Nanomedicine

Table of Contents

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

• Study Reliability and Reporting Limitations
• Disclaimers
• Data Interpretation & Reporting Level
• Quantitative Techniques & Analytics
• Product Definitions and Scope of Study
• Drug Delivery
• In Vitro Diagnostics
• In Vivo Imaging
• Biomaterials
• Others

II. EXECUTIVE SUMMARY

1. INDUSTRY OVERVIEW

• Introduction
• Current and Future Analysis
• Industry Drivers
• Industry Challenges
• Developing World Ready to Adopt Nanomedicine in a Major Way
• India
• China
• Japan
• Taiwan
• Nanotechnology Based Medical Products
• Table 1: Global Nanomedicine Market (2007): Percentage Breakdown of Number of Nano-Based Products by Application Area - Drug Delivery, Biomaterials, In Vivo Imaging, and Others (includes corresponding Graph/Chart)
• Nanotechnology Based Drug Delivery Products
• Table 2: Global Nanomedicine Market (2007): Percentage Breakdown of Number of Nano-Based Drug Delivery Products by Category - Liposomes, Nanocristals, Virosomes, and Others (includes corresponding Graph/Chart)
• Nanomedicine Patent Filings
• Table 3: Global Nanomedicine Market (1993-2003): Percentage Breakdown of Nanomedicine Patents by Application Area - Drug Delivery, In Vitro Diagnostics, Imaging, Biomaterials, and Others (includes corresponding Graph/Chart)
• Table 4: Global Nanomedicine Market (1993-2003): Percentage Breakdown of Patents by Country - US, Germany, Japan, and Others (includes corresponding Graph/Chart)

2. TRENDS & ISSUES

• Nanomedicine - The Future Direction
• Transforming Healthcare Sector Generating Demand for Nanomedicine
• Nanobiotechnology - A Promising Area
• High Demand for Tiny Healthcare Devices
• Research in Nanomedicine Continues to Surge
• Nanotechnology in Healthcare to Sustain R&D Funding
• Nanomedicine Clinical Pipeline to Sustain the Momentum
• Nanotechnology Gaining Ground in Fast Growing Drug Delivery Market
• Nanotechnology - Generating More Enthusiasm Among Entrants
• Demand for Supplies and Devices to Grow Rapidly
• Nanomedicine Needs Analysis of Ethical Implications
• Nanotechnology-based Drug Delivery Market on an Upbeat
• Nanotechnology Opens Up New Frontiers in Drug Discovery
• Nanotechnology Raises Hope for Tuberculosis Treatment
• Demand for Nano-Based Medical Products to Rise Significantly
• Medical Nanorobotics to Raise the Standards
• Nanomedicine - A Useful Element in Surgical Procedures
• Nano-based Diagnosis and Medical Imaging Helps Treatment of Critical Diseases
• More Efficient Nanoparticles Could be Made Possible by Modeling Software
• Major Issues Daunting Nanomedicine Sector

3. PRODUCT/TECHNOLOGY OVERVIEW

• Nanomedicine - A Primer
• Nanopores
• Radio-Controlled Biomolecules
• Quantum Dots
• Nanotubes
• Fullerenes
• Nanoshells
• Nanoprobes
• Nanoparticles
• Ceramic Nanoparticles
• Solid Lipid Nanoparticles
• Nanocapsules
• Dendrimers
• Liposomes
• Micelles
• Nanosuspensions
• Liquid Crystals
• Hydrogels
• Polymeric Nanoparticles
• Molecularly Imprinted Polymers

