Spinal Orthopaedics: A bright future for new technologies?

Table of Contents

• EXECUTIVE SUMMARY
• OVERVIEW
• THE SPINAL SURGERY MARKET
• Global Spinal Market by Procedure, 2006-2007 (US$ million)
  • Fig.1: Global Spinal Market by Procedure, 2007
• Global Spinal Market by Region, 2006-2007 (US$ million)
  • Fig.2: Global Spinal Market by Region, 2007
• United States
• US Clinical Procedures by CCS Code 158 (Spinal Fusion), 1996-2006
• Europe
• Asia-Pacific Region
• MARKET PLAYERS
  • Fig.3: Global Spinal Market Shares, 2007*
  • Fig.4: Global Spinal Market Shares, 2006*
• Manufacturers' Spinal Sales, 2003-2008 (US$ million)*
• Companies Ranked by Spinal Sales Growth, 2006-2007 (US$ million)
• MARKET DYNAMICS
• Gaining Clinical Evidence
• SPORT Study
• Intervertebral Disc Herniation
• Degenerative Spondylolisthesis
• Spinal Stenosis
• Increasing Competition
• The Role of Private Equity
• Major Private Equity Companies' Spinal Portfolios
• Industry Consolidation
• Major Spinal Acquisitions, 2006-2008
• FUTURE TRENDS AND FORECASTS
  • Fig.5: Global Spinal Market, 2006-2015 (US$ million)
• Global Spinal Market by Procedure Type, 2007-2013 (US$ million)
  • Fig.6: Global Spinal Market, 2006-2015 (US$ million)
  • Fig.7: Global Spinal Market by Procedure, 2013
• SPINAL PRODUCTS AND TECHNOLOGIES
• SPINAL FUSION
• The Fusion Market
  • Fig.8: Global Spinal Fusion Market, 2006-2013 (US$ million)
• Fusion: Market Drivers, Restraints & Future Opportunities
• Thoracolumbar Products
• Product Highlights
• Abbott' s Universal Clamp
• Alphatec' s Zodiac Line
• Amedica' s Valeo Pedicle Screw System
• Custom Spine' s ISSYS Products
• DePuy' s Expedium Products
• Globus Medical' s Reverse and Gateway Systems
• Life Spine' s Lynx Cross Connector System
• MEDICREA' s PASS Products
• Medtronic Products
• Pioneer Surgical Technology' s LowTop Pedicle Screw System
• SIGNUS Medizintechnik' s TPN
• Stryker' s Xia Spinal System
• Surgicraft' s Products
• Synthes' Pangea Degenerative Spine System
• US Spine' s Facet Fixation System
• X-spine Systems' Capless Pedicle Screw Systems
• New Anterior Lumbar Plates
• Interbody Devices
• Product Highlights
• Alphatec' s Novel Spinal Spacer Systems
• Amedica' s Valeo and Arx System
• Globus Medical' s NIKO Corpectomy Spacer System
• K2M' s Aleutian Systems
• LDR Holdings' ROI Partial VBRs
• Medtronic' s Capstone
• RSB Spine' s InterPlate VBRs
• Spinal Elements' VBRs
• Stryker' s AVS PL PEEK Spacers
• Synthes' Products
• Vertebration' s XYcor Spinal Implant
• Cervical Products
• New Anterior Cervical Plate Systems
• Spinal Elements' Mosaic Spinal Implant System
• MEDICREA' s C-JAWS
• Minimally-Invasive Spinal Fusion
• MIS Fusion: Market Drivers, Restraints & Future Opportunities
• Leading Products and New Innovations
• Abbott' s Minimally-Invasive Systems
• Alphatec' s Illico Minimally Invasive System
• Biomet' s VuePASS Portal Access Surgical System
• coLigne' s Erriva ELIF
• DePuy' s MIS Products
• Globus Medical' s MARS Minimal Access Retractor System
• Innovative Spinal Technologies' Paramount Systems
• Interventional Spine' s MIS Products
• K2M' s Serengeti Minimally Invasive Retractor System
• Medtronic Minimal Access Spinal Technologies
• NuVasive Maximum Access Surgery
• Pioneer Surgical Technology' s Quantum MIS Rodding System
• Spinal Elements' Mercury Spinal System
• Stryker' s MANTIS
• TranS1' s MIS Approach
• VertiFlex' Silverbolt MIS Systems
• Zimmer' s Endius Products
• BIOLOGIC PRODUCTS
• Orthobiologics Market by Product, 2007-2012 (US$ million)
