Proteomics

Table of Contents

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

• Study Reliability and Reporting Limitations
• Disclaimers
• Data Interpretation & Reporting Level
• Quantitative Techniques & Analytics
• Product Definitions and Scope of Study
• Expression Proteomics
• Functional Proteomics
• Structural Proteomics

II. EXECUTIVE SUMMARY

1. Global Market Overview

• Current Spotlight
• Genesis of Proteomics
• Tales From Times Gone By
• Proteomics: A Critical Drug Discovery Tool
• Factors Influencing the Market
• Market Drivers
• Factors Limiting Market Growth
• Major Challenges
• Proteomics Sample Preparation Market
• Protein Chemistry and its Complexities
• Integration of Data & Equipment
• Data Validation - A Burning Issue
• Standardization & Consistency- A Prime Concern

2. Industry Competition

• Industry Participants
• Proteomics Market Worldwide: Competitive Landscape
• Proteomics Supplier Market
• Challenges Ahead
• Designing a Novel Business Model

3. Product and Technology Overview

• Proteins, Proteome and Proteomics...!!!- What are They?
• Proteomics - An Introduction
• Components of Proteomics
• Expression Proteomics
• Functional Proteomics
• Cell-map Proteomics
• Structural Proteomics
• Technologies and Proteomics
• Proteomics and Genomics
• Proteomics and Genomics: A Comparison
• Protein Production Pathway: From Gene Expression to Functional Protein with Controls
• From Genomics to Proteomics
• Functional Genomics and Proteomics
• Push From Genomic Information
• Standard Proteomics Approach
• Sample Preparation- Step I
• Protein Separation-Step II
• Protein Visualization
• Protein Expression Analysis-Step III
• Protein Identification -Step IV
• Data Storage and Processing-Step V

4. Overview of Proteomics Technologies

• A Snapshot of Various Proteomics Tools
• An Insight into Various Proteomics Technologies and their Application Areas
• Protein Separation
• Table 1: Worldwide Protein Separation Market (2003-2008P): Market Share of Leading Players- Applied Biosystems, Waters Corp., Amersham Biosciences, Agilent Technologies Inc., Bio-Rad/ Micromass, Thermo Electron, and Others (Includes corresponding Graph/Chart)
• 2-Dimensional Gel Electrophoresis (2DGE)
• Protein Characterization
• Analysis of Protein Through Mass Spectrometry
• MS and Proteins
• Y2H, Yeast 2-Hybrid System
• Protein Microarrays
• Chip Technology
• Microfluidic Applications
• Role of Bioinformatics in Proteomics
• Bioinformatics Applications and Tools in Proteomics
• Emerging Proteomics Technologies
• MudPIT
• ICAT
• Phage Display Technique
• Advanced Proteomics Technologies: Structural Analysis Tools
• X-ray Crystallography
• Nuclear Magnetic Resonance (NMR)
• In silico Modelling
• Physicochemical Factors Constraining Metabolic Functions

5. End-Use Application Areas

• Proteomics in Drug and Diagnostic Discovery
• Proteomics and Drug Discovery
• Proteomic Approaches Gaining Prominence in Cancer Drug Discovery
• Leading Companies in Proteomics-Based Drug Discovery
• Future of Proteomics in Drug Discovery

