Table of Contents
- EXECUTIVE SUMMARY
- Definitions
- Materials and Their Uses
- Bone
- Polymers
- Ceramics
- Other Orthopaedic Biomaterials
- Growth Factors
- Surgical Sealants and Glues
- Anti-Adhesion Products
- Tissue Engineering
- The Market
- Total Orthopaedic Market
- Orthopaedic Biomaterials
- Industry
Section 1: INTRODUCTION TO ORTHOPEDIC SURGERY AND BIOMATERIALS
- 1.1 Definitions
- 1.1.1 Bone
- 1.1.2 Bone Formation
- 1.2 Orthopedic Surgery
- 1.2.1 Hip Replacement
- 1.2.1.1 Procedures and Biomaterials
- 1.2.1.2 Caseload
- 1.3 Knee Replacement and Repair
- 1.3.1 Knee Replacement: Technique and Biomaterials
- 1.3.1.1 Anterior Cruciate Ligament (ACL) Repair
- 1.3.1.2 Caseload
- 1.3.2 Spinal Surgery
- 1.3.2.1 Surgical Procedures and Biomaterials
- 1.3.2.2 Caseload
- 1.3.3 Fractures
- 1.4 Orthopedic Biomaterials
- 1.4.1 Graft Materials
- 1.4.1.1 Bone Allografts
- 1.4.1.2 Cartilage Allografts
- 1.4.1.3 Tendon Allografts
- 1.4.1.4 Safety Concerns with Allografts
- 1.4.2 Polymers
- 1.4.2.1 Polymers Used as Biomaterials
- 1.4.2.2 Bioresorbable Polymers
- 1.4.3 Ceramics
- 1.4.3.1 Ceramic Bone Implants
- 1.4.3.2 Ceramic-on-Ceramic Implants
- 1.4.3.3 Ceramic Dental Implants
- 1.4.4 Surgical Glues and Sealants
- 1.4.4.1 Types of Surgical Sealants
- 1.4.5 Anti-Adhesives
- 1.4.5.1 Research in Anti-Adhesives
- 1.4.6 Tissue Engineering
- 1.4.6.1 Comparison with Other Therapies
- 1.4.6.2 Current Research in Tissue Engineering
- 1.4.7 Growth Factors
Section 2: PRODUCT AND TECHNOLOGY OFFERINGS
- 2.1 Advances in Bone Graft Materials
- 2.1.1 Selected Product Offerings
- 2.1.1.1 Allosource
- 2.1.1.2 AltivaCorp
- 2.1.1.3 Cortek
- 2.1.1.4 LifeNet
- 2.1.1.5 Osteotech Inc.
- 2.1.1.6 Tutogen Medical
- 2.2 Synthetic Bone Substitutes
- 2.2.1 Selected Product Offerings
- 2.2.1.1 Biocoral Inc.
- 2.2.1.2 CeraPedics
- 2.2.1.3 CryoLife
- 2.2.1.4 ETEX Corp.
- 2.2.1.5 Medtronic Sofamor Danek
- 2.2.1.6 Novabone LLC
- 2.2.1.7 OsteoBiologics Inc.
- 2.3 Polymer-based Biomaterials
- 2.3.1 Selected Product Offerings
- 2.3.1.1 Arthrex Inc.
- 2.3.1.2 Arthrotek Inc.
- 2.3.1.3 Biocoat Inc.
- 2.3.1.4 Durect Corp.
- 2.3.1.5 Invibio Material Solutions
- 2.3.1.6 Protein Polymer Technologies Inc (PPTI)
- 2.3.1.7 Smith & Nephew plc
- 2.3.1.8 Zimmer Holdings
- 2.4 Ceramics
- 2.4.1 Selected Product Offerings
- 2.4.1.1 Amedica Corp.
- 2.4.1.2 Angstrom Medica Inc
- 2.4.1.3 ApaTech Ltd
- 2.4.1.4 Berkeley Advanced Biomaterials
- 2.4.1.5 CeramTec AG
- 2.4.1.6 Encore Medical
- 2.4.1.7 Interpore Cross International Inc.
