North America Orthopedic Devices Investment Opportunities, Analysis and Forecasts to 2015

Table of Contents

1 Table of Contents
1 Table of Contents 2
1.1 List of Tables 11
1.2 List of Figures 14
2 Introduction 16
2.1 What Is This Report About? 16
3 Definitions of the Markets Covered in the Report 17
3.1 Orthopedic Devices 17
3.2 Orthobiologics 17
3.3 Joint Reconstruction 17
3.4 Spinal Surgery 17
3.5 Trauma Fixation 17
3.6 Arthroscopy 17
3.7 Orthopedic Accessories 17
3.8 Orthopedic Braces and Supports 17
4 Orthopedic Devices in North America 19
4.1 Orthopedic Devices, North America, Overall Revenue ($ mn), 2000-2015 19
4.2 Orthopedic Devices, North America, Category Volume (Units), 2000-2015 25
4.3 Orthopedic Devices, North America, Company Share (2007-2008) 30
5 Orthopedic Devices In United States 31
5.1 Orthopedic Devices, United States, Overall Revenue ($ mn), 2000-2015 31
5.2 Orthopedic Devices, United States, Category Volume (Units), 2000-2015 35
5.3 Orthopedic Devices, United States, Distribution Share (2006-2007) 40
5.3.1 Arthroscopy Distribution Share (2007-2008) 40
5.3.2 Joint Reconstruction Distribution Share (2007-2008) 40
5.3.3 Orthobiologics Distribution Share (2007-2008) 41
5.3.4 Orthopedic Accessories Distribution Share (2007-2008) 41
5.3.5 Orthopedic Braces and Supports Distribution Share (2007-2008) 42
5.3.6 Spinal Surgery Distribution Share (2007-2008) 42
5.3.7 Trauma Fixation Distribution Share (2007-2008) 43
5.4 Orthopedic Devices, United States, Company Share (2007-2008) 44
5.4.1 Orthopedic Devices, United States, Company Share (2007-2008) 44
5.4.2 Arthroscopy, United States, Company Share (2007-2008) 45
5.4.3 Joint Reconstruction, United States, Company Share (2007-2008) 46
5.4.4 Orthobiologics, United States, Company Share (2007-2008) 47
5.4.5 Orthopedic Accessories, United States, Company Share (2007-2008) 49
5.4.6 Orthopedic Braces and Supports, United States, Company Share (2007-2008) 50
5.4.7 Spinal Surgery, United States, Company Share (2007-2008) 51
5.4.8 Trauma Fixation, United States, Company Share (2007-2008) 52
6 Orthopedic Devices In Canada 53
6.1 Orthopedic Devices, Canada, Overall Revenue ($ mn), 2000-2015 53
6.2 Orthopedic Devices, Canada, Category Volume (Units), 2000-2015 58
6.3 Orthopedic Devices, Canada, Distribution Share (2006-2007) 63
6.3.1 Arthroscopy Distribution Share (2007-2008) 63
6.3.2 Joint Reconstruction Distribution Share (2007-2008) 63
6.3.3 Orthobiologics Distribution Share (2007-2008) 64
6.3.4 Orthopedic Accessories Distribution Share (2007-2008) 64
6.3.5 Orthopedic Braces and Supports Distribution Share (2007-2008) 65
6.3.6 Spinal Surgery Distribution Share (2007-2008) 65
6.3.7 Trauma Fixation Distribution Share (2007-2008) 66
6.4 Orthopedic Devices, Canada, Company Share (2006-2007) 67
6.4.1 Orthopedic Devices, Canada, Company Share (2007-2008) 67
6.4.2 Arthroscopy, Canada, Company Share (2007-2008) 68
6.4.3 Joint Reconstruction, Canada, Company Share (2007-2008) 69
6.4.4 Orthobiologics, Canada, Company Share (2007-2008) 70
6.4.5 Orthopedic Accessories, Canada, Company Share (2007-2008) 72
6.4.6 Orthopedic Braces and Supports, Canada, Company Share (2007-2008) 73
6.4.7 Spinal Surgery, Canada, Company Share (2007-2008) 74
6.4.8 Trauma Fixation, Canada, Company Share (2007-2008) 75
7 Overview of Key Companies in North America Orthopedic Devices Market 76
7.1 DePuy, Inc. 76
7.1.1 Company Overview 76
7.1.2 DePuy, Inc. Pipeline Products 76