4. APPLICATIONS

• Drug Delivery
• Targeted Nanodrug Delivery & Release
• Active and Passive Targeting Mechanisms in Drug Delivery
• Sustained and Pulsatile Release Mechanisms in Drug Delivery
• In Vitro Diagnostics
• In Vivo Imaging
• Biomaterials
• Others
• Drugs and Therapy
• Active Medical Implants
• Oncology
• Key Applications in Cancer Therapy
• Advanced Imaging, Early-Stage Detection, and Targeting
• In-vivo Imaging
• Effective Tracking of Process Efficiency
• Advancing Bioinformatics and Proteomics Research
• Carbon Nanotubes in Cancer Treatment
• Regenerative Medicine
• Futuristic Applications
• Bio-molecular Motors
• Genetic and Tissue Engineering
• External Tissue Products
• Internal Tissue Implants
• Dental and Bone Replacement
• Protein and Gene Analysis
• Nanorobot Therapeutics
• Lab-on-a-Chip Techniques
• Medical Diagnostic Sensors
• Nano Medical Devices - From Surgical Tools to Contact Lenses
• Nanoengineered Prosthetics
• Nanotubes - Potential Drug Delivery Vehicles

5. NANOTECHNOLOGY - AN OVERVIEW

• Building Blocks of Nanotechnology Used, Components and Final End-Use Products
• Global Nanotechnology Market
• Table 5: Global Nanotechnology Market (2008 & 2009): Percentage Breakdown of Revenues by End-Use Segments - Chemicals, Automotive, Aerospace & Defense, Semi- Conductors & Electronics, Nanomedicine and Others (includes corresponding Graph/Chart)
• Commercial Applications at an Embryonic Stage
• Recent Commercial Applications of Nanotechnology
• Nanotech Players - Germany Tops Europe While China Leads Asia-Pacific
• Table 6: Nanotech Companies in Europe (2007): Number of Players in Major Regional Markets - Germany, United Kingdom, Switzerland, France, and Sweden (includes corresponding Graph/Chart)
• Table 7: Nanotech Companies in Asia-Pacific (2007): Number of Players in Major Regional Markets - China, South Korea, Japan, Australia, and Taiwan (includes corresponding Graph/Chart)
• Nanotech Funding by Regional Governments
• Table 8: Nanotech Funding by Regional Governments (2008): Leading National Markets Ranked by Funding in US$ Million for United States, Japan, Russia, Germany and China (includes corresponding Graph/Chart)

6. TECHNOLOGICAL DEVELOPMENTS

• German Scientists Develop Nanoparticle-Driven Gene Transfer Method
• Oxford Sees Progress in its Novel DNA Sequencing Technology Project
• Philips Releases First 3D Imaging Findings
• Researchers in University of Pennsylvania Invent Novel Carbon Nanopipette
• UCLA Scientists Develop Localized and Controlled Drug Delivery Method
• Minerva Makes New Discovery in Cancer Treatment
• NanoBio Releases Positive Data with NB-002
• NanoBio Receives Positive Pre-Clinical Results with Intranasal Influenza Vaccine
• Abraxis Announces Interim Results of Abraxane(r) for Metastatic Breast Cancer
• Abraxis Reveals Positive Data with Abraxane(r) and Gemzar(r)
• BioDelivery Commences Clinical Study with Bioral(r) Amphotericin B
• NanoCarrier Develops Protein Nanoencapsulation Technology
• Flamel Releases Positive Preliminary Data from FT-105 Phase I Study
• Abraxis Releases Positive Pre-Clinical Data with nab(tm) Technology Platform and SPARC Expression in Cancer Treatment
• American Scientists Develop Unique Nano-Based Drug Delivery System
• Researchers at University of Queensland Focus to Develop Novel Nano-based Diagnostics for Cancer Detection
• Indian Researchers Synthesize Polymeric Nanocurcumin for Cancer Therapy
• Researchers Mull on Using Nanoparticles to Develop Anti-Tumor Vaccines
• Nanomedicine Creates New Avenues for Regeneration of Nerve Cells
• University of Illinois Develop Enhanced Biomimetic Membranes
• Johns Hopkins Faculty develop Nanoparticle-Embedded Microcapsules
• Max Planck Research Team Develops Gold Nanoparticles
• Nanotechnology based Panacea for Facial Wrinkles

