Orthopedic Biomaterials, The World Market, 2nd Edition

Table of Contents

CHAPTER ONE: EXECUTIVE SUMMARY

• Overview
• Scope and Methodology
• Musculoskeletal Conditions/Treatments
• Prevelance of Musculoskeletal Conditions
• Most Common Musculoskeletal Conditions
• Joint Replacement Procedures
• Future Directions in the Treatment of Musculoskeletal Conditions
• Gene Therapy
• Stem Cell Therapy
• Orthopedic Biomaterials Products and Markets
• World Orthopedic Biomaterials Market
• Market Segment Analysis
• Allograft Bone Substitutes
• Ceramic Bone Substitutes
• Polymer Bone Substitutes
• rhBMP
• HA Viscosupplemental Substitutes

CHAPTER TWO: INTRODUCTION

• Overview of the Form/Function of Bone
• Bone Characteristics
• Types of Bone
• Cortical Bone
• Cancellous Bone
• Bone Cells
• Osteoblasts
• Osteoclasts
• Osteocytes
• The Functions of Bone
• Bone Matrix
• Joint Components
• Cartilage
• Joint Capsule
• Synovium
• Ligaments
• Prevalence of Musculoskeletal Conditions
• Musculoskeletal Conditions In Europe
• Musculoskeletal Conditions In the United States
• Common Musculoskeletal Conditions
• Osteoarthritis
• Osteoporosis
• Bone Fractures
• Ligament Injuries
• Joint Replacement Procedures
• Introduction
• Most Common Procedures
• Knee Reconstruction
• Hip Reconstruction
• Spinal Fusion
• Future Directions in the treatment of Musculoskeletal conditions
• Gene Therapy
• Stem Cell Therapy

CHAPTER THREE: ORTHOPEDIC BIOMATERIALS

• Overview
• Brief History of Orthopedic Biomaterials
• Categories of Orthopedic Biomaterials
• Bone Grafts
• Types of Bone Grafts
• Autografts
• Advantages
• Disadvantages
• Allograft
• Disadvantages
• Xenografts
• Disadvantages
• Allograft Bone Graft Substitutes
• Overview
• Demineralized Bone Matrix
• Types of DBM Products
• Conventional Allograft
• Machined Allograft
• Ceramic-based Bone Graft Substitutes
• Overview
• Types of Materials
• Hydroxyapatites
• Ceramic Coated Joint Implants
• Coralline Hydroxyapatite
• Tricalcium Phosphate
• Calcium Phosphate
• Calcium Sulphate
• Polymer-based Bone Graft Substitutes
• Overview
• Nondegradable Polymers
• Bioabsorbable Polymer Biomaterials
• Polylactic Acid (PLA)
• Polyglycolic Acid (PGA)
• Copolymers
• Factor-based Bone Graft Substitutes
• Overview
• Types of Growth Factors
• Bone Morphogenic Protein (BMP)
• Transforming Growth Factor-Beta (TGF-ün
• Fibroblast Growth Factors (FGFs)
• Insulin-Like Growth Factors (IGFs)
• Platelet-Derived Growth Factor (PDGF)
• Carriers/Delivery Systems for Growth Factors
• Type-1 Collagen
• Demineralized Bone Matrix (DBM)
• Polymers
• Ceramics
• Hyaluronic Acid
• Gene Therapy
• Hyaluronic Acid Synovial Fluid Substitute
• Overview
• Viscosupplementation

CHAPTER FOUR: ORTHOPEIC BIOMATERIAL MARKET ANALYSIS

• World Market Analysis and Forecast
• Orthopedic Biomaterial Market Drivers
• Orthopedic Biomaterials Market Forecast
• World Regional Markets
• Market Segment Analysis
• Market Value and Growth by Segment
• Allograft Bone Market Analysis
• Allograft Applications
• Allograft Bone Products
• DBM
• Machined Bone Products
• Allograft Market
• Market Drivers and Limitations
• Allograft Competitors' Market Share
• Ceramic Bone Substitute Market Analysis
• Ceramic Applications and Products
• Ceramic-coated Implants
• Ceramic-based Bone Substitute Products
• Ceramic Biomaterials Market
• Market Drivers and Limitations
• Ceramic Competitors' Market Share
• Polymer Bone Substitutes Market Analysis
• Nondegradable Polymers
• PEEK Applications
• Bioabsorbable Polymers
• Applications for Polymer Bioabsorbable Biomaterials
• Bioaborable Polymers as Delivery Systems
• Combination Products
• Polymer Biomaterials Market
• Market Drivers
• Competitors' Market Share
• Bone Morphogenetic Proteins Market Analysis
• Products and Applications
• InFuse and InductOS (RhBMP-2)
• OP-1 (rhBMP-7)
• Carrier Materials for BMPs
• BMP World Market
• Market Drivers
• HA Viscosupplementational Market Analysis
• HA Viscosupplemental Products and Applications
• HA Viscosupplementational Market
• Market Drivers
• HA Viscosupplemental Competitors' Market Share