6. New Product Solutions/Developments

• Bruker Daltonics Introduces Advanced ETD II Module
• Applied Biosystems Expands its iTRAQ® Line of Labeling Reagents
• PerkinElmer Expands Its Imaging Technologies and Protein Analysis Product Portfolio
• Sigma-Aldrich Introduces new Proteomics Dynamic Range Standard
• Thermo Fisher Scientific Expands Mass Spectrometry Portfolio
• Bruker Daltonics Launches New Versions of Compass™ and ProteinScape™ Softwares
• Applied Biosystems and Sciex Roll Out New Proteomic Tools
• Bruker Daltonics Rolls Out New Compass™ 1.2 Software
• Bruker Daltonics Unveils New Mass Spectrometer, apex®-ultra FTMS
• Thermo Fisher Unveils the Latest LTQ XL mass spectrometer
• Genedata Introduces Genedata Expressionist® Pro 3.0
• Biozentrum to Employ GeneBio' s Phenyx as Primary Search Engine
• Shimadzu Biotech Unveils AXIMA-TOF2
• Waters Corporation Unveils Latest Columns for Peptide Analysis and Isolation
• Applied Biosystems and MDS Sciex Unveil QSTAR® Elite LC/MS/MS System
• Waters Corporation to Roll out Updated ProteinLynx Global SERVER™ Version
• Syngene Unveils the Latest Integrated Proteomics Products
• Sigma Unveils the Latest ProteoPrep 20 Plasma Immunodepletion Kit
• Sigma-Aldrich Introduces First Commercial Proteomics Standard
• Bruker Daltonics and Serva Electrophoresis Unveil ICPL Triplex kit
• Agilent Unveils 3100 OFFGEL Fractionator
• Agilent Technologies Unveils Multiple Affinity Removal System 7
• Bio-Rad Unveils Proteon XPR36 Protein Interaction Array System
• Sigma-Aldrich Adds Panorama Human Kinase v1 Array to Extend Panorama Protein Array Line
• PerkinElmer Expands Proteomic Research Tools Offering
• Waters Launches Advanced Version of Proteomics Research Software
• Lumera to Develop New Protein Biochip in Collaboration with HMS
• Agilent Launches Ion Trap Mass Spectrometer, LC/MSD Trap XCT Ultra...
• Bruker Launches Novel Mass Spectrometer System, HCTultra...
• Bruker Launches Novel Post-Translational Protein Technique
• Kinexus Launches New Functional Proteomic Database
• Applied Biosystems Launches Series of Liquid Chromatography Systems
• Pall Introduces Three Novel Protein Purification Kits
• Ciphergen Launches Nex-Gen ProteinChip System, Series 4000
• Ciphergen Introduces Protein Software in Collaboration with Salford
• Bruker Launches New Proteomics RIMS
• Invitrogen Launches High-Density Protein Microarray
• Amersham Biosciences Introduces Improved 2-D Software...
• Proteome Introduces Latest Version of Proteomic Software Solutions...
• Proteome Systems Introduces Intelligent Electrophoresis Solutions
• Applied Biosystems Develops 4700 System
• Biacore Launches Functional Proteomics System
• Biacore Launches Software and Sensor Chips
• Biacore Launches Procel™
• Agilent Introduces Dual Loop Autosampler for HPLC Purification
• Agilent Introduces New Methods for RNAi
• Agilent Introduces Human 1B Oligo Microarray Kit
• Agilent Introduces New Seperation System
• Agilent Introduces Nano-flow LC System
• Ciphergen Launches IDM Platform
• Dionex Releases Monolithic Capillary Columns
• Beckman Enhances the Product Line of ProteomeLab

7. Recent Industry Activity

• Sigma-Aldrich Enters an Exclusive Alliance with Atlas Antibodies to Distribute New Prestige Antibodies™
• Nonlinear Dynamics Inks Distribution Agreement with UVP, LLC
• Plexera Enters into an Access Agreement with Auguron for NAPPA
• NextGen and Paragon Bioservices Enter into a Commercial Partnership Agreement
• Digilab Acquires Genomic Solutions and MAIA Scientific from Harvard Bioscience
• Power3 Ropes in FAH to Distribute its BC-SeraPro™ in the Middle East
• Thallion Sells Majority Stake to US-based Private Equity Firm, Great Point Partners
• Ecopia and Caprion Merge to Form Thallion Pharmaceuticals
• BG Medicine and Applied Biosystems Collaborate for Biomarker Discovery and Development
• Bio-Rad Acquires Ciphergen' s Proteomics Instrument Business
• BioMachines Establishes New Proteomics Services Unit
• GE Acquires Biacore
• Fuji Film Acquires Minority Stake in Perseus
• Cenix BioScience, Applied Biosystems, and Biotec of the Technische Universitat Dresden Collaborate
• GeneBio and Goodlett Enter into Collaboration
• Genetix Group to Acquire Applied Imaging
• Massively Parallel Technologies Signs a Deal with University of Colorado
• Genospectra Plans Merger with Panomics
• PerkinElmer Announces Acquisition of Proteomics Labeling Technology...
• ActivX Biosciences Extends Alliance with Pfizer...
• Invitrogen Acquires Zymed...
• FALCO Signs a Collaborative Agreement with PPD
• Invitrogen Acquires BioSource International...
• Agilix and Protana Enters into a Licensing Agreement...
• Invitrogen Pacts Marketing Agreement with Applied Biosystems...
• Waters Corp. Pacts a Technical Collaboration with Matrix
• Kyorin Acquires ActivX Biosciences...
• Bruker Signs Marketing Agreement with Serva Electrophoresis...
• PerkinElmer Enters into a Marketing Agreement with NLD...
• Pepscan Collaborates with Cytos Biotechnology....
• BD Acquires Protein Separation Technology of FFE Weber...
• Invitrogen Acquires Caltag Laboratories...
• Qiagen Acquires Major Assets of LumiCyte
• LifeSpan BioSciences Inks Long-Term Agreement with Pfizer
• Dana-Farber Cancer Institute To Establish Proteomics Research Center
• Bruker, University of Goettingen and PANATecs Signs an Development Agreement
• NextGen Sciences Partners with Protagen
• GeneBio Collaborates with Genedata...
• Sage-N Research to Establish R&D Center in China
• Sage-N Research Integrates Sorcerer™ Systems with TPP analysis Platform of ISB
• Agilent Introduces Whole Human Genome Microarray
• Invitrogen Acquires Protometrix...
• Nanogen Acquires SXP...
• BioCrossroads Establishes INCAPS, Protein Center of Excellence
• Ciphergen Acquires Remaining Stake in Ciphergen Biosystems K.K.
• Shimadzu Inks OEM Agreement with Nonlinear Dynamics
• Whatman Acquires Schleicher & Schuell
• GE Healthcare Acquires Amersham Plc
• GeneProt Extends Collaborative Agreement with Novartis
• GeneProt Collaborates with Lundbeck to Conduct CNS Proteomics Study

