Table of Contents
Chapter 1 Executive Summary
Chapter 2 Introduction
- 2.1 What are Migraines
- 2.1.1 What Causes Migraine?
- 2.1.2 Symptom Phases of Migraine
- 2.1.2.1 Prodrome Phase
- 2.1.2.2 Auras Phase
- 2.1.2.3 Attack Phase
- 2.1.2.4 Postdrome Phase
- 2.2 What is Headache Pain?
- 2.2.1 Tension Headaches
- 2.2.2 Cluster Headaches
- 2.3 Which Drugs are Approved for Migraine Treatment?
- 2.3.1 Acute Symptomatic Relief of Migraine Pain
- 2.3.1.1 What are the Triptans?
- 2.3.1.1.1 Sumatriptan (Imitrex, Imigran, Imigran Recovery)
- 2.3.1.1.2 Rizatriptan (Maxalt)
- 2.3.1.1.3 Zolmitriptan (Zomig)
- 2.3.1.1.4 Eletriptan (Relpax)
- 2.3.1.1.5 Naratriptan (Naramig)
- 2.3.1.1.6 Almotriptan (Axert, Almogran)
- 2.3.1.1.7 Frovatriptan (Frova)
- 2.3.1.2 Which Ergots have the FDA Approved for Migraine Treatment?
- 2.3.1.2.1 Side Effects of Ergots
- 2.3.1.2.2 Withdrawal of Drug
- 2.3.1.3 Which Analgesics Have the FDA Approved for Migraine Treatment?
- 2.3.1.4 Which Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Have Been
Approved by the FDA?
- 2.4 Opioids on the Market
- 2.5 Beta Blockers on the Market
- 2.6 Anticonvulsants for Migraine (Depakote and Topamax)
- 2.7 Antidepressants
- 2.8 Calcium-Channel Blockers
- 2.9 Other Drug Classes Under Investigation
Chapter 3 The Global Anti-Migraine Market
- 3.1 The Global Anti-Migraine Market Analysis
- 3.1.1 GSK' s Blockbuster Migraine Drug Imitrex Faces Loss of Sales
- 3.1.1.1 GSK Waiting Approval for New Potential Anti-Migraine
Blockbuster Drug
- 3.1.2 AstraZeneca' s Zomig - The New Market Leader Perhaps?
- 3.1.3 Relpax Shows Positive Growth
- 3.1.4 What Does the Future Hold for Migraine Therapy?
- 3.1.5 What are the Unmet Needs in the Management of Migraine?
- 3.1.6 Visiongain Believes That Significant Advances Will Occur in this
Market with Potentially High Revenues for Next-Generation Products
- 3.1.7 GSK Currently Leads the Anti-Migraine Market
- 3.1.8 Imitrex will be Overtaken by Zomig as the Leading Anti-Migraine
Product
- 3.1.9 The Top Ten Countries in the Anti-Migraine Market
Chapter 4 Forces Affecting the Anti-Migraine Market
- 4.1 SWOT Analysis of the Anti-Migraine Market
- 4.1.1 Market Drivers
- 4.1.2 Market Restraints
- 4.1.3 Why Growth in the Market is Expected?
- 4.2 Success of the Triptan Drugs
- 4.2.1 Niche Markets and the Success of the Triptan
- 4.2.2 What are the Therapeutic Advantages Offered by the Newer Triptans?
- 4.2.3 Will a Single Triptan Reign Supreme?
- 4.3 Lack of Adequate Reimbursement Limits Potential of Anti-Migraine Drugs
- 4.4 Choosing the Right Medication
- 4.5 Patient Problems with Anti-Migraine drugs
- 4.6 What are the Costs of Migraine to the US?
- 4.6.1 Cost of Migraine
- 4.6.2 How much Does Migraine Cost the US in Terms of Medical, Missed
Workdays and Lost Productivity?
- 4.7 FDA Reject Endo' s Attempt to Expand the Label for Frova
- 4.8 Complications of the Triptans
Chapter 5 The Prevalence of Migraine
- 5.1 What is the Global Prevalence of Migraine?
- 5.1.1 Why Will the Prevalence of Migraine Increase?
- 5.2 Prevalence of Migraine in the US
- 5.3 What are the Affects of Migraine on Specific Populations?
