Collagen and HA-Based Biomaterials

Table of Contents

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

• Study Reliability and Reporting Limitations
• Disclaimers
• Data Interpretation & Reporting Level
• Quantitative Techniques & Analytics
• Product Definitions and Scope of Study
• Product Definitions
• Collagen Based Biomaterials
• Urinary Incontinence
• Corneal Shields
• Facial Aesthetic Dermal Implants
• Wound Dressings
• Hyaluronic Acid (HA)
• Viscosupplements
• Viscoelastics
• Facial Aesthetic Dermal Implants

II. EXECUTIVE SUMMARY

1. Market Dynamics

• Outlook
• Review of Major Segments
• Collagen Based Biomaterials
• Hyaluronic acid Based Biomaterials
• Regional Perspective
• Growth Drivers
• Challenges Faced
• Biomaterials Face Competition
• Industry Participants
• Leading Players in the Worldwide Collagen Based and HA-Based Biomaterials Market

2. Trends and Issues

• Aging Population/Baby Boomers- Play a Major Role
• Injectables Market on a High Growth Curve
• Skin Care Products Continue to Dominate Cosmeceuticals
• Botox and Hyaluronic Acid Replacing Collagen in Facial Implants
• Biomaterial Research- Develop New Applications
• Potential Shortage of Biomaterials
• Reasons for Shortage of Biomaterials
• Inadequate Reimbursement Diminish Revenue Growth

3. Biomaterial - A Brief Overview

• Definition
• Types of Biomaterials for Medical Devices
• Polymers
• Composites
• Metals & Alloys
• Ceramics
• Biological biomaterials
• Applications of Various Forms of Biomaterials

4. Collagen & HA-Based Biomaterials

• Collagen Based Biomaterials
• What is Collagen?
• Collagen-Based Biomaterials
• Various Forms of Collagen and Applications
• Soft Tissue Fillers Offer Patients More Options
• Review of Collagen Dermal Implants Available
• Threatened by Alternatives
• Hyaluronic Acid (HA)
• Table 1: HA Distribution in the Body (includes corresponding Graph/Chart)
• Properties of HA

5. Segment Overview

• Collagen Based Products
• Urinary Incontinence
• Definition
• Classification of Urinary Incontinence
• Stress Incontinence
• Urge Incontinence
• Overflow Incontinence
• Functional Incontinence
• Treatment of Urinary Incontinence
• Periurethral injections (Collagen Injections)
• Collagen Corneal Shields
• Research Proceedings
• Applications of the Collagen Shields
• Ocular Surface Lubrication
• Ocular Surface Protection
• Drug Delivery
• Wound Healing
• Facial Aesthetic Dermal Implants
• Functions of Collagen-based Facial Implants
• Aesthetic Dermal Implants-Playing a Major Role
• Normal Skin Changes Associated with Aging
• Collagen Injections as Facial implants
• Wound Dressings
• Leading Players in the Collagen Based Wound Dressing Market
• The Global Woundcare Market Flaunts Steady Growth
• Other Applications of Collagen
• Collagen Gene Delivery Systems
• Collagen as Bone Graft Substitution
• Artificial Skin
• Hyaluronic Acid Based Biomaterials
• Viscosupplementation
• Hyaluronic Acid as Viscosupplement
• Viscosupplementation Treatment for Osteoarthritis
• Viscosupplementation - High Rate in Japan
• Major Hyaluronic Acid based Viscosupplements
• Viscoelastics
• Facial Aesthetic Dermal Implants
• Commercially Available HA Soft Tissue Fillers
• Review of Select HA based Products
• Advantages of HA Based Over Collagen Products
• Vesicoureteral Reflux Implants
• Botox - A Competing Biomaterial

6. Technological Research & Developments

• Transgenic Plant Based Recombinant Human Collagen from CollPlant
• Composite Cultured Skin from Ortechs
• Multi-Gene Method
• FortaFlex™ Technology

