Table of Contents
1. Executive Summary: Anti-Obesity Treatments 2009-2024
2. An Introduction to Obesity and Its Treatment
- 2.1 What is Obesity?
- 2.1.1 Fat is a Necessary Component of the Body
- 2.1.2 Obesity is a Chronic Disease
- 2.1.3 Body Weight is Dependent upon Several Factors
- 2.2 How is Obesity Measured?
- 2.2.1 Weight-for-Height Tables
- 2.2.2 Waist Circumference
- 2.2.3 Body Mass Index (BMI)
- 2.3 How Serious is the Problem?
- 2.3.1 Prevalence
- 2.3.2 Risk Factors of Other Diseases (Co-Morbidities)
- 2.3.3 Economic Costs
- 2.4 Historical Causes and Lifestyle Changes
- 2.4.1 Urbanisation, Modernisation and Economic Development
- 2.4.2 Developed Countries and in Developing Nations
- 2.5 Factors Causing Obesity
- 2.5.1 Lifestyle, Environment and Diet
- 2.5.2 Behaviour
- 2.5.3 Psychological Factors
- 2.5.4 Genetics
- 2.5.5 Antecedent Illnesses and Treatments
- 2.5.6 Other Causes
- 2.6 Treatment of Obesity
- 2.6.1 Lifestyle and Behavioural Changes
- 2.6.2 Unapproved Drugs
- 2.6.3 Alternative Therapies
- 2.6.4 Pharmacotherapy
- 2.6.5 Surgical Options
- 2.6.6 Drugs have a Role in the Treatment of Obesity.
- 2.7 Pharmacotherapy in the Treatment of Obesity
- 2.7.1 Lipase Inhibitors
- 2.7.2 Anorectic Drugs
- 2.7.3 Off-Label Use of Drugs
- 2.8 Need for Future Development in the Treatment of Obesity
- 2.8.1 Unmet Needs and Market Potential
3. The World Market for Anti-Obesity Drugs, 2009-2024
- 3.1 The Current Anti-Obesity Market Climate - a Potential Blockbuster
Market
- 3.2 Leading Companies in the Anti-Obesity Market
- 3.3 Market History and the Current Situation
- 3.3.1 The Effect of Pondimin, Redux and Public Opinion on the
Anti-Obesity Market
- 3.3.2 Rimonabant and other Cannabinoid Receptor Antagonists
- 3.3.3 Phentermine
- 3.4 Total Anti-Obesity Market Forecast 2009-2024
- 3.4.1 Market Growth in 2009-2024
- 3.4.2 Drugs after 2012
- 3.5 Xenical Forecast 2009-2024
- 3.5.1 Will Generic Erosion Drive Down Xenical' s Sales?
- 3.5.2 Competition Increases with New Releases
- 3.5.3 Will Xenical be Driven Out by Newer Rivals?
- 3.6 Reductil/Meridia Forecast 2009-2024
- 3.6.1 How Will Competition Affect Sales?
- 3.6.2 Expiry of Patents in 2013
- 3.7 Alli Forecast 2009-2024
- 3.7.1 Early Launch-Stocking
- 3.7.2 European Launch
- 3.7.3 Is Alli Failing to Distinguish Itself?
- 3.8 Dinintel Forecast 2009-2024
- 3.8.1 Will the Rapidly Evolving Anti-Obesity Market Will Leave Dinintel
Behind?
- 3.9 Total Other Drugs Forecast 2009-2024
- 3.9.1 Generic Competitors
- 3.9.2 New Drug: Contrave (Orexigen)
- 3.9.3 New Drug: Lorcaserin (Arena)
- 3.9.4 New Drug: Qnexa (Vivus)
- 3.9.5 New Drug: Liraglutide (Novo Nordisk)
- 3.9.6 New Drug: Empatic/Excalia (Orexigen)
- 3.10 Market Summary
- 3.10.1 New Drugs and the Market
- 3.10.2 Lack of Innovation and the Market Opportunities?