7.1.2.1 DePuy, Inc. Pipeline Products by Equipment Type 76
7.1.2.2 DePuy, Inc. Pipeline Products by Development Stage 77
7.1.2.3 DePuy, Inc. Pipeline Products by Therapy Area 77
7.1.2.4 DePuy, Inc. Pipeline Products by Clinical Trials 78
7.1.2.5 DePuy, Inc. Pipeline Products by News Summary 78
7.2 Stryker Corporation 79
7.2.1 Company Overview 79
7.2.2 Value Chain Analysis 79
7.2.2.1 Manufacturing 80
7.2.2.2 Product Development 80
7.2.2.3 Sales and Marketing 81
7.2.3 Stryker Corporation Pipeline Products 81
7.2.3.1 Stryker Corporation Pipeline Products by Equipment Type 81
7.2.3.2 Stryker Corporation Pipeline Products by Development Stage 81
7.2.3.3 Stryker Corporation Pipeline Products by Therapy Area 82
7.2.3.4 Stryker Corporation Pipeline Products by Clinical Trials 82
7.3 Zimmer Holdings, Inc. 83
7.3.1 Company Overview 83
7.3.2 Value Chain Analysis 84
7.3.2.1 Manufacturing 84
7.3.2.2 Product Development 84
7.3.2.3 Sales and Marketing 85
7.3.3 Zimmer Holdings, Inc. Pipeline Products 86
7.3.3.1 Zimmer Holdings, Inc. Pipeline Products by Equipment Type 86
7.3.3.2 Zimmer Holdings, Inc. Pipeline Products by Development Stage 86
7.3.3.3 Zimmer Holdings, Inc. Pipeline Products by Therapy Area 86
7.3.3.4 Zimmer Holdings, Inc. Pipeline Products by Clinical Trials 87
7.4 Medtronic, Inc. 88
7.4.1 Company Overview 88
7.4.2 Value Chain Analysis 88
7.4.2.1 Manufacturing 88
7.4.2.2 Product Development 89
7.4.2.3 Sales and Marketing 89
7.4.3 Medtronic, Inc. Pipeline Products 91
7.4.3.1 Medtronic, Inc. Pipeline Products by Equipment Type 91
7.4.3.2 Medtronic, Inc. Pipeline Products by Development Stage 93
7.4.3.3 Medtronic, Inc. Pipeline Products by Therapy Area 95
7.4.3.4 Medtronic, Inc. Pipeline Products by Clinical Trials 97
7.4.3.5 Medtronic, Inc. Pipeline Products by News Summary 98
7.5 Synthes GmbH 99
7.5.1 Company Overview 99
7.5.2 Value Chain Analysis 100
7.5.2.1 Manufacturing 100
7.5.2.2 Product Development 100
7.5.2.3 Sales and Marketing 101
7.5.3 Synthes, Inc. Pipeline Products 101
7.5.3.1 Synthes, Inc. Pipeline Products by Equipment Type 101
7.5.3.2 Synthes, Inc. Pipeline Products by Development Stage 102
7.5.3.3 Synthes, Inc. Pipeline Products by Therapy Area 102
7.5.3.4 Synthes, Inc. Pipeline Products by Clinical Trials 102
7.6 Smith & Nephew Plc 103
7.6.1 Company Overview 103
7.6.2 Value Chain Analysis 103
7.6.2.1 Manufacturing 104
7.6.2.2 Product Development 104
7.6.2.3 Sales and Marketing 105
7.6.3 Smith & Nephew Plc Pipeline Products 106
7.6.3.1 Smith & Nephew Plc Pipeline Products by Equipment Type 106
7.6.3.2 Smith & Nephew Plc Pipeline Products by Development Stage 106
7.6.3.3 Smith & Nephew Plc Pipeline Products by Therapy Area 107
7.7 Biomet, Inc. 107
7.7.1 Company Overview 107
7.7.2 Value Chain Analysis 108
7.7.2.1 Manufacturing 108
7.7.2.2 Product Development 108
7.7.2.3 Sales and Marketing 109
7.7.3 Biomet, Inc. Pipeline Products 110
7.7.3.1 Biomet, Inc. Pipeline Products by Equipment Type 110
7.7.3.2 Biomet, Inc. Pipeline Products by Development Stage 110
7.7.3.3 Biomet, Inc. Pipeline Products by Therapy Area 111
7.7.3.4 Biomet, Inc. Pipeline Products by Clinical Trials 111
7.8 Arthrex, Inc. 112
7.8.1 Company Overview 112
7.9 BREG Incorporated 112
7.9.1 Company Overview 112
7.10 Arthrocare Corporation 113
7.10.1 Company Overview 113
7.10.2 Value Chain Analysis 114
7.10.2.1 Manufacturing 114
7.10.2.2 Product Development 115
7.10.2.3 Sales and Marketing 116
7.10.3 Arthrocare Corporation Pipeline Products 116
