Brachytherapy

Table of Contents

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITION

• Study Reliability and Reporting Limitations
• Disclaimers
• Data Interpretation & Reporting Level
• Quantitative Techniques & Analytics
• Product Definition and Scope of Study
• Implantable Prostate Seeds Brachytherapy
• Post-Operative Brachytherapy

II. EXECUTIVE SUMMARY

1. INDUSTRY OVERVIEW

• Cancer - A Major Health Concern
• Quick Cancer Statistics
• Table 1: Worldwide New Cancer Cases (2007) - Percentage Share Breakdown by Region (includes corresponding Graph/Chart)
• Table 2: Worldwide New Cancer Cases (2007) - Percentage Share by Region and Sex (includes corresponding Graph/Chart)
• Growing Cancer Cases in Developing Countries
• Table 3: Worldwide Cancer Causes (%) by Level of Economic Development (includes corresponding Graph/Chart)

2. BRACHYTHERAPY MARKET

• Brachytherapy - A Prelude
• Growth Driving Factors
• Brachytherapy Provides Hope for Cancer Patients
• Growing Brachytherapy Acceptance
• Aging Population: An Important Demographic Driver
• Prostate Brachytherapy Offers Bright Prospects
• Reimbursement Scenario
• Competition Heats Up in the Brachytherapy Market
• Macular Degeneration - An Emerging Brachytherapy Application
• APBI Therapy Rise in Popularity
• Balloon Brachytherapy Gains Prominence

3. BRACHYTHERAPY - AN INTRODUCTION

• What is Brachytherapy?
• Implantable Prostate Seeds Brachytherapy
• Post-Operative Brachytherapy
• Mechanism of Action
• Brachytherapy - Under the Microscope
• Brachytherapy Sources
• The Team
• Historical Perspective
• Brachytherapy - A Classification
• Types As Per Seed Positioning
• Mold Brachytherapy
• Interstitial Brachytherapy
• Endovascular Brachytherapy
• Stent-Based Techniques
• Catheter-Based Techniques
• Intracavitary Brachytherapy
• Classification As Per Irradiation Duration
• Temporary Brachytherapy
• Permanent Brachytherapy
• Categorization As Per the Dose Rate
• HDR Brachytherapy
• LDR Brachytherapy
• PDR Brachytherapy
• PDR Brachytherapy Vs HDR Brachytherapy
• PDR Brachytherapy Vs LDR Brachytherapy

4. BRACHYTHERAPY EQUIPMENT

• Brachytherapy Systems
• Remote Afterloading Machines
• Manual Afterloading Machines
• Brachytherapy Applicators
• Types of Brachytherapy Applicators
• Automated Brachytherapy Applicators
• Manual Brachytherapy Applicators

5. PROSTATE CANCER - A MAJOR BRACHYTHERAPY INDICATION

• Prostate Cancer - A Deadly Disease
• Brachytherapy Revolutionizes Prostate Cancer Treatment
• History Behind the Development
• Prostate Brachytherapy Procedure
• Seed Brachytherapy Clinical Outcomes
• Side Effects Do Exist
• Types of Brachytherapy Procedures for Prostate Cancer Treatment
• Interstitial Brachytherapy
• Combination Radiotherapy
• Whole Pelvic Radiation Therapy
• Seed Migration - A Cause of Concern?

6. OTHER MAJOR BRACHYTHERAPY INDICATIONS

• Breast Cancer
• Breast Brachytherapy - An Introduction
• How is Breast Brachytherapy Performed?
• Breast Brachytherapy Techniques
• Brain Brachytherapy
• Brain Tumor
• Types of Brain Tumor
• Treatment Techniques
• Brain Brachytherapy
• Whole Brain Radiation Therapy
• Bronchial Carcinoma
• Bronchial Brachytherapy
• Procedure
• Head and Neck Brachytherapy
• Cervical Brachytherapy
• Esophageal Brachytherapy
• Brachytherapy for Eyelid Tumors
• Other Indications

7. RESEARCH/STUDY FINDINGS

• CyberKnife(r) Effective for HDR Brachytherapy
• SAVI Breast Brachytherapy Offers Enhanced Dose Control
• Electronic Brachytherapy Treats Early Stage Breast Cancer
• Brachytherapy Treats Head And Neck Cancers
• Brachytherapy and External Radiation Therapy Offer Impressive Outcomes
• Brachytherapy Effective in Single Brain Metastases Treatment
• MRI-based Brachytherapy Treats Cervical Cancer