- 3.10.3 The Problems with Anorectic Drugs
- 3.10.4 The Problems with Lipase Inhibitors
- 3.10.5 The Future of Anti-Obesity Treatments
4. Anti-Obesity Treatments - SWOT Analysis
- 4.1 Strengths
- 4.1.1 Long-Term Therapy with Anti-Obesity Drugs
- 4.1.2 Prospects of Multiple Indications for Anti-Obesity Drugs
- 4.1.3 Off-Label Potential and Competition
- 4.1.4 The Anti-Obesity Market is Ready to be Revolutionised
- 4.1.5 Failure of Rimonabant Leaves Vacuum in the Market
- 4.1.6 New Drugs May Not Fill the Entirety of Customer Needs
- 4.2 Weaknesses
- 4.2.1 Limited Efficacy
- 4.2.2 Undesirable Side-Effects Limit Market Potential of Anti-Obesity
Medications
- 4.2.3 Increased Competition by both Impending New Releases and Generic
Competitors
- 4.2.4 Regulatory Hurdles have Become Stricter - Companies Pay the Price
- 4.2.5 Pharmacotherapy Will Never be the First Line of Treatment?
- 4.3 Opportunities
- 4.3.1 Rising Prevalence Drives Market Potential
- 4.3.2 Unmet Market Needs - Can Drugs Solve this Problem?
- 4.3.3 A Safe and Effective Anti-Obesity Treatment has Applications in
Both the Clinical and Cosmetic Sectors
- 4.3.4 How the Changing Government Agenda and the High Economic Costs of
Obesity Will Drive Growth in the Anti-Obesity Market
- 4.3.5 Diet and Exercise May be the Mainstay Treatment, but this Approach
is not Always Effective
- 4.4 Threats
- 4.4.1 Reimbursement May Continue to be a Limiting Factor
- 4.4.2 Long-Term Safety Issues Continue to Stunt Growth
- 4.4.3 Opinion of Both the Public and Prescribing Bodies is Heavily
Dependent upon Individual Drug Successes and Success of the Market as a Whole
- 4.4.4 Will Healthier Lifestyles Limit the Current Need for Anti-Obesity
Drugs?
5. Pipeline Developments in Anti-Obesity Treatments
- 5.1 Treatments in Phase III
- 5.1.1 Lorcaserin
- 5.1.2 Qnexa
- 5.1.3 Contrave
- 5.1.4 Cetilistat
- 5.2 Treatments in Phase II
- 5.2.1 Empatic/Excalia
- 5.2.2 Liraglutide
- 5.2.3 Obinepitide
- 5.2.4 Solabegron
- 5.2.5 Tesofensine
- 5.2.6 Velneperit
- 5.2.7 Histalean
- 5.2.8 Sodium Tungstate
- 5.2.9 Serglifozin Etabonate
- 5.2.10 Pramlintide & Metreleptin
- 5.2.11 Hoodia gordonii Extract
- 5.2.12 MTP Inhibitor
- 5.2.13 TM 30339
- 5.2.14 SLx 4090
- 5.2.15 MK 0493
- 5.2.16 KRP 204
- 5.2.17 FM VP4
- 5.2.18 AZD 2207
- 5.2.19 CE 326597
- 5.3 Treatments in Phase I
- 5.3.1 Trodusquemine
- 5.3.2 THCV
- 5.3.3 Oral PYY3-36
- 5.3.4 ATHX 105
- 5.3.5 AZD 1175
- 5.3.6 AZD 1656
- 5.3.7 BVT 74316
- 5.3.8 CP 404
- 5.3.9 KD 3010
- 5.3.10 PRX 07034
- 5.3.11 PSN 602
- 5.3.12 TKS 1225
- 5.3.13 V 24343
- 5.3.14 TTP 435
- 5.4 Other Promising Pipeline Developments
- 5.4.1 Melanotan
- 5.4.2 Increasing Mitochondrial Activity to Increase Energy Expenditure
- 5.4.3 Inhibiting the Creation of Fat Stores after Gut Absorption
6. Obesity in the Leading World Markets
- 6.1 The Total Market for Anti-Obesity Treatments
- 6.1.1 Drug Development Will Drive the Market
- 6.2 US Anti-Obesity Market Forecast 2009-2024
- 6.2.1 Patent Expiries and New Drug Releases Will Create a Turbulent
Market
- 6.2.2 Will The Market Show Uninhibited Growth During the Forecast Period?