8. Focus on Select Key Players

• Agilent Technologies, Inc. (USA)
• Applied Biosystems (USA)
• Bio-Rad Laboratories, Inc.
• Dionex Corporation (USA)
• GE Healthcare (United Kingdom)
• Biacore Life Sciences
• Invitrogen Corporation (USA)
• PerkinElmer, Inc. (USA)
• Proteome Systems Ltd. (Australia)
• Shimadzu Biotech (Japan)
• Thermo Fisher Scientific (USA)

9. Global Market Perspective

• Table 2: World Recent Past, Current & Future Analysis for Proteomics by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2003 through 2010 (Includes corresponding Graph/Chart)
• Table 3: World Long-term Projections for Proteomics by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (Includes corresponding Graph/Chart)
• Table 4: World 10-Year Perspective for Proteomics by Geographic Region/Country - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe and Rest of World Markets for Years 2003, 2008 and 2012 (Includes corresponding Graph/Chart)
• Table 5: World Recent Past, Current & Future Analysis for Proteomics by Product Segment - Expression Proteomics, Functional Proteomics and Structural Proteomics Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2003 through 2010 (Includes corresponding Graph/Chart)
• Table 6: World Long-term Projections for Proteomics by Product Segment - Expression Proteomics, Functional Proteomics and Structural Proteomics Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (Includes corresponding Graph/Chart)
• Table 7: World 10-Year Perspective for Proteomics by Product Segment - Percentage Breakdown of Dollar Sales for Expression Proteomics, Functional Proteomics and Structural Proteomics Markets for Years 2003, 2008 and 2012 (Includes corresponding Graph/Chart)

10. Glossary of Terms

• 1-D, 2-D, 3-D
• Atmospheric Pressure Ionisation
• Electrophoresis
• Functional Genomics
• High-Throughput
• Liquid Chromatography (LC)
• Mass Spectrometry (MS)
• Matrix-Assisted Laser Desorption Ionisation (MALDI)
• Nuclear Magnetic Resonance
• X-ray Diffraction
• Yeast Two-Hybrid System
• 2D-PAGE (Two-dimensional PolyAcrylamide Gel Electrophoresis)
• TOF (Time of Flight)
• Quadrupole
• Q-TOF (Quadrupole Time of Flight)
• ESI (Electrospray Ionisation)

III. MARKET

1. The United States

• A. Market Analysis
  • Proteomics Sample Preparation Market
  • Table 8: US Proteomics Market (2004): Market Share of Leading Players in Proteomics Sample Preparation Markets -GE Healthcare, Agilent Technologies,, Millipore Corporation, Bio-Rad Laboratories, Inc., Invitrogen Corp., Sigma-Aldrich Co and Others (Ranked by Breakdown of Revenues) (Includes corresponding Graph/Chart)
  • Proteomics Arrays Markets
  • Table 9: US Proteomics Market (2005): Market Share of Leading Players in Proteomics Array Segment- Bio- Rad Laboratories, Invitrogen Corporation, and Others (Includes corresponding Graph/Chart)
  • Product Launches/Developments
  • Strategic Corporate Developments
  • Focus on Select Players
  • ActivX Biosciences, Inc.
  • Adnexus
  • Agilent Technologies Inc.
  • Applied Biosystems
  • Bio-Rad Laboratories, Inc.
  • Bruker Daltonics, Inc.
  • Caliper Life Sciences
  • Digilab Genomic Solutions, Inc.
  • Dionex Corporation
  • Human Genome Sciences, Inc.
  • Invitrogen Corporation
  • Millipore Corp.
  • PerkinElmer, Inc.
  • Thermo Fisher Scientific
  • Waters Corp.
  • Xencor,Inc.
  • Zyomyx, Inc.
• B. Market Analytics
  • Table 10: US Recent Past, Current & Future Analysis for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2003 through 2010 (Includes corresponding Graph/Chart)
  • Table 11: US Long-term Projections for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2011 through 2015 (Includes corresponding Graph/Chart)