8. PRODUCT INNOVATIONS/INTRODUCTIONS

• Varian Medical Systems Launch VariSeed 8.0
• Nucletron Introduces 3 New Brachytherapy Products
• Xoft to Launch Axxent Xpress(tm) Mobile Electronic Brachytherapy Vehicles
• SenoRx Launches Contura Multi-Lumen Balloon Catheter
• BrachySciences Introduces TheraSeed(r) Palladium-103 Isotope AnchorSeed
• Cianna Medical Launches New Version of SAVI(tm) Applicator
• Nucletron Introduces Oncentra(r) Brachy Cancer Treatment Solution
• Varian to Introduce New RapidArc Radiotherapy Technology
• Prowess Launches Inverse Planning Brachytherapy System
• IBA Introduces New COMPACT Proton Therapy System
• Varian Introduces Brachytherapy Treatment Planning System
• Nucletron Unveils IPSA for HDR Brachytherapy
• B-K Medical Introduces New Transducer
• FDA Approves NASI' s New Range of Brachytherapy Offerings
• NASI Launches ClearPath(tm)
• BioLucent Launches Innovative SAVI Device for Breast Brachytherapy

9. RECENT INDUSTRY ACTIVITY

• IsoRay and BrachySciences Ink Distribution Agreement
• North American Scientific Agrees to Divest Prostate Brachytherapy Products
• IsoRay Receives Health Canada' s Approval for Selling Proxcelan Cs-131
• Nucletron Enters into Partnership with Isodose Control
• Xoft Gains FDA Approval for Applicators
• Varian Medical Collaborates with BK Medical
• Oncologix Inks MoU with IUT
• NeoVista Gains Approval from BSI Product Services
• Xoft and Elekta Inks an Agreement
• IsoRay Acquires Minority Stake in UralDial
• IBt-BEBIG Receives Supply Contract from Hospital Universitario Ramon y Cajal
• Eckert & Ziegler to Supply Radiation Therapy Products to Spanish Hospitals
• North American Scientific Changes Name to NAS Medical
• Theragenics Acquires NeedleTech
• Implant to Divest IP and Medical Assets of Brachytherapy Products Business
• IBt to Form Joint Venture with RNT and 000 Bebig
• Nucletron and AKH/MUW Extend Cooperation with Multi-Tiered Partnership
• IsoAid Secures 3-Year Contract for Supply of Brachytherapy Products
• Envisioneering Inks Distribution Agreement with Isodose Control
• Biocompatibles Acquires BrachySciences
• Nucletron and BrachySolutions Form Partnership
• SIUT Inaugurates New Brachytherapy Center
• IBt to Acquire Brachytherapy Business Segments from EZAG
• North American Scientific Enters into an Agreement with Carbon Medical
• Varian Receives FDA Approval for Brachytherapy Applicator
• IBt Completes Acquisition of Urorad
• IsoRay Inks an Agreement with Applied Process Engineering Laboratory
• International Brachytherapy Inks an Agreement with IBA
• IsoRay Medical Inks Letter of Intent with International Brachytherapy
• IsoRay Medical to Shift Production Facility to APEL in Richland
• Radiation Therapy Services Acquires Radiation Therapy Facility
• Hologic Plans BioLucent Acquisition
• Core Oncology Acquires Mills Biopharmaceuticals
• International Isotopes Takes Over Minority Stake in RadQual
• ONCURA Inks Agreement with Premier
• MDS Nordion and Best Medical International Sign an Agreement
• North American Scientific Divests NOMOS(r) to Best Medical International
• Premier Renews Contract with North American Scientific
• Sirtex Expands its Research and Development Program
• Xoft Axxent(tm) Electronic Brachytherapy System Receives FDA Approval
• North American Scientific Launches Initiative for Breast Brachytherapy
• Coloplast Acquires Urology Business Unit of Mentor
• Implant Sciences Signs an Agreement with International Brachytherapy
• BrachySciences Enters into Distribution Agreement with Envisioneering
• IBt Inks a Distribution Agreement with Isodose Control
• ONCURA Inks an Agreement with Novation and UHC
• ONCURA Inks an Agreement with HealthTrust Purchasing Group
• IsoRay Commences Cesium-131 Production Testing
• InterCommunity Cancer Center Offers Cesium-131 for Prostrate Cancer

10. OTHER DEVELOPMENTS

• The U.S. Patent and Trademark Office Issues Patents for SAVI(tm)
• Sirtex Obtains FDA Approval for Producing SIR-Spheres(r) Microspheres
• MDS Nordion Secures FDA Approval for TheraSphere(r)
• Health Commission Wales to Provide Brachytherapy Services in Wales
• IBt Receives Reimbursement for InterStrand-125 and InterSource-125
• MDS Nordion Sets Up Centers of Excellence for TheraSphere(r)
• Aarhus University Hospital Begins Using IGBT
• WellStar Kennestone Hospital Acquires Axxent Electronic Brachytherapy System
• Silicon Valley Urology Center Starts Using Cesium-131
• MDS Nordion Receives US FDA Approval to Test Efficacy of TheraSphere(r)
• ONCURA Bags Contract to Supply Seeds to The Cookridge Hospital

11. FOCUS ON SELECT GLOBAL PLAYERS

• Best Medical International, Inc. (US)
• Best Vascular, Inc. (US)
• BrachySciences, Inc. (US)
• Core Oncology (US)
• C. R. Bard, Inc. (US)
• Cytyc Corporation (US)
• Eckert & Ziegler Strahlen- und Medizintechnik AG (Germany)
• International Brachytherapy SA (Belgium)
• NAS Medical (US)
• Oncura, Inc. (US)
• Sirtex Medical Ltd. (Australia)
• Theragenics Corporation (US)
• Varian Medical Systems, Inc. (US)
• Xoft, Inc. (US)

