Vaccines 2009: World Market Analysis, Key Players, and Critical Trends in a Fast-Changing Industry

Table of Contents

CHAPTER ONE: EXECUTIVE SUMMARY

• THE GLOBAL VACCINES INDUSTRY
• Scope And Methodology
• Overview
• Pediatric Preventative Vaccines
• The Market
• Adult Preventative Vaccines
• The Market
• Total Market
• Issues and Trends

CHAPTER TWO: INTRODUCTION TO VACCINES

• A Brief History: The Development of Vaccines
• The Immune Response
• Mechanism of Action
• Types of Vaccines
• Attenuated (Weakened) Live Viruses
• Killed (Inactivated) Viruses
• Toxoid Vaccines
• Genetically Engineered/Modified Vaccines
• Subunit Vaccines
• Conjugate Vaccines
• DNA Vaccination
• Vaccine Approval Process

CHAPTER THREE: PEDIATRIC PREVENTIVE VACCINES

• Introduction
• Childhood Immunization in the United States
  • Childhood Immunization Rates
  • Challenges to the Vaccine Delivery System
  • Recommended Childhood Immunization Schedule
  • State Immunization Recommendations
• Pediatric Vaccine Products
  • BCG
  • Diphtheria, Tetanus, Pertussis, Hepatitis B and Polio
  • Diphtheria
  • Pertussis
  • Tetanus
  • Hepatitis B
  • Poliomyelitis
  • Enterotoxigenic Escherichia coli
  • Haemophilus Influenzae Type B
  • Hepatitis A
  • Measles, Mumps and Rubella
  • Measles
  • Mumps
  • Rubella
  • Meningococcal Disease
  • Parainfluenza Virus Type 3
  • Pneumococcal Conjugate
  • Respiratory Syncytial Virus
  • Rotavirus
  • Varicella
• Pediatric Vaccines in Development
  • Global Initiatives for Vaccine Research
• Cost of Vaccines in the United States
• The World Market for Pediatric Preventive Vaccines
  • Total Market Size and Forecast
  • Hepatitis Vaccine Market
  • Market Analysis
  • Leading Products and Competitors
  • Haemophilus Influenzae Type B Vaccine Market
  • Market Analysis
  • Leading Products and Competitors
  • Measles, Mumps and Rubella Vaccines
  • Market Analysis
  • Combination Vaccines Market
  • Market Analysis
  • Leading Products and Competitors
  • Pneumococcal Vaccine
  • Leading Products and Competitors
  • Poliovirus Vaccine
  • Market Analysis
  • Leading Products and Competitors
  • Varicella Vaccines
  • Market Analysis
  • Leading Products and Competitors
  • Other Vaccines Market
  • Market Analysis
  • Leading Products and Competitors

CHAPTER FOUR: ADULT PREVENTIVE VACCINES

• Introduction
• Adult Vaccine-Preventable Diseases: Facts and Figures
• Global Virological Surveillance Program
• Recommendations for Adult Immunizations
• WHO International Health Regulations
• Adult Vaccine Products
  • Allergy
  • BCG
  • Cancer
  • Cervical Cancer
  • Cholera
  • Diphtheria-Tetanus
  • Helicobacter Pylori
  • Hepatitis
  • Hepatitis A
  • Hepatitis B
  • Hepatitis C
  • Hepatitis D
  • Hepatitis E
  • Herpesvirus
  • HIV/AIDS
  • Influenza
  • Japanese Encephalitis
  • Leishmaniasis
  • Malaria
  • Pneumococcal Disease
  • Rabies
  • Shingles
  • Tuberculosis
  • Typhoid Fever
  • West Nile Virus
  • Yellow Fever
• Adult Vaccines in Development
• Global Initiatives for Vaccine Research
• The World Market for Adult Preventive Vaccines
  • Total Market Size and Forecast
  • Cervical Cancer Market
  • Market Analysis
  • Leading Products and Competitors
  • Hepatitis Market
  • Market Analysis
  • Leading Products and Competitors
  • Influenza Vaccine Market
  • Market Analysis
  • Leading Products and Competitors
  • Market Analysis
  • Leading Products and Competitors
  • Travel, DT, and Miscellaneous Vaccine Market
  • Market Analysis
  • Leading Products and Competitors

