Table of Contents
Chapter 1: EXECUTIVE SUMMARY
- Understanding Drug Discovery
- Role of Lead Optimization
- Report Objectives & Structure
- Results Summary
Chapter 2 LEAD OPTIMIZATIONS & "-OMICS"
- Understanding ADMET
- Structure Activity Relationships
- In-silico, In-vitro, In-vivo Approaches
- Genomics & Pharmaco-Genomics
- Proteomics
- Transcriptomics
- Metabonomics
- Toxicogenomics
Chapter 3: MARKETS FOR LEAD OPT TOOLS
- ADMET Assays
- In-silico Software
- Chemical Synthesis Instruments & Arrays
Chapter 4: MARKETS FOR LEAD OPT SERVICES
- Case Study: Evotec OAI
- Early ADMET
- Predictive Modeling
- Compound Synthesis
- Focused Libraries
Chapter 5: CUSTOMERS FOR LEADOPT
- Big Pharma Approaches to LeadOpt
- Biotech Approaches to LeadOpt
- How Suppliers are Selected
Chapter 6: FUTURE OF LEADOPT
- Customer Wants & Needs
- Service Suppliers
- Tools Suppliers
- Opportunities & Growth
Chapter 7. SUPPLIER PROFILES
- Service Suppliers
- Absorption Systems
- Albany Molecular
- Amedis
- Argenta
- ArQule,
- BioFocus
- CMT
- Cerep
- ChemBridge
- ComGenex
- Entelos
- Evotec OAI
- Gene Logic
- Inpharmatica
- Millennium
- NiKem
- NoAb
- Pharmacopeia
- Quintiles
- Upstate
Tools Suppliers:
- Accelyrs
- Aclara
- Affymetrix
- Amersham
- Biacore
- Bio-Rad
- CST
- Charles River Labs
- Gene Logic
- Invitrogen
- Lion
- MDS Sciex
- PHASE-1
- Pierce
- pION
- Promega
- Simulations Plus
- Tecan
- Tripos
- Xceleron
Appendix: DIRECTORY OF SUPPLIERS |
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