7. Recent Industry Activity

• Corgenix and NIDDK Sign CRADA for NASH Research
• Orthovita and Allergan Sign a Raw Material Supply Agreement
• Warburg Pincus Acquires Bausch & Lomb
• Healtheuniverse To Develop Collagen-Based Skin Solutions
• Covalon Signs an Agreement with Smith & Nephew
• Ortec Seeks PMA for Orcel(R)
• Healthpoint Ltd Acquires Biospecifics Technologies Corp
• Terumo and Olympus To Start Combined Biomaterial Business
• SSC and CMT Inks Exclusive Distribution Agreement
• Aastrom and Orthovita Inks Collaboration Agreement
• Allergan Acquires Inamed
• CollPlant Submits PCT Patent Application
• Bioniche Pharma Signs Distribution Agreement with Grünenthal
• Lifecore Extends Supply Agreement with Alcon
• Inamed and Medicis Terminate Merger Agreement
• Genzyme Purchases Synvisc Sales and Marketing Rights from Wyeth
• Anika Terminates Partnership with OrthoNeutrogena
• Anika Inks Supply Agreement with Bausch & Lomb
• Advanced Medical Acquires Pfizer' s Ophthalmic Surgical…
• Q-Med Receives Marketing Licenses
• Collagen Matrix Receives NIH Grant
• Genzyme Enters the Japanese Hyaluronic Acid Market
• Mentor Acquires Two Subsidiaries from Vitrolife
• Mentor Acquires Surgical Implants From ProSurg

8. New Launches and Product Approvals

• Jarrow Formulas Rolls Out New Products Incorporating BioCell Collagen II®
• Medicis’ Perlane® Obtains US FDA Aprroval
• NMT Medical Launches BioSTAR in Canada and Europe
• Allergan Releases JUVEDERM ULTRA and JUVEDERM ULTRA PLUS
• Laresse Dermal Filler Gets TGA Approval
• Veritas (R) Obtains FDA Clearance
• Pegasus’ DermADAPT(TM) Receives FDA Clearance
• Innocoll’s CollaGUARD Obtains FDA Approval
• PTMC Receives Canadian CMDCAS and European CE Mark Approval
• Covalon Receives FDA Approval for Collagran and Collagran Ag
• Captique Obtains FDA Approval
• Q-MED Introduces RESTYLANE Touch
• Genzyme’s Hylaform Plus Receives FDA Stamp of Approval
• Q-Med’s RESTYLANE SubQ Gains CE Certification
• Orthovisc Bags FDA Approval for Treatment of Osteoarthritis of the Knee
• IDT GmbH Receives CE Certification for Curavisc®
• Inamed and Genzyme Receives FDA Approval for Hylafor®
• Inamed Receives FDA Approval for Cosmoderm and Cosmoplast
• Vitrolife Receives Approval for Ophthalin
• Collagen Matrix Receives Approval for DuraMatrix™

9. Focus on Key Players

• Alcon, Inc (US)
• Anika Therapeutics, Inc. (US)
• Bioniche Pharma USA, LLC (US)
• Genzyme Biosurgery (US)
• Allergan Medical (US)
• Q-Med AB (Sweden)
• Seikagaku Corporation (Japan)