- 2.4.1.8 Japan Medical Materials Company
- 2.4.1.9 Metoxit AG
- 2.4.1.10 Morgan Technical Ceramics
- 2.4.1.11 NovaBone Products LLC
- 2.4.1.12 OrthoVita Inc
- 2.4.1.13 OsteoBiologics Inc
- 2.4.1.14 Stryker
- 2.4.1.15 Teknimed SA
- 2.4.1.16 Wright Medical Technology
- 2.5 Growth Factors
- 2.5.1 Selected Product Offerings
- 2.5.1.1 Acologix
- 2.5.1.2 BioMimetic Therapeutics
- 2.5.1.3 BD Biosciences
- 2.5.1.4 Biodesign International
- 2.5.1.5 OrthoLogic
- 2.5.1.6 Stryker
- 2.6 Tissue Engineering
- 2.6.1 Selected Product Offerings
- 2.6.1.1 Aastrom Biosciences Inc.
- 2.6.1.2 Encelle Inc.
- 2.6.1.3 Integra Life Sciences
- 2.6.1.4 Isto Technologies Inc.
- 2.6.1.5 Ortec International Inc.
- 2.6.1.6 Osiris Therapeutics Inc.
- 2.6.1.7 TEI Biosciences Inc.
- 2.7 Sealants and Glues
- 2.7.1 Selected Product Offerings
- 2.7.1.1 Abbott Laboratories
- 2.7.1.2 Closure Medical
- 2.7.1.3 Angiotech Pharmaceuticals
- 2.7.1.4 Baxter
- 2.7.1.5 Confluent Surgical Inc.
- 2.7.1.6 Haemacure Corp.
- 2.7.1.7 Cryolife
- 2.7.1.8 Nycomed
- 2.7.1.9 ThermoGenesis Corp.
- 2.7.1.10 Tissuemed Ltd.
- 2.8 Anti-Adhesion Products
- 2.8.1 Selected Product Offerings
- 2.8.1.1 Angiotech Pharmaceuticals
- 2.8.1.2 Confluent Surgical
- 2.8.1.3 Genzyme Inc.
- 2.8.1.4 Johnson & Johnson Inc.
- 2.8.1.5 Tissuemed
- 2.9 Orthopedic Surgical Trends
Section 3: THE ORTHOPEDIC BIOMATERIALS MARKET: SIZE, GROWTH, PARTICIPANTS AND
TRENDS
- 3.1 Market Size
- 3.2 The Market for Orthopaedic Biomaterials
- 3.3 Regional Markets
- 3.3.1 North America
- 3.3.2 Western Europe
- 3.3.3 Japan
- 3.4 Markets by Materials
- 3.4.1 Allografts
- 3.4.1.1 Companies and Products
- 3.4.2 Synthetic Bone Substitutes
- 3.4.3 Polymers
- 3.4.3.1 Companies and Products
- 3.4.4 Ceramics
- 3.4.4.1 Companies and Products
- 3.4.5 Growth Factors
- 3.4.5.1 Companies and Products
- 3.4.6 Tissue Engineering
- 3.4.7 Sealants and Glues
- 3.4.7.1 Companies and Products
- 3.4.8 Anti-Adhesion Products
- 3.4.8.1 Companies and Products
- 3.4.9 Other - Viscosupplementation
- 3.4.9.1 Market
- 3.4.9.2 Companies and Products
- 3.5 Market Analysis by Clinical Use
- 3.5.1 Hip and Knee Surgery
- 3.5.2 Spinal Surgery
- 3.5.3 Trauma
- 3.6 Leading Companies
Section 4: Company profiles
- 4.1 Aastrom Biosciences, Inc.
- 4.1.1 Products
- 4.1.2 Financials
- 4.2 Absorbable Polymer International
- 4.3 Acologix Inc.
- 4.3.1 Products
- 4.3.2 Financials
- 4.4 Advanced Cell Technology Inc.
- 4.5 Allograft Tissue Systems Inc (ATSI)
- 4.6 Allosource
- 4.7 Alphatec Spine, Inc.
- 4.8 Altiva Corporation
- 4.9 Amedica Corporation
- 4.9.1 Products
- 4.9.2 Financials
- 4.10 Angstrom Medica Inc.
- 4.10.1 Product
- 4.10.2 Financials
- 4.11 ApaTech Ltd.
