technology platform
  • Association studies/clinical data
  • Management strategy
  • Application & market potential
  • Biomarker analysis
• Nanosphere, Inc.
  • Biomarker novelty & technology platform
    • Figure 22. Nanosphere' s gold nanoparticle technology
  • Association studies/clinical data
  • Management strategy
  • Application & market potential
  • Biomarker analysis
• Nymox Pharmaceutical
  • Biomarker novelty & technology platform
  • Association studies/clinical data
  • Management strategy
  • Application & market potential
  • Biomarker analysis
    • Competitor Ratio Analysis Score = 12/40
• Osta Biotechnologies
  • Biomarker novelty & technology platform
  • Association studies/clinical data
  • Management strategy
  • Application & market potential
  • Biomarker analysis
• Phenomenome Discoveries, Inc.
  • Biomarker novelty & technology platform
  • Association studies/clinical data
  • Management strategy
  • Application & market potential
  • Biomarker analysis
• PPD, Inc.
  • Biomarker novelty & technology platform
  • Association studies/clinical data
  • Management strategy
  • Application & market potential
  • Biomarker analysis
    • Competitor Ratio Analysis Score = 16/40
• Power3 Medical Products
  • Biomarker novelty & technology platform
  • Association studies/clinical data
  • Management strategy
  • Application & market potential
  • Biomarker analysis
• Provista Life Sciences
  • Biomarker novelty & technology platform
  • Association studies/clinical data
  • Management strategy
  • Application & market potential
  • Biomarker analysis
• Psynova Neurotech Ltd.
  • Biomarker novelty & technology platform
  • Association studies/clinical data
    • Figure 23: Two proteins identified in CSF are also biomarkers in serum
  • Management strategy
  • Application & market potential
  • Biomarker analysis
• Satoris, Inc.
  • Biomarker novelty & technology platform
  • Association studies/clinical data
    • Figure 24: Early identification of Alzheimer' s disease in at-risk MCI patients
  • Management strategy
  • Application & market potential
  • Biomarker analysis
• Siemens Medical Solutions
  • Biomarker novelty & technology platform
    • Figure 25: Siemens Integrated in vivo & in vitro diagnostic suites
  • Association studies/clinical data
  • Management strategy
  • Application & market potential
  • Biomarker analysis
    • Competitor Ratio Analysis Score = 20/40
• SuperArray Bioscience Corporation
  • Biomarker novelty & technology platform
  • Association studies/clinical data
  • Management strategy
  • Application & market potential
  • Biomarker analysis

CNS BIOMARKER APPENDIX 1

• Table 9: Global biomarker sales 2007-20015E

CNS BIOMARKER APPENDIX 2

• Table 10: Global CNS biomarker sales 2007-20015E

CNS BIOMARKER APPENDIX 3

• Company Analysis Criteria
  • Biomarker technology & platforms
  • Association studies
  • Management strategy
  • Application & potential
    • Table 9: Key CNS Biomarker Companies
    • Figure 26: Leading CNS Biomarker Companies - Service Providers, Technology Providers, Biomarker Discovery & Diagnostic Developers

GLOSSARY

ACRONYMS

BIBLIOGRAPHY