- 5.3.1 Prevalence by Gender
- 5.3.1.1 Menstrual Migraine
- 5.3.1.2 Pregnancy and Migraine
- 5.3.2 Prevalence by Age
- 5.3.2.1 Migraine in Children
- 5.3.2.2 Migraine in Later Life
Chapter 6 Pipeline Developments
- 6.1 Agents in Phase II of Clinical Development
- 6.1.1 Addex' s ADX10059
- 6.1.2 GSK' s 274150, 468816 and 705498
- 6.2 Agents in Phase III of Clinical Development
- 6.2.1 Merck' s MK0974
- 6.2.2 GSK' s 406381
- 6.3 Time is Running out for Pozen & GSK After the FDA Request More
Clinical Data on Trexima
- 6.4 Pozen' s MT-100
- 6.5 Discussion of Current Pipeline Developments
- 6.6 Summary of Pipeline Products Phase II and Above
Chapter 7 Alternative Therapies
- 7.1 Acupuncture
- 7.2 Biofeedback
- 7.3 Butterbur Root
- 7.4 Chiropractic
- 7.5 CoQ10
- 7.6 Feverfew Leaf
- 7.7 Ginkgo
- 7.8 Glucosamine
- 7.9 Hormones
- 7.9.1 Melatonin
- 7.9.2 Estriol
- 7.10 Magnesium
- 7.11 NTI Tension Suppression System
- 7.12 Vitamin B2
Chapter 8 Conclusion
- 8.1 Migraine is a Serious Condition with High Prevalence
- 8.2 Migraine Market Analysis
- 8.2.1 The Anti-Migraine Market Will Suffer From the Patent Expiry of its
Leading Product
- 8.2.2 How have Anti-Migraine Drugs Succeeded?
- 8.2.3 How an Increase in Prevalence will affect Sales Growth
- 8.2.4 Why is a Growth in the Market Expected?
- 8.2.5 Niche Markets - Menstrual Migraine
- 8.2.6 Market Drivers
- 8.2.7 Market Restraints
- 8.3 Geographical Breakdown of Revenues in the Anti-Migraine Market
- 8.3.1 Sales of Anti-Migraine Drugs Will Decrease in the US from 2007 to
2012
- 8.3.2 France Will Have the Second-Highest Sales of Anti-Migraine Drugs
- 8.4 There are Promising Developments Currently in Mid to Late Stage
Clinical Testing
- 8.5 Outlook for the Future of the Anti-Migraine Market
Appendix A: About Visiongain
Appendix B: Visiongain Report Evaluation Form
TABLES
- Table 2.1 FDA Approved Triptans for Migraine Treatment
- Table 2.2 FDA Approved Ergots for Migraine Treatment
- Table 2.3 FDA Approved Analgesics for Migraine Treatment
- Table 2.4 FDA Approved NSAIDs for Migraine Treatment
- Table 3.1 The World Anti-Migraine Market Forecast ($m), 2007-2022
- Table 3.2 Imitrex Forecast ($m), 2007-2012
- Table 3.3 Zomig Forecast ($m), 2007-2012
- Table 3.4 Relpax Forecast ($m), 2007-2012
- Table 3.5 Top 10 Leading Companies in the Anti-Migraine Market, Revenue
and Market Share, 2006
- Table 3.6 Top Ten Countries in the Anti-Migraine Market Revenue ($m)
Forecast 2007-2012
- Table 4.1 SWOT Analysis of the Anti-Migraine Market
- Table 4.2 Economic Burden of Migraine in the US
- Table 5.1 Lifetime Prevalence of Headaches among Gender
- Table 6.1 Summary of Pipeline Products Phase II and Above, 2007
- Table 8.1 Geographical Breakdown of Revenues in the Anti-Migraine Market
($m), 2006-2012
GRAPHS
- Graph 1.1 Top Anti-Migraine Products Revenue Forecast ($m), 2007-2012
- Graph 3.1 Anti-Migraine World Market Revenue Forecast ($m), 2007-2022
- Graph 3.2 Imitrex Revenue Forecast ($m), 2007-2012
- Graph 3.3 Zomig Revenue Forecast ($m), 2007-2012
- Graph 3.4 Relpax Revenue Forecast ($m), 2007-2012
- Graph 3.5 Top 10 Leading Companies in the Anti-Migraine Market ($m), 2006
- Graph 8.1 Total Sales of Anti-Migraine Drugs ($m), 2007-2022
- Graph 8.2 Sales of the Leading Anti-Migraine Drugs ($m), 2007-2012
CHARTS
- Chart 3.1 Leading Companies in the Anti-Migraine Market, Market Share (%),
2006
- Chart 3.2 Top Countries in the Anti-Migraine Market, Market Share (%), 2006
- Chart 3.3 Top Countries in the Anti-Migraine Market, Market Share (%), 2009
- Chart 3.4 Top Countries in the Anti-Migraine Market, Market Share (%), 2012
Companies Mentioned in this Report
- Abbott Laboratories
- Addex
- Alexza
- Almirall Prodesfarma
- Apothecon
- AstraZeneca
- Bayer
- Bedford
- Bristol-Myers Squibb
- CeNeS
- Dr. Reddy' s
- Elan
- Faust Pharmaceuticals
- FDA
- GD Searle
- Geneva Pharmaceuticals
- GSK
- Harvest Pharms
- Houston University
- J&J
- Lilly
- Menarini
- Merck & Co
- MHRA
- Novartis
- Odyssey Pharms
- Ortho-McNeil
- Pfizer
- Pharmacia
- Pozen
- Reckitt Benckiser
- Roche
- Roxro
- Sanofi
- UCB
- Vernalis
- Winston Laboratories
- Wyeth
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