7.10.3.1 Arthrocare Corporation Pipeline Products by Equipment Type 116
7.10.3.2 Arthrocare Corporation Pipeline Products by Development Stage 116
7.10.3.3 Arthrocare Corporation Pipeline Products by Therapy Area 117
7.10.3.4 Arthrocare Corporation Pipeline Products by News Summary 117
7.11 CONMED Corporation 118
7.11.1 Company Overview 118
7.11.2 Value Chain Analysis 118
7.11.2.1 Manufacturing 118
7.11.2.2 Product Development 119
7.11.2.3 Sales and Marketing 119
7.12 Genzyme Corporation 121
7.12.1 Company Overview 121
7.12.2 Genzyme Corporation Pipeline Products 121
7.12.2.1 Genzyme Corporation Pipeline Products by Equipment Type 121
7.12.2.2 Genzyme Corporation Pipeline Products by Development Stage 122
7.12.2.3 Genzyme Corporation Pipeline Products by Therapy Area 123
7.12.2.4 Genzyme Corporation Pipeline Products by Clinical Trials 123
7.12.2.5 Genzyme Corporation Pipeline Products by News Summary 124
7.13 Osteotech, Inc. 124
7.13.1 Company Overview 124
7.13.2 Osteotech, Inc. Pipeline Products 124
7.13.2.1 Osteotech, Inc. Pipeline Products by Equipment Type 124
7.13.2.2 Osteotech, Inc. Pipeline Products by Development Stage 125
7.13.2.3 Osteotech, Inc. Pipeline Products by Therapy Area 125
7.14 Hanger Orthopedic Group, Inc. 126
7.14.1 Company Overview 126
7.14.2 Value Chain Analysis 126
7.14.2.1 Manufacturing 127
7.14.2.2 Product Development 127
7.14.2.3 Sales and Marketing 128
7.15 Orthofix International N.V. 129
7.15.1 Company Overview 129
7.15.2 Value Chain Analysis 129
7.15.2.1 Manufacturing 129
7.15.2.2 Product Development 130
7.15.2.3 Sales and Marketing 130
7.15.3 Orthofix International N.V. Pipeline Products 131
7.15.3.1 Orthofix International N.V. Pipeline Products by Equipment Type 131
7.15.3.2 Orthofix International N.V. Pipeline Products by Development Stage 131
7.15.3.3 Orthofix International N.V. Pipeline Products by Therapy Area 131
7.15.3.4 Orthofix International N.V. Pipeline Products by Clinical Trials 132
7.15.3.5 Orthofix International N.V. Pipeline Products by News Summary 132
7.16 DJO Incorporated 133
7.16.1 Company Overview 133
7.16.2 Value Chain Analysis 133
7.16.2.1 Manufacturing 133
7.16.2.2 Product Development 134
7.16.2.3 Sales and Marketing 135
7.17 Johnson & Johnson 136
7.17.1 Company Overview 136
7.17.2 Value Chain Analysis 136
7.17.2.1 Manufacturing 137
7.17.2.2 Product Development 137
7.17.2.3 Sales and Marketing 138
7.18 Biorthex Inc. 139
7.18.1 Company Overview 139
7.18.2 Biorthex Inc. Pipeline Products 139
7.18.2.1 Biorthex Inc. Pipeline Products by Equipment Type 139
7.18.2.2 Biorthex Inc. Pipeline Products by Development Stage 139
7.18.2.3 Biorthex Inc. Pipeline Products by Therapy Area 139
7.19 BioSyntech, Inc. 140
7.19.1 Company Overview 140
7.19.2 BioSyntech, Inc. Pipeline Products 140
7.19.2.1 BioSyntech, Inc. Pipeline Products by Equipment Type 140
7.19.2.2 BioSyntech, Inc. Pipeline Products by Development Stage 140
7.19.2.3 BioSyntech, Inc. Pipeline Products by Therapy Area 141
7.19.2.4 BioSyntech, Inc. Pipeline Products by Clinical Trials 141
7.19.2.5 BioSyntech, Inc. Pipeline Products by News Summary 141
7.20 BBG Orthopaedic Appliances Inc. 142
7.20.1 Company Overview 142
7.21 Citagenix Inc. 142
7.21.1 Company Overview 142
7.22 DeRoyal Industries, Inc. 143
7.22.1 Company Overview 143
7.23 Anchor Products Co., Inc. 143
7.23.1 Company Overview 143
8 Financial Deals Landscape 144
8.1 Acquisition 144
8.1.1 NuVasive To Acquire Cervitech 144