- 4.12 Arthrex
- 4.13 Arthrotek
- 4.14 Artimplant
- 4.14.1 Products
- 4.14.1.1 Artelon Bone Scaffold
- 4.14.1.2 Artelon Membrane
- 4.14.1.3 Artelon TMC Spacer
- 4.14.1.4 SportMesh
- 4.14.2 Financials
- 4.15 Berkeley Advanced Biomaterials Inc.
- 4.15.1 Products
- 4.15.1.1 Bi-Ostetic
- 4.15.1.2 Cem-Ostetic
- 4.15.1.3 GenerOs
- 4.15.1.4 Demineralized Bone Matrix
- 4.16 Biocoat Inc.
- 4.16.1 Product: Hyaluronan
- 4.17 Biocomposites Ltd
- 4.17.1 Prducts
- 4.17.1.1 Bilok
- 4.17.1.2 Biosteon
- 4.17.1.3 Genex
- 4.17.1.4 Allogran-R
- 4.17.1.5 Stimulan
- 4.18 Biocoral, Inc.
- 4.19 BioMimetic Therapeutics Inc.
- 4.19.1 Products
- 4.19.2 Financials
- 4.20 Biopharm GmbH
- 4.20.1 Product: rhGDF-5/MP52
- 4.21 BioSyntech Inc.
- 4.22 CeramTec AG
- 4.22.1 Products
- 4.22.1.1 Hip Joint Components
- 4.22.1.2 Knee Joint Components
- 4.23 CeraPedics LLC
- 4.24 Clearant Inc.
- 4.25 Closure Medical Corporation
- 4.26 Cortek, Inc.
- 4.27 Cryolife, Inc.
- 4.27.1 Products
- 4.27.1.1 BioGlue
- 4.27.1.2 BioDisc
- 4.27.2 Financials
- 4.28 De Puy Inc.
- 4.28.1 Products
- 4.28.1.1 α-BSM Bone Substitute Material
- 4.28.1.2 Conduit TCP Granules
- 4.28.1.3 Cellect
- 4.28.1.4 Symphony II PCS
- 4.28.1.5 I/C Graft Chamber
- 4.28.1.6 Charité Artificial Disc
- 4.28.2 Financials
- 4.29 Encelle Inc.
- 4.29.1 Product: E-Matrix
- 4.29.2 Financials
- 4.30 Encore Medical
- 4.30.1 Products
- 4.30.1.1 Keramos
- 4.30.1.2 3DMatrix porous coating
- 4.30.2 Financials
- 4.31 Enobia Pharma Inc.
- 4.32 Etex Corporation.
- 4.33 Fidia Advanced Biopolymers s.r.l.
- 4.33.1 Products
- 4.33.1.1 HYAFF
- 4.33.1.2 TissueTech
- 4.34 FzioMed Inc.
- 4.35 Genzyme Biosurgery, Inc.
- 4.35.1 Products
- 4.35.2 Financials
- 4.36 Haemacure Corporation
- 4.37 Inion Ltd
- 4.38 Integra Lifesciences Holdings Corporation
- 4.38.1 Products
- 4.38.1.1 Duraplasty Products
- 4.38.1.2 Adhesion Barrier for the Spine
- 4.38.2 Financials
- 4.39 Interpore Cross International
- 4.40 Invibio Material Solutions
- 4.41 Isotis, N.V.
- 4.41.1 Products
- 4.41.1.1 Accell
- 4.41.1.2 Other Products
- 4.41.2 Financials
- 4.42 Isto Technologies Inc.
- 4.42.1 Products
- 4.42.2 Financials
- 4.43 Japan Medical Materials Corporation
- 4.44 LifeCell Corp.
- 4.44.1 Product: AlloDerm
- 4.44.2 Financials
- 4.45 LifeNet Allografts
- 4.46 Medtronic Sofamor Danek
- 4.46.1 Products
- 4.46.1.1 Prestige LP Cervical Disc
- 4.46.1.2 Infuse Bone Graft
- 4.46.1.3 Minimal Access Spinal Surgery
- 4.46.2 Financials
- 4.47 Metoxit AG
- 4.48 Morgan Advanced Ceramics
- 4.48.1 Products
- 4.48.2 Financials
- 4.49 NovaBone Products LLC
- 4.49.1 Products
- 4.49.1.1 PerioGlas
- 4.49.1.2 NovaBone-C/M
- 4.49.1.3 NovaBone
- 4.50 Ortec International, Inc.
