Gene Amplification Technologies

Table of Contents

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

• Study Reliability and Reporting Limitations
• Disclaimers
• Data Interpretation & Reporting Level
• Quantitative Techniques & Analytics
• Product Definitions and Scope of Study
• Definitions
• Polymerase Chain Reaction
• Other Gene Amplification Technologies

II. EXECUTIVE SUMMARY

1. Industry Overview

• PCR Dominates Amplification Technologies
• Miniaturization - The Next Big Focus
• Critical in Diagnostic Procedures
• Leading Players

2. Technology Overview

• Definition of Gene Amplification
• Target vs. Signal Amplification
• Available Types of Gene Amplification Technologies
• Polymerase Chain Reaction
• Reagents and Equipment required for PCR
• Reaction Steps
• Denaturation
• Annealing
• Extension
• Detection of Amplified Product/DNA
• (Q&Q) PCR
• Reverse Transcriptase PCR (RT-PCR)
• Alternative Technologies to PCR
• OmniPlex
• Strand Displacement Amplification
• Ligase Chain Reaction
• LCR Involves a Cyclic Two-Step Reaction
• Gene Amplification Technology (GAT)
• Hybrid Capture
• Isothermal DNA Amplification Techniques
• Rolling circle Amplification in Diagnostics
• Ican Isothermal Gene Amplification Technology
• Other Amplification Technologies
• Signal Amplification Technology
• Transcription Mediated Amplification
• DNA cleavage-based signal amplification
• Ramification Amplification Method

3. End Use Market Analysis

• Medical and Diagnostics
• Role of Amplification Technology in Diagnostics of Infectious Diseases
• Diagnosis of Infectious Diseases by PCR
• Detection of Antimicrobial Resistance
• PCR Based Nucleic Acid Amplification for Detection of Antimicrobial Agents
• Nucleic Acid Amplification Testing (NAT)
• Nucleic Acid Amplification Methods
• DNA Amplification Technology in the Diagnosis of Infectious Diseases
• Forensic and Paternity
• Food Safety

4. Product Innovations/Launches

• Bio-Rad Launches New CFX96 PCR Detection System
• Roche Introduces Genome Sequencer FLX System
• QIAGEN Launches TopTaq DNA Polymerase
• Applied Biosystems Introduces TaqMan Array Human MicroRNA Panel
• Spartan Introduces Spartan DX
• Applied Biosystems Launches Forensic Tools
• Applied Biosystems Introduces StepOne Real-Time PCR System
• Sigma-Aldrich Unveils GenomePlex Tissue Whole Genome Amplification Kit
• QIAGEN Rolls Out Wide RNAi and SYBR(r) Green-based RT- PCR
• Applied Biosystems Launches 7500 Fast Real-Time PCR System
• Applied Biosystems Launches 9800 Fast PCR System
• 7900HT Fast Real-Time PCR System from Applied Biosystems
• Enzo Life Sciences Introduces New Advanced Amplification Technology
• Applied Biosystems Unveils AmpFSTR(r) Yfiler(tm) PCR Amplification Kit
• Amersham Launches GenomiPhi
• Rubicon Genomics Launches GenomePlex WGA
• Agilent Introduces Amplification Kit
• Linden Introduces Snapshot mRNA
• Rubicon Launches OmniPlex(tm)