• Orthobiologics Market by Region 2007-2012
  • Fig.9: Global Orthobiologics Market Shares, 2007
• Bone Graft Substitutes
• Spinal Biologics: Market Drivers, Restraints & Future Opportunities
• Allograft
• Demineralised Bone Matrix
• Bone Morphogenetic Proteins
• Medtronic' s Infuse Bone Graft
• Medtronic' s InductOs
• Stryker' s OP-1
• Synthetic Bone Grafts
• New Synthetic Bone Grafts
• Cell-Based Products
• NuVasive' s Osteocel
• SpineSmith' s Fusionary
• Technologies in Development
• Orthovita' s Cortoss Bone Augmentation Material
• Other Biologic Spinal Products
• co.don' s chondrotransplant DISC
• ISTO Technologies' NuQu Injectable Cell-Based Therapy
• Spinal Restoration' s Biostat Disc Augmentation System
• SpineOvations' DiscSeal
• Integra LifeSciences' DuraGen Plus Adhesion Barrier Matrix
• DYNAMIC STABILISATION
  • Fig.10: Dynamic Stabilisation Market, 2006-2013 (US$ million)
• Dynamic Stabilisation: Market Drivers, Restraints & Future Opportunities
• Pedicle Screw-Based Systems
• Pedicle Screw-Based Systems - Competitive Landscape
• Zimmer' s Dynesys Dynamic Stabilization System
• Zimmer DTO Implant
• Scient' x' Isobar Products
• Paradigm Spine' s coflex Devices
• Paradigm Spine' s DSS System
• SpineVision' s FlexPLUS
• Disc Motion Technologies' True TSMS
• Interventional Spine' s PercuDyn
• Applied Spine Technologies' Stabilimax NZ
• Vertiflex' Dynabolt Dynamic Stabilization System
• Eden Spine' s FX-1 System
• ulrich Medical' s cosmic Products
• Products in Development
• DePuy' s Expendium Dynamic Rod System
• Globus Medical' s Transition Posterior Dynamic Stabilization System
• Innovative Spinal Technologies' Axient Total Dynamic Fixation
• Interspinous Spacer Systems
• Interspinous Spacers - Competitive Landscape
• Medtronic/Kyphon' s X-STOP Interspinous Process Decompression System
• Abbott' s Wallis System
• Medtronic' s DIAM Spinal Stabilization System
• Medtronic/Kyphon' s Aperius PercLID
• VertiFlex' Superion
• Synthes' In-Space
• Orthofix' InSWing
• Globus Medical' s FLEXUS Interspinous Spacer
• Pioneer Surgical Technology' s BacJac
• Eden Spine' s Wellex Interspinous Technology
• GMReis' Dynafix Interspinous Dynamic Fixation System
• TOTAL DISC REPLACEMENT
  • Fig.11: Global TDR Market, 2006-2013 (US$ million)
• Lumbar Discs
• Market Potential and Future Opportunities
  • Fig.12: Lumbar TDR Market, 2006-2013 (US$ million)
• Lumbar TDR: Market Drivers, Restraints & Future Opportunities
• Lumbar TDR Products and Technologies
• Lumbar TDR: Competitive Landscape
• DePuy' s Charite Artificial Disc
• Synthes' ProDisc-L
• Medtronic' s Maverick Artificial Lumbar Disc
• Nexgen Spine' s Physio-L
• Stryker' s FlexiCore Artificial Lumbar Disc
• SpinalMotion' s Kineflex
• Aesculap' s Activ-L Artificial Lumbar Disc
• Disc Motion Technologies' TrueDisc Posterior Artificial Disc
• LDR Holdings' Mobidisc
• Zimmer' s Dynardi Artificial Lumbar Disc
• Products in Development
• Cervical Discs
  • Fig.13: Cervical TDR Market, 2006-2013 (US$ million)
• Cervical TDR: Market Drivers, Restraints & Future Opportunities
• Cervical TDR Products and Technologies
• Cervical TDRs - Competitive Landscape
• Synthes' ProDisc-C
• Medtronic' s Prestige Cervical Disc
• Medtronic' s Prestige LP Cervical Disc
• Medtronic' s Bryan Cervical Disc System
• Scient' x' Discocerv
• Cervitech' s PCM Artificial Cervical Disc
• LDR' s Mobi-C
• Globus Medical' s Secure-C
• SpinalMotion' s Kineflex|C
• DePuy' s Discover Cervical Disc
• Spinal Kinetics' M6-C
• Vertebron' s CMP
