Genetic Engineering

Table of Contents

1. INDUSTRY OVERVIEW

• Genetic Engineering: A Prelude
• The Evolution and Progress of GM Crops
• GM Crops Gain Global Acceptance
• GM Cultivation Gains Prominence in Developing Nations
• Rising Prices, Food Shortage Make Biotech Grains Attractive
• Challenges to GM Crops Adoption
• Biotech Regulatory Measures Hinder Crop Domestication
• Governments Not to Give Up on GM Hope
• US - The Largest Producer of GM Crops
• Major Market Participants

2. MARKET DYNAMICS

• Global Food Demand to Drive Need for GM Crops
• Genetic Engineering - A Solution for Food Crisis!
• Harmful or Healthy: Breaking The Myth About GM Crops
• Non-food Sectors to Benefit from GE Technology
• Genetic Engineering and Enzymes
• GE to Help Starch and Sugar Processing Enzyme Market
• GE to Drive Demand for Bakery Enzymes

3. ISSUES AND CONCERNS

• The GM Food Issue Continues
• Nations at Crossroads to Accept or Object GE Crops
• Nations Set Global Agenda to Settle GM Crop Controversies

4. REGIONAL TRENDS

• US Soybean and Corn Crop to Witness Robust Growth
• GMO Crops' Future Hinges on Co-Existence Measures in EU
• UK Government' s GM Crops Proposal Faces Rebuff
• Spanish Transgenic Corn Plantation Increases
• Chinese Biopharmaceutical Market to Continue its Growth Spurt
• Government to Support Biopharmaceutical Innovation
• India - The Leading Cultivator of Bt Cotton
• India Ousts China in Bt Cotton Cultivation
• GM Crops to Earn Good Returns for Australia
• Biotechnology - A Boon for Agriculture in Malaysia
• Biotech Crops Cultivation Zooms in South Africa

5. GENETIC ENGINEERING: AN OVERVIEW

• The Concept...
• Molecular Basics - The Gene
• Genome - The Information Pool
• Evolution of Genetic Engineering
• Historical Developments in Genetic Engineering:
• The Human Genome Project
• Significant Events in the Past
• Gene Therapy
• Types of Gene Therapy
• Monogenic Gene Therapy
• Suicide Gene Therapy
• Antisense Gene Therapy
• Human Genetic Engineering
• Genetic Engineering in Animals
• Role of Biotechnology in Agriculture
• Insect Resistant Crops Vs. Herbicide Tolerant Crops
• Genetically Modified Foods
• GM Food Faces Worldwide Criticism During Initial Years
• Benefits of Genetically Modified Foods
• Pest Resistance
• Cold Tolerance
• Herbicide Tolerance
• Drought and Salinity Tolerance
• Disease Resistance
• Phytoremediation
• Nutrition
• Pharmaceuticals
• Negative Impacts of GM Foods
• Possibility of Crosspollination
• Decreased Pesticides Effectiveness
• Unintentional Destruction of Other Species
• Health Concerns Related to GM Foods
• Cost Concerns Related to GM Foods
• Genetic Engineering and Food Processing
• Genetic Engineering and Regulatory Environment
• Patents - An Overview

6. GENE THERAPY - A REVIEW

• Factors Influencing Gene Therapy' s Future Development
• Human Genome Analysis
• Gene Therapy - The Next Generation Cardiovascular Therapy
• Public Support for Gene Therapy
• RNAi Bode Bright Prospects
• Factors Hampering Gene Therapy FutureDevelopment
• Stringent US and European Regulatory Laws Prolongs Gene Therapy Development
• Identifying Genetic Fault
• Immune Response
• Delivering Genetic Materials into Patient Cells
• Multigene Disorders
• Side Effects
• Push Towards Germline Gene Transfer
• Technical Limitations
• Commercialization: A Road Uphill
• Time Line in Gene Therapy Drug Development
  • Table 1: Gene Therapy Clinical Trials (2007): Percentage Breakdown by Geographic Region for the US, Europe, Canada, Japan and Rest of World
  • Table 2: Gene Therapy Clinical Trials Worldwide (2007): A Split by Development Phase
• Various Gene Therapy Products Under Development (2007)
• Target Diseases and Players Involved
• Key Players by Application Area
  • Table 3: Gene Therapy Clinical Trials Worldwide (2007): Percentage Breakdown by Disease/ Application Area for Cancer, Heart Disease, Monogenic Diseases, Infectious Diseases and Others
  • Table 4: Gene Therapy Clinical Trials Worldwide (2007):Percentage Breakdown by Gene Type Transferred for Antigen, Cytokine, Tumor Suppressor, Growth Factor, Suicide, Deficiency and Others
  • Table 5: Gene Therapy Clinical Trials Worldwide (2007): Percentage Breakdown by Vector Type for Adenovirus, Retrovirus, Naked/Plasmid DNA, Lipofection, Vaccinia Virus, Poxvirus, Adeno- associated Virus, and Others
• Gene Therapy Industry in Europe and the US - A Comparison