8.1.2 Arkema Acquires Oxford Performance Materials 145
8.1.3 Michigan Orthopedic Services Acquires O&P Professional Care 146
8.1.4 Hanger Orthopedic Group Completes Six Acquisitions 147
8.1.5 Advanced Technology Acquisition To Acquire Bioness 148
8.1.6 NovaMed Acquires Majority Interest In Physicians Surgical Center 149
8.2 Partnerships 150
8.2.1 Tornier Enters Into Licensing Agreement With T.A.G. Medical Products 150
8.2.2 DJO Surgical Signs An Agreement With LimaGroup 151
8.2.3 RTI Biologics Enters Into An Agreement With Aesculap Implant Systems 152
8.2.4 StemCor Systems Enters Into An Agreement With Hospira 153
8.2.5 NeuralStem Enters Into An Agreement With The Cleveland Clinic 154
9 Recent Developments 155
9.1 Strategy and Business Planning 155
9.1.1 May 21, 2009: Johnson & Johnson Acquires Cougar For $1b 155
9.1.2 May 11, 2009: Medtronic Announces San Antonio As Home Of New Diabetes Facility 155
9.1.3 Mar 25, 2009: Medtronic Leases Nearly 50,000 Square-Foot Facility For Ablation Frontiers Unit 156
9.1.4 Mar 02, 2009: CUREXO Technology Corporation Announces New Headquarters 157
9.1.5 Feb 24, 2009: Medtronic Plans To Reduce Global Workforce 157
9.1.6 Feb 10, 2009: Orthofix Plans To Close Its Huntersville, Facility 157
9.1.7 Jan 30, 2009: Codman Plans To Close Its Manufacturing Operations In Miami Lakes 157
9.1.8 Jan 30, 2009: Smith & Nephew Signs Grant Administration Agreement With OREF 158
9.1.9 Dec 31, 2008: Wright Medical Plans To Unveil New Devices In 2009 158
9.1.10 Dec 17, 2008: Teleflex Plans To Consolidate Commercial Segment Operations 159
9.1.11 Nov 06, 2008: Orthofix Announces Restructuring Plan For Blackstone 159
9.1.12 Nov 01, 2008: Greatbatch Plans To Close Three Facilities 159
9.2 Legal and Regulatory 160
9.2.1 May 20, 2009: Wright Medical To Settle Bulk Of Biologic Products Lawsuits 160
9.2.2 May 11, 2009: Stryker Receives Subpoena From New Jersey Attorney General 160
9.2.3 May 11, 2009: Biomet To Settle Bulk Of Bone Stimulator Lawsuits 161
9.2.4 May 05, 2009: Synthes Settles With New Jersey Attorney General And Agrees To Reimburse Investigation Costs Of $236,000 161
9.2.5 Apr 27, 2009: Zynex CEO Responds To Class-Action Lawsuits 162
9.2.6 Apr 16, 2009: Smith & Nephew Recieves Subpoena From DOJ 162
9.2.7 Apr 15, 2009: DJO Announces Unsealing Of False Claims Act Complaint Against Bone Growth Stimulator Manufacturers 162
9.2.8 Apr 03, 2009: Rosen Law Firm Announces Investigation of Federal Securities Fraud Claims Against Zynex 163
9.2.9 Mar 30, 2009: Implant Sciences Settles Lawsuit With Evans 163
9.2.10 Mar 30, 2009: Smith & Nephew Orthopaedics Announces End Of DPA And Dismissal Of Complaint By USAO 163
9.2.11 Mar 30, 2009: DOJ Dismisses Charges Against Orthopedic Device Makers 164
9.2.12 Mar 11, 2009: Medtronic Announces Dismissal Of Lawsuit 164
9.2.13 Mar 10, 2009: Stryker Biotech Unit Faces Federal Investigation In Massachusetts 164
9.2.14 Feb 18, 2009: ArthroCare Announces Investigations By SEC And US Attorney Offices 164
9.2.15 Jan 06, 2009: Court Rules In Favor Of Medtronic In Fidelis Litigation 165
9.3 Government and Public Interest 165
9.3.1 Apr 29, 2009: Justice Department Investigates Devicemakers For Improper Billing 165
9.3.2 Apr 09, 2009: Rush University Medical Center Tests New Surgical Procedure For Regenerating Cartilage In Damaged Knee Joints 165
9.3.3 Apr 02, 2009: FDA To Study Long-Term Safety Of Joint Replacement Devices 166
9.3.4 Mar 05, 2009: AdvaMed Sets New Advertising Rules 166