• Osteon' s MCD Mobile Cervical Disc
• Aesculap' s Activ-C
• Products in Development
• PARTIAL DISC REPLACEMENT
• Nucleus Replacement
  • Fig.14: Nucleus Replacement Market, 2006-2013 (US$ million)
• Nucleus Replacement: Market Drivers, Restraints and Future Opportunities
• Nucleus Replacement Products and Technologies
• Nucleus Replacement - Competitive Landscape
• Raymedica' s Products
• Disc Dynamics' Dascor Disc Arthroplasty System
• Pioneer Surgical Technology' s NuBac Intradiscal Arthroplasty System
• Sinitec' s SINUX ANR
• Products in Development
• NuVasive' s NeoDisc Cervical Partial Disc Replacement
• TranS1' s PDR Lumbar Partial Disc Replacement
• NUCLEUS REMOVAL
• FACET REPLACEMENT
• Archus Orthopedics' Total Facet Arthroplasty Systems
• Facet Solutions' Anatomic Facet Replacement System
• Spinal Elements' Zyre Facet Arthroplasty System
• Gerraspine' s FENIX Facet Implant
• TOTAL POSTERIOR ARTHROPLASTY
• TOPS-on-Fusion System
• ANNULAR REPAIR
• Anulex Technologies' Inclose and Xclose Systems
• Intrinsic Therapeutics' Barricaid
• Arthro Kinetics' AnReS
• FRACTURE TREATMENT
• Current Options
• VCF Treatment Options: Vertebroplasty vs Kyphoplasty
• Market Players
  • Fig.15: VCF Treatment Market, 2006-2013 (US$ million)
• Vertebroplasty
• ArthroCare - Parallax Medical and Cavity SpineWand
• Kyphoplasty and Kyphon
  • Fig.16: Kyphon: Kyphoplasty Procedure Growth, 2000-2006
  • Fig.17: Kyphon' s Revenue, Y/E 31st December 2000-2006 (US$ million)
• Kyphon' s SKy Bone Expander System
• Spine Wave' s StaXx FX Structural Kyphoplasty System
• Cement & Cement Delivery Systems
• DePuy' s Confidence Spinal Cement System
• Biomet' s VCF Products
• Orthovita' s Cortoss Bone Augmentation Material
• Spineology' s OptiMesh
• Products in Development
• Alphatec' s OsseoFix Spinal Fracture Reduction System
• AOI Medical' s Ascendx VCF Reduction System
• SPINAL IMPLANT MANUFACTURERS
• THE MARKET LEADERS
• Abbott
• Abbott: Recent Spinal Product Approvals
• Alliances
• Replication Medical
• AlloSource
• Invibio
• Financial Performance
• Abbott Revenue, 2004-2007 (US$ million)
  • Fig.18: Abbott Spine Sales, 2004-2007 (US$ million)*
• Alphatec Holdings
• Alphatec: Recent Product Approvals
• R&D Projects
• Alliances
• DePuy
• Scient' x
• Stout Medical Group
• Progressive Spinal Technologies
• JGMG Bengochea
• Roger P Jackson, MD
• Biomet
• Hansen A Yuan
• Invibio
• Financial Performance
• Alphatec Revenue, 2004-2007 (US$ million)
• B Braun/Aesculap
• Alliances
• Premier
• Inion
• Integra OrthoBiologics
• Allez Spine
• Financial Performance
• B Braun Revenue, 2004-2007 (US$ million)
• Biomet
• Alliances
• Premier
• Alphatec Holdings
• Altiva
• Financial Performance
• Biomet Revenue, 2005-2008 (US$ million)
  • Fig.19: Biomet: Spinal Revenue, 1998-2008 (US$ million)
• DePuy
• DePuy: Recent Spinal Product Launches
• R&D Projects
• Alliances
• Alphatec Holdings
• Biomerix
• Axial Biotech
• Archus Orthopedics
• Sinitec
• Osteotech and LifeNet
• FzioMed
• Harvest Technologies
• DJO
• Biedermann Motech GmbH
• Legal Proceedings
• Financial Performance
• DePuy Revenue, 2004-2007 (US$ million)
• Globus Medical
  • Fig.20: Globus Medical' s Revenue, 2003-2008 (US$ million)
• Globus: Recent Product Approvals
• R&D Projects
• Medtronic
• Medtronic: Recent Spinal Product Approvals
• R&D Projects
• Alliances
• Chinese Spine and Orthopaedics Joint Venture
• Orthofix International (Blackstone Medical)
• Kensey Nash
• aap Implantate
• RTI Biologics
• Premier
• Wyeth, Integra OrthoBiologics and Astellas