- 4.50.1 Products
- 4.50.1.1 Orcel
- 4.50.1.2 Other Product Candidates
- 4.51 OrthoLogic Corporation
- 4.51.1 Products
- 4.51.2 Financials
- 4.52 Orthovita, Inc.
- 4.52.1 Products
- 4.52.1.1 Vitoss
- 4.52.1.2 Cortoss
- 4.52.1.3 Rhakoss
- 4.52.2 Financials
- 4.53 Osiris Therapeutics Inc.
- 4.53.1 Products
- 4.53.1.1 Osteocel
- 4.53.1.2 Prochymal
- 4.53.1.3 Provacel
- 4.53.1.4 Chondrogen
- 4.53.2 Financials
- 4.54 OsteoBiologics Inc
- 4.55 Osteohealth Company
- 4.55.1 Products
- 4.55.1.1 Bio-Oss
- 4.55.1.2 Bio-Gide
- 4.55.1.3 Bio-Oss Collagen
- 4.55.1.4 Gem 21S
- 4.56 Osteotech, Inc.
- 4.56.1 Products
- 4.56.2 Financials
- 4.57 Protein Polymer Technologies Inc.
- 4.57.1 Spinal Product: Injectable Disc Nucleus
- 4.58 Regen Biologics, Inc.
- 4.59 Regeneration Technologies, Inc.
- 4.59.1 Products
- 4.59.1.1 BioCleanse
- 4.59.1.2 Sterling Biological Matrix
- 4.60 Smith & Nephew, plc.
- 4.60.1 Products
- 4.60.1.1 Exogen
- 4.60.1.2 Supartz
- 4.60.2 Financials
- 4.61 Stryker Biotech
- 4.61.1 Products
- 4.61.1.1 OP-1
- 4.61.1.2 TissueMend
- 4.61.1.3 HydroSet
- 4.61.1.4 BoneSource
- 4.61.1.5 BoneSave
- 4.61.2 Financials
- 4.62 Synthes, Inc.
- 4.62.1 Products
- 4.62.1.1 Norian SRS
- 4.62.1.2 chronOS
- 4.62.1.3 PolyMax
- 4.62.1.4 Norian Craniofacial Repair System
- 4.62.2 Financials
- 4.63 TEI Biosciences
- 4.63.1 Products
- 4.63.1.1 SurgiMend
- 4.63.1.2 PriMatrix
- 4.63.1.3 Durepair
- 4.63.1.4 TissueMend
- 4.63.1.5 Xenform
- 4.64 Teknimed SA
- 4.64.1 Products
- 4.64.1.1 Hydroxyapatite
- 4.64.1.2 Cementek
- 4.64.1.3 TRIHA +
- 4.64.1.4 Ceraform
- 4.65 Tutogen Medical, Inc.
- 4.66 Wright Medical Technology, Inc.