CHAPTER FIVE: VACCINES MARKET SUMMARY

• Trends Driving the Vaccines Market
• Market Size and Forecast
• Vaccine Market Competitors
• Pediatric Vaccines
• Major Manufacturer' s Market Share
• Adult Vaccines
• Major Manufacturer' s Market Share

CHAPTER SIX: ISSUES AND TRENDS

• Vaccine Safety
  • Refusal to Immunize
  • Post-Licensure Surveillance
  • Vaccine Adverse Event Reporting System
  • The Vaccine Safety Datalink Project
  • Phase IV studies
  • The Vaccine Injury Compensation Program
  • World Health Organization
  • Other Initiatives
  • The Future of Vaccine Safety
• Vaccine Shortages
  • Preventing Shortages in the Developed Countries
  • Financial incentives
  • Equitable pricing
  • Vaccine stockpiles
  • Preventing Shortages in Developing Nations
  • Vaccine bonds
• Economic Effects
  • Industrialized Nations
  • Developing Nations
• Preventing Pandemics
  • U.S. National Vaccine Plan
• Vaccines and Bioterrorism
• Overview
• Project Bioshield Act of 2004
• National Bio and Agro-Defense Facility
• Vaccine Treatment and Evaluation Units
• Anthrax
• Smallpox
• Plague
• Botulism
• Tularemia
• Viral Hemorrhagic Fevers
• DNA Vaccination
• Innovations in Vaccine Delivery Systems
  • Edible Vaccines
  • Mucosal Delivery
  • Intranasal Delivery
  • Vaccine Patches
  • DTC Advertising

CHAPTER SEVEN: COMPANY PROFILES

• Acambis plc
  • History and Lines of Business
  • Strategic Alliances
  • Vaccine Products
  • Financial Information
• AlphaVax, Inc.
  • History and Lines of Business
  • Strategic Alliances
  • Vaccine Products
  • Financial Information
• Bavarian Nordic A/S
  • History and Lines of Business
  • Strategic Alliances
  • Vaccine Products
  • Financial Information
• Baxter Healthcare
  • History and Lines of Business
  • Strategic Alliances
  • Vaccine Products
  • Financial Information
• Celldex Therapeutics
  • History and Lines of Business
  • Strategic Alliances
  • Vaccine Products
  • Financial Information
• Crucell
  • History and Lines of Business
  • Strategic Alliances
  • Vaccine Products
  • Financial Information
• Emergent Biosolutions
  • History and Lines of Business
  • Strategic Acquisition and Alliance
  • Vaccine Products
  • Financial
• GlaxoSmithKline
  • History and Lines of Business
  • Strategic Alliances
  • Vaccine Products
  • Financial Information
• Medimmune
  • History and Lines of Business
  • Strategic Alliances
  • Vaccine Products
  • Financial Information
• Merck & Co. Inc
  • History and Lines of Business
  • Strategic Alliances
  • Vaccine Products
  • Financial Information
• Nabi Biopharmaceuticals
  • History and Lines of Business
  • Strategic Alliance
  • Vaccine Products
  • Financial Information
• Novartis
  • History and Lines of Business
  • Strategic Alliances
  • Vaccine Products
  • Financial Information
• History and Lines of Business
  • Strategic alliances
  • Vaccine products
  • Financial Information
• Pharmexa
  • History and Lines of Business
  • Strategic alliances
  • Vaccine Products
  • Financial Information
• Sanofi Pasteur
  • History and Lines of Business
  • Strategic Alliances
  • Vaccine Products
  • Financial Information
• Wyeth
  • History and Lines of Business
  • Vaccine Products
  • Financial Information

APPENDIX: COMPANY DIRECTORY

LIST OF EXHBITS

CHAPTER ONE: EXECUTIVE SUMMARY

• Figure 1-1: World Market for Pediatric Vaccines 2004-2013
• Figure 1-2: World Market for Adult Vaccines 2004-2013

CHAPTER TWO: INTRODUCTION TO VACCINES

• Table 2-1: Impact of Vaccines in the 20th Century Annual Morbidity in the 20th Century vs 2008
• Table 2-2: Vaccine-Preventable Diseases, April 2009
• Table 2-3: VAERS Table of Reportable Events Following Vaccination
• Table 2-3 (cont.): VAERS Table of Reportable Events Following Vaccination