• Axial Biotech
• Purdue Research Foundation
• Kyphon Agreements
• Financial Performance
  • Fig.21: Medtronic' s Spinal Sales by Product Area, 2008
  • Fig.22: Medtronic' s Spinal Sales by Region, 2008
• Medtronic' s Spinal Revenue, 2007-2008 (US$ million)
  • Fig.23: Kyphon' s Revenue, Y/E 31st December 2000-2006 (US$ million)
• NuVasive
• NuVasive: Recent Product Launches
• R&D Projects
• Alliances
• Orthofix/Blackstone Medical
• Theken Spine
• Maxigen Biotech
• Tissue Banks International and AlloSource
• Pearsalls
• Invibio
• Peak Industries
• Financial Performance
  • Fig.24: NuVasive' s Revenue, 2003-2007 (US$ million)
• Orthofix International
• R&D Projects
• Alliances
• Musculoskeletal Transplant Foundation
• RTI Biologics
• UnitedHealth
• NuVasive
• Innovative Spinal Technologies
• Legal Proceedings
• Financial Performance
• Orthofix Revenue By Product, 2004-2007 (US$ million)
• Orthofix Spine Sales by Segment, 2004-2007 (US$ million)
• Stryker
• Stryker: Recent Spinal Product Launches
• R&D Projects
• Next-generation Spinal Implants
• New Indications for OP-1
• Alliances
• LifeCell
• Mayo Clinic
• Financial Performance
• Stryker Revenue, 2005-2007 (US$ million)
  • Fig.25: Stryker Sales by Product Line, 2007*
  • Fig.26: Stryker' s Spinal Sales, 2003-2007 (US$ million)
• Synthes
• Synthes: Recent Spinal Product Launches
• Alliances
• Innovative Spinal Technologies
• MTF (Musculoskeletal Transplant Foundation)
• Financial Performance
• Synthes Revenue, 2004-2007 (US$ million)
• Zimmer
• Zimmer: Recent Spinal Product Approvals
• Spinal R&D Projects
• Alliances
• U&I Corporation
• RTI Biologics
• Financial Performance
• Zimmer Revenue, 2004-2007 (US$ million)
• Zimmer Spine Sales by Region, 2004-2007 (US$ million)
• EMERGING PLAYERS
• Allez Spine
• Altiva (Exactech)
• Amedica
• Amedica: Recent Spinal Product Launches
• Anulex Technologies
• AOI Medical
• Applied Spine Technologies
• Archus Orthopedics
• ArthroCare
• Financial Performance
• ArthroCare Revenue: 2005-2007 (US$ million)*
• Arthro Kinetics
• Financial Performance
• Arthro Kinetics Revenue, 2005-2007 (EUR million)*
• Atlas Spine
• AxioMed Spine
• Benvenue Medical
• Biomerix
• Cervitech
• co.don
• coLigne
• CoreSpine Technologies
• Corin
• CryoLife
• Custom Spine
• Disc Dynamics
• Disc Motion Technologies
• Dynamic Spine
• Eden Spine
• Facet Solutions
• Gentis
• Gerraspine
• GMReis
• Impliant
• Inion
• Inion Revenue, 2006-2007 (EUR million)*
• Innovative Spinal Technologies
• Interventional Spine
• Intrinsic Therapeutics
• K2M
• K2M: Recent Product Launches
• Kensey Nash
• Lanx
• LDR Holding
• LDR: Recent Product Launches
• Life Spine
• MEDICREA International
• Nexgen Spine
• Osteon
• Paradigm Spine
• Pioneer Surgical Technology
• Pioneer: Recent Product Launches
• Ranier Technology
• Raymedica
• Replication Medical
• RSB Spine
• Scient' x
• Scient' x Revenue, 2004-2006 (US$ million)
• SeaSpine
• SIGNUS Medizintechnik
• Sinitec
• Smart Disc
• Spinal Elements
• Spinal Kinetics
• SpinalMotion
• Spinal Restoration
• SpineMedica
• Spineology
• SpineOvations
• SpineSmith
• SpineVision
• Spine Wave
• Surgicraft
• Theken Group (Integra LifeSciences)
• Theken Spine
• Theken Spine: Recent Spinal Product Approvals
• Theken Disc
• TranS1
• Financial Performance
• TranS1 Revenue, 2005-2007 (US$ million)*
• ulrich medical
• US Spine
• Vertebration
• Verterbron
• VertiFlex
• X-spine
• APPENDICES
• APPENDIX 1 - LIST OF ABBREVIATIONS
• APPENDIX 2 - REPORT METHODOLOGY
• Secondary Sources
• Primary Sources
• Market forecasts