5. Recent Industry Activity

• Hologic Acquires Third Wave Technologies
• BIOTECON Acquires Roche' s Technology License
• QIAGEN Signs a Global Licensing Agreement with BioHelix
• BioTrove and Gene Express Receive NIH Grant for Innovative Bio-experimentation
• SuperArray Bioscience Inks License Agreement with Applied Biosystems
• Merck Capital Takes Over Minority Interest in High Throughput Genomics
• NuGEN Enters into a Service Agreement with ExonHit
• Qiagen Enters into License Agreements with Roche and Ortho-Clinical
• Agilent Takes Over Stratagene
• Eiken Chemical Inks Licensing Agreement with Meridian Bioscience
• Sigma-Aldrich Acquires JRH
• Sigma-Aldrich Snaps Up Proligo
• Beckman to Acquire Agencourt
• Roche Diagnostics and Applera Corporation Expand PCR Licensing Program
• Mount and Hamilton Receive Patent
• Invitrogen Bags License from Applied Biosystems
• OriGene to Access TrueClone
• Orchid BioSciences to Turn into Orchid Cellmark
• QIAGEN Purchases Assets of Molecular Staging
• Cepheid, Applied Biosystems and Celera Diagnostics Sign Patent License Agreement
• Abbott Enters into Agreement with BioGenex
• Roche Inks Licensing Agreement with Incyte Corp
• Rubicon Genomics Signs Licensing Agreement with Sigma-Aldrich
• BioMerieux Teams-up with Cepheid
• Molecular Staging Collaborates with Eli Lilly
• Pacific Biometrics Inc. Receives Gene Amplification Patent...
• Rubicon Introduces Service for Genome Amplification...
• Takara Obtains Patent for New Amplification Method

6. Focus on Select Global Players

• Abbott Laboratories (US)
• Applied Biosystems (US)
• Becton, Dickinson and Company (US)
• bioMerieux (France)
• Bio-Rad Laboratories (US)
• Cepheid (US)
• QIAGEN N.V (The Netherlands)
• Roche Diagnostics (Switzerland)
• Rubicon Genomics (US)
• Takara Bio, Inc.

7. Global Market Perspective

• Table 1: World Recent Past, Current & Future Market Analysis for Gene Amplification Technologies by Geographic Region - US, Canada, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 2: World Long-term Projections for Gene Amplification Technologies by Geographic Region - US, Canada, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 3: World 10-Year Perspective for Gene Amplification Technologies by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, and Rest of World Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart)
• Table 4: World Recent Past, Current & Future Market Analysis for Polymerase Chain Reaction (PCR) by Geographic Region - US, Canada, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 5: World Long-term Projections for Polymerase Chain Reaction (PCR) by Geographic Region - US, Canada, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 6: World 10-Year Perspective for Polymerase Chain Reaction (PCR) by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, and Rest of World Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart)
• Table 7: World Recent Past, Current & Future Market Analysis for Other Gene Amplification Technologies by Geographic Region - US, Canada, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 8: World Long-term Projections for Other Gene Amplification Technologies by Geographic Region - US, Canada, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 9: World 10-Year Perspective for Other Gene Amplification Technologies by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, and Rest of World Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart)

III. MARKET

1. The United States

• A. Market Analysis
  • Product Launches
  • Strategic Corporate Developments
  • Key Players
  • Abbott Laboratories
  • Applied Biosystems
  • Bio-Rad Laboratories
  • Cepheid
  • Rubicon Genomics
• B. Market Analytics
  • Table 10: US Recent Past, Current & Future Analysis for Gene Amplification Technologies by Segment - Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
  • Table 11: US Long-term Projections for Gene Amplification Technologies by Segment - Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
  • Table 12: US 10-Year Perspective for Gene Amplification Technologies by Segment - Percentage Breakdown of Dollar Sales for Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets for 2003, 2008 & 2012

2. Canada

• A. Market Analysis
  • Strategic Corporate Developments
• B. Market Analytics
  • Table 13: Canadian Recent Past, Current & Future Analysis for Gene Amplification Technologies by Segment - Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
  • Table 14: Canadian Long-term Projections for Gene Amplification Technologies by Segment - Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
  • Table 15: Canadian 10-Year Perspective for Gene Amplification Technologies by Segment - Percentage Breakdown of Dollar Sales for Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets for 2003, 2008 & 2012

3. Japan

• A. Market Analysis
  • Key Player
  • Takara Bio, Inc.
• B. Market Analytics
  • Table 16: Japanese Recent Past, Current & Future Analysis for Gene Amplification Technologies by Segment - Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
  • Table 17: Japanese Long-term Projections for Gene Amplification Technologies by Segment - Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
  • Table 18: Japanese 10-Year Perspective for Gene Amplification Technologies by Segment - Percentage Breakdown of Dollar Sales for Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets for 2003, 2008 & 2012