CHAPTER THREE: PEDIATRIC PREVENTIVE VACCINES

• Table 3-1: Global Immunization Rates by Vaccine Type 2007
• Table 3-2: Immunization Profile of the United States: Population by Age Group, Number of Vaccine-Preventable Diseases Reported by Disease 2000-2007
• Table 3-3: U.S. Recommended Immunization Schedule for Children Ages 0 Through 6 Years, 2009
• Table 3-4: U.S. Recommended Immunization Schedule for Adolescents Ages 7 to 18 Years, 2009
• Table 3-5: Selected Pediatric Vaccines in Development, April 2009
• Table 3-6: World Market for Pediatric Vaccines by Type (DTaP/DTP, Hep, HiB, MMR, Combos, Pneumococcal, Polio, Varicella, Others) 2004-2013 Revenues (in millions)
• Figure 3-1: Market Share of Pediatric Vaccines by Type 2008 (DTaP/DTP, Hep, HiB, MMR, Combos, Pneumococcal, Polio, Varicella, Others)
• Figure 3-2: Market Share of Pediatric Vaccines, by Type 2013 (DTaP/DTP, Hep, HiB, MMR, Combos, Pneumococcal, Polio, Varicella, Others)
• Table 3-7: World Pediatric Hepatitis Vaccine Market 2004-2013
• Table 3-8: World Hib Vaccine Market, 2004-2013
• Table 3-9: World MMR Vaccines Market 2004-2013
• Table 3-10: World Combination Vaccines Market 2004-2013
• Table 3-11: World Pediatric Pneumococcal Vaccine Market 2004-2013
• Table 3-12: World Poliovirus Vaccine Market 2004-2013
• Table 3-13: World Varicella Vaccine Market 2004-2013
• Table 3-14: Other Vaccines Market 2004-2013

CHAPTER FOUR: ADULT PREVENTIVE VACCINES

• Table 4-1: Universal Adult Immunization Schedule 2009
• Table 4-2: Adult Immunization Schedule for Populations with Special Medical Conditions, 2008
• Table 4-3: Initiatives to Require HPV Vaccination by U.S. State, 2009
• Table 4-4: WHO Pandemic Classification Schedule
• Table 4-5: Selected Adult Preventive Vaccines in Development, 2009
• Table 4-6: World Market for Adult Preventive Vaccines by Type (Hepatitis, Influenza, Pneumococcal, Travel/DT/Misc.), 2004-2013 Revenues (in millions)
• Figure 4-1: Market Share of Adult Vaccines, by Type, 2009
• Figure 4-2: Market Share of Adult Vaccines, by Type, 2013
• Table 4-7: World Cervical CancerVaccine Market 2004-2013
• Table 4-8: World Hepatitis Vaccine Market 2004-2014
• Table 4-9: World Influenza Vaccine Market 2004-2013
• Table 4-10: CDC Goal to Double Flu Immunization by 2010 Group and Estimated Immunization Rate (2000 vs 2010)
• Table 4-11: 2007 Estimated Population by Region and Selected Age Group (in millions)
• Table 4-12: World Pneumococcal Vaccine Market 2004-2013
• Table 4-13: World Travel; Diphtheria-Tetanus; Miscellaneous Vaccines Market 2004-2013

CHAPTER FIVE: VACCINES MARKET SUMMARY

• Figure 5-1: Sales Growth of Vaccines vs. Pharmaceuticals 2004-2013
• Figure 5-2: World Market for Vaccines by Type 2004-2013
• Table 5-1: The World Vaccines Market by Vaccine Type 2004-2013 Revenues (in millions)
• Figure 5-3: World Market for Vaccines Share by Type, 2004, 2008 and 2013
• Table 5-2: Major Manufacturers' Shares of the World Vaccine Market, 2008
• Figure 5-3: 2008 World Vaccines Market Share, by Leading Competitors
• Table 5-3: Major Manufacturer' s Shares of the World Pediatric Vaccine Market 2008
• Figure 5-5: Market Share of Pediatric Vaccines Market, 2008
• Table 5-4: Major Manufacturer' s Shares of the World Adult Vaccine Market 2008
• Figure 5-6: Market Share of Adult Vaccines Market 2008

CHAPTER SIX: ISSUES AND TRENDS

• Table 7-1: Selected Companies/Laboratories Developing Biodefense Vaccines