- 4.66.1 Products
- 4.66.1.1 Osteogenic Grafting Solutions
- 4.66.1.2 Synthetic Grafting Solutions
- 4.66.1.3 Advanced Membrane Technology
- 4.66.2 Financials
APPENDIX
Company Contact Details
List of Exhibits
- Exhibit ES-1: Examples of Polymers Used in Orthopaedics
- Exhibit ES-2: Worldwide Market for Orthopaedic Devices
- Exhibit ES-3: Size and Growth of Worldwide Orthopaedic Biomaterials
Market, 2006-2011
- Exhibit ES-4: Orthopaedic Biomaterials Market by Region, 2006
- Exhibit ES-5: Company Shares of the U.S. Orthopaedic Biomaterials Market,
2005
- Exhibit 2-1: Allograft Products
- Exhibit 2-2: Synthetic Bone Products
- Exhibit 2-3: Polymer-Based Products
- Exhibit 2-4: Ceramic-Based Products
- Exhibit 2-5: Growth Factor Products
- Exhibit 2-6: Tissue Engineering Products
- Exhibit 2-7: Sealants and Haemostat Products
- Exhibit 2-8: Anti-Adhesion Products
- Exhibit 3-1: Current Value and Growth of Orthopaedic Device Market
- Exhibit 3-2: Countries Having at Least 10% of Their Population Age 65 and
Over, by Population Totals and Percentages, 2003
- Exhibit 3-3: Size and Growth of Worldwide Orthopaedic Biomaterials Market,
2006-2011
- Exhibit 3-4: Main Product Groups in US Orthopaedic Biomaterials Market,
2005
- Exhibit 3-5: European Orthopaedics Market, 2005
- Exhibit 3-6: Orthopaedic Biomaterials Market by Region, 2006
- Exhibit 3-7: Allograft Market in 2006 and 2011
- Exhibit 3-8: Regional Distribution of World Allograft Market, 2006
- Exhibit 3-9: Worldwide Market for Synthetic Bone Substitutes, 2006-2011
- Exhibit 3-10: Polymers in Orthopaedic Biomaterials: Market Value and Growth
- Exhibit 3-11: Regional Distribution of World Market for Orthopaedic
Polymers, 2006
- Exhibit 3-12: Worldwide Market for Ceramic Biomaterials, 2006-2011
- Exhibit 3-13: Regional Distribution of World Market for Orthopaedic
Ceramics, 2006
- Exhibit 3-14: Worldwide Market for Bone Growth Factors, 2006-2011
- Exhibit 3-15: Regional Distribution of World Market for Orthopaedic Bone
Growth Factors, 2006
- Exhibit 3-16: Worldwide Market for Surgical Sealants, Glues and Haemostats
- Exhibit 3-17: Regional Distribution of World Market for Sealants, Glues
and Haemostats in Orthopaedics, 2006
- Exhibit 3-18: Worldwide Market for Anti-Adhesive Products
- Exhibit 3-19: Regional Distribution of World Anti-Adhesion Products
Market, 2006
- Exhibit 3-20: World Orthopaedic Biomaterials Market, 2006-2011, By Product
Categories
- Exhibit 3-21: World and Regional Viscosupplementation Markets, 2006
- Exhibit 3-22: Sales of Leading Hyaluronic Acid Products, 2005
- Exhibit 3-23: Orthopaedic Market by Clinical Use and Device Type, 2006
- Exhibit 3-24: Hip and Knee replacements, USA
- Exhibit 3-25: Company Shares in the Main Regional Orthopaedic Biomaterials
Markets, 2005
- Exhibit 4-1: Aastrom Financial Data, Year to June 30th 2006
- Exhibit 4-2: Advanced Cell Technology Financial Data for Six months to
June 30, 2006
- Exhibit 4-3: Artimplant Selected Financial Data, 2004-2005
- Exhibit 4-4: BioMimetic Selected Financial Data for Six Months to June 30
2006 and 2005
- Exhibit 4-5: CryoLife Selected Financial Data, 2005
- Exhibit 4-6: Encore Medical Selected Financial Data, 2004-2005
- Exhibit 4-7: Integra Lifesciences Selected Financial Data, 2004-2005
- Exhibit 4-8: IsoTis Selected Financial Data, 2004-2005
- Exhibit 4-9: LifeCell Selected Financial Data, 2005
- Exhibit 4-10: Medtronic Selected Financial Data for Years to April 30th
2006 and 2005
- Exhibit 4-11: The Morgan Crucible Company Selected Financial Data for The
Morgan Crucible Company, 2005
- Exhibit 4-12: OrthoLogic Selected Financial Data, 2003-2005
- Exhibit 4-13: OrthoVita Selected Financial Data, 2004-2005
- Exhibit 4-14: Osiris Therapeutics Selected Financial Data, Six Months to
June 30th, 2006
- Exhibit 4-15: Osteotech Selected Financial Data, 2003-2005
- Exhibit 4-16: Smith & Nephew, Selected Financial Data, 2004-2005
- Exhibit 4-17: Stryker Selected Financial Data for 9 months to September
30th 2006 and 2005
- Exhibit 4-18: Synthes Selected Dinancial Data, 2004-2005
- Exhibit 4-19: Wright Medical Group Selected Financial Data for the first 9
months of 2006 and 2005
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