2. Canada

• A. Market Analysis
  • Research Funding
  • Product Launches
  • Strategic Corporate Developments
  • Key Player
  • Caprion Proteomics, Inc.
• B. Market Analytics
  • Table 12: Canadian Recent Past, Current & Future Analysis for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2003 through 2010 (Includes corresponding Graph/Chart)
  • Table 13: Canadian Long-term Projections for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2011 through 2015 (Includes corresponding Graph/Chart)

3. Japan

• A. Market Analysis
  • Strategic Corporate Developments
  • Shimadzu Biotech - A Key Player
• B. Market Analytics
  • Table 14: Japanese Recent Past, Current & Future Analysis for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2003 through 2010 (Includes corresponding Graph/Chart)
  • Table 15: JapaneseLong-term Projections for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2011 through 2015 (Includes corresponding Graph/Chart)

4. Europe

• A. Market Analysis
  • Europe on the Fast Track
  • Table 16: European Proteomics Market (2007): Percentage Breakdown of Deployment of Proteomics Technologies in End-Use Segment- Research and Academia Institutions, Pharmaceutical Companies and Clinical Laboratories (Includes corresponding Graph/Chart)
• B. Market Analytics
  • Table 17: European Recent Past, Current & Future Analysis for Proteomics by Geographic Region/Country- France, Germany, UK and Rest of Europe Markets Independently Analyzed with Annual Sales in US$ Million for Years 2003 through 2010 (Includes corresponding Graph/Chart)
  • Table 18: European Long-term Projections for Proteomics by Geographic Region/Country- France, Germany, UK and Rest of Europe Markets Independently Analyzed with Annual Sales in US$ Million for Years 2011 through 2015 (Includes corresponding Graph/Chart)
  • Table 19: European 10-Year Perspective for Proteomics by Geographic Region/Country - Percentage Breakdown of Dollar Sales for France, Germany, UK and Rest of Europe Markets for Years 2003, 2008 and 2012 (Includes corresponding Graph/Chart)

4a. France

• A. Market Analysis
  • Key Player Review
  • Hybrigenics SA
• B. Market Analytics
  • Table 20: French Recent Past, Current & Future Analysis for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2003 through 2010 (Includes corresponding Graph/Chart)
  • Table 21: French Long-term Projections for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2011 through 2015 (Includes corresponding Graph/Chart)

4b. Germany

• A. Market Analysis
  • Outlook
  • Strategic Corporate Developments
• B. Market Analytics
  • Table 22: German Recent Past, Current & Future Analysis for Proteomics Market Independently Analyzed with Annual Sales in US$ Million fo Years 2003 through 2010 (Includes corresponding Graph/Chart)
  • Table 23: German Long-term Projections for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2011 through 2015 (Includes corresponding Graph/Chart)

4c. The United Kingdom

• A. Market Analysis
  • Current Trends in the UK Market for Proteomics
  • Highlights
  • Product Launches
  • Strategic Corporate Developments
• B. Market Analytics
  • Table 24: United Kingdom Recent Past, Current & Future Analysis for Proteomics Market Independently Analyzed with Annual Sales in US$ Million fo Years 2003 through 2010 (Includes corresponding Graph/Chart)
  • Table 25: United Kingdom Long-term Projections for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2011 through 2015 (Includes corresponding Graph/Chart)

4d. Rest of Europe

• A. Market Analysis
  • Switzerland
  • Portugal
  • Strategic Corporate Developments
  • Key Players
  • Biacore Life Sciences
  • Geneva Bioinformatics S.A. (Switzerland)
• B. Market Analytics
  • Table 26: Rest of Europe Recent Past, Current & Future Analysis for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2003 through 2010 (Includes corresponding Graph/Chart)
  • Table 27: Rest of Europe Long-term Projections for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2011 through 2015 (Includes corresponding Graph/Chart)

5. Rest of World

• A. Market Analysis
  • Outlook
  • Australia
  • India
  • Indian Scientific Research towards Functional Genomics and Proteomics
  • Strategic Corporate Developments
  • Key Player
  • Proteome Systems Ltd. (Australia)
• B. Market Analytics
  • Table 28: Rest of World Recent Past, Current & Future Analysis for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2003 through 2010 (Includes corresponding Graph/Chart)
  • Table 29: Rest of World Long-term Projections for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2011 through 2015 (Includes corresponding Graph/Chart)

COMPETITIVE LANDSCAPE