10. Global Market Perspective

• Table 2: World Recent Past, Current & Future Analysis for Collagen and HA-Based Biomaterials by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010(includes corresponding Graph/Chart)
• Table 3: World Long-term Projections for Collagen and HA-Based Biomaterials by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 4: World 10-Year Perspective for Collagen and HA-Based Biomaterials by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe and Rest of World Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart)
• Table 5: World Recent Past, Current & Future Analysis for Biomaterials by Product Groups - Collagen Based and Hyaluronic Acid Based Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 6: World Long-term Projections for Biomaterials by Product Groups - Collagen Based and Hyaluronic Acid Based Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 7: World 10-Year Perspective for Biomaterials by Product Groups - Percentage Breakdown of Dollar Sales for Collagen Based and Hyaluronic Acid Based Markets for Years 2000, 2007 & 2010
• Table 8: World Recent Past, Current & Future Analysis for Collagen Based Biomaterials by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 9: World Long-term Projections for Collagen Based Biomaterials by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 10: World Recent Past, Current & Future Analysis for Collagen Based Biomaterials by Product Segments - Urinary Incontinence, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 11: World Long-term Projections for Collagen Based Biomaterials by Product Segments - Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 12: World 10-Year Perspective for Collagen Based Biomaterials by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe and Rest of World Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart)
• Table 13: World 10-Year Perspective for Collagen Based Biomaterials by Product Segment - Percentage Breakdown of Dollar Sales for Urinary Incontinence, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart)
• Table 14: World Recent Past, Current & Future Analysis for Collagen Based Urinary Incontinence by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 15: World Long-term Projections for Collagen Based Urinary Incontinence Products by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe and Rest of World Markets for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 16: World 10-Year Perspective for Collagen Based Urinary Incontinence by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe and Rest of World Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart)
• Table 17: World Recent Past, Current & Future Analysis for Collagen Based Corneal Shields by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 18: World Long-term Projections for Collagen Based Corneal Shields by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 19: World 10-Year Perspective for Collagen Based Corneal Shields by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe and Rest of World Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart)
• Table 20: World Recent Past, Current & Future Analysis for Collagen Based Facial Aesthetic Dermal Implants by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 21: World Long-term Projections for Collagen Based Facial Aesthetic Dermal Implants by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 22: World 10-Year Perspective for Collagen Based Facial Aesthetic Dermal Implants by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe and Rest of World Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart)
• Table 23: World Recent Past, Current & Future Analysis for Collagen Based Wound Dressings by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 24: World Long-term Projections for Collagen Based Wound Dressings by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 25: World 10-Year Perspective for Collagen Based Wound Dressings by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe and Rest of World Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart)
• Table 26: World Recent Past, Current & Future Analysis for Hyaluronic Acid Based Biomaterials by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 27: World Long-term Projections for Hyaluronic Acid Based Biomaterials by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 28: World 10-Year Perspective for Hyaluronic Acid Based Biomaterials by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe and Rest of World Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart)
• Table 29: World Recent Past, Current & Future Analysis for Hyaluronic Acid Based Biomaterials by Product Segments- Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 30: World Long-term Projections for Hyaluronic Acid Based Biomaterials by Product Segments - Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 31: World 10-Year Perspective for Hyaluronic Acid Based Biomaterials by Product Segments - Percentage Breakdown of Dollar Sales for Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart)
• Table 32: World Recent Past, Current & Future Analysis for Hyaluronic Acid Based Viscosupplements by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 33: World Long-term Projections for Hyaluronic Acid Based Viscosupplements by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 34: World 10-Year Perspective for Hyaluronic Acid Based Viscosupplements by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe and Rest of World Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart)
• Table 35: World Recent Past, Current & Future Analysis for Hyaluronic Acid Based Viscoelastics by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 36: World Long-term Projections for Hyaluronic Acid Based Viscoelastics by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 37: World 10-Year Perspective for Hyaluronic Acid Based Viscoelastics by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe and Rest of World Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart)
• Table 38: World Recent Past, Current & Future Analysis for Hyaluronic Acid Based Facial Aesthetic Dermal Implants by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 39: World Long-term Projections for Hyaluronic Acid Based Facial Aesthetic Dermal Implants by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 40: World 10-Year Perspective for Hyaluronic Acid Based Facial Aesthetic Dermal Implants by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe and Rest of World Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart)