9.3.5 Feb 03, 2009: University Responds To Probe, Orthopedic Industry Cautious 167
9.4 Product Approvals 168
9.4.1 May 04, 2009: CoreSpine Technologies' XTEND-ST Nucleus Removal System Receives 510(k) Clearance 168
9.4.2 May 04, 2009: X-spine' s Calix Spinal Implant System Receives FDA Clearance 168
9.4.3 Apr 27, 2009: FDA Clears ETEX Corporation' s Small Size Beta-bsm Injectable Paste And Gamma-bsm Moldable Putty 168
9.4.4 Apr 22, 2009: US FDA Approves MiMedx Group' s Paradis Vaso Shield Device 168
9.4.5 Apr 16, 2009: DJO Receives FDA 510(k) Clearance For Intelect SWD Shortwave Diathermy Device 169
9.4.6 Apr 08, 2009: Core Essence Announces 510(k) Clearance For SECURUS Suture Anchor System 169
9.4.7 Apr 02, 2009: LDR Corporation Receives US FDA Approval For Its ROI-A ALIF Device 170
9.4.8 Feb 26, 2009: Genzyme Announces FDA Approval For Synvisc-One For Osteoarthritis Of The Knee 170
9.4.9 Feb 10, 2009: US FDA Grants 510(k) Clearance For K2M' s tifix CAYMAN Plate Systems 171
9.4.10 Feb 02, 2009: NIMS Receives FDA Approval To Market Exer-Rest 171
10 Appendix 172
10.1 Global Markets Direct Research Methodology 172
10.2 Coverage 173
10.3 Secondary Research 173
10.4 Primary Research 174
10.5 Models 174
10.6 Forecasts 175
10.7 Expert Panel Validation 175
10.8 Currency Conversion 176
10.9 Contact Us 177
10.10 Disclaimer 177



1.1 List of Tables
Table 1: Orthopedic Devices, North America, Overall Revenue ($ mn), 2000-2015 19
Table 2: North America, Orthopedic Devices, Cross Category Analysis, 2000-2015 20
Table 3: Orthopedic Devices, North America, Overall Revenue ($ mn), Historic, 2000-2008 22
Table 4: Orthopedic Devices, North America, Overall Revenue ($ mn), Forecast, 2008-2015 24
Table 5: Orthopedic Devices, North America, Category Volume (Units), 2000-2015 25
Table 6: Orthopedic Devices, North America, Category Volume (Units), Historic, 2000-2008 27
Table 7: Orthopedic Devices, North America, Category Volume (Units), Forecast, 2008-2015 29
Table 8: Orthopedic Devices, North America, Company Share by Revenue ($ mn), 2007-2008 30
Table 9: Orthopedic Devices, United States, Overall Revenue ($ mn), 2000-2015 31
Table 10: Orthopedic Devices, United States, Overall Revenue ($ mn), Historic, 2000-2008 32
Table 11: Orthopedic Devices, United States, Overall Revenue ($ mn), Forecast, 2008-2015 34
Table 12: Orthopedic Devices, United States, Category Volume (Units), 2000-2015 35
Table 13: Orthopedic Devices, United States, Category Volume (Units), Historic, 2000-2008 37
Table 14: Orthopedic Devices, United States, Category Volume (Units), Forecast, 2008-2015 39
Table 15: Arthroscopy, United States, Distribution Share by Revenue ($mn), 2007-2008 40
Table 16: Joint Reconstruction, United States, Distribution Share by Revenue ($mn), 2007-2008 40
Table 17: Orthobiologics, United States, Distribution Share by Revenue ($mn), 2007-2008 41
Table 18: Orthopedic Accessories, United States, Distribution Share by Revenue ($mn), 2007-2008 41
Table 19: Orthopedic Braces and Supports, United States, Distribution Share by Revenue ($mn), 2007-2008 42
Table 20: Spinal Surgery, United States, Distribution Share by Revenue ($mn), 2007-2008 42
Table 21: Trauma Fixation, United States, Distribution Share by Revenue ($mn), 2007-2008 43
Table 22: Orthopedic Devices, United States, Company Share by Revenue ($ mn), 2007-2008 44
Table 23: Arthroscopy, United States, Company Share by Revenue ($ mn), 2007-2008 45