- 6.3 Mexico Anti-Obesity Market Forecast 2009-2024
- 6.3.1 The Health Care System Currently Limits Treatment Accessibility
- 6.3.2 Prevalence of Obesity Driving the Market
- 6.4 Brazil Anti-Obesity Market Forecast 2009-2024
- 6.4.1 Increasing Prevalence Will Force an Increase in Sales over the
Forecast Period
- 6.5 UK Anti-Obesity Market Forecast 2009-2024
- 6.5.1 Lagging Sales Will Turn to Positive Growth in the Early Forecast
Period
- 6.5.2 Government Agenda Will Support Growth of Anti-Obesity Treatments
in the UK
- 6.6 South Korea Anti-Obesity Market Forecast 2009-2024
- 6.6.1 Government Agenda Will Maintain High Sales
- 6.7 Spain Anti-Obesity Market Forecast 2009-2024
- 6.7.1 New Drug Releases and Patent Expiries
- 6.7.2 The Market Will Show Consistent Positive Growth
- 6.8 France Anti-Obesity Market Forecast 2009-2024
- 6.8.1 Reimbursement will Drive Sales
- 6.9 Total Other Countries Anti-Obesity Market Forecast 2009-2024
- 6.9.1 Total Other Countries Sales
- 6.9.2 The Impact of Emerging Markets
- 6.9.3 Emerging Market: India
- 6.9.4 Emerging Market: China
7. Experts' Views on the Main Issues in the Treatment of Obesity
- 7.1 An Interview with Dr. Tyrberg from The Burnham Institute Diabetes and
Obesity Research Centre
- 7.1.1 The Effect of Anti-Obesity Drugs on the Obese Population
- 7.1.2 The Cause-Effect Relationship between Diet, Obesity and Type 2
Diabetes
- 7.1.3 Off-Label Indications and Diabetes Treatments Used to Treat Obesity
- 7.1.4 Obesity as a Lifestyle Disease?
- 7.1.5 The Future of Anti-Obesity Treatments and the Role Diet and
Exercise Will Play
- 7.1.6 The Role of Pharmaceutical Companies, Ethics and the Cosmetic Use
of Anti-Obesity Treatments
- 7.1.7 Unmet Medical Needs in the Treatment of Obesity
- 7.1.8 The Future of the Anti-Obesity Market
- 7.2 Commentaries and Views from Other Experts in the Field
- 7.2.1 The Most Important Unmet Medical Needs in the Treatment of Obesity
- 7.2.2 The Future of Anti-Obesity Treatment
- 7.2.3 Funding of Anti-Obesity Treatments
- 7.2.4 The Anti-Obesity Market in Developing Nations
- 7.2.5 Concluding Thoughts
8 .Conclusions
- 8.1 Obesity is a Chronic Disease with Serious Health Implications
- 8.2 The Prevalence and Economic Costs of Obesity
- 8.3 The Modern Lifestyle has Contributed Significantly to Obesity
- 8.4 Obesity is Caused by a Complex Interplay of Factors
- 8.5 Obesity Treatments and the Role of Pharmaceuticals
- 8.6 The Unmet Needs and Market Potential for Anti-Obesity Treatments
- 8.7 The Anti-Obesity Market Will Expand from 2009-2024
- 8.8 The Main Drivers and Restraints of the Anti-Obesity Market
- 8.9 Geographical Overview of the Anti-Obesity Market
- 8.10 Outlook for the Future
Appendices
- Appendix 1: Conditions Associated with Obesity