7. PRODUCT INTRODUCTIONS/INNOVATIONS

• Starpharma Holdings Releases the NanoJuice(tm) Transfection Kit
• Telomolecular Introduces Nano-Based Aging Solution
• CytoViva(r) Unveils Advanced Nanotechnology Research Tool
• eBioscience Introduces eFluor(tm) Brand
• eBioscience Launches eFluor(tm) Nanocrystals
• BioForce Nanosciences Unveils Surface Patterning Service
• Eastman Kodak Unveils KODAK X-SIGHT Imaging Agents
• Biomet Launches NanoTite Dental Implant
• Deerac Introduces Equator HTS/2 Liquid Handling Solution
• IMEC Develops Functionalized Magnetic Nanoparticles
• Ivoclar Vivadent Introduces New Version of Tetric Flow
• Calando to Begin Human Clinical Trials for siRNA-based Therapeutic Drug for Cancer
• Dabur Pharma Launches Nano-Based Drug Delivery System

8. RECENT INDUSTRY ACTIVITY

• APR Acquires New Drug Delivery Platform
• Merck Inks Merger Agreement with Schering-Plough
• Nanobiotix to Collaborate with SonoDrugs Project Consortium
• Liquidia and Abbott to Jointly Develop siRNA Therapeutics
• Pro-Tect Acquires Medivices' Nanotechnology Method
• APR to Create Dedicated Nanotechnology Unit
• Agilent Takes Over Nano Instruments
• Veridex Acquires Immunicon
• Thermo Fisher Takes Over nAscent
• Labcyte and Deerac Fluidics Combine Operations
• Invitrogen and Applied Biosystems Merge to Form Life Technologies
• Insert Therapeutics Merges with Calando Pharmaceuticals
• Capsulution Nanoscience and NanoDel Technologies Merge
• BioForce Forms Collaboration with UAlbany NanoCollege
• Advion and Bruker Daltonik Enter into Joint Marketing Agreement
• Midatech Group Inks Agreement with MonoSol Rx
• Advion Signs Co-Marketing Agreement with Agilent Technologies
• Abraxis Inks Deal to Re-Acquire US Rights to Abraxane
• NanoKTN and Bio Nano to Develop Nanomedicine
• Evolved Machines Inks License Contract with Nanosys
• Abraxis Bags European Commission Approval to Market Abraxane
• Nanogen Eyes European Molecular Diagnostics Market
• Abraxis Receives Approval for Marketing ABRAXANE in Korea and China
• BioForce Receives MIT Validation for Nano eNabler Molecular Printer
• Oxonica and Becton, Dickinson and Co. Sign Strategic Deal
• Nanogen Sells Royalties to DRI Capital
• Nanogen Signs Deal with Thermo Fisher
• Midatech Establishes New Nanotechnology Subsidiary
• Nanogen and HX Diagnostics Extend Collaboration
• CytImmune Joins Hands with University of Maryland
• Abraxis Inks Licensing Deal with Japan' s Taiho
• Abraxis Files Marketing Application for Abraxane in Japan
• BioForce Secures State Funding for ViriChip(tm)
• Capsulution and Advanced Materials Ink Patent License Deal
• Midatech Bags US Grant on Patent Application
• Nanobiotix Wins European Patent for Activable Particles
• Nanotherapeutics Submits IND Application for NanoDOX (tm) Hydrogel
• Nanobiotix to Focus on Development of Diagnostics for Tropical Diseases
• Ceres to Develop Novel Nanotechnology Products
• Batist to Commence Production of Nanotechnology- Based Bandage
• Unidym Creates Spin-Off Unit
• Avanti Creates Dedicated Targeted Drug Delivery Company
• Hill-Rom Chooses Anti-Microbial Technology of NanoHorizons
• Advion Acquires NanoTek
• Pioneer Surgical Acquires Angstrom Medica
• Arrowhead Acquires C Sixty
• Veritek Completes Acquisition of Omni-Lite E-Form
• Wyeth Extends Collaboration with Ablynx
• Starpharma Inks Agreement with Stiefel
• Nanosys Signs Collaboration Deal with Bruker Daltonics
• Abraxis Selects Green Cross to Commercialize Abraxane in Korea
• Abraxis Signs Deal to Partner California NanoSystems Institute
• BioForce Nanosciences Inflates Clientele Base for Nano eNabler(tm) System
• Xidex Bags Contract to Make Carbon Nanotube Sources for Electron Microscopes
• Novartis Extends Deal with Ablynx
• BioSante Inks License Agreement with Medical Aesthetics
• NanoImaging Launches Imaging Services Unit
• Midatech Inaugurates cGMP Standard Nanoparticles Production Facility
• Abraxis Announces Dedicated Proprietary Biotechnology Business
• Eksigent Signs Distribution Deal in Brazil
• NanoVic Establishes Two Nano-bio Companies
• Veeco Signs Collaboration Deal with Leica
• NanoViricides Inks CRADA with USDoD Agency
• Rexahn Wins Maryland Industrial Partnerships Funding
• Azaya Therapeutics Gains Patent for Nanotech-Based Cancer Treatment Platform
• Flamel Inks Deal with Wyeth Pharmaceuticals
• Flamel Signs Deal with Merck Serono
• NanoChip(r) 400 Platform of Nanogen Now a GSA Schedule Product
• Nanogen Bags Canadian Funding for Veterinary and Bio-Terror Diagnostics Development Project
• Nanogen Signs Deal in Australia for Schizophrenia Markers
• Wyeth Wins FDA Approval for New Labeling for Rapamune
• Arrowhead Infuses Capital into Tego
• GSK Extends Collaboration with Exelixis
• Oncologix Collaborates with Dendritic Nanotechnologies to Redesign its Oncosphere Product
• Abraxis Signs Licensing Contract in India
• Abraxis Receives Australian TGA' s Acceptance to Review Marketing Application for Abraxane(r)
• Nanotherapeutics and National Cancer Institute Sign CRADA
• Relisys and Cinvention Extend Licensing Agreement
• Lumera Extends Collaboration Pact with Medical University of South Carolina