III. MARKET

1. The United States

• A. Market Analysis
  • The Largest Market
  • Market Outlook by Segment
  • Urinary Incontinence Products
  • Leading Players
  • Table 41: Leading Players in the US Collagen- Based Urinary Incontinence Implants Market (2004-2006): Percentage Sales Breakdown for Allergan Medical /C.R. Bard, and Others (includes corresponding Graph/Chart)
  • Corneal Shields
  • Facial Aesthetic Dermal Implants HighlyCompetitive
  • Wound Dressings Market
  • Viscosupplements Spur Industry Growth
  • Hyaluronic Acid Knee Procedures on the Rise
  • Medicare for Viscosupplements
  • Leading Players
  • Table 42: Leading Players in the US Viscosupplementation Market (HA based) (2005 &2006): Percentage Share Breakdown by Value Sales for Genzyme, Sanofi, and Others (includes corresponding Graph/Chart)
  • Viscoelastics
  • Table 43: Leading Players in the US Viscoelastics # Market (HA based) (2005-2006): Percentage Share Breakdown by Value Sales for Alcon, Advanced Medical Optics, Bausch & Lomb, and Others (includes corresponding Graph/Chart)
  • Dermal Implants -The Fastest GrowingBiomaterial
  • Trends
  • US Biomaterials Market Elicits Rosy Future
  • US - A promising Facial Aesthetic DermalImplants Market
  • Enhanced Cosmetic Surgery Procedures toBoost Sales
  • US Facial Aesthetics Implants- Open Doors forNew Players
  • Table 44: Leading Players in the US Collagen Based Facial Aesthetics Implants Market (2005-2006)
  • Baby Boomers Trigger Growth
  • Non-Surgical Cosmetic Procedures in US
  • Strategic Corporate Developments
  • Product Launches
  • Focus on Key Players
  • Alcon, Inc
  • Anika Therapeutics, Inc.
  • Bioniche Pharma USA, LLC (USA)
  • Datascope Corporation
  • FibroGen, Inc
  • Genzyme Biosurgery
  • Allergan Medical
  • Isolagen Inc.
  • Lifecore Biomedical Inc.
• B. Market Analytics
  • Table 45: US Recent Past, Current & Future Analysis for Collagen and HA-based Biomaterials by Product Groups- Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
  • Table 46: US Long-term Projections for Collagen and HA-based Biomaterials by Product Segment - Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
  • Table 47: US 10-Year Perspective for Collagen and HA-based Biomaterials by Product Groups - Percentage Breakdown of Dollar Sales for Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets for Years 2000, 2007 & 2010(includes corresponding Graph/Chart)

2. Canada

• A. Market Analysis
  • Strategic Corporate Developments
  • Product Launches
• B. Market Analytics
  • Table 48: Canadian Recent Past, Current & Future Analysis for Collagen and HA-based Biomaterials by Product Groups- Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
  • Table 49: Canadian Long-term Projections for Collagen and HA-based Biomaterials by Product Segment - Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
  • Table 50: Canadian 10-Year Perspective for Collagen and HA-based Biomaterials by Product Groups - Percentage Breakdown of Dollar Sales for Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart)

3. Japan

• A. Market Analysis
  • Competitors
  • Strategic Corporate Developments
  • Focus on Key Players
  • Seikagaku Corporation
• B. Market Analytics
  • Table 51: Japanese Recent Past, Current & Future Analysis for Collagen and HA-based Biomaterials by Product Groups- Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
  • Table 52: Japanese Long-term Projections for Collagen and HA-based Biomaterials by Product Segment - Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets Independently Analyzed with annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
  • Table 53: Japanese 10-Year Perspective for Collagen and HA-based Biomaterials by Product Groups - Percentage Breakdown of Dollar Sales for Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart)