- Appendix 2: Bariatric Surgery Options
- Appendix 3: About visiongain
- Appendix 4: Visiongain Report Evaluation Form
List of Tables
- Table 2.1 - BMI Classification Bands
- Table 2.2 - Obesity Prevalence Amongst US Adults 1991-2007
- Table 3.1 - Leading Anti-Obesity Drugs in Sales ($m), Market Share (%) and
Growth (%), 2007
- Table 3.2 - Leading Companies for Anti-Obesity Drugs in Sales ($m) and
Market Share (%), 2007
- Table 3.3 -Total Anti-Obesity Market Forecast in Sales ($m) and Growth
(%), 2009-2024
- Table 3.4 - Total Anti-Obesity Market CAGR Values (%), 2009-2024
- Table 3.5 - Xenical Forecast in Sales ($m) and Growth (%), 2009-2024
- Table 3.6 - Xenical CAGR Values (%), 2009-2024
- Table 3.7 - Reductil/Meridia Forecast in Sales ($m) and Growth (%),
2009-2024
- Table 3.8 - Reductil/Meridia CAGR Values (%), 2009-2024
- Table 3.9 - Alli Forecast in Sales ($m) and Growth (%), 2009-2024
- Table 3.10 - Alli CAGR Values (%), 2009-2024
- Table 3.11 - Dinintel Forecast in Sales ($m) and Growth (%), 2009-2024
- Table 3.12 - Dinintel CAGR Values (%), 2009-2024
- Table 3.13 - Total Other Drugs Forecast in Sales ($m) and Growth (%),
2009-2024
- Table 3.14 - Total Others Drugs CAGR Values (%), 2009-2024
- Table 4.1 - SWOT Chart of the Anti-Obesity Market, 2009-2024
- Table 5.1 -The Anti-Obesity Pipeline 2009
- Table 6.1 - US Anti-Obesity Market Forecast in Sales ($m) and Growth (%),
2009-2024
- Table 6.2 - US Anti-Obesity Market CAGR Values (%), 2009-2024
- Table 6.3 - Mexico Anti-Obesity Market Forecast in Sales ($m) and Growth
(%), 2009-2024
- Table 6.4 - Mexico Anti-Obesity Market CAGR Values (%), 2009-2024
- Table 6.5 - Brazil Anti-Obesity Market Forecast in Sales ($m) and Growth
(%), 2009-2024
- Table 6.6 - Brazil Anti-Obesity Market CAGR Values (%), 2009-2024
- Table 6.7 - UK Anti-Obesity Market Forecast in Sales ($m) and Growth (%),
2009-2024
- Table 6.8 - UK Anti-Obesity Market CAGR Values (%), 2009-2024
- Table 6.9 - South Korea Anti-Obesity Market Forecast in Sales ($m) and
Growth (%), 2009-2024
- Table 6.10 - South Korea Anti-Obesity Market CAGR Values (%), 2009-2024
- Table 6.11 - Spain Anti-Obesity Market Forecast in Sales ($m) and Growth
(%), 2009-2024
- Table 6.12 - Spain Anti-Obesity Market CAGR Values (%), 2009-2024
- Table 6.13 - France Anti-Obesity Market CAGR Values (%), 2009-2024
- Table 6.14 - France Anti-Obesity Market Forecast in Sales ($m) and Growth
(%), 2009-2024
- Table 6.15 - Total Other Countries Anti-Obesity Market Forecast in Sales
($m) and Growth (%), 2009-2024
- Table 6.16 - Total Other Countries Anti-Obesity Market CAGR Values (%),
2009-2024
- Table A2.1 - Bariatric Surgery Options
List of Figures
- Figure 2.1 - Obesity Prevalence Amongst US Adults 1991-2007
