Table of Contents
CHAPTER ONE: EXECUTIVE SUMMARY
- Scope and Methodology
- Cells for Biopharmaceutical Production
- Bacteria and Yeasts Systems
- Animal Cell Systems
- Insect Cell Systems
- Cell Lines and Cell Banks
- Fermentors and Bioreactors
- Stirred-tank Reactors
- Airlift Fermentors
- Packed Bed Reactors
- Hollow-fiber Reactor
- Disposable Systems
- Fermentation Processes
- Batch and Fed-Batch Fermentation
- Suspended vs. Anchored Cells
- Microencapsulation
- Cell Culture Environment
- Functions and Components of Basal Media
- pH and Osmotic Pressure
- Energy Sources
- Nutrients
- Cell Culture Media
- Lysogeny broth (LB)
- Classical Media
- Serum-free Media
- Protein-free Media
- Chemically Defined Media
- Specialty Media
- Sera
- Reagents
- Shifting Towards Non-animal Derived Reagents
- Addressing Reagent Safety Issues
- World Cell Culture Market
- Impact of Shift to Serum-free Products on Cell Culture Suppliers
- Impact of Shift to Serum-free Products on Research
- Impact of Shift Serum-free Products on Biopharmaceutical Manufacturers
- Cell Culture Market and Forecast
- Trends Impacting The Cell Culture Market
CHAPTER TWO: GENETICALLY MODIFIED CELLS FOR BIOPHARMACEUTICAL DEVELOPMENT
- Growing Demand for Biopharmaceuticals
- Demand Increasing for Cell Culture Products
- A Brief History of Biotechnology
- Science of Genetic Manipulation
- From Petri Dish to Biopharmaceutical
- Upstream Bioprocessing: Cell Culture Expression Systems
- Cells for Biopharmaceutical Production
- Bacteria and Yeasts Systems
- Animal Cell Systems
- Insect Cell Systems
- Advantages/Disadvantages of Cell Culture Systems
- Cell Lines and Cell Banks
- Biopharmaceuticals Produced from Cell Culture
- Cell Culture Practices and Regulatory Guidelines
- Validation of Facilities
- Maintaining Sterilization Standards
CHAPTER THREE: CELL CULTURE TECHNOLOGY
- Introduction and Overview
- Milestones in Cell Culture Development
- Cell Lines for Bioproduction
- Predominant Cell Lines
- Chinese Hamster Ovary (CHO)
- SP2/0, and NS0
- HEK 293 and PER. C6
- Sources: Largest Collections of Cell Lines
- Fermentors and Bioreactors
- Types of Bioreactors/Fermentors
- Stirred-tank Reactors
- Airlift Fermentors
- Packed Bed Reactors
- Hollow-fiber Reactor
- Disposable Systems
- Fermentation Processes
- Batch and Fed-Batch Fermentation
- Suspended vs. Anchored Cells
- Microencapsulation
- Cell Culture Environment
- Functions and Components of Basal Media
- pH and Osmotic Pressure
- Energy Sources
- Nutrients
- Cell Culture Media
- Types of Media
- Lysogeny broth (LB)
- Classical Media
- Serum-free Media
- Protein-free Media
- Chemically Defined Media
- Specialty Media
- Sera
- Sources of Sera
- Bovine Serum Safety Issues and Regulations
- Shift to Serum-free Media
- Reagents
- Major Types of Biologic Reagents
- Amino Acids
- Growth Factors and Cytokines
- Albumin
- Transferrin
- Thrombin
- Growth Supplements
- Protease Inhibitor
- Attachment Factors
- Shifting Towards Non-animal Derived Reagents
- Addressing Reagent Safety Issues
CHAPTER FOUR: CELL CULTURE MARKET: CURRENT AND FUTURE TRENDS
- Overview
- Shift Away From Serum-Based Cell Culture
- Impact of Shift to Serum-free Products on Cell Culture Suppliers
- Impact of Shift to Serum-free Products on Research
- Life Technologies' End Run Around the BSE Issue
- Cell Culture Market
- Market Drivers
- Cell Culture Market and Forecast
- Segment Analysis
- Market Characteristics
- Market Share: Cell Culture Suppliers
- Trends Impacting The Cell Culture Market
- Stem Cell Research
- Life Technologies
- Sigma-Aldrich
- Millipore Corporation
- ThermoFisher Scientific
- Lonza Bioscience
- Cell Culture-based Vaccine Production
- Generic Biopharmaceuticals
- Transgenically Produced Biopharmaceuticals