4. Europe

• Market Analysis
• Table 19: European Recent Past, Current & Future Analysis for Gene Amplification Technologies by Geographic Region - France, Germany, UK, Italy, and Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 20: European Long-term Projections for Gene Amplification Technologies by Geographic Region - France, Germany, UK, Italy, and Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 21: European Recent Past, Current & Future Analysis for Gene Amplification Technologies by Segment - Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 22: European Long-term Projections for Gene Amplification Technologies by Segment - Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 23: European 10-Year Perspective for Gene Amplification Technologies by Geographic Region - Percentage Breakdown of Dollar Sales for France, Germany, UK, Italy, & Rest of Europe Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart)
• Table 24: European 10-Year Perspective for Gene Amplification Technologies by Segment - Percentage Breakdown of Dollar Sales for Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets for 2003, 2008 & 2012

4a. France

• A. Market Analysis
  • Key Player
  • bioMerieux
• B. Market Analytics
  • Table 25: French Recent Past, Current & Future Analysis for Gene Amplification Technologies by Segment - Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
  • Table 26: French Long-term Projections for Gene Amplification Technologies by Segment - Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
  • Table 27: French 10-Year Perspective for Gene Amplification Technologies by Segment - Percentage Breakdown of Dollar Sales for Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets for 2003, 2008 & 2012

4b. Germany

• Market Analysis
• Table 28: German Recent Past, Current & Future Analysis for Gene Amplification Technologies by Segment - Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 29: German Long-term Projections for Gene Amplification Technologies by Segment - Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 30: German 10-Year Perspective for Gene Amplification Technologies by Segment - Percentage Breakdown of Dollar Sales for Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets for 2003, 2008 & 2012

4c. United Kingdom

• Market Analysis
• Table 31: UK Recent Past, Current & Future Analysis for Gene Amplification Technologies by Segment - Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 32: UK Long-term Projections for Gene Amplification Technologies by Segment - Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 33: UK 10-Year Perspective for Gene Amplification Technologies by Segment - Percentage Breakdown of Dollar Sales for Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets for 2003, 2008 & 2012

4d. Italy

• Market Analysis
• Table 34: Italian Recent Past, Current & Future Analysis for Gene Amplification Technologies by Segment - Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 35: Italian Long-term Projections for Gene Amplification Technologies by Segment - Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 36: Italian 10-Year Perspective for Gene Amplification Technologies by Segment - Percentage Breakdown of Dollar Sales for Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets for 2003, 2008 & 2012

4e. Rest of Europe

• A. Market Analysis
  • Product Launches
  • Strategic Corporate Development
  • Key Players
  • Roche Diagnostics (Switzerland)
  • QIAGEN N.V (Netherlands)
• B. Market Analytics
  • Table 37: Rest of Europe Market for Gene Amplification Technologies - Recent Past, Current & Future Market Analysis by Segment for Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
  • Table 38: Rest of Europe Long-term Projections for Gene Amplification Technologies by Segment - Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
  • Table 39: Rest of Europe 10-Year Perspective for Gene Amplification Technologies by Segment - Percentage Breakdown of Dollar Sales for Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets for 2003, 2008 & 2012

5. Rest of World

• A. Market Analysis
  • Product Launch
  • Strategic Corporate Developments
• B. Market Analytics
  • Table 40: Rest of World Market for Gene Amplification Technologies - Recent Past, Current & Future Market Analysis by Segment for Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
  • Table 41: Rest of World (*) Long-term Projections for Gene Amplification Technologies by Segment - Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
  • Table 42: Rest of World 10-Year Perspective for Gene Amplification Technologies by Segment - Percentage Breakdown of Dollar Sales for Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets for 2003, 2008 & 2012

COMPETITIVE LANDSCAPE