Table 24: Joint Reconstruction, United States, Company Share by Revenue ($ mn), 2007-2008 46
Table 25: Orthobiologics, United States, Company Share by Revenue ($ mn), 2007-2008 48
Table 26: Orthopedic Accessories, United States, Company Share by Revenue ($ mn), 2007-2008 49
Table 27: Orthopedic Braces and Supports, United States, Company Share by Revenue ($ mn), 2007-2008 50
Table 28: Spinal Surgery, United States, Company Share by Revenue ($ mn), 2007-2008 51
Table 29: Trauma Fixation, United States, Company Share by Revenue ($ mn), 2007-2008 52
Table 30: Orthopedic Devices, Canada, Overall Revenue ($ mn), 2000-2015 53
Table 31: Orthopedic Devices, Canada, Overall Revenue ($ mn), Historic, 2000-2008 55
Table 32: Orthopedic Devices, Canada, Overall Revenue ($ mn), Forecast, 2008-2015 57
Table 33: Orthopedic Devices, Canada, Category Volume (Units), 2000-2015 58
Table 34: Orthopedic Devices, Canada, Category Volume (Units), Historic, 2000-2008 60
Table 35: Orthopedic Devices, Canada, Category Volume (Units), Forecast, 2008-2015 62
Table 36: Arthroscopy, Canada, Distribution Share by Revenue ($mn), 2007-2008 63
Table 37: Joint Reconstruction, Canada, Distribution Share by Revenue ($mn), 2007-2008 63
Table 38: Orthobiologics, Canada, Distribution Share by Revenue ($mn), 2007-2008 64
Table 39: Orthopedic Accessories, Canada, Distribution Share by Revenue ($mn), 2007-2008 64
Table 40: Orthopedic Braces and Supports, Canada, Distribution Share by Revenue ($mn), 2007-2008 65
Table 41: Spinal Surgery, Canada, Distribution Share by Revenue ($mn), 2007-2008 65
Table 42: Trauma Fixation, Canada, Distribution Share by Revenue ($mn), 2007-2008 66
Table 43: Orthopedic Devices, Canada, Company Share by Revenue ($ mn), 2007-2008 67
Table 44: Arthroscopy, Canada, Company Share by Revenue ($ mn), 2007-2008 68
Table 45: Joint Reconstruction, Canada, Company Share by Revenue ($ mn), 2007-2008 69
Table 46: Orthobiologics, Canada, Company Share by Revenue ($ mn), 2007-2008 71
Table 47: Orthopedic Accessories, Canada, Company Share by Revenue ($ mn), 2007-2008 72
Table 48: Orthopedic Braces and Supports, Canada, Company Share by Revenue ($ mn), 2007-2008 73
Table 49: Spinal Surgery, Canada, Company Share by Revenue ($ mn), 2007-2008 74
Table 50: Trauma Fixation, Canada, Company Share by Revenue ($ mn), 2007-2008 75
Table 51: DePuy, Inc. Pipeline Products by Equipment Type 76
Table 52: DePuy, Inc. Pipeline Products by Development Stage 77
Table 53: DePuy, Inc. Pipeline Products by Therapy Area 77
Table 54: DePuy, Inc. Pipeline Products by Clinical Trials 78
Table 55: DePuy, Inc. Pipeline Products by News Summaries 78
Table 56: Stryker Corporation Pipeline Products by Equipment Type 81
Table 57: Stryker Corporation Pipeline Products by Development Stage 81
Table 58: Stryker Corporation Pipeline Products by Therapy Area 82
Table 59: Stryker Corporation Pipeline Products by Clinical Trials 82
Table 60: Zimmer Holdings, Inc. Pipeline Products by Equipment Type 86
Table 61: Zimmer Holdings, Inc. Pipeline Products by Development Stage 86
Table 62: Zimmer Holdings, Inc. Pipeline Products by Therapy Area 86
Table 63: Zimmer Holdings, Inc. Pipeline Products by Clinical Trials 87
Table 64: Medtronic, Inc. Pipeline Products by Equipment Type 91
Table 65: Medtronic, Inc. Pipeline Products by Development Stage 93
Table 66: Medtronic, Inc. Pipeline Products by Therapy Area 95
Table 67: Medtronic, Inc. Pipeline Products by Clinical Trials 97
Table 68: Medtronic, Inc. Pipeline Products by News Summaries 98