4. Europe

• A. Market Analysis
  • Regional Analysis
  • Hyaluronic Acid Biomaterials Market in Europe
  • Table 54: Leading Manufacturers of Viscosupplemen-tation Products in Europe (2006) : Percentage Breakdown by Value Sales for Fidia, Genzyme/Wyeth, Curasan, Seikagaku/Smith & Nephew, and Others (includes corresponding Graph/Chart)
  • Strategic Corporate Developments
  • Product Launches
• B. Market Analytics
  • Table 55: European Recent Past, Current & Future Analysis for Collagen and HA-Based Biomaterials by Geographic Region - France, Germany, Italy, UK & Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
  • Table 56: European Long-term Projections for Collagen and HA-Based Biomaterials by Geographic Region - France, Germany, Italy, UK & Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
  • Table 57: European 11- Year Perspective for Collagen and HA-Based Biomaterials by Geographic Region - Percentage Breakdown of Dollar Sales for France, Germany, Italy, UK & Rest of Europe Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart)
  • Table 58: European Recent Past, Current & Future Analysis for Collagen and HA-based Biomaterials by Product Groups- Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
  • Table 59: European Long-term Projections for Collagen and HA-based Biomaterials by Product Segment - Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
  • Table 60: European 10-Year Perspective for Collagen and HA-based Biomaterials by Product Groups - Percentage Breakdown of Dollar Sales for Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart)

4a. France

• Market Analysis
• Table 61: French Recent Past, Current & Future Analysis for Collagen and HA-based Biomaterials by Product Groups- Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants)Biomaterial Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 62: French Long-term Projections for Collagen and HA-based Biomaterials by Product Segment - Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 63: French 10-Year Perspective for Collagen and HA-based Biomaterials by Product Groups - Percentage Breakdown of Dollar Sales for Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart)

4b. Germany

• A. Market Analysis
  • Key Player
  • Curasan AG
• B. Market Analytics
  • Table 64: German Recent Past, Current & Future Analysis for Collagen and HA-based Biomaterials by Product Groups- Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
  • Table 65: German Long-term Projections for Collagen and HA-based Biomaterials by Product Segment - Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
  • Table 66: German 10-Year Perspective for Collagen and HA-based Biomaterials by Product Groups - Percentage Breakdown of Dollar Sales for Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart)

4c. Italy

• Market Analysis
• Table 67: Italian Recent Past, Current & Future Analysis for Collagen and HA-based Biomaterials by Product Groups- Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 68: Italian Long-term Projections for Collagen and HA-based Biomaterials by Product Segment - Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 69: Italian 10-Year Perspective for Collagen and HA-based Biomaterials by Product Groups - Percentage Breakdown of Dollar Sales for Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart)

4d. United Kingdom

• Market Analysis
• Table 70: UK Recent Past, Current & Future Analysis for Collagen and HA-based Biomaterials by Product Groups- Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 71: UK Long-term Projections for Collagen and HA-based Biomaterials by Product Segment - Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implant) Biomaterial Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 72: UK 10-Year Perspective for Collagen and HA-based Biomaterials by Product Groups - Percentage Breakdown of Dollar Sales for Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart)

4e. Rest of Europe

• A. Market Analysis
  • Strategic Corporate Developments
  • Focus on Key Players
  • FibroGen Europe Corporation (Finland)
  • Q-Med AB (Sweden)
• B. Market Analytics
  • Table 73: Rest of Europe Recent Past, Current & Future Analysis for Collagen and HA-based Biomaterials by Product Groups- Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
  • Table 74: Rest of Europe Long-term Projections for Collagen and HA-based Biomaterials by Product Segment - Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
  • Table 75: Rest of Europe 10-Year Perspective for Collagen and HA-based Biomaterials by Product Groups - Percentage Breakdown of Dollar Sales for Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart)

5. Rest of World

• A. Market Analysis
  • Focus on Key Player
  • ColBar LifeScience Ltd (Israel)
  • Recent Industry Activity
• B. Market Analytics
  • Table 76: Rest of World Recent Past, Current & Future Analysis for Collagen and HA-based Biomaterials by Product Groups- Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
  • Table 77: Rest of World Recent Long-term Projections for Collagen and HA-based Biomaterials by Product Segment - Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
  • Table 78: Rest of World 10-Year Perspective for Collagen and HA-based Biomaterials by Product Groups - Percentage Breakdown of Dollar Sales for Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart)

COMPETITIVE LANDSCAPE