III. MARKET

1. THE UNITED STATES

• A. Market Analysis
• Current & Future Analysis
• Cancer Presumes Epidemic Proportion
• A Glance at Cancer Statistics
• Table 4: Cancer-Affected Population in the US (2007): Percentage Share Breakdown by Cancer Type (includes corresponding Graph/Chart)
• Table 5: US New Cancer Cases (2008) - Percentage Share Breakdown by Leading State (includes corresponding Graph/Chart)
• Growing Cancer Prevalence Drives Brachytherapy Demand
• Brachytherapy - Effective Option for Cancer Treatment
• Rapid Growth in Prostate Brachytherapy Market
• Leading Players
• Table 6: Leading Players in the US Implantable Seeds Brachytherapy Market (2009E): Percentage Share Breakdown of Sales for Oncura Corp., CR Bard, and Others (includes corresponding Graph/Chart)
• Technology Advancements Accelerate Growth
• Breast Brachytherapy Witnesses Slow Growth
• Balloon Brachytherapy Making Inroads into Mainstream Market
• Competitive Scenario
• Table 7: US Balloon Brachytherapy Market (2008): Percentage Value Share Breakdown by Leading Company - Cytyc, SenoRx, and Xoft (includes corresponding Graph/Chart)
• Reimbursement Scenario
• Growth Drivers
• Positive Research Results Drive Acceptance of Brachytherapy
• Market Consolidation Drives Growth
• New Developments Propel Market Growth
• Product Launches
• Strategic Corporate Developments
• Other Developments
• Key Players
• B. Market Analytics
• Table 8: US Recent Past, Current & Future Analysis for Brachytherapy: Annual Number of Implantable Prostate Seed and Post-Operative Brachytherapy Procedures for Years 2005 through 2015 (in Thousands) (includes corresponding Graph/Chart)
• Table 9: US 10-Year Perspective for Brachytherapy by Segment - Percentage Breakdown of Implantable Prostate Seed and Post-Operative Brachytherapy Procedures for Years 2006, 2009 & 2015
• Table 10: US Recent Past, Current & Future Analysis for Brachytherapy by Segment - Implantable Prostate Seed and Post-Operative Brachytherapy Procedures Markets Independently Analyzed with Annual Revenues in US$ Million for Years 2005 through 2015 (includes corresponding Graph/Chart)
• Table 11: US 10-Year Perspective for Brachytherapy by Segment - Percentage Breakdown of Revenues for Implantable Prostate Seed and Post-Surgical Brachytherapy Markets for Years 2006, 2009 & 2015
• Table 12: US Recent Past, Current & Future Analysis for Endovascular Brachytherapy Market with Annual Revenues in US$ Million for Years 2005 through 2015 (includes corresponding Graph/Chart)

2. EUROPE

• A. Market Analysis
• Market Outlook
• Brachytherapy in Europe
• Seed Brachytherapy Market - An Overview
• Strategic Initiatives to Drive Growth
• Leading Players
• Table 13: Leading Players in the European Implantable Prostate Seeds Market (Iodine) (2009E): Percentage Breakdown of Value Sales for Oncura Corp., C.R. Bard, and Others (includes corresponding Graph/Chart)
• Reimbursement Changes Accelerate Radiation Seed Sales
• Prostate Brachytherapy Gains Strength
• Prostate Seed Market
• An Overview
• Competitive Analysis
• Seed Pricing Analysis
• Table 14: Average Prices of Prostate Brachytherapy Seeds for the years 2003 & 2010
• A Focus on the French Market
• UK Prostate Brachytherapy Market - An Overview
• Strategic Corporate Developments
• Key Players
• B. Market Analytics
• Table 15: European Recent Past, Current & Future Analysis for Brachytherapy: Annual Number of Implantable Prostate Seed and Post-Operative Brachytherapy Procedures for Years 2005 through 2015 (in Thousands) (includes corresponding Graph/Chart)
• Table 16: European 10-Year Perspective for Brachytherapy by Segment - Percentage Breakdown of Implantable Prostate Seed and Post-Operative Brachytherapy Procedures for Years 2006, 2009 & 2015
• Table 17: European Recent Past, Current & Future Analysis for Brachytherapy by Segment - Implantable Prostate Seed and Post-Operative Brachytherapy Procedures Markets Independently Analyzed with Annual Revenues in US$ Million for Years 2005 through 2015 (includes corresponding Graph/Chart)
• Table 18: European 10-Year Perspective for Brachytherapy by Segment - Percentage Breakdown of Annual Revenues for Implantable Prostate Seed and Post-Operative Brachytherapy Markets for Years 2006, 2009 & 2015

IV. COMPETITIVE LANDSCAPE