- Figure 3.1 - Leading Anti-Obesity Drugs Sales ($m), 2007
- Figure 3.2 - Leading Anti-Obesity Drugs Market Share (%), 2007
- Figure 3.3 - Leading Companies of Anti-Obesity Drugs Sales ($m), 2007
- Figure 3.4 - Leading Companies Anti-Obesity Market Share (%), 2007
- Figure 3.5 - Total Anti-Obesity Market Sales ($m), 2009-2024
- Figure 3.6 - Xenical Sales ($m), 2009-2024
- Figure 3.7 - Reductil/Meridia Sales ($m), 2009-2024
- Figure 3.8 - Alli Sales ($m), 2009-2024
- Figure 3.9 - Dinintel Sales ($m), 2009-2024
- Figure 3.10 - Total Other Drugs Sales ($m), 2009-2024
- Figure 3.11 - All Drugs Market Share (%), 2009-2024
- Figure 6.1 - Total Anti-Obesity Market Sales ($m), 2009-2024
- Figure 6.2 - US Anti-Obesity Market Forecast Sales ($m), 2009-2024
- Figure 6.3 - Mexico Anti-Obesity Market Forecast Sales ($m), 2009-2024
- Figure 6.4 - Brazil Anti-Obesity Market Forecast Sales ($m), 2009-2024
- Figure 6.5 - UK Anti-Obesity Market Forecast Sales ($m), 2009-2024
- Figure 6.6 - South Korea Anti-Obesity Market Forecast Sales ($m), 2009-2024
- Figure 6.7 - Spain Anti-Obesity Market Forecast Sales ($m), 2009-2024
- Figure 6.8 - France Anti-Obesity Market Forecast Sales ($m), 2009-2024
- Figure 6.9 - Total Other Countries Anti-Obesity Market Forecast Sales
($m), 2009-2024
- Figure 6.10 - Anti-Obesity Combined Country Forecast Sales ($m), 2009-2024
- Figure 6.11 - Anti-Obesity Market Country Market Share Forecast (%),
2009-2024
- Figure 8.1 - Total Anti-Obesity Market Sales ($m), 2009-2024
- Figure 8.2 - Anti-Obesity Drugs Forecast by Market Share (%), 2009-2024
- Figure 8.3 - Anti-Obesity Combined Country Forecast Sales ($m), 2009-2024
- Figure 8.4 - Anti-Obesity Market Country Market Share Forecast, 2009-2024
Companies Listed
- 7TM Pharma
- Abbott
- Ache Laboratories
- Actavis
- Alizyme
- American Home Products
- Amylin
- Arena
- AstraZeneca
- Athersys
- Barcelona University
- Bayer
- Biovitrum
- Bristol-Myers Squibb
- Clinuvel
- Compellis
- Council for Scientific and Industrial Research
- Duke University
- Eli Lilly
- EMEA
- Emisphere
- EMS
- Epix
- FDA
- Forbes Medi-Tech
- Gate Pharmaceuticals
- Genaera
- GlaxoSmithKline
- Graceway Pharma
- GW Pharmaceuticals
- Han Wha
- Hanmi
- Inova Pharma
- Johnson & Johnson
- Kalypsys
- Kissei
- Kyorin
- Louisiana State University
- Medley
- Merck & Co.
- NeuroSearch
- Novartis
- Novo Nordisk
- Nycomed Pharma
- OBEcure
- Orexigen
- OSI Pharmaceuticals
- Pfizer
- Phytopharm
- Roche
- Sanofi-Aventis
- Shionogi
- Sirtris Pharmaceuticals
- Solvay
- Surface Logix
- Takeda
- Teva
- The Burnham Institute
- Transition
- TransTech
- URL Pharma
- Vernalis
- Vivus
- Wyeth Pharmaceuticals
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