7. RESEARCH AND DEVELOPMENT

• Anti-Clotting Drug from GE Goats to Win Approval
• British Midlands University to Reveal Genetic Code of Bacterium Causing
• Hospital Acquired Infection
• Genetically Engineered BMPs to Facilitate Bone Formation in Orthopedic Surgeries
• GE Finds Application in Obesity Control
• Trubion Develops Advanced mAbs
• New Study Reveals microRNA' s Role in Heart Failure
• Cell-based Assays to Aid in Early Drug Discovery
• Inhibition of SHIP Gene to Minimize Risk in Stem Cell Transplants
• Drug Discovery to Employ Chemical Genetics
• GE to Aid in the Discovery of New Enzyme Sources
• Demand for Lactose-Free Products Boosts Enzymes Applications Market

8. MERGERS & ACQUISITIONS

• RJH Industries Acquires Philippines Royal Oil
• Monsanto Takes Over Aly Participacoes
• Monsanto Acquires De Ruiter Seeds Group
• Lydall Announces Acquisition of DSM Solutech
• Biotie Completes Acquisition of elbion
• Pfizer Animal Health Acquires Catapult Genetics
• Monsanto Completes Marmot Acquisition
• BioEnergy Takes Over Assets of OmniGene Bioproducts
• BRAIN Takes Over Industrial Biotech Assets of MerLion Pharmaceuticals
• MTS Health Investors Acquires DNA Diagnostic Center
• Bayer HealthCare Takes Over Direvo Biotech
• QIAGEN Completes Acquisition of Corbett Life Science
• ChemVentures to Acquire BioFocus DPI Chemistry Facility
• Nanobac Pharmaceuticals to Take Over DNAPrint Genomics
• GlaxoSmithKline to Take Over Genelabs Technologies
• Invitrogen Merges with Applied Biosystems
• NitroMed Enters into Definitive Merger Agreement with Archemix
• Monsanto Completes Acquisition of Delta & Pine Land
• Inverness Medical Innovations Acquires Biosite
• Avesta Biotherapeutics Takes Over Siegfried Biologics
• Entelos Takes Over Iconix Biosciences
• Illumina Takes Over Solexa
• Celera Group Acquires Atria Genetics
• CytoDyn Acquires Advanced Genetic Technologies
• Takeda Europe to Take Over Paradigm Therapeutics
• AmerisourceBergen Announces Acquisition of IgG of America
• GlaxoSmithKline Plans Praecis Acquisition

9. RECENT INDUSTRY ACTIVITY

• Eureka, Glycos Partner to Develop Bacterium for Biorefinery
• Genzyme Acquires Rights to MabCampath, Fludara and Leukine
• Quantel Announces Genetic Engineering Technology Support for Lasergraphics
• USDA to Deregulate Syngenta' s GE Corn
• Archer Daniels, Deere & Company and Monsanto to Form Partnership
• Genzyme Collaborates with ICGEB
• Veredus Partners with STMicroelectronics to Establish Bio-Application Lab
• Invitrogen Gains License for Stem Cell Line
• Millipore Enters into Agreement with Solabia
• Advanced Cell Forms Joint Venture with CHA Biotech
• Luminex Enters into Agreement with Mingyuan
• ProGenTech Inks Agreement with Human Genetic Signatures
• Monsanto and China National Seed Group Sign Agreement
• Monsanto and Syngenta Sign Royalty-Bearing Licensing Agreement
• Affymetrix Signs Definitive Agreement with Panomics
• Sanofi-Aventis to Use Regeneron' s Genetic Modification Method
• Monsanto to Build DEKALB Corn Seed Production Facility
• Qatar Receives Grant to Augment Agro-Genetic Engineering Capacity
• Monsanto Expands Jerseyville Facility
• Sirtris Pharmaceuticals Obtains Approval for NamPRT
• Origin Agritech Obtains License for Phytase Corn
• Shenyang Xiehe Establishes Genetic Engineering Subsidiary
• BioServe Enters into Alliance with DNAPrint Genomics
• Evogene Teams Up with Ormat on Biodiesel
• EMD and Dendritic Nanotechnologies Enter into License and Supply Agreement
• AureoGen Biosciences Enters into Agreement with Takara Bio
• Shanghai Wanxing Inks Agreement with Blue Blood Biotech
• Stem Cell Sciences Signs Agreement with RIKEN Centre
• Olympus and National Center for Biological Sciences Open New Facility
• Biocentury Obtains Approval for Hybrid Cotton Seed in India
• Novozymes to Expand Operation Base
• Cell Therapeutics to Develop More Targeted Treatments for Cancer

10. PRODUCT/SERVICE LAUNCHES

• Affymetrix Introduces MyGeneChip Program
• Genomnz to Unveil DNA Testing Service
• Whatman Introduces EasiCollect
• Nanoxis Launches Membrane Protein
• Few Important Terms Used in Genetic Engineering
• Chromosomes
• Genome
• Recombinant DNA
• Retroviruses
• Plasmids
• Transgenic Animals and Plants
• Gene Therapy

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