Table 69: Synthes, Inc. Pipeline Products by Equipment Type 101
Table 70: Synthes, Inc. PipeAline Products by Development Stage 102
Table 71: Synthes, Inc. Pipeline Products by Therapy Area 102
Table 72: Synthes, Inc. Pipeline Products by Clinical Trials 102
Table 73: Smith & Nephew Plc Pipeline Products by Equipment Type 106
Table 74: Smith & Nephew Plc Pipeline Products by Development Stage 106
Table 75: Smith & Nephew Plc Pipeline Products by Therapy Area 107
Table 76: Biomet, Inc. Pipeline Products by Equipment Type 110
Table 77: Biomet, Inc. Pipeline Products by Development Stage 110
Table 78: Biomet, Inc. Pipeline Products by Therapy Area 111
Table 79: Biomet, Inc. Pipeline Products by Clinical Trials 111
Table 80: Arthrocare Corporation Pipeline Products by Equipment Type 116
Table 81: Arthrocare Corporation Pipeline Products by Development Stage 116
Table 82: Arthrocare Corporation Pipeline Products by Therapy Area 117
Table 83: Arthrocare Corporation Pipeline Products by News Summary 117
Table 84: Genzyme Corporation Pipeline Products by Equipment Type 121
Table 85: Genzyme Corporation Pipeline Products by Development Stage 122
Table 86: Genzyme Corporation Pipeline Products by Therapy Area 123
Table 87: Genzyme Corporation Pipeline Products by Clinical Trials 123
Table 88: Genzyme Corporation Pipeline Products by News Summaries 124
Table 89: Osteotech, Inc. Pipeline Products by Equipment Type 124
Table 90: Osteotech, Inc. Pipeline Products by Development Stage 125
Table 91: Osteotech, Inc. Pipeline Products by Therapy Area 125
Table 92: Orthofix International N.V. Pipeline Products by Equipment Type 131
Table 93: Orthofix International N.V. Pipeline Products by Development Stage 131
Table 94: Orthofix International N.V. Pipeline Products by Therapy Area 131
Table 95: Orthofix International N.V. Pipeline Products by Clinical Trials 132
Table 96: Orthofix International N.V. Pipeline Products by News Summaries 132
Table 97: Biorthex Inc. Pipeline Products by Equipment Type 139
Table 98: Biorthex Inc. Pipeline Products by Development Stage 139
Table 99: Biorthex Inc. Pipeline Products by Therapy Area 139
Table 100: BioSyntech, Inc. Pipeline Products by Equipment Type 140
Table 101: BioSyntech, Inc. Pipeline Products by Development Stage 140
Table 102: BioSyntech, Inc. Pipeline Products by Therapy Area 141
Table 103: BioSyntech, Inc. Pipeline Products by Clinical Trials 141
Table 104: BioSyntech, Inc. Pipeline Products by News Summary 141
Table 105: NuVasive To Acquire Cervitech 144
Table 106: Arkema Acquires Oxford Performance Materials 145
Table 107: Michigan Orthopedic Services Acquires O&P Professional Care 146
Table 108: Hanger Orthopedic Group Completes Six Acquisitions 147
Table 109: Advanced Technology Acquisition To Acquire Bioness 148
Table 110: NovaMed Acquires Majority Interest In Physicians Surgical Center 149
Table 111: Tornier Enters Into Licensing Agreement With T.A.G. Medical Products 150
Table 112: DJO Surgical Signs An Agreement With LimaGroup 151
Table 113: RTI Biologics Enters Into An Agreement With Aesculap Implant Systems 152
Table 114: StemCor Systems Enters Into An Agreement With Hospira 153
Table 115: NeuralStem Enters Into An Agreement With The Cleveland Clinic 154
Table 116: USD to Local Currency, Average Exchange Rate 2008 176



1.2 List of Figures
Figure 1: Orthopedic Devices, North America, Overall Revenue ($ mn), 2000-2015 19