9. FOCUS ON SELECT PLAYERS

• Abraxis BioScience, Inc. (US)
• Acusphere, Inc. (US)
• Advion Biosciences, Inc. (US)
• Agilent Technologies, Inc. (US)
• AMAG Pharmaceuticals, Inc. (US)
• Amgen, Inc. (US)
• Arrowhead Research Corporation (US)
• Calando Pharmaceuticals, Inc. (US)
• Nanotope, Inc. (US)
• Tego BioSciences Corporation (US)
• BioForce Nanosciences, Inc. (US)
• BioSante Pharmaceuticals, Inc. (US)
• Crucell N.V. (The Netherlands)
• Elan Corporation Plc (Ireland)
• Elan Drug Technologies (Ireland)
• Ensysce Biosciences, Inc. (US)
• Enzon Pharmaceuticals, Inc. (US)
• eSpin Technologies, Inc. (US)
• Flamel Technologies S.A. (France)
• Johnson & Johnson (US)
• Life Technologies Corporation (US)
• Merck & Co., Inc. (US)
• Nanobiotix (France)
• NanoCarrier Co., Ltd. (Japan)
• Nanospectra Biosciences, Inc. (US)
• Nanosphere, Inc. (US)
• Nanosys, Inc. (US)
• Nektar Therapeutics (US)
• Novavax, Inc. (US)
• Oxonica Plc (UK)
• Par Pharmaceutical Companies, Inc. (US)
• pSivida Limited (Australia)
• Starpharma Holdings Limited (Australia)
• Dendritic Nanotechnologies, Inc. (US)
• Starpharma Pty. Ltd. (Australia)
• Wyeth Pharmaceuticals, Inc. (US)

10. GLOBAL MARKET PERSPECTIVE

• Table 9: World Recent Past, Current & Future Analysis for Nanomedicine Market by Application Area - Drug Delivery, In Vitro Diagnostics, In Vivo Imaging, Biomaterials and Other Applications Independently Analyzed with Annual Revenues in US$ Million for the Years 2006 through 2015 (includes corresponding Graph/Chart)
• Table 10: World 10-Year Perspective for Nanomedicine Market by Application Area - Percentage Breakdown of Revenues for Drug Delivery, In Vitro Diagnostics, In Vivo Imaging, Biomaterials and Other Applications for the Years 2006, 2009 and 2015 (includes corresponding Graph/Chart)

III. COMPETITIVE LANDSCAPE