CHAPTER FIVE: COMPANY PROFILES

• Biomet, Inc.
• Genzyme Corporation
• IsoTis OrthoBiologics, Inc.
• LifeCell Corporation
• Medtronic Sofamor Danek, Inc.
• Orthovita, Inc.
• Osteotech, INC.
• Smith & Nephew, Inc.
• Stryker Corporation
• Synthes, Inc
• Tutogen Medical, Inc.
• Wright Medical Group, Inc.

TABLE OF EXHIBITS

• Exhibit 1-1: World Orthopedic Biomaterials Market
• Exhibit 1-2 World Orthopedic Biomaterials Market (in millions of dollars)
• Exhibit 1-3: Segment Market Share, 2006 (Allograft Products, Ceramic Products, Polymer Products, rhBMP Products, HA Viscosupplemental Products)

INTRODUCTION

• Exhibit 2-1: Emergency Room Visits for Muscolskeletal Symptoms, 1998-2004 (Procedure, Year, Number of Patients, Number of Procedures, Mean Age of Patient, Mean Length of Stay)
• Exhibit 2-2: Emergency Room Visits for Fractures, 1998-2004 (Procedure, Year, Number of Patients, Number of Procedures, Mean Age of Patient, Mean Length of Stay)
• Exhibit 2-3: Knee Replacement Procedures, 1998-2004 (Procedure, Year, Number of Patients, Number of Procedures, Mean Age of Patient, Mean Length of Stay)
• Exhibit 2-4 Hip Replacement Procedures, 1998-2004 (Procedure, Year, Number of Patients, Number of Procedures, Mean Age of Patient, Mean Length of Stay)
• Exhibit 2-5: Spinal Fusion Procedures, 1998-2004 (Procedure, Year, Number of Patients, Number of Procedures, Mean Age of Patient, Mean Length of Stay)

ORTHOPEDIC BIOMATERIAL MARKET ANALYSIS

• Exhibit 4-1: World Orthopedic Biomaterials Market
• Exhibit 4-2: World Regional Biomaterials Markets by Revenue, 2006
• Exhibit 4-3 World Regional Biomaterilas Markets by Percentage, 2006
• Exhibit 4-4: Orthopedic Biomaterials Market by Segment (Allograft Products, Ceramic Products, Polymer Products, rhBMP Products, HA Viscosupplemental Products)
• Exhibit 4-5: Segment Market Share in 2006 (Allograft Products, Ceramic Products, Polymer Products, rhBMP Products, HA Viscosupplemental Products)
• Exhibit 4-6: Segment Market Share in 2012 (Allograft Products, Ceramic Products, Polymer Products, rhBMP Products, HA Viscosupplemental Products)
• Exhibit 4-7: Sample Allograft Distribution Relationships (Tissue, Source, Processor, Distributor)
• Exhibit 4-8: Selected Allograft Prdoucts on the Market
• Exhibit 4-9: World Allograft Market
• Exhibit 4-10: Allograft Product Categories, by Percent, 2006 (DBM, Machined Bone, Standard Allograft)
• Exhibit 4-11: Allograft Market Share, 2006
• Exhibit 4-12: Selected Ceramic-Based Biomaterials (Product, Manufacturer, Description)
• Exhibit 4-13: World Market for Ceramic-Based Biomaterials
• Exhibit 4-14: Ceramic-Based Products Market Share,2006
• Exhibit 4-15: Selected Polymer Products (Product, Composition, Company)
• Exhibit 4-16: Bioresorbable Polymer Resorption (Polymer, Crystallinity, Beginning of Resorption, Time of Complete Resorption)
• Exhibit 4-17: World Polymer Biomaterials Market (millions)
• Exhibit 4-18: Polymer Biomaterials Market Share, 2006
• Exhibit 4-19: Various Carrier Materials Available for BMPs
• Exhibit 4-20: The World Market for rhBMP Products
• Exhibit 4-21 Osteoporosis and Low Bone Mass in the United States
• Exhibit 4-22 Definitions and Charactertistics of Hyaluronic Acid and Hylans
• Exhibit 4-23 Osteoporosis and Low Bone Mass in the United States
• Exhibit 4-24: Selected HA Viscosupplemental Products
• Exhibit 4-25: World HA Viscosupplementational Market (in millions of dollars)
• Exhibit 4-26: World Viscosupplementation Market Share, 2006