CHAPTER FIVE: COMPANY PROFILES
- Advanced Biotechnologies, Inc
- History and Lines of Business
- Cell Culture Products and Services
- Amresco, Inc
- History and Lines of Business
- Cell Culture Products
- Analytical Biological Services Inc
- History and Lines of Business
- Cell Culture Products
- Mammalian Cell Culture
- Cell in Microtiter Plates for HTS
- Primary Cultures
- Insect Cell Culture
- Atlanta Biologicals, Inc
- History and Lines of Business
- Cell Culture Products
- Athena Enzyme Services
- History and Lines of Business
- Cell Culture Products
- BD Biosciences
- History and Lines of Business
- Cell Culture Products
- Financial Information
- Biochrom AG
- History and Lines of Business
- Cell Culture Products
- Cell Essentials, Inc
- History and Lines of Business
- Cell Culture Products
- CellGenix Technologie Transfer GmbH
- History and Lines of Business
- Cell Culture Products and Services
- Irvine Scientific
- History and Lines of Business
- Cell Culture Products
- J R Scientific, Inc
- History and Development
- Cell Culture Products
- Life Technologies Corporation
- History and Lines of Business
- Cell Culture Products
- Financial Information
- Lonza Bioscience
- History and Lines of Business
- Cell Culture Products and Services
- Culture Media Development
- Cell Line Creation
- Cell Banking
- Financial Information
- Mediatech, Inc
- History and Lines of Business
- Cell Culture Products
- Millipore Corporation
- History and Lines of Business
- Cell Culture Products
- Financial Information
- MP Biomedicals
- History and Lines of Business
- Cell Culture Products
- PAA laboratories, Inc
- History and Lines of Business
- Cell Culture Products
- PromoCell GmbH
- History and Lines of Business
- Cell Culture Products
- Quality Biological, Inc
- History and Lines of Business
- Cell Culture Products
- R&D Systems, Inc
- History and Lines of Business
- Cell Culture Products
- SBH Sciences
- History and Lines of Business
- Cell Culture Products
- Selexis SA
- History and Lines of Business
- Cell Culture Products
- SeraCare Life Sciences, Inc
- History and Lines of Business
- Cell Culture Products
- Financial Information
- Sigma-Aldrich Corporation
- History and Lines of Business
- Cell Culture Products
- Financial Information
- Thermo Fisher Scientific, Inc
- History and Lines of Business
- Cell Culture Products
- Financial Information
- USB Corporation
- History and Lines of Business
- Cell Culture Products
- Wisent, Inc
- History and Lines of Business
- Cell Culture Products
APPENDIX: A: COMPANY DIRECTORY
APPENDIX: B: PROFESSIONAL ORGANIZATIONS
TABLE OF EXHIBITS
CHAPTER ONE: EXECUTIVE SUMMARY
- Table 1-1: Worldwide Cell Culture Market
- Figure 1-1: Cell Culture World Market Share, by Region, 2008 (US,
Asia/Pacific, EU)
CHAPTER TWO: GENETICALLY MODIFIED CELLS FOR BIOPHARMACEUTICAL DEVELOPMENT
- Table 2-1: Biopharmaceuticals Approved in the USA and/or the EU in 2007
- Table 2-2: Approximate times from Introduced Gene to Protein Production at
Useable Levels
- Table 2-3: Disadvantages/Advantages of Cell Culture Systems
- Table 2-4: Selected Biopharmaceuticals Produced from Bacteria, Yeast and
Mammalian Cells
CHAPTER THREE: CELL CULTURE TECHNOLOGY
- Table 3-1: Selected Products/Companies Offering Alternatives to Animal
Sera Products for Hybridoma, Myeloma and CHO cell lines
CHAPTER FOUR: CELL CULTURE MARKET: CURRENT AND FUTURE TRENDS
- Table 4-1: Selected Brandname Serum-Free Formulations of Cell Culture
Products Currently on the Market
- Table 4-2: Worldwide Cell Culture Market
- Figure 4-1: Cell Culture World Market Share, by Region, 2008 (US, Asia, EU)
- Table 4-3: World Cell Culture Market by Segment: Media, Sera and Reagents
- Table 4-4: Cell Culture Market Share, 2008
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