Figure 2: North America, Orthopedic Devices, Cross -Category Analysis, 2000-2015 20
Figure 3: Orthopedic Devices, North America, Overall Revenue ($ mn), Historic, 2000-2008 21
Figure 4: Orthopedic Devices, North America, Overall Revenue ($ mn), Forecast, 2008-2015 23
Figure 5: Orthopedic Devices, North America, Category Volume (Units), 2000-2015 25
Figure 6: Orthopedic Devices, North America, Category Volume (Units), Historic, 2000-2008 26
Figure 7: Orthopedic Devices, North America, Category Volume (Units), Forecast, 2008-2015 28
Figure 8: Orthopedic Devices, North America, Company Share (%), 2008 30
Figure 9: Orthopedic Devices, United States, Overall Revenue ($ mn), 2000-2015 31
Figure 10: Orthopedic Devices, United States, Overall Revenue ($ mn), Historic, 2000-2008 32
Figure 11: Orthopedic Devices, United States, Overall Revenue ($ mn), Forecast, 2008-2015 33
Figure 12: Orthopedic Devices, United States, Category Volume (Units), 2000-2015 35
Figure 13: Orthopedic Devices, United States, Category Volume (Units), Historic, 2000-2008 36
Figure 14: Orthopedic Devices, United States, Category Volume (Units), Forecast, 2008-2015 38
Figure 15: Orthopedic Devices, United States, Company Share (%), 2008 44
Figure 16: Arthroscopy, United States, Company Share (%), 2008 45
Figure 17: Joint Reconstruction, United States, Company Share (%), 2008 46
Figure 18: Orthobiologics, United States, Company Share (%), 2008 47
Figure 19: Orthopedic Accessories, United States, Company Share (%), 2008 49
Figure 20: Orthopedic Braces and Supports, United States, Company Share (%), 2008 50
Figure 21: Spinal Surgery, United States, Company Share (%), 2008 51
Figure 22: Trauma Fixation, United States, Company Share (%), 2008 52
Figure 23: Orthopedic Devices, Canada, Overall Revenue ($ mn), 2000-2015 53
Figure 24: Orthopedic Devices, Canada, Overall Revenue ($ mn), Historic, 2000-2008 54
Figure 25: Orthopedic Devices, Canada, Overall Revenue ($ mn), Forecast, 2008-2015 56
Figure 26: Orthopedic Devices, Canada, Category Volume (Units), 2000-2015 58
Figure 27: Orthopedic Devices, Canada, Category Volume (Units), Historic, 2000-2008 59
Figure 28: Orthopedic Devices, Canada, Category Volume (Units), Forecast, 2008-2015 61
Figure 29: Orthopedic Devices, Canada, Company Share (%), 2008 67
Figure 30: Arthroscopy, Canada, Company Share (%), 2008 68
Figure 31: Joint Reconstruction, Canada, Company Share (%), 2008 69
Figure 32: Orthobiologics, Canada, Company Share (%), 2008 70
Figure 33: Orthopedic Accessories, Canada, Company Share (%), 2008 72
Figure 34: Orthopedic Braces and Supports, Canada, Company Share (%), 2008 73
Figure 35: Spinal Surgery, Canada, Company Share (%), 2008 74
Figure 36: Trauma Fixation, Canada, Company Share (%), 2008 75
Figure 37: Stryker Corporation Value Chain Analysis 79
Figure 38: Zimmer Holdings, Inc. Value Chain Analysis 84
Figure 39: Medtronic, Inc. Value Chain Analysis 88
Figure 40: Synthes, Inc. Value Chain Analysis 100
Figure 41: Smith & Nephew Plc Value Chain Analysis 103
Figure 42: Biomet, Inc. Value Chain Analysis 108
Figure 43: Arthrocare Corporation Value Chain Analysis 114
Figure 44: CONMED Corporation, Value Chain Analysis 118
Figure 45: Hanger Orthopedic Group, Inc. Value Chain Analysis 126
Figure 46: Orthofix International N.V., Value Chain Analysis 129
Figure 47: DJO Incorporated, Value Chain Analysis 133
Figure 48: Johnson & Johnson Value Chain Analysis 136
Figure 49